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1.发明申请Genetically Intact Induced Pluripotent Cells Or Transdifferentiated Cells And Methods For The Production Thereof 审中-公开基因完整诱导多能细胞或转分化细胞及其生产方法公开(公告)号：US20110286978A1
公开(公告)日：2011-11-24
申请号：US12787175
申请日：2010-05-25
申请人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
发明人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
CPC分类号： C12N5/0696 , C07K2319/10 , C07K2319/60 , C07K2319/71 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608
摘要： The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
摘要翻译： 本公开涉及用于去分化和转分化受体细胞，优选人体细胞的方法。 这些方法使不希望的基因组序列改变的风险最小化。 这些方法采用重编程因子，其可以单独使用或以某种组合使用。 这些方法特别适用于基于细胞的疗法，细胞系的建立以及转基因细胞的生产。
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公开(公告)号：US20100167404A1
公开(公告)日：2010-07-01
申请号：US11989988
申请日：2006-08-03
CPC分类号： C12N5/0606 , A01K67/0271 , C12N5/0676 , C12N5/16 , C12N15/873 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2501/606 , C12N2501/72 , C12N2506/00 , C12N2506/11 , C12Q1/6881 , C12Q2600/158
摘要： This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
摘要翻译： 本发明一般涉及获得具有与发育中的哺乳动物胚胎或胎儿相似的基因表达模式的哺乳动物细胞和组织的方法，以及这些细胞和组织在治疗人类疾病和年龄相关病症中的用途。 更具体地说，本发明涉及用于鉴定，扩增培养和配制哺乳动物多能干细胞和分化细胞的方法，所述哺乳动物多能干细胞和分化细胞在成年人的细胞基因表达模式中不同，因此提供独特的特征，其提供新颖的治疗策略 退行性疾病的治疗。
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3.发明申请Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof 审中-公开遗传完整的诱导多能细胞或转分化细胞及其生产方法公开(公告)号：US20110171185A1
公开(公告)日：2011-07-14
申请号：US12700545
申请日：2010-02-04
申请人： IRINA V. KLIMANSKAYA , SHI-JIANG LU , ROBERT LANZA , MICHAEL D. WEST , KAREN B. CHAPMAN , ROY GEOFFREY SARGENT , RAYMOND PAGE , TANJA DOMINKO , CHRISTOPHER MALCUIT
发明人： IRINA V. KLIMANSKAYA , SHI-JIANG LU , ROBERT LANZA , MICHAEL D. WEST , KAREN B. CHAPMAN , ROY GEOFFREY SARGENT , RAYMOND PAGE , TANJA DOMINKO , CHRISTOPHER MALCUIT
CPC分类号： C12N5/0696 , C07K2319/10 , C07K2319/60 , C07K2319/71 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608
摘要： The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
摘要翻译： 本公开涉及用于去分化和转分化受体细胞，优选人体细胞的方法。 这些方法使不希望的基因组序列改变的风险最小化。 这些方法采用重编程因子，其可以单独使用或以某种组合使用。 这些方法特别适用于基于细胞的疗法，细胞系的建立以及转基因细胞的生产。
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公开(公告)号：US20110143441A1
公开(公告)日：2011-06-16
申请号：US12856043
申请日：2010-08-13
IPC分类号： C12N15/87 , C12N5/071 , C12N5/078 , C12N5/0793
CPC分类号： C12N5/0606 , A01K67/0271 , C12N5/0676 , C12N5/16 , C12N15/873 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2501/606 , C12N2501/72 , C12N2506/00 , C12N2506/11 , C12Q1/6881 , C12Q2600/158
摘要： This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
摘要翻译： 本发明一般涉及获得具有与发育中的哺乳动物胚胎或胎儿相似的基因表达模式的哺乳动物细胞和组织的方法，以及这些细胞和组织在治疗人类疾病和年龄相关病症中的用途。 更具体地说，本发明涉及用于鉴定，扩增培养和配制哺乳动物多能干细胞和分化细胞的方法，所述哺乳动物多能干细胞和分化细胞在成年人的细胞基因表达模式中不同，因此提供独特的特征，其提供新颖的治疗策略 退行性疾病的治疗。
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