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1.发明授权Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration 有权用于产生视网膜色素上皮细胞的富集群体用于治疗视网膜变性的方法公开(公告)号：US08268303B2
公开(公告)日：2012-09-18
申请号：US12857911
申请日：2010-08-17
CPC分类号： C12N5/0621 , A61K35/12 , A61K35/30 , A61K35/36 , A61K35/44 , A61K35/545 , C12N5/062 , C12N2500/32 , C12N2500/44 , C12N2501/01 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/235 , C12N2501/33 , C12N2501/60 , C12N2506/02
摘要： This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
摘要翻译： 本发明涉及用于改善基于视网膜变性的基于细胞的疗法和用于分化人类胚胎干细胞和人类胚胎来源于视网膜色素上皮（RPE）细胞和其它视网膜祖细胞的细胞的治疗方法。
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2.发明申请Genetically Intact Induced Pluripotent Cells Or Transdifferentiated Cells And Methods For The Production Thereof 审中-公开基因完整诱导多能细胞或转分化细胞及其生产方法公开(公告)号：US20110286978A1
公开(公告)日：2011-11-24
申请号：US12787175
申请日：2010-05-25
申请人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
发明人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
CPC分类号： C12N5/0696 , C07K2319/10 , C07K2319/60 , C07K2319/71 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608
摘要： The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
摘要翻译： 本公开涉及用于去分化和转分化受体细胞，优选人体细胞的方法。 这些方法使不希望的基因组序列改变的风险最小化。 这些方法采用重编程因子，其可以单独使用或以某种组合使用。 这些方法特别适用于基于细胞的疗法，细胞系的建立以及转基因细胞的生产。
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公开(公告)号：US20110256622A1
公开(公告)日：2011-10-20
申请号：US13172027
申请日：2011-06-29
IPC分类号： C12N5/073 , C12N5/0735 , C12N5/02
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。
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4.发明授权Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration 有权用于产生视网膜色素上皮细胞的富集群体用于治疗视网膜变性的方法公开(公告)号：US07794704B2
公开(公告)日：2010-09-14
申请号：US11041382
申请日：2005-01-24
申请人： Irina V. Klimanskaya , Robert Lanza
发明人： Irina V. Klimanskaya , Robert Lanza
CPC分类号： C12N5/0621 , A61K35/12 , A61K35/30 , A61K35/36 , A61K35/44 , A61K35/545 , C12N5/062 , C12N2500/32 , C12N2500/44 , C12N2501/01 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/235 , C12N2501/33 , C12N2501/60 , C12N2506/02
摘要： This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
摘要翻译： 本发明涉及用于改善基于视网膜变性的基于细胞的疗法和用于分化人类胚胎干细胞和人类胚胎来源于视网膜色素上皮（RPE）细胞和其它视网膜祖细胞的细胞的治疗方法。
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公开(公告)号：US08742200B2
公开(公告)日：2014-06-03
申请号：US13004260
申请日：2011-01-11
CPC分类号： C12N5/0606 , A61K35/12 , C12N5/0603 , C12N5/0604 , C12N15/873 , C12N2500/34 , C12N2501/115 , C12N2501/998 , C12N2502/02 , C12N2506/02
摘要： This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.
摘要翻译： 本发明提供了用于从胚胎中衍生胚胎干细胞和胚胎衍生细胞而不需要破坏胚胎的新方法。 本发明进一步提供不衍生胚胎破坏的细胞和细胞系，以及细胞用于治疗和研究目的。 它还涉及在植入胚胎之前建立和储存自体干细胞系的新方法，例如与生殖治疗如IVF结合。
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公开(公告)号：US08597944B2
公开(公告)日：2013-12-03
申请号：US13172027
申请日：2011-06-29
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。
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公开(公告)号：US09080150B2
公开(公告)日：2015-07-14
申请号：US13477763
申请日：2012-05-22
申请人： Irina V. Klimanskaya , Robert Lanza
发明人： Irina V. Klimanskaya , Robert Lanza
IPC分类号： A61K35/12 , C12N5/0793 , A61K35/44 , A61K49/00 , A61P27/02 , C12N5/071 , C12N5/079 , A61K35/30 , A61K35/36 , A61K35/545
CPC分类号： C12N5/0621 , A61K35/12 , A61K35/30 , A61K35/36 , A61K35/44 , A61K35/545 , C12N5/062 , C12N2500/32 , C12N2500/44 , C12N2501/01 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/235 , C12N2501/33 , C12N2501/60 , C12N2506/02
摘要： This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
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公开(公告)号：US20130022680A1
公开(公告)日：2013-01-24
申请号：US13477763
申请日：2012-05-22
申请人： Irina V. Klimanskaya , Robert Lanza
发明人： Irina V. Klimanskaya , Robert Lanza
CPC分类号： C12N5/0621 , A61K35/12 , A61K35/30 , A61K35/36 , A61K35/44 , A61K35/545 , C12N5/062 , C12N2500/32 , C12N2500/44 , C12N2501/01 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/235 , C12N2501/33 , C12N2501/60 , C12N2506/02
摘要： This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
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公开(公告)号：US07910369B2
公开(公告)日：2011-03-22
申请号：US11211174
申请日：2005-08-24
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。
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公开(公告)号：US07893315B2
公开(公告)日：2011-02-22
申请号：US11800366
申请日：2007-05-03
CPC分类号： C12N5/0606 , A61K35/12 , C12N5/0603 , C12N5/0604 , C12N15/873 , C12N2500/34 , C12N2501/115 , C12N2501/998 , C12N2502/02 , C12N2506/02
摘要： This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.
摘要翻译： 本发明提供了用于从胚胎中衍生胚胎干细胞和胚胎衍生细胞而不需要破坏胚胎的新方法。 本发明进一步提供不衍生胚胎破坏的细胞和细胞系，以及细胞用于治疗和研究目的。 它还涉及在植入胚胎之前建立和储存自体干细胞系的新方法，例如与生殖治疗如IVF结合。
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