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14 条记录 (耗时 0.038 秒)

    Screening Method Using Antibody Heavy Chains
    7.
    发明申请
    Screening Method Using Antibody Heavy Chains 审中-公开
    使用抗体重链的筛选方法

    公开(公告)号：US20070298443A1

    公开(公告)日：2007-12-27

    申请号：US10594190

    申请日：2005-05-12

    申请人： Yiyou Chen

    发明人： Yiyou Chen

    IPC分类号： G01N33/53 ,  C12N15/13 ,  G01N33/566

    CPC分类号： G01N33/6857 ,  C07K16/005 ,  C07K2317/22

    摘要： The present invention relates to a method of screening which includes an antibody heavy chain and a reporter gene, such as a camel antibody and beta-lactamase, respectively.

    摘要翻译： 本发明涉及一种筛选方法，其分别包括抗体重链和报告基因，例如骆驼抗体和β-内酰胺酶。

    Methods For Selective Targeting
    8.
    发明申请
    Methods For Selective Targeting 有权
    选择性定位方法

    公开(公告)号：US20090093393A1

    公开(公告)日：2009-04-09

    申请号：US12099632

    申请日：2008-04-08

    申请人： Christopher J. Murray ,  Pilar Tijerina ,  David A. Estell ,  Yiyou Chen

    发明人： Christopher J. Murray ,  Pilar Tijerina ,  David A. Estell ,  Yiyou Chen

    IPC分类号： C11D1/10 ,  C40B30/04 ,  C07K7/00

    CPC分类号： G01N33/54393 ,  C07K7/06 ,  C07K7/08 ,  C12N15/1034 ,  C12N15/1037 ,  C12N15/1072 ,  C40B40/02 ,  G01N33/6845 ,  G01N2500/02

    摘要： A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10−7 to 10−10 M. Additionally claimed are the ligands identified according to the method.

    摘要翻译： 公开了一种选择性靶向方法，其包括将配体文库，特别是肽文库与抗靶相接触，以允许配体结合抗靶; 将非结合配体与抗靶结合配体分离，使非结合抗靶配体与允许未结合配体与靶结合以形成靶结合配体复合物的靶; 将靶结合的配体络合物与不结合靶的配体分离，并鉴定靶结合的配体配合物上的靶结合配体，其中靶结合配体的KD在约10-7至10范围内 另外要求的是根据该方法鉴定的配体。