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1.发明授权Rod-derived cone viability factor (RDCVF) and a method of enhancing cone cell survival by RDCVF 有权Rod衍生的锥形存活因子（RDCVF）和通过RDCVF增强锥细胞存活的方法公开(公告)号：US07795387B2
公开(公告)日：2010-09-14
申请号：US10473008
申请日：2002-04-05
IPC分类号： C07K14/00 , C07K2/00 , G01N33/53 , G01N33/567 , C12N15/00 , C12N5/06 , C12N5/08 , C12P21/06 , C07K4/00 , C07K5/00
CPC分类号： A61K38/1709 , C07K14/47
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, chroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed 2Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with non-sufferers, antibodies which recongnize this protein, and methods for diagnosing such conditions.
摘要翻译： 公开了用于早期诊断，监测和治疗视网膜营养不良，年龄相关性黄斑变性，Bardet-Biedel综合征，Bassen-kornzweig综合征，最佳疾病，chroidema，旋转萎缩，先天性乳头状瘤，refsun综合征，stargardt病和Usher的方法和组合物 综合征 特别地，本发明涉及一种称为2Rdcvf1的蛋白质，其与非视网膜营养不良症相关的视网膜营养不良症等视网膜营养不良症和年龄相关性黄斑变性患者差异转录并表达，与非受试者相比，认为该抗体 蛋白质，以及诊断这些病症的方法。
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公开(公告)号：US20120108657A1
公开(公告)日：2012-05-03
申请号：US13348435
申请日：2012-01-11
IPC分类号： A61K31/711 , A61P27/02
CPC分类号： A61K38/1709 , C07K14/47
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.
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公开(公告)号：US20090215679A1
公开(公告)日：2009-08-27
申请号：US11596327
申请日：2005-05-12
申请人： Thirry Leveillard , Jose Alain Sahel , Saddek Mohand-Said , Olivier Poch , David Hicks , Carlos Alvarez
发明人： Thirry Leveillard , Jose Alain Sahel , Saddek Mohand-Said , Olivier Poch , David Hicks , Carlos Alvarez
IPC分类号： A61K38/16 , C07K14/00 , C07H21/00 , C12N15/74 , C12N5/00 , C12Q1/68 , C07K16/18 , G01N33/53 , C12P21/00 , A61K31/7088 , A61P27/02
CPC分类号： C07K14/435 , C07K14/47 , Y10T436/143333
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of an ocular disorder. In particular, the invention relates to a novel protein, that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with healthy subjects, antibodies which recognize this protein, and methods for diagnosing such conditions.
摘要翻译： 公开了用于眼部疾病的早期诊断，监测和治疗的方法和组合物。 特别地，本发明涉及一种新的蛋白质，其与健康受试者相比，识别该蛋白质的抗体，以及方法中的视网膜营养不良等受试者，如视网膜营养不良症和年龄相关性黄斑变性受试者差异转录和表达 用于诊断这种情况。
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4.发明授权Methods of increasing RDCVF 1 or RDCVF 2 polypeptides in retinal cells 有权增加视网膜细胞中RDCVF 1或RDCVF 2多肽的方法公开(公告)号：US08394756B2
公开(公告)日：2013-03-12
申请号：US13348383
申请日：2012-01-11
CPC分类号： A61K38/1709 , C07K14/47
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.
摘要翻译： 公开了用于早期诊断，监测和治疗视网膜营养不良，年龄相关性黄斑变性，Bardet-Biedel综合征，Bassen-kornzweig综合征，最佳疾病，脉络膜炎，旋转萎缩，先天性青春期，refsun综合征，星状病和Usher的方法和组合物 综合征 特别地，本发明涉及一种名为Rdcvf1的蛋白质，其与非消化子，认识该蛋白质的抗体相比，在视网膜营养不良等受试者，如视网膜营养不良症和年龄相关性黄斑变性的受试者中差异转录和表达，以及 诊断这种病症的方法。
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公开(公告)号：US20110105411A1
公开(公告)日：2011-05-05
申请号：US12985741
申请日：2011-01-06
申请人： Thirry Leveillard , Jose Alain Sahel , Saddek Mohand-Said , Olivier Poch , David Hicks , Carlos Alvarez
发明人： Thirry Leveillard , Jose Alain Sahel , Saddek Mohand-Said , Olivier Poch , David Hicks , Carlos Alvarez
IPC分类号： A61K38/16 , C07K14/00 , C07H21/00 , C12N5/10 , C12N15/63 , G01N33/50 , G01N33/53 , C07K16/00 , C12P21/00 , A61P27/02
CPC分类号： C07K14/435 , C07K14/47 , Y10T436/143333
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of an ocular disorder. In particular, the invention relates to a novel protein, that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with healthy subjects, antibodies which recognize this protein, and methods for diagnosing such conditions.
摘要翻译： 公开了用于眼部疾病的早期诊断，监测和治疗的方法和组合物。 特别地，本发明涉及一种新的蛋白质，其与健康受试者相比，识别该蛋白质的抗体，以及方法中的视网膜营养不良等受试者，如视网膜营养不良症和年龄相关性黄斑变性受试者差异转录和表达 用于诊断这种情况。
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6.发明授权公开(公告)号：US08518695B2
公开(公告)日：2013-08-27
申请号：US13348435
申请日：2012-01-11
CPC分类号： A61K38/1709 , C07K14/47
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.
摘要翻译： 公开了用于早期诊断，监测和治疗视网膜营养不良，年龄相关性黄斑变性，Bardet-Biedel综合征，Bassen-kornzweig综合征，最佳疾病，脉络膜炎，旋转萎缩，先天性青春期，refsun综合征，星状病和Usher的方法和组合物 综合征 特别地，本发明涉及一种称为“Rdcvf1”的蛋白质，其在与非脱发剂相比较时，与视网膜营养不良等受试者相比差异转录和表达，如视网膜营养不良和年龄相关性黄斑变性，识别该蛋白质的抗体 ，以及诊断这些病症的方法。
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公开(公告)号：US20120108523A1
公开(公告)日：2012-05-03
申请号：US13348383
申请日：2012-01-11
CPC分类号： A61K38/1709 , C07K14/47
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.
摘要翻译： 公开了用于早期诊断，监测和治疗视网膜营养不良，年龄相关性黄斑变性，Bardet-Biedel综合征，Bassen-kornzweig综合征，最佳疾病，脉络膜炎，旋转萎缩，先天性青春期，refsun综合征，星状病和Usher的方法和组合物 综合征 特别地，本发明涉及一种称为“Rdcvf1”的蛋白质，其在与非脱发剂相比较时，与视网膜营养不良等受试者相比差异转录并表达，如视网膜营养不良和年龄相关性黄斑变性，识别该蛋白质的抗体 ，以及诊断这些病症的方法。
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公开(公告)号：US08114849B2
公开(公告)日：2012-02-14
申请号：US11739739
申请日：2007-04-25
IPC分类号： C12N15/11 , C12N15/12 , C12N15/861
CPC分类号： A61K38/1709 , C07K14/47
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with non-sufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.
摘要翻译： 公开了用于早期诊断，监测和治疗视网膜营养不良，年龄相关性黄斑变性，Bardet-Biedel综合征，Bassen-kornzweig综合征，最佳疾病，脉络膜炎，旋转萎缩，先天性青春期，refsun综合征，星状病和Usher的方法和组合物 综合征 特别地，本发明涉及一种被称为“Rdcvf1”的蛋白质，其在非视网膜营养不良症等视网膜营养不良症和与年龄相关的黄斑变性患者中差异转录并表达，与非患者相比，识别的抗体 这种蛋白质，以及用于诊断这些病症的方法。
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9.发明授权Polynucleotides encoding rod-derived cone viability factor (rdcvf) and methods of using the same 有权编码棒衍生的锥形存活因子（rdcvf）的多核苷酸及其使用方法公开(公告)号：US08071745B2
公开(公告)日：2011-12-06
申请号：US11739734
申请日：2007-04-25
IPC分类号： C07H19/00 , C07H21/00 , C07H21/04 , C12P21/00 , C12P21/02 , C12N15/00 , C12N15/09 , C12N15/10
CPC分类号： A61K38/1709 , C07K14/47
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with non-sufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.
摘要翻译： 公开了用于早期诊断，监测和治疗视网膜营养不良，年龄相关性黄斑变性，Bardet-Biedel综合征，Bassen-kornzweig综合征，最佳疾病，脉络膜炎，旋转萎缩，先天性青春期，refsun综合征，星状病和Usher的方法和组合物 综合征 特别地，本发明涉及一种被称为“Rdcvf1”的蛋白质，其在非视网膜营养不良症等视网膜营养不良症和与年龄相关的黄斑变性患者中差异转录并表达，与非患者相比，识别的抗体 这种蛋白质，以及用于诊断这些病症的方法。
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公开(公告)号：US20090062188A1
公开(公告)日：2009-03-05
申请号：US11739734
申请日：2007-04-25
CPC分类号： A61K38/1709 , C07K14/47
摘要： Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with non-sufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.
摘要翻译： 公开了用于早期诊断，监测和治疗视网膜营养不良，年龄相关性黄斑变性，Bardet-Biedel综合征，Bassen-kornzweig综合征，最佳疾病，脉络膜炎，旋转萎缩，先天性青春期，refsun综合征，星状病和Usher的方法和组合物 综合征 特别地，本发明涉及一种被称为“Rdcvf1”的蛋白质，其在非视网膜营养不良症等视网膜营养不良症和与年龄相关的黄斑变性患者中差异转录并表达，与非患者相比，识别的抗体 这种蛋白质，以及用于诊断这些病症的方法。
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