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公开(公告)号：US20070189114A1
公开(公告)日：2007-08-16
申请号：US11679665
申请日：2007-02-27
申请人： Roland Reiner , Peter Geigle , Herma Glockner , Frank Thurmer
发明人： Roland Reiner , Peter Geigle , Herma Glockner , Frank Thurmer
CPC分类号： A61L31/042 , A61K9/0024 , A61K9/5036 , A61L27/20 , C08L5/04
摘要： The invention relates to a device for the molecular integration or disintegration of solid, liquid and/or gaseous flowing, entrained and/or countercurrent components by means of cavitation in order to modify, build or disintegrate molecular compounds. The invention allows to obtain stable mixtures from immiscible or difficult-to-mix components or to separate such mixtures. The supercavitation molecular reactor allows to build up or disintegrate or modify, with low expenditure in terms of energy, even complex compounds that so far have not been accessible to modification and/or production or only by very extensive multiple processes and a large amount of technical complexity.
摘要翻译： 本发明涉及通过空化使固体，液体和/或气态流动，夹带和/或逆流成分分子整合或分解的装置，以便改变，构建或分解分子化合物。 本发明允许从不混溶的或难以混合的组分获得稳定的混合物或分离这些混合物。 超空化分子反应器允许以能量消耗低的方式建立或分解或改造，甚至复杂的化合物，迄今为止，无法进行改性和/或生产，或仅通过非常广泛的多种工艺和大量的技术 复杂。
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公开(公告)号：US5169771A
公开(公告)日：1992-12-08
申请号：US568468
申请日：1990-08-15
摘要： A method for making a stable aqueous liquid formulation containing at least one enzyme having proteolytic activity is disclosed. The method involves precipitating the enzyme from an aqueous medium with a salt to form a dispersion of the enzyme. The dispersion has a density of 1.22 g/cm.sup.3 to 1.23 g/cm.sup.3 due to the use of the salt. This process yields a sedimentation-resistant stable enzyme dispersion.
摘要翻译： 公开了一种制备含有至少一种具有蛋白水解活性的酶的稳定含水液体制剂的方法。 该方法包括用盐从水性介质中沉淀酶以形成酶的分散体。 分散体由于使用盐而具有1.22g / cm 3至1.23g / cm 3的密度。 该方法产生耐沉降稳定的酶分散体。
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公开(公告)号：US4680408A
公开(公告)日：1987-07-14
申请号：US872320
申请日：1986-06-09
申请人： Roland Reiner , Urs Weiss
发明人： Roland Reiner , Urs Weiss
IPC分类号： C07D293/06 , C07D501/20 , C07D505/00
CPC分类号： C07D293/06 , C07D505/00
摘要： There are presented compounds of the formula ##STR1## wherein R.sup.1 is one of the 3-substituents usable in cephalosporin chemistry, R.sup.2 is hydrogen, lower alkyl or COOR.sup.3 -lower alkyl, wherein R.sup.3 is hydrogen, a cation of a base or a readily hydrolyzable ester group, and X is sulphur, oxygen or one of the groups --SO-- and --SO.sub.2 --, and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of these compounds and hydrates of the compounds of formula I or of their esters, ethers and salts, also presented are methods for the manufacture of these compounds as well as compounds used in their manufacture.
摘要翻译： 呈现下式的化合物其中R 1是可用于头孢菌素化学的3-取代基之一，R 2是氢，低级烷基或COOR 3 - 低级烷基，其中R 3是氢，碱的阳离子或容易的 可水解的酯基，X是硫，氧或-SO-和-SO2-基团之一，以及易水解的酯，这些化合物的易水解的醚和盐以及式I化合物或其酯的水合物， 醚和盐也是用于制造这些化合物的方法以及用于其制造的化合物。
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公开(公告)号：US4292428A
公开(公告)日：1981-09-29
申请号：US51669
申请日：1979-06-25
申请人： Marc Montavon , Roland Reiner
发明人： Marc Montavon , Roland Reiner
IPC分类号： A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/36 , C07D501/46 , C07D501/56
CPC分类号： C07D501/36
摘要： There is presented cephalosporin derivatives which are the readily hydrolysable esters and ethers of compounds of the general formula ##STR1## wherein R represents furyl, thienyl or phenyl optionally substituted by halogen, hydroxy, lower alkoxy or lower alkyl, R.sub.1 represents lower alkyl or aminocarbonylmethyl and X represents a group of the formula ##STR2## in which one of the two symbols R.sub.2 and R.sub.3 represents hydrogen and the other represents lower alkyl and R.sub.4 represents lower alkyl,as well as salts of said esters and ethers and hydrates of said esters, ethers and salts.
摘要翻译： 提出了头孢菌素衍生物，它们是通式（I）化合物的易水解的酯和醚，其中R表示呋喃基，噻吩基或任选被卤素，羟基，低级烷氧基或低级烷基取代的苯基，R 1表示低级烷基 或氨基羰基甲基，X表示下式的基团：其中两个符号R2和R3之一表示氢，另一个表示低级烷基，R4表示低级烷基，以及所述酯的盐 所述酯，醚和盐的醚和水合物。
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公开(公告)号：US4242159A
公开(公告)日：1980-12-30
申请号：US14952
申请日：1979-02-26
申请人： Albrecht Klimmek , Wolfram Krieger , Roland Reiner
发明人： Albrecht Klimmek , Wolfram Krieger , Roland Reiner
CPC分类号： B01D69/122
摘要： A process for the production of a composite membrane consisting of a porous supporting membrane and a thin separating membrane. The separating membrane is produced on the surface of a carrier film (consisting essentially of a soluble polymer). The carrier film coated with the separating membrane is placed with its separating membrane side on a porous supporting membrane such that the separating membrane is between the supporting membrane and the carrier film. The carrier film is then dissolved.
摘要翻译： 一种由多孔支撑膜和薄分离膜组成的复合膜的制造方法。 分离膜在载体膜（主要由可溶性聚合物组成）的表面上产生。 涂布有分离膜的载体膜将其分离膜侧放置在多孔支撑膜上，使得分离膜在支撑膜和载体膜之间。 然后将载体膜溶解。
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公开(公告)号：US4202055A
公开(公告)日：1980-05-13
申请号：US796164
申请日：1977-05-12
申请人： Roland Reiner , Helmut Heide , Kari Koster
发明人： Roland Reiner , Helmut Heide , Kari Koster
CPC分类号： A61L27/32 , A61F2/30767 , A61L27/46 , A61L27/56 , A61F2/3094 , A61F2/3662 , A61F2002/30064 , A61F2002/30242 , A61F2002/30968 , A61F2230/0071 , A61F2310/00796
摘要： An implantable prosthesis anchorage which contains a non-porous outer coating in the regions which is positioned in contact with bone. The non-porous outer coating consists of (i) at least one bioactive resorbable ceramic material which is a calcium phosphate and (ii) at least one polymer which is mechanically and chemically stable in the body. The ceramic material is in particulate form having particle diameters between 0.5 and 1 mm. The ceramic material particles is incorporated in the polymer in such a way that resorption of the ceramic material leads to a polymer structure with continuous pores filled with living bone tissue. Bioactivating bonding residues of the ceramic material are left on the inner surfaces of the filled pores which were created by the resorption of the ceramic material.
摘要翻译： 一种植入式假体锚固件，其在与骨骼定位的区域中包含无孔外涂层。 无孔外涂层包括（i）至少一种生物活性可再吸收陶瓷材料，其为磷酸钙，和（ii）至少一种在体内机械和化学稳定的聚合物。 陶瓷材料为粒径为0.5-1mm的颗粒形式。 将陶瓷材料颗粒以这样一种方式结合到聚合物中，使得陶瓷材料的吸收导致具有填充有活骨组织的连续孔的聚合物结构。 陶瓷材料的生物活化粘合残留物留在由陶瓷材料吸收产生的填充孔的内表面上。
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公开(公告)号：US4593093A
公开(公告)日：1986-06-03
申请号：US600249
申请日：1984-04-16
申请人： Roland Reiner , Urs Weiss
发明人： Roland Reiner , Urs Weiss
IPC分类号： C07D293/06 , C07D501/20 , C07D501/24 , C07D505/00 , C07D421/14
CPC分类号： C07D505/00 , C07D293/06
摘要： There are presented compounds of the formula ##STR1## wherein R.sup.1 is one of the 3-substituents usable in cephalosporin chemistry, R.sup.2 is hydrogen, lower alkyl or COOR.sup.3 -lower alkyl, wherein R.sup.3 is hydrogen, a cation of a base or a readily hydrolyzable ester group, and X is sulphur, oxygen or one of the groups --SO-- and --SO.sub.2 --,and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of these compounds and hydrates of the compounds of formula I or of their esters, ethers and salts, also presented are methods for the manufacture of these compounds as well as compounds used in their manufacture.
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公开(公告)号：US4458072A
公开(公告)日：1984-07-03
申请号：US305870
申请日：1981-09-28
申请人： Roland Reiner , Urs Weiss
发明人： Roland Reiner , Urs Weiss
IPC分类号： C07D293/06 , C07D501/20 , C07D501/24 , C07D505/00 , C07D51/56 , A61K31/545
CPC分类号： C07D505/00 , C07D293/06
摘要： There are presented compounds of the formula ##STR1## wherein R.sup.1 is one of the 3-substituents usable in cephalosporin chemistry, R.sup.2 is hydrogen, lower alkyl or COOR.sup.3 -lower alkyl, wherein R.sup.3 is hydrogen, a cation of a base or a readily hydrolyzable ester group, and X is sulphur, oxygen or one of the groups --SO-- and --SO.sub.2 --, and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of these compounds and hydrates of the compounds of formula I or of their esters, ethers and salts, also presented are methods for the manufacture of these compounds as well as compounds used in their manufacture.
摘要翻译： 呈现下式的化合物其中R 1是可用于头孢菌素化学的3-取代基之一，R 2是氢，低级烷基或COOR 3 - 低级烷基，其中R 3是氢，碱的阳离子或容易的 可水解的酯基，X是硫，氧或-SO-和-SO2-基团之一，以及易水解的酯，这些化合物的易水解的醚和盐以及式I化合物或其酯的水合物， 醚和盐也是用于制造这些化合物的方法以及用于其制造的化合物。
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公开(公告)号：US4322398A
公开(公告)日：1982-03-30
申请号：US13068
申请日：1979-02-21
IPC分类号： A61K9/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61K9/14 , A61K9/20 , A61K9/26 , A61K47/02 , A61L27/12 , A61L27/54 , A61K9/32 , A61L15/03
CPC分类号： A61F2/28 , A61K9/2009 , A61L27/12 , A61L27/54 , A61F2002/30062 , A61F2002/30677 , A61F2002/30968 , A61F2210/0004 , A61F2250/0067 , A61F2310/00293 , A61L2300/406 , A61L2300/602 , A61L2300/802 , A61L2430/02
摘要： An implantable drug depot for the treatment of diseases of the bone or bone marrow. The depot consisting of a matrix in which at least one active ingredient is incorporated and contains at least one adjuvant agent to control the kinetics of the drug release. The matrix material consists of resorbable sintered calcium phosphate composed of CaO and P.sub.2 O.sub.5 in a ratio between 5:1 and 2:1.
摘要翻译： 用于治疗骨或骨髓疾病的可植入药物库。 由其中加入至少一种活性成分并含有至少一种佐剂的基质组成，以控制药物释放的动力学。 基质材料由CaO和P2O5组成的可再吸收烧结磷酸钙组成，比例为5：1和2：1。
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10.发明授权
公开(公告)号：US4309453A
公开(公告)日：1982-01-05
申请号：US116308
申请日：1980-01-28
申请人： Roland Reiner , Hildulf Kaiser
发明人： Roland Reiner , Hildulf Kaiser
IPC分类号： C08J7/18 , C07C67/00 , C07C301/00 , C07C303/22 , C07C309/02 , C07C309/03 , C07C313/00 , C07C323/25 , C07C323/29 , C07C323/36 , C07C323/48 , C07C323/52 , C07C323/60 , C08J7/12 , B05D3/06
CPC分类号： C08J7/12
摘要： For surface modification of natural or synthetic macromolecular substrates, organic compounds are used that have hydrophilic, hydrophobic, oleophobic, ionic and/or cross-linkable groups and that also have groups which are easily convertible to nitrene or carbene, e.g., azide or diazo groups. Such organic compounds are applied to the surface to be modified as a monolayer or oligolayer from a solution thereof and then are photochemically activated. Conditions which cause orientation of the molecule with the azide or diazo group toward the surface of the substrate are advantageous. The other cross-linkable groups may promote diagonal cross-linking of the applied layer.
摘要翻译： 对于天然或合成大分子底物的表面改性，使用具有亲水，疏水，疏油，离子和/或可交联基团的有机化合物，并且还具有易于转化为氮或卡宾的基团，例如叠氮化物或重氮基团 。 将这样的有机化合物从其溶液中涂覆到待修饰的单层或低聚物层上，然后进行光化学活化。 导致分子与叠氮基或重氮基团朝向衬底表面的取向的条件是有利的。 其他可交联基团可以促进所施加的层的对角交叉。
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