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公开(公告)号：US20050158825A1
公开(公告)日：2005-07-21
申请号：US11007886
申请日：2004-12-09
Applicant: Scott Power , Huaming Wang , Michael Ward
Inventor： Scott Power , Huaming Wang , Michael Ward
CPC classification number: C07K16/2818 , C07K16/00 , C07K16/32 , C07K2317/10 , C07K2317/41 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2319/00
Abstract: Described herein are methods for the production of monoclonal antibodies in filamentous fungi host cells. The monoclonal antibodies are expressed as full-length fusion proteins that retain functional antigen binding and antibody-dependent cellular cytotoxicity capabilities. Improvements in the cleavage of the glucoamylase-light chain fusion protein to yield a mature antibody are also provided. The antibodies produced in filamentous fungi show equivalent pharmacokinetic disposition to antibodies produced in mammalian cells.
Abstract translation: 本文描述了在丝状真菌宿主细胞中生产单克隆抗体的方法。 单克隆抗体表达为全长融合蛋白，其保留功能性抗原结合和抗体依赖性细胞毒性能力。 还提供了葡糖淀粉酶 - 轻链融合蛋白切割产生成熟抗体的改进。 在丝状真菌中产生的抗体对哺乳动物细胞中产生的抗体显示出等效的药代动力学位置。
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2.发明申请公开(公告)号：US20050069978A1
公开(公告)日：2005-03-31
申请号：US10492782
申请日：2002-10-25
Applicant: Benjamin Bower , Frits Goedegebuur , Kathleen Clarkson , Scott Power
Inventor： Benjamin Bower , Frits Goedegebuur , Kathleen Clarkson , Scott Power
CPC classification number: C12N9/16
Abstract: DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed phytase protein in feed as a supplement.
Abstract translation: 提供了编码具有从青霉，镰刀霉，腐质霉和Emericicella分离的植酸酶活性的酶的DNA。 还提供了分离编码具有植酸酶活性的酶的DNA从具有这种DNA的生物中分离的DNA的方法，将DNA转化为合适的宿主生物体，转化的DNA的表达和在饲料中使用表达的植酸酶蛋白作为补充 。
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公开(公告)号：USD707453S1
公开(公告)日：2014-06-24
申请号：US29401119
申请日：2011-09-07
Applicant: Scott Power
Designer： Scott Power
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公开(公告)号：US20070207525A1
公开(公告)日：2007-09-06
申请号：US11698523
申请日：2007-01-26
Applicant: Benjamin Bower , Frits Goedegebuur , Kathleen Clarkson , Scott Power
Inventor： Benjamin Bower , Frits Goedegebuur , Kathleen Clarkson , Scott Power
CPC classification number: C12N9/16
Abstract: DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed phytase protein in feed as a supplement.
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公开(公告)号：US20070037151A1
公开(公告)日：2007-02-15
申请号：US10546497
申请日：2004-04-23
Applicant: Lilia Babe , Lawrence De Young , Fiona Harding , Manley Huang , Scott Power , Marcia Stickler
Inventor： Lilia Babe , Lawrence De Young , Fiona Harding , Manley Huang , Scott Power , Marcia Stickler
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/57 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , G01N33/505 , G01N2333/025 , G01N2333/70514 , G01N2333/70517
Abstract: The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
Abstract translation: 本发明提供来自人乳头状瘤病毒（HPV）的各种菌株的E6，E7和E2蛋白中的CD4 + T细胞表位。 在一些优选实施方案中，本发明提供用于开发HPV疫苗，特别是用于预防高危HPV病毒感染的多价疫苗的方法。 在另外的实施方案中，本发明提供了用于开发针对预防感染个体中良性和/或恶性肿瘤发展的高危HPV类型的治疗性疫苗的手段。 本发明还提供了适用于预防和治疗疫苗的表位。
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Patent Agency Ranking
公开(公告)号：US20070207524A1
公开(公告)日：2007-09-06
申请号：US11698326
申请日：2007-01-26
Applicant: Benjamin Bower , Frits Goedegebuur , Kathleen Clarkson , Scott Power
Inventor： Benjamin Bower , Frits Goedegebuur , Kathleen Clarkson , Scott Power
CPC classification number: C12N9/16
Abstract: DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed phytase protein in feed as a supplement.
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公开(公告)号：US20050238607A1
公开(公告)日：2005-10-27
申请号：US10984410
申请日：2004-11-08
Applicant: Anthony Day , Christopher Murray , Scott Power , Beverley Rider Turnquest
Inventor： Anthony Day , Christopher Murray , Scott Power , Beverley Rider Turnquest
IPC: A61K38/08 , A61K38/54 , A61K38/55 , C07H21/04 , C07K7/06 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/62 , C12N15/74 , C12P21/06 , A61K7/06 , A61K7/11
CPC classification number: C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
Abstract: The present invention provides peptides and supported peptides that bind to FGF-5.
Abstract translation: 本发明提供了结合FGF-5的肽和负载的肽。
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公开(公告)号：US20070048330A1
公开(公告)日：2007-03-01
申请号：US10677754
申请日：2003-10-03
Applicant: Alessandro Sette , Robert Chesnut , Mark Newman , Brian Livingston , Lilia Babe , Yiyou Chen , Lawrence Deyoung , Manley Huang , Scott Power
Inventor： Alessandro Sette , Robert Chesnut , Mark Newman , Brian Livingston , Lilia Babe , Yiyou Chen , Lawrence Deyoung , Manley Huang , Scott Power
CPC classification number: A61K39/292 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/6031 , A61K2039/605 , A61K2039/645 , C07K14/005 , C12N2730/10122 , C12N2730/10134
Abstract: The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.
Abstract translation: 本发明涉及生物学领域。 特别地，其涉及多表位核酸和肽疫苗以及设计这种疫苗以提供增加的免疫原性的方法。
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9.发明申请公开(公告)号：US20070014810A1
公开(公告)日：2007-01-18
申请号：US11027670
申请日：2005-01-03
Applicant: Denise Baker , Scott Power , Mark Newman , Robert Chesnut , Scott Southwood , Bianca Mothe , Manley Huang , Lilia Babe , Lawrence DeYoung , Yiyou Chen
Inventor： Denise Baker , Scott Power , Mark Newman , Robert Chesnut , Scott Southwood , Bianca Mothe , Manley Huang , Lilia Babe , Lawrence DeYoung , Yiyou Chen
IPC: C12Q1/70 , C07H21/04 , A61K39/12 , C12N7/00 , C07K14/025
CPC classification number: A61K39/0011 , A61K39/00 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/545 , A61K2039/57 , A61K2039/645 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20034
Abstract: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
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公开(公告)号：US20060134086A1
公开(公告)日：2006-06-22
申请号：US10881221
申请日：2004-06-30
Applicant: Yiyou Chen , Anthony Day , David Estell , Christopher Murray , Scott Power , Volker Schellenberger
Inventor： Yiyou Chen , Anthony Day , David Estell , Christopher Murray , Scott Power , Volker Schellenberger
CPC classification number: B82Y5/00 , A61K38/00 , A61K47/67 , A61K47/6891 , A61K48/00 , C07K2319/00 , C07K2319/01 , C12N9/00 , C12N9/50 , C12N9/86 , C12N15/1093 , C12Y305/02006
Abstract: The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.
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