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公开(公告)号：US06890710B1
公开(公告)日：2005-05-10
申请号：US08444994
申请日：1995-05-19
Applicant: Peter Palese , Robert O'Neill
Inventor： Peter Palese , Robert O'Neill
IPC: G01N33/566 , A61K38/00 , A61P31/12 , C07K14/47 , C12N1/21 , C12N15/09 , C12P21/02 , C12Q1/70 , C12R1/19 , G01N33/50 , G01N33/569
CPC classification number: G01N33/502 , C07K14/4703 , C12Q1/70 , G01N33/5008 , G01N33/56983 , G01N2333/11 , G01N2500/20
Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection.The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS1. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.
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2.发明申请Techniques for employing electric brakes to control movement of rotatable components 有权采用电动刹车来控制旋转部件运动的技术公开(公告)号：US20060208565A1
公开(公告)日：2006-09-21
申请号：US11081437
申请日：2005-03-16
Applicant: Robert O'Neill
Inventor： Robert O'Neill
IPC: B60T7/00
Abstract: A brake assembly includes a mounting plate, pressure members disposed in a substantially coplanar manner relative to the mounting plate, and electric actuators mounted to the mounting plate. The electric actuators are configured to selectively move the pressure members relative to the mounting plate (i) from a non-braking position to a braking position in response to a first command, and (ii) from the braking position to the non-braking position in response to a second command. Such a brake assembly is well-suited for a variety of applications including vehicle brakes such as aircraft brakes.
Abstract translation: 制动组件包括安装板，相对于安装板以基本共面的方式设置的压力构件以及安装到安装板的电致动器。 电动执行器构造成响应于第一命令，将压力构件相对于安装板（i）选择性地从非制动位置移动到制动位置，并且（ii）从制动位置到非制动位置 响应于第二个命令。 这种制动组件非常适用于各种应用，包括诸如飞机制动器的车辆制动器。
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3.发明授权Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication 失效鉴定和使用抑制病毒复制所需的宿主细胞蛋白和病毒蛋白相互作用的抗病毒化合物
公开(公告)号：US5750394A
公开(公告)日：1998-05-12
申请号：US246583
申请日：1994-05-20
Applicant: Peter Palese , Robert O'Neill
Inventor： Peter Palese , Robert O'Neill
IPC: G01N33/566 , A61K38/00 , A61P31/12 , C07K14/47 , C12N1/21 , C12N15/09 , C12P21/02 , C12Q1/70 , C12R1/19 , G01N33/50 , G01N33/569 , C07H21/04 , C12N5/10 , C12N15/63
CPC classification number: G01N33/502 , C07K14/4703 , C12Q1/70 , G01N33/5008 , G01N33/56983 , G01N2333/11 , G01N2500/20
Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the discovery described herein of a novel interaction between the NP of influenza virus and a human host cell protein. The host cell protein, referred to herein as NPI-1, may be an accessory protein required for replication of influenza virus. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.
Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白质，以及用于鉴定干扰病毒和宿主细胞蛋白质之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于本文所述的流感病毒的NP与人宿主细胞蛋白之间的新的相互作用的发现。 本文称为NPI-1的宿主细胞蛋白可以是复制流感病毒所需的辅助蛋白质。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。
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4.发明授权Nucleic acids encoding a novel influenza virus non-structural protein (NS1)-binding host factor designated NS1I-1 有权编码新型流感病毒非结构蛋白（NS1）结合宿主因子的指定NS1I-1的核酸公开(公告)号：US07498424B2
公开(公告)日：2009-03-03
申请号：US10724273
申请日：2003-11-24
Applicant: Peter Palese , Robert O'Neill
Inventor： Peter Palese , Robert O'Neill
IPC: C07H21/02
CPC classification number: G01N33/502 , C07K14/4703 , C12Q1/70 , G01N33/5008 , G01N33/56983 , G01N2333/11 , G01N2500/20
Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection.The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS1. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.
Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白，以及用于鉴定干扰病毒和宿主细胞蛋白之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于申请人发现流感病毒的蛋白质与人宿主细胞蛋白质之间的新的相互作用。 这些宿主细胞蛋白之一，本文称为NPI-1，与流感病毒蛋白NP相互作用，并且可能是复制流感病毒所需的辅助蛋白。 这些宿主细胞蛋白质（本文称为NS1I-1）中的另一种与流感病毒蛋白NS1相互作用。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。
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Patent Agency Ranking
公开(公告)号：US06503703B1
公开(公告)日：2003-01-07
申请号：US09636791
申请日：2000-08-11
Applicant: Peter M Palese , Robert O'Neill , Ronald Harty
Inventor： Peter M Palese , Robert O'Neill , Ronald Harty
IPC: C12Q100
CPC classification number: C07K14/005 , A61K38/00 , C12N15/1055 , C12N2760/16122 , G01N33/56983 , G01N2333/11
Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the Applicants' discovery of novel interactions between viral proteins and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP. Also, host cell proteins, referred to herein as NS1I-1 and NS1-BP interact with influenza virus protein NS1. In addition, host cell proteins containing WW domains that interact with viral proteins such as Rhabdoviral M protein are described. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.
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6.发明申请Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication 有权鉴定和使用抑制病毒复制所需的宿主细胞蛋白和病毒蛋白相互作用的抗病毒化合物公开(公告)号：US20050191703A1
公开(公告)日：2005-09-01
申请号：US10724273
申请日：2003-11-24
Applicant: Peter Palese , Robert O'Neill
Inventor： Peter Palese , Robert O'Neill
IPC: G01N33/566 , A61K38/00 , A61P31/12 , C07K14/47 , C12N1/21 , C12N15/09 , C12P21/02 , C12Q1/70 , C12R1/19 , G01N33/50 , G01N33/569 , C12Q1/68 , C12P21/06 , G01N33/53
CPC classification number: G01N33/502 , C07K14/4703 , C12Q1/70 , G01N33/5008 , G01N33/56983 , G01N2333/11 , G01N2500/20
Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the Applicants' discovery of novel interactions between proteins of the influenza virus and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP, and may be an accessory protein required for replication of influenza virus. Another of these host cell proteins, referred to herein as NS1I-1, interacts with influenza virus protein NS1. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.
Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白质，以及用于鉴定干扰病毒和宿主细胞蛋白质之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于申请人发现流感病毒的蛋白质与人宿主细胞蛋白质之间的新的相互作用。 这些宿主细胞蛋白之一，本文称为NPI-1，与流感病毒蛋白NP相互作用，并且可能是复制流感病毒所需的辅助蛋白。 这些宿主细胞蛋白质（本文称为NS1I-1）中的另一种与流感病毒蛋白NS1相互作用。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。
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公开(公告)号：US5701356A
公开(公告)日：1997-12-23
申请号：US567154
申请日：1995-12-05
Applicant: Thomas H. Stanford , Farhad Noroozi Sahne , Thomas P. Riches , Robert O'Neill
Inventor： Thomas H. Stanford , Farhad Noroozi Sahne , Thomas P. Riches , Robert O'Neill
CPC classification number: H04R5/023
Abstract: The transducer support assembly includes a transducer secured to a U-shaped strap having a pair of chest engageable leg portions connected integrally to a curved neck engageable portion by a pair of twisted intermediate portions for engaging the body of the user. The chest engageable leg portions are adapted to fit over the shoulders and to lie substantially flat against the chest of the user. A wide portion of the neck engageable portion extends in overlying substantially continuous engagement with the neck or back of the user to resist the chest engageable leg portions from swinging away from the chest. A gripping material forms an underside surface of the strap to frictionally engage the user, thereby inhibiting the strap from moving relative to the body of the user. Another transducer support assembly includes a flexible U-shaped neck support having a chest engageable portion. A transducer secured within a transducer support is coupled slidably to the chest engageable portion to enable it to be selectively positioned relative to the chest engageable portion.
Abstract translation: 传感器支撑组件包括固定到U形带的换能器，该U形带具有一对胸部可接合的腿部，通过一对扭转的中间部分一体地连接到弯曲的颈部可接合部分，用于接合使用者的身体。 胸部可接合的腿部适于装配在肩部上并且基本上平坦地抵靠使用者的胸部。 颈部可接合部分的大部分以覆盖与使用者的颈部或背部的基本上连续的接合方式延伸，以抵抗胸部可接合的腿部部分远离胸部摆动。 夹持材料形成带的下表面以摩擦地接合使用者，从而阻止带相对于使用者的身体移动。 另一换能器支撑组件包括具有胸部可接合部分的柔性U形颈部支撑件。 固定在换能器支撑件内的换能器可滑动地联接到胸部可接合部分，以使其相对于胸部可接合部分被选择性地定位。
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8.发明授权Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication 有权鉴定和使用抑制病毒复制所需的宿主细胞蛋白和病毒蛋白相互作用的抗病毒化合物公开(公告)号：US07632801B2
公开(公告)日：2009-12-15
申请号：US10337213
申请日：2003-01-06
Applicant: Peter M. Palese , Robert O'Neill , Ronald Harty
Inventor： Peter M. Palese , Robert O'Neill , Ronald Harty
CPC classification number: C07K14/005 , A61K38/00 , C12N15/1055 , C12N2760/16122 , G01N33/56983 , G01N2333/11
Abstract: The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the Applicants' discovery of novel interactions between viral proteins and a human host cell proteins. One of these host cell proteins, referred to herein as NPI-1, interacts with influenza virus protein NP. Also, host cell proteins, referred to herein as NS1I-1 and NS1-BP interact with influenza virus protein NS1. In addition, host cell proteins containing WW domains that interact with viral proteins such as Rhabdoviral M protein are described. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.
Abstract translation: 本发明涉及鉴定与病毒复制所需的病毒蛋白相互作用的宿主细胞蛋白质，以及用于鉴定干扰病毒和宿主细胞蛋白质之间特异性相互作用的化合物的高通量测定。 抑制病毒复制的干扰化合物可用于治疗性治疗病毒感染。 本发明部分地基于申请人发现病毒蛋白和人宿主细胞蛋白之间的新的相互作用。 这些宿主细胞蛋白之一，本文称为NPI-1，与流感病毒蛋白NP相互作用。 此外，本文称为NS1I-1和NS1-BP的宿主细胞蛋白与流感病毒蛋白NS1相互作用。 此外，描述了含有与病毒蛋白如Rhabdoviral M蛋白相互作用的WW结构域的宿主细胞蛋白质。 干扰宿主细胞和病毒蛋白结合并抑制病毒复制的化合物可用于在体内治疗病毒感染。
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9.发明申请公开(公告)号：US20050033009A1
公开(公告)日：2005-02-10
申请号：US10942262
申请日：2004-09-16
Applicant: Alan Schrock , Ralph Priester , Wayne Willkom , Robert O'Neill , Martin Cornell , Christopher Christenson
Inventor： Alan Schrock , Ralph Priester , Wayne Willkom , Robert O'Neill , Martin Cornell , Christopher Christenson
CPC classification number: C08G18/6651 , B29C67/246 , B29K2075/00 , B60C17/06 , C08G18/10 , C08G18/4841 , C08G18/4866 , C08G2120/00 , C08G2380/00 , Y10T152/10054 , Y10T152/10522 , Y10T152/10738 , C08G18/6685
Abstract: A polyurethane-polymer composition suitable for preparing a lightweight tire support includes at least one isocyanate, at least one polyol, and at least one chain extender. A polyurethane-polymer composition can also include an additive such as a catalyst, a filler, a surfactant, a colorant, and a mold-release agent. A lightweight tire support can be prepared from a polyurethane-polymer composition by, for example, reaction injection molding. Such a tire support desirably has temperature stability and load-bearing capability.
Abstract translation: 适用于制备轻质轮胎支承体的聚氨酯 - 聚合物组合物包括至少一种异氰酸酯，至少一种多元醇和至少一种扩链剂。 聚氨酯 - 聚合物组合物还可以包括添加剂如催化剂，填料，表面活性剂，着色剂和脱模剂。 可以通过例如反应注射成型由聚氨酯 - 聚合物组合物制备轻质轮胎支撑体。 这样的轮胎支撑件期望地具有温度稳定性和承载能力。
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