公开(公告)号：US20250009452A1

公开(公告)日：2025-01-09

申请号：US18763880

申请日：2024-07-03

Applicant: SHANGHAI NINTH PEOPLE'S HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE

Inventor： Hao WU ,  Huan JIA ,  Haoyue TAN ,  Weilong GUO ,  Lianchao LI ,  Azhar Aulia Saputra

IPC: A61B34/37 ,  A61B17/00 ,  A61B17/29 ,  A61B34/10 ,  A61B34/30

Abstract: An implantation system for a cochlear implant microelectrode with remote motion center control includes: an electrode implantation device including at least one pair of forceps, and a distal end part of the forceps is used as a remote motion center; a six-degree-of-freedom motion mechanism; an input unit, configured to input a surgical trajectory; and a control unit, configured to calculate, a displacement of the forceps in a first body coordinate system, an offset compensation of each motion execution unit at the front end at a corresponding degree of freedom in the first body coordinate system, and an offset compensation of each motion execution unit at the rear end at a corresponding degree of freedom in a second body coordinate system, and drive, based on the corresponding offset compensation and a preset motion priority, the forceps and the corresponding motion execution unit to act.

公开(公告)号：US20240228921A1

公开(公告)日：2024-07-11

申请号：US17377956

申请日：2021-07-16

Applicant: SHANGHAI JIAOTONG UNIVERSITY

Inventor： Qihui SHI ,  Shun LU ,  Yuliang DENG ,  Yin TANG

IPC: C12M1/34 ,  C12Q1/02 ,  G01N33/569 ,  G01N33/574

CPC classification number: C12M1/34 ,  C12Q1/02 ,  G01N33/569 ,  G01N33/57492 ,  G01N2333/70589

Abstract: Provided are a method for detecting a free rare tumor cell in a human biological fluid sample and assay kit. Specifically, the method of the invention determines the existence of an active tumor cell in a biological fluid sample of a cancer patient by detecting and confirming the existence of glucose absorption capability of a karyocyte and expression of a leukocyte marker (CD45).

公开(公告)号：US20240167135A1

公开(公告)日：2024-05-23

申请号：US18280419

申请日：2023-06-30

Applicant: SHANGHAI JIAOTONG UNIVERSITY

Inventor： Yujie WANG ,  Bo MAO ,  Jiao ZHANG ,  Baode SUN ,  Qing DONG ,  Jiangbo YANG ,  Haitao JIANG

IPC: C22C38/36 ,  B22D17/20 ,  C21D1/19 ,  C21D1/58 ,  C21D1/60 ,  C22C38/02 ,  C22C38/04 ,  C22C38/22 ,  C22C38/24

CPC classification number: C22C38/36 ,  B22D17/2023 ,  C21D1/19 ,  C21D1/58 ,  C21D1/60 ,  C22C38/02 ,  C22C38/04 ,  C22C38/22 ,  C22C38/24

Abstract: The present disclosure provides a carbide refining method of a high-carbon high-alloy steel. The carbide refining method of a high-carbon high-alloy steel includes the following steps: formulating a raw material according to chemical element compositions of the high-carbon high-alloy steel, and smelting to obtain a high-carbon high-alloy molten steel; performing an overheat treatment on the high-carbon high-alloy molten steel to Tm+(50˜100)° C., to obtain a high-carbon high-alloy melt, and making the high-carbon high-alloy melt to be deposited in a preset water-cooled copper mold at a speed of 30˜160 g/s by an inert gas, to obtain a high-carbon high-alloy billet through solidification molding; and performing a heat treatment process on the high-carbon high-alloy billet.

公开(公告)号：US20240165037A1

公开(公告)日：2024-05-23

申请号：US18474990

申请日：2023-09-26

Applicant: Shanghai Jiaotong University School of Medicine

Inventor： Zeyu Xiao ,  Gaoxian Chen ,  Kai Cui

IPC: A61K9/48 ,  A61P1/00 ,  C08B37/00

CPC classification number: A61K9/4816 ,  A61P1/00 ,  C08B37/0006

Abstract: The invention provides a colonic microbiota responsive polymer characterized in that it is prepared by the polymerization of a response monomer and a linking monomer, wherein the response monomer is a cellobiose with a B-(1,4)-glucoside bond or/and a lactose with a p-galactoside bond; the linking monomer is a monomer that reacts with the hydroxyl group of the response monomer to form an ester or ether directly or by a crosslinking agent. The invention also provides a method for preparation of a colonic microbiota responsive polymer, a degradable film based on the polymer and a preparation method thereof. By means of the characteristics that B-(1,4)-glucoside bond provided by cellobiose or/and p-galactoside bond provided by lactose monomer unit in the polymer can specifically respond to the high abundance of microbiotas (p-glucosidase or/and p-galactosidase) in the colon to specifically degrade in the colon, a colon-targeted delivery system for diagnosis and treatment of colon diseases is constructed.

公开(公告)号：US11986575B2

公开(公告)日：2024-05-21

申请号：US18280275

申请日：2022-03-29

Applicant: XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE

Inventor： Kun Sun ,  Jing Sun ,  Sun Chen ,  Kai Bai ,  Yanan Lu ,  Lu Wang ,  Fujun Wang ,  Fan Zhao ,  Jihong Huang

IPC: A61L31/16 ,  A61L31/10 ,  A61L31/14

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/21 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/626 ,  A61L2300/802 ,  A61L2420/02 ,  A61L2420/06

Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.

公开(公告)号：US20240115504A1

公开(公告)日：2024-04-11

申请号：US18271947

申请日：2022-01-12

Applicant: SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE

Inventor： Xiaoling GAO ,  Jialin HUANG ,  Gan JIANG ,  Qingxiang SONG ,  Hongzhuan CHEN

IPC: A61K9/127 ,  A61K31/728 ,  A61K38/00 ,  A61K47/36 ,  A61K47/42 ,  B82Y5/00

CPC classification number: A61K9/1277 ,  A61K31/728 ,  A61K38/00 ,  A61K47/36 ,  A61K47/42 ,  B82Y5/00

Abstract: Disclosed is a nanocomplex, a preparation method therefor, and a use thereof. The nanocomplex comprises 0-60% a protein drug, 0.03-15% hyaluronic acid, 0.8-20% protamine, 35-95% lipid components, and 2.5-40% a apolipoprotein and/or a mimetic peptide thereof; the lipid components comprise an electrically neutral lipid and an anionic lipid; and the total amount of hyaluronic acid and protamine is 0.03-15%. The nanocomplex of the present invention provides a general-type carrier for protein drugs having different physicochemical properties (such as molecular weights of 10-255 KDa and PIs of 4-11), implements highly efficient intracellular, in vivo, and even in-brain delivery, utilized technology is universal in nature, and said invention can effectively solve the current problem of insufficient in vivo and in vitro transport of protein drugs (comprising a protein drug exceeding the molecular weight and PI of an embodiment).

公开(公告)号：US11952913B2

公开(公告)日：2024-04-09

申请号：US18304387

申请日：2023-04-21

Applicant: Shanghai Jiaotong University

Inventor： Yu Rao ,  Yong Luan ,  Yamin Xu

IPC: F01D5/18

CPC classification number: F01D5/187 ,  F05D2240/303 ,  F05D2260/202 ,  F05D2260/2214

Abstract: A turbine blade includes a blade body, a division plate, a plurality of first protruding ridges, a plurality of second protruding ridges, a first jet hole group, and a second jet hole group. The blade body includes a suction-side wall surface and a pressure-side wall surface, which are provided with multiple film cooling holes. The stagnation region at the leading edge of the blade body is provided with multiple film cooling holes. The first and second jet hole groups are provided on the division plate. The first protruding ridges are provided on a suction-side inner wall surface, and the second ridges are provided on a pressure-side inner wall surface. An engine including the turbine blade is further provided.

公开(公告)号：US20240069027A1

公开(公告)日：2024-02-29

申请号：US18035270

申请日：2021-12-28

Applicant: SHANGHAI NINTH PEOPLE'S HOSPITAL, SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE ,  SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY, CHINESE ACADEMY OF SCIENCES

Inventor： JIPENG LI ,  SIWEI YANG ,  GUQIAO DING ,  HUIFANG ZHOU ,  XIANQUN FAN

IPC: G01N33/574 ,  C01B32/194 ,  C09K11/65 ,  G01N21/64

CPC classification number: G01N33/57407 ,  C01B32/194 ,  C09K11/65 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/57492 ,  B82Y20/00 ,  C01B2204/32 ,  C01P2002/54 ,  C01P2004/64 ,  C01P2006/60

Abstract: A use of nitrogen-doped carbon fluorescent quantum dots in preparation of aerobic glycolysis detection products is provided. The carbon-nitrogen fluorescent quantum dots are selected from one or more of C3N4 quantum dots, C2N quantum dots, and C3N quantum dots. The aerobic glycolysis detection products are reagents, based on a final volume of the reagents, the reagents comprise the carbon-nitrogen fluorescent quantum dots with a final concentration of 1 μg/mL-1 mg/mL. The present disclosure realizes fluorescent labeling of NAD+ in living cells using the carbon-nitrogen fluorescent quantum dots, thus achieving fluorescent labeling and imaging of cells having aerobic glycolysis, which has the advantages of low cost, high efficiency, rapidity, and high accuracy. Meanwhile, the present disclosure is conducive to developing a series of technologies such as fluorescence identification of exfoliated tumor cells, very early warning of tumors, detection of tumor metastases, and assessment of tumor proliferation and malignancy.

公开(公告)号：US11881015B2

公开(公告)日：2024-01-23

申请号：US17433994

申请日：2020-06-08

Applicant: Shanghai Jiaotong University

Inventor： Yadong Liu ,  Yingjie Yan ,  Siheng Xiong ,  Ling Pei ,  Zhe Li ,  Peng Xu ,  Lei Su ,  Xiaofei Fu ,  Xiuchen Jiang

IPC: G06V10/94 ,  G06V10/82 ,  G06V10/776 ,  G06V10/764 ,  G06V10/22 ,  G06V10/40 ,  G06T7/73 ,  G06T7/60 ,  G06V10/32 ,  G06N3/044

CPC classification number: G06V10/95 ,  G06N3/044 ,  G06T7/60 ,  G06T7/73 ,  G06V10/22 ,  G06V10/32 ,  G06V10/40 ,  G06V10/764 ,  G06V10/776 ,  G06V10/82 ,  G06T2207/20084

Abstract: The present invention provides a high-precision identification method and system for substations, including building a Mask RCNN objection recognition network model based on convolutional neural networks; inputting acquired image information of a object into the Mask RCNN object recognition network model for preliminary recognition and outputting a recognition result of the object; using an information entropy to create a semantic decision tree and correcting the recognition result of the object according to a principle of relative correlation between different objects and outputting a final recognition decision result; reading the recognition decision result to obtain a true type of the object to be recognized. The present invention greatly improves the accuracy of image recognition of substations, and has a positive role in the research and development of automatic inspection equipment for inspection robots.

公开(公告)号：US20230404763A1

公开(公告)日：2023-12-21

申请号：US18022253

申请日：2020-11-18

Applicant: SHANGHAI NINTH PEOPLE'S HOSPITAL, SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE

Inventor： CHI YANG ,  JISI ZHENG ,  ZIXIAN JIAO ,  MINJIE CHEN ,  WENBO JIANG

IPC: A61F2/30 ,  A61B17/80

CPC classification number: A61F2/3099 ,  A61B17/8071 ,  A61F2002/30991 ,  A61F2002/30993

Abstract: A muscle function preservation type total temporomandibular joint prosthesis includes an articular fossa member (1) and an articular head member (2) abutting against the articular fossa member (1). The articular head member (2) includes a mandibular trailing edge fixing plate (21), a sigmoid notch fixing plate (22) and an articular head portion (23). The mandibular trailing edge fixing plate (21) is connected to a bottom end of the articular head portion (23) and extends downwards, and has a plate-shaped structure and includes a mandibular-trailing-edge-surface attaching surface. The sigmoid notch fixing plate (22) protrudes from one side of the mandibular trailing edge fixing plate (21) and extends in a direction away from the mandibular trailing edge fixing plate (21), and has a plate-shaped structure and includes a mandibular-ramus-proximal-sigmoid-notch-portion attaching surface.