公开(公告)号：US20210309958A1

公开(公告)日：2021-10-07

申请号：US16763161

申请日：2018-11-13

申请人： Satoshi IZUMI ,  Manabu SEO ,  Yudai KAWASHIMA ,  Yusuke OSAKI

发明人： Satoshi IZUMI ,  Manabu SEO ,  Yudai KAWASHIMA ,  Yusuke OSAKI

IPC分类号： C12M1/00 ,  C12M1/32 ,  C12Q1/6851

摘要： Provided is a device including at least one well and an amplifiable reagent contained in a specific copy number in the at least one well. In a preferable mode, the device includes information on the specific copy number of the amplifiable reagent. In a more preferable mode, the device includes information on uncertainty as the information on the specific copy number, and the information on uncertainty includes a coefficient of variation CV of the amplifiable reagent, and the coefficient of variation CV satisfies a relational expression: CV

公开(公告)号：US20210147906A1

公开(公告)日：2021-05-20

申请号：US16766117

申请日：2018-11-22

申请人： Yusuke OSAKI ,  Satoshi IZUMI ,  Yudai KAWASHIMA ,  Michie HASHIMOTO ,  Manabu SEO ,  Koei SUZUKI ,  Hirotaka UNNO

发明人： Yusuke OSAKI ,  Satoshi IZUMI ,  Yudai KAWASHIMA ,  Michie HASHIMOTO ,  Manabu SEO ,  Koei SUZUKI ,  Hirotaka UNNO

IPC分类号： C12Q1/6806 ,  B01L3/02 ,  C12Q1/689 ,  C12Q1/70

摘要： Provided is a detection determining method used in detection of a testing target in a sample by amplification of the testing target and an amplifiable reagent, wherein the amplifiable reagent is provided in a number of 200 or less, the detection determining method including a determining step of determining that the testing target is present and a detection result is positive when the amplifiable reagent is amplified and the testing target is amplified, and determining that the testing target is absent or at least less than a specific copy number of the amplifiable reagent and a detection result is negative when the amplifiable reagent is amplified and the testing target is not amplified. Also provided are a detection determining device, a detection determining program, and a device used for the detection determining method.

公开(公告)号：US10646873B2

公开(公告)日：2020-05-12

申请号：US15846393

申请日：2017-12-19

申请人： Hiroki Somada ,  Satoshi Izumi ,  Takahiko Matsumoto ,  Daisuke Takagi

发明人： Hiroki Somada ,  Satoshi Izumi ,  Takahiko Matsumoto ,  Daisuke Takagi

IPC分类号： B01L3/00

摘要： A multi-well plate lid includes a well-side surface to cover a plurality of wells of a multi-well plate. The well-side surface includes two or more regions with different adhesive strengths to the multi-well plate.

公开(公告)号：US20190284611A1

公开(公告)日：2019-09-19

申请号：US16356591

申请日：2019-03-18

申请人： YUDAI KAWASHIMA ,  MASAYUKI YUMOTO ,  SATOSHI IZUMI ,  MANABU SEO

发明人： YUDAI KAWASHIMA ,  MASAYUKI YUMOTO ,  SATOSHI IZUMI ,  MANABU SEO

IPC分类号： C12Q1/6806 ,  B01L7/00 ,  B01L3/00 ,  C12Q1/6809 ,  G01N21/64 ,  B41M5/00

摘要： Provided is a nucleic acid sample-contained container including; a first nucleic acid molecule including an intended base sequence and a base sequence for detection different from the intended base sequence; and a second nucleic acid molecule free of the intended base sequence but including the base sequence for detection, wherein the nucleic acid sample-contained container includes the first nucleic acid molecule in a predetermined number. In a preferable mode, the copy number of the intended base sequence is less than 1,000, and the coefficient of variation (CV value) for the copy number is lower than 20%. In a more preferable mode, the nucleic acid molecules are artificially synthesized nucleic acid molecules. In a yet more preferable mode, the first nucleic acid molecule includes the intended base sequence in a plural number in the same molecule.

公开(公告)号：US20150353677A1

公开(公告)日：2015-12-10

申请号：US14763538

申请日：2014-01-27

申请人： Satoshi IZUMI ,  Taichi NEMOTO ,  Yoko ARAI ,  Yasuo KAMADA ,  Chiaki TANAKA

发明人： Satoshi IZUMI ,  Taichi NEMOTO ,  Yoko ARAI ,  Yasuo KAMADA ,  Chiaki TANAKA

IPC分类号： C08G63/08 ,  B01J19/00 ,  B01J19/18

CPC分类号： C08G63/08 ,  B01J4/02 ,  B01J19/0066 ,  B01J19/18 ,  B01J19/20 ,  B01J2219/00087 ,  B01J2219/00761 ,  C08G63/785

摘要： To provide a polymer production apparatus, which contains: a first supply unit configured to supply raw materials including a monomer; a second supply unit configured to supply a compressive fluid; a contact unit configured to bring the monomer into contact with the compressive fluid; and a reaction unit configured to allow the monomer, which has been brought into contact with the compressive fluid, to react in the presence of the compressive fluid, wherein the reaction unit contains one, or two or more extrusion devices, and one, or two or more stirring devices.

摘要翻译： 提供一种聚合物制造装置，其包含：第一供给单元，其构造成供给包含单体的原料; 第二供应单元，构造成供应压缩流体; 构造成使单体与压缩流体接触的接触单元; 以及反应单元，其构造成允许已经与压缩流体接触的单体在压缩流体存在下反应，其中反应单元包含一个或两个或更多个挤出装置，以及一个或两个 或更多的搅拌装置。

公开(公告)号：US20150322201A1

公开(公告)日：2015-11-12

申请号：US14762604

申请日：2014-01-27

申请人： Yoko ARAI ,  Taichi NEMOTO ,  Yasuo KAMADA ,  Satoshi IZUMI ,  Chiaki TANAKA ,  Yukihiro IMANAGA ,  Tatsuya MORITA

发明人： Yoko ARAI ,  Taichi NEMOTO ,  Tatsuya MORITA ,  Yasuo KAMADA ,  Satoshi IZUMI ,  Chiaki TANAKA ,  Yukihiro IMANGA

IPC分类号： C08G63/78 ,  B01J19/24 ,  C08G63/08

CPC分类号： C08G63/785 ,  B01J19/24 ,  B01J2219/00051 ,  B01J2219/24 ,  C08G63/08 ,  C08G63/78 ,  C08G63/88

摘要： Provided is a polymer product that has a melting point difference (Tm1−Tm0) of 3° C. or more between a polymer melting point Tm0 before it is heated and a polymer melting point Tm1 after it is heated under a nitrogen atmosphere for 60 minutes at a temperature that is higher than the highest polymer melting point by from 10° C. to 50° C.

摘要翻译： 提供在氮气气氛下加热60分钟之前，在加热前的聚合物熔点Tm0与聚合物熔点Tm1之间的熔点差（Tm1-Tm0）为3℃以上的聚合物产物 在高于最高聚合物熔点10℃至50℃的温度下进行。

公开(公告)号：US20210010072A1

公开(公告)日：2021-01-14

申请号：US16766125

申请日：2018-11-22

申请人： Koei SUZUKI ,  Hirotaka UNNO ,  Manabu SEO ,  Satoshi IZUMI ,  Yusuke OSAKI ,  Yudai KAWASHIMA ,  Michie HASHIMOTO

发明人： Koei SUZUKI ,  Hirotaka UNNO ,  Manabu SEO ,  Satoshi IZUMI ,  Yusuke OSAKI ,  Yudai KAWASHIMA ,  Michie HASHIMOTO

IPC分类号： C12Q1/6851 ,  C12Q1/686

摘要： Provided is a device including: a plurality of wells; a reagent composition located in each of the wells and containing an amplifiable reagent in a specific copy number; and two or more groups into which the wells are divided to have the amplifiable reagent located in the same specific copy number but to be varied in composition of the reagent composition except for the specific copy number. Preferably, composition except for the specific copy number of the amplifiable reagent includes at least any one of primer and amplifying reagent. More preferably, the device includes two or more groups varied in the specific copy number. Yet more preferably, the groups of wells include at least a negative control group in which the specific copy number of the amplifiable reagent is 0, and a group in which the specific copy number of the amplifiable reagent is close to the limit of detection.

公开(公告)号：US20190025185A1

公开(公告)日：2019-01-24

申请号：US16041603

申请日：2018-07-20

申请人： Ikuo KATOH ,  Manabu SEO ,  Yunong JI ,  Nobuaki TOYOSHIMA ,  Hiroki SOMADA ,  Ryuya MASHIKO ,  Satoshi IZUMI ,  Takahiko MATSUMOTO ,  Daisuke TAKAGI

发明人： Ikuo KATOH ,  Manabu SEO ,  Yunong JI ,  Nobuaki TOYOSHIMA ,  Hiroki SOMADA ,  Ryuya MASHIKO ,  Satoshi IZUMI ,  Takahiko MATSUMOTO ,  Daisuke TAKAGI

IPC分类号： G01N15/14

摘要： A particle counting apparatus is provided that includes: a droplet discharger configured to discharge a droplet containing at least one luminescent particle capable of emitting light upon receiving light; a light irradiator configured to irradiate the droplet discharged by the droplet discharger with light; at least one light receiver configured to receive light emitted by the at least one luminescent particle irradiated with the light emitted by the light irradiator; and circuitry configured to count luminescent particles contained in the droplet based on the light received by the at least one light receiver, the circuitry being configured to measure a presence or absence of the luminescent particles contained in the droplet; and to measure a number of the luminescent particles contained in the droplet.

公开(公告)号：US20180169650A1

公开(公告)日：2018-06-21

申请号：US15846393

申请日：2017-12-19

申请人： Hiroki Somada ,  Satoshi Izumi ,  Takahiko Matsumoto ,  Daisuke Takagi

发明人： Hiroki Somada ,  Satoshi Izumi ,  Takahiko Matsumoto ,  Daisuke Takagi

IPC分类号： B01L3/00

CPC分类号： B01L3/50853 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/041 ,  B01L2300/0829 ,  B01L2300/123 ,  B01L2300/165

摘要： A multi-well plate lid includes a well-side surface to cover a plurality of wells of a multi-well plate. The well-side surface includes two or more regions with different adhesive strengths to the multi-well plate.

公开(公告)号：US09447228B2

公开(公告)日：2016-09-20

申请号：US14542804

申请日：2014-11-17

申请人： Yuuichi Satoh ,  Satoshi Izumi ,  Taichi Nemoto ,  Yoko Arai ,  Yasuo Kamada ,  Chiaki Tanaka

发明人： Yuuichi Satoh ,  Satoshi Izumi ,  Taichi Nemoto ,  Yoko Arai ,  Yasuo Kamada ,  Chiaki Tanaka

IPC分类号： C08G63/08 ,  C08G64/30 ,  B01J19/24 ,  C08G63/78 ,  C08G63/81 ,  C08G63/02

CPC分类号： C08G63/08 ,  B01J19/24 ,  B01J2219/24 ,  C08G63/785 ,  C08G63/81 ,  C08G64/30

摘要： A polymer production apparatus, including: supplying unit containing first supplying unit to supply raw materials containing monomer, and second supplying unit to supply compressive fluid; contacting unit to bring the monomer and the compressive fluid into contact together; and outlet configured to discharge reaction product of the monomer, wherein reaction unit is provided between the contacting unit and the outlet, where the reaction unit is to pass the monomer from the contacting unit side to the outlet side, while allowing the monomer to carry out a polymerization reaction in the presence of the compressive fluid, and wherein the reaction unit contains circulation unit containing first pipe and second pipe, where a fluid is passed through the first pipe from the contacting unit side to the outlet side, and the second pipe is to return the fluid from return port provided upstream extrusion unit to inlet provided upstream the return port.

摘要翻译： 一种聚合物制造装置，包括：含有第一供给单元的供给单元，供给含有单体的原料，第二供给单元供给压缩流体; 接触单元使单体和压缩流体接触在一起; 和排出口，用于排出单体的反应产物，其中反应单元设置在接触单元和出口之间，其中反应单元将单体从接触单元侧通过到出口侧，同时允许单体进行 在压缩流体存在下的聚合反应，其中反应单元包含含有第一管和第二管的循环单元，其中流体从接触单元侧通过第一管至出口侧，第二管为 将流体从提供的上游挤出单元的返回口返回到在返回端口上游提供的入口。