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公开(公告)号：US08278063B2
公开(公告)日：2012-10-02
申请号：US12666601
申请日：2008-06-27
Applicant: Gunjan Pandey , Chris M. Coppin , Susan J. Dorrian , Robyn Russell , John Oakeshott
Inventor： Gunjan Pandey , Chris M. Coppin , Susan J. Dorrian , Robyn Russell , John Oakeshott
CPC classification number: B09C1/10 , C02F3/34 , C02F2103/343 , C12N9/48 , C12R1/365
Abstract: The invention relates to bacteria, bacterial extracts, supernatants obtained from the culturing of said bacteria, polypeptides and compositions for degrading benzimidazole carbamate fungicides, carbanilate fungicides, sulfonamide herbicides, thioamide herbicides and/or synthetic pyrethroid insecticides. In particular, the invention relates to the identification of Nocardioides sp. which degrades benzimidazole carbamate fungicides, carbanilate fungicides, sulfonamide herbicides, thioamide herbicides and/or synthetic pyrethroid insecticides.
Abstract translation: 本发明涉及细菌，细菌提取物，从培养所述细菌获得的上清液，多肽和用于降解苯并咪唑氨基甲酸酯杀真菌剂的组合物，氨基苯甲酸盐杀真菌剂，磺酰胺除草剂，硫代酰胺除草剂和/或合成的拟除虫菊酯杀虫剂。 特别地，本发明涉及诺卡氏菌属的鉴定。 其降解苯并咪唑氨基甲酸酯杀真菌剂，氨基苯甲酸盐杀真菌剂，磺酰胺除草剂，硫代酰胺除草剂和/或合成拟除虫菊酯杀虫剂。
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公开(公告)号：US20100279380A1
公开(公告)日：2010-11-04
申请号：US12666601
申请日：2008-06-27
Applicant: Gunjan Pandey , Chris M. Coppin , Susan J. Dorrian , Robyn Russell , John Oakeshott
Inventor： Gunjan Pandey , Chris M. Coppin , Susan J. Dorrian , Robyn Russell , John Oakeshott
CPC classification number: B09C1/10 , C02F3/34 , C02F2103/343 , C12N9/48 , C12R1/365
Abstract: The invention relates to bacteria, bacterial extracts, supernatants obtained from the culturing of said bacteria, polypeptides and compositions for degrading benzimidazole carbamate fungicides, carbanilate fungicides, sulfonamide herbicides, thioamide herbicides and/or synthetic pyrethroid insecticides. In particular, the invention relates to the identification of Nocardioides sp. which degrades benzimidazole carbamate fungicides, carbanilate fungicides, sulfonamide herbicides, thioamide herbicides and/or synthetic pyrethroid insecticides.
Abstract translation: 本发明涉及细菌，细菌提取物，从培养所述细菌获得的上清液，多肽和用于降解苯并咪唑氨基甲酸酯杀真菌剂的组合物，氨基苯甲酸盐杀真菌剂，磺酰胺除草剂，硫代酰胺除草剂和/或合成的拟除虫菊酯杀虫剂。 特别地，本发明涉及诺卡氏菌属的鉴定。 其降解苯并咪唑氨基甲酸酯杀真菌剂，氨基苯甲酸盐杀真菌剂，磺酰胺除草剂，硫代酰胺除草剂和/或合成拟除虫菊酯杀虫剂。
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公开(公告)号：US20050176118A1
公开(公告)日：2005-08-11
申请号：US10503691
申请日：2002-02-06
Applicant: John Oakeshott , Alan Devonshire , Christopher Coppin , Rama Heidari , Susan Dorrian , Robyn Russell
Inventor： John Oakeshott , Alan Devonshire , Christopher Coppin , Rama Heidari , Susan Dorrian , Robyn Russell
IPC: A23G9/32 , A23D7/00 , A23G9/44 , A23G9/52 , C07B57/00 , C12N9/18 , C12N9/20 , C12N15/00 , C12P7/02 , C12P7/40 , C12P7/62 , C12P41/00 , C12Q1/44 , C12Q1/46 , C12R1/645 , C12P7/64 , C12P13/00
CPC classification number: C12N9/20 , C12N9/18 , C12P7/02 , C12P7/40 , C12P41/003
Abstract: The present invention relates to the use of insect esterases or lipases, or mutants thereof, as catalysts in biotransformation processes. The present invention may have application in any process involving hydrolysis, esterification, transesterification, interesterification or acylation reactions. The invention also has application in the enzymatic resolution of compounds to produce optically active compounds and has particular, but not exclusive, application to substrates having a hydrophobic moiety such as pyrethroids and fatty acid esters.
Abstract translation: 本发明涉及昆虫酯酶或脂肪酶或其突变体在生物转化过程中作为催化剂的用途。 本发明可以应用于涉及水解，酯化，酯交换，酯交换或酰化反应的任何方法中。 本发明还可用于化合物的酶拆分以产生光学活性化合物，并且具有但不排他地应用于具有疏水部分的底物，例如拟除虫菊酯和脂肪酸酯。
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Patent Agency Ranking
公开(公告)号：US20050176117A1
公开(公告)日：2005-08-11
申请号：US10503643
申请日：2002-02-06
Applicant: Robyn Russell , Rama Heidari , Alan Devonshire , Susan Dorrian , John Oakeshott
Inventor： Robyn Russell , Rama Heidari , Alan Devonshire , Susan Dorrian , John Oakeshott
IPC: C12N15/09 , B09C1/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/18 , C12N15/82 , C12P7/62 , C12Q1/44 , C07H21/04 , C12N5/06 , C12P13/00 , C12P21/06
CPC classification number: C12N9/18 , B09C1/10 , C12N15/8259
Abstract: The present invention relates to methods and enzymes for degrading hydrophobic ester pesticides and toxins. In particular, the present invention relates to the use of insect esterases, and mutants thereof, in the bioremediation of hydrophobic ester pesticides and toxins residues, such as pyrethroid residues, contaminating the environment and horticultural commodities.
Abstract translation: 本发明涉及降解疏水酯类农药和毒素的方法和酶。 特别地，本发明涉及昆虫酯酶及其突变体在疏水性酯类农药和毒素残留物例如拟除虫菊酯残留物的污染环境和园艺商品的生物修复中的用途。
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公开(公告)号：US20060154329A1
公开(公告)日：2006-07-13
申请号：US10522427
申请日：2003-07-28
Applicant: Irene Horne , Robyn Russell , John Oakeshott , Tara Sutherland
Inventor： Irene Horne , Robyn Russell , John Oakeshott , Tara Sutherland
CPC classification number: C12N15/75 , C07K14/345 , C07K2319/02 , C07K2319/034 , C07K2319/10 , C12N15/625
Abstract: The present invention provides a recombinant polynucleotide, the polynucleotide comprising a first and a second sequence, the first sequence encoding a signal peptide comprising a TAT signal and a Sec avoidance signal and the second sequence encoding a heterologous protein. The sequence of the signal peptide is M-X1—K/R—X2—K/R—X3—RR—X4—K/R-A in which X1 is a sequence of 0 to 10 amino acids, X2 is a sequence of 0 to 3 amino acids, X3 is a sequence of 0 to 10 amino acids and X4 is a sequence of 15 to 24 amino acids in which at least 75% up to about 90% of the residues are hydrophobic.
Abstract translation: 本发明提供重组多核苷酸，所述多核苷酸包含第一和第二序列，编码包含TAT信号和Sec避免信号的信号肽的第一序列和编码异源蛋白质的第二序列。 信号肽的序列是MX 1 -K / RX 2 -K / RX 3 -RR-X 4， 其中X 1是0至10个氨基酸的序列的SUBK-RA，其中X 2是0至3个氨基酸的序列，X < 3是0至10个氨基酸的序列，X 4是15至24个氨基酸的序列，其中至少75％至多90％的残基是疏水性的。
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公开(公告)号：US09796990B2
公开(公告)日：2017-10-24
申请号：US14233878
申请日：2012-07-20
Applicant: Colin Scott , John Oakeshott , Robyn Russell , Nigel French , Steven Kotsonis , Kaiyan Liu
Inventor： Colin Scott , John Oakeshott , Robyn Russell , Nigel French , Steven Kotsonis , Kaiyan Liu
IPC: C12N9/16 , C12P9/00 , C12Q1/44 , C12Q1/00 , C12Q1/42 , A62D3/02 , A61K38/00 , A62D101/04 , A62D101/26
CPC classification number: C12P9/00 , A61K38/00 , A62D3/02 , A62D2101/04 , A62D2101/26 , C07K2319/00 , C07K2319/036 , C12N9/16 , C12Q1/005 , C12Q1/42 , C12Q1/44 , C12Y301/08001 , C12Y301/08002 , G01N2430/10
Abstract: The present invention relates to enzymes capable of hydrolysing organophosphate (OP) molecules. In particular, the invention relates to variants of the OpdA enzyme from Agrobacterium that display improved activity when compared to the naturally occurring OpdA. The invention is also towards polypeptides that have organophosphate hydrolysing activity for the organophosphates chlorpyrifos methyl, diazinon and parathion ethyl.
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公开(公告)号：US20140342387A1
公开(公告)日：2014-11-20
申请号：US14233878
申请日：2012-07-20
Applicant: Colin Scott , John Oakeshott , Robyn Russell , Nigel French , Steven Kotsonis , Kaiyan Liu
Inventor： Colin Scott , John Oakeshott , Robyn Russell , Nigel French , Steven Kotsonis , Kaiyan Liu
CPC classification number: C12P9/00 , A61K38/00 , A62D3/02 , A62D2101/04 , A62D2101/26 , C07K2319/00 , C07K2319/036 , C12N9/16 , C12Q1/005 , C12Q1/42 , C12Q1/44 , C12Y301/08001 , C12Y301/08002 , G01N2430/10
Abstract: The present invention relates to enzymes capable of hydrolysing organophosphate (OP) molecules. In particular, the invention relates to variants of the OpdA enzyme from Agrobacterium that display improved activity when compared to the naturally occurring OpdA. The invention is also towards polypeptides that have organophosphate hydrolysing activity for the organophosphates chlorpyrifos methyl, diazinon and parathion ethyl.
Abstract translation: 本发明涉及能够水解有机磷酸酯（OP）分子的酶。 特别地，本发明涉及与天然存在的OpdA相比显示改善的活性的来自农杆菌的OpdA酶的变体。 本发明还涉及对有机磷酸盐毒死蜱甲基，二嗪农和对硫磷乙基具有有机磷酸酯水解活性的多肽。
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公开(公告)号：US08293244B2
公开(公告)日：2012-10-23
申请号：US10477469
申请日：2002-05-15
Applicant: Irene Horne , Tara Sutherland , Rebecca Harcourt , Robyn Russell , John Oakeshott
Inventor： Irene Horne , Tara Sutherland , Rebecca Harcourt , Robyn Russell , John Oakeshott
IPC: A61K39/02
CPC classification number: C12N9/16 , C07K2319/00
Abstract: The present invention provides enzymes capable of hydrolysing organophosphate (OP) molecules. In particular, the invention provides a phosphotriesterase enzyme identified from an Agrobacterium radiobacter strain isolated from soil that hydrolyses OP pesticides, and the gene encoding that enzyme. The invention also provides mutants of the identified phosphotriesterase enzyme which have altered substrate specificity. The use of these enzymes in bioremediation strategies is also provided.
Abstract translation: 本发明提供能够水解有机磷酸酯（OP）分子的酶。 特别地，本发明提供了从分离自水解OP农药的土壤中的放射性土壤杆菌菌株鉴定的磷酸三聚酶，以及编码该酶的基因。 本发明还提供已经改变的底物特异性的鉴定的磷酸三聚酶的突变体。 还提供了这些酶在生物修复策略中的使用。
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