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    Method for producing biodegradable polyoxyalkylene derivative
    1.
    发明授权
    Method for producing biodegradable polyoxyalkylene derivative 有权
    生产可降解聚氧化烯衍生物的方法

    公开(公告)号：US08557929B2

    公开(公告)日：2013-10-15

    申请号：US11863977

    申请日：2007-09-28

    申请人： Kazuhiro Kubo ,  Shigeru Kitano ,  Chika Ito

    发明人： Kazuhiro Kubo ,  Shigeru Kitano ,  Chika Ito

    IPC分类号： C08F4/46 ,  C08G65/329

    CPC分类号： C08L71/02 ,  C08L2205/05 ,  C08L2666/18

    摘要： A method for producing a biodegradable polyoxyalkylene derivative, includes: reacting a biodegradable polyoxyalkylene compound represented by the formula (1) as defined herein with a compound represented by one of the formulae (I) to (IV) as defined herein in a presence of an alkaline solid salt, the biodegradable polyoxyalkylene derivative being represented by the formula (2) as defined herein.

    摘要翻译： 一种可生物降解的聚氧化烯衍生物的制造方法，其特征在于，包括：使如本文所定义的式（1）表示的生物可降解聚氧化烯化合物与本文所定义的式（I）〜（IV）之一所表示的化合物在 碱性固体盐，可生物降解的聚氧化烯衍生物由如本文所定义的式（2）表示。

    Phospholipid derivative
    4.
    发明授权
    Phospholipid derivative 有权
    磷脂衍生物

    公开(公告)号：US07531604B2

    公开(公告)日：2009-05-12

    申请号：US10529692

    申请日：2003-09-30

    申请人： Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Chika Itoh ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Kurosawa ,  Hitoshi Yamauchi

    发明人： Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Chika Itoh ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Kurosawa ,  Hitoshi Yamauchi

    IPC分类号： C08F8/32 ,  C08F8/40 ,  A61K9/127 ,  A61K47/32 ,  A61P35/00

    CPC分类号： C08F8/40 ,  A61K8/14 ,  A61K8/8164 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K31/795 ,  A61Q19/00 ,  C08F220/28 ,  C08F222/06 ,  C08L53/00 ,  C08F222/04 ,  C08L2666/02

    摘要： A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4≦m≦100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium] wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.

    摘要翻译： 可用于脂质体改性的磷脂衍生物等，其是以式（1）表示的成分单元A，式（2A）表示的成分单元B和/或式 式（2B）和式（3）表示的成分单元C [R1和R2表示氢原子或甲基，条件是R1和R2不同时表示甲基; R3表示碳原子数为1〜3的二价烃基; AO表示碳原子数2〜4的氧化烯基， m表示加成的氧化烯基的平均摩尔数，为4≤m≤100的范围内的数; R4表示氢原子，碳原子数为1〜20的烃基或酰基， R5CO和R6CO表示碳原子数为8〜24的酰基， R 7表示碳原子数为2〜4的二价烃基; 并且X和Y表示氢原子，碱金属原子，铵或有机铵]，其中组分单元A相对于组分单元B和组分单元C的总量的摩尔比为7/3至3 / 7，组分单元C的含量相对于1摩尔共聚物为1〜4摩尔。

    Cell having modified cell membrane
    5.
    发明授权
    Cell having modified cell membrane 有权
    细胞具有改变的细胞膜

    公开(公告)号：US07198945B2

    公开(公告)日：2007-04-03

    申请号：US10211587

    申请日：2002-08-05

    申请人： Teruyuki Nagamune ,  Chika Itoh ,  Tohru Yasukohchi ,  Syunsuke Ohhashi ,  Kazuhiro Kubo

    发明人： Teruyuki Nagamune ,  Chika Itoh ,  Tohru Yasukohchi ,  Syunsuke Ohhashi ,  Kazuhiro Kubo

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0006

    摘要： A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).

    摘要翻译： 其中待修饰物质和两亲性化合物的反应产物与细胞膜非共价结合的细胞，其中所述化合物具有以下特征

    Counter weight
    6.
    发明授权
    Counter weight 有权
    配重

    公开(公告)号：US07147250B2

    公开(公告)日：2006-12-12

    申请号：US10769983

    申请日：2004-02-03

    申请人： Kazuhiro Kubo ,  Masatoshi Kajiya ,  Morihiko Kawahashi

    发明人： Kazuhiro Kubo ,  Masatoshi Kajiya ,  Morihiko Kawahashi

    IPC分类号： B60R21/00

    CPC分类号： B66C23/74 ,  B62D49/085 ,  E02F9/18

    摘要： To provide a counter weight capable of forming an attaching part to a vehicle frame with high precision, capable of improving attaching precision to this vehicle frame, and further, capable of decreasing a manufacture cost thereof. The counter weight includes a base made of cast iron having an attaching part, whereby the counter weight is attached to a vehicle frame; and a weight part made of a slab material having a block body made of a slab material; wherein the weight part made of the slab material is attached on the above-described base made of cast iron. The outer surface of the above-described weight part made of the slab material is coated with the cover. In addition, the connection plate is attached to the above-described base made of cast iron, the lower end edge of the above-described cover is joined to the base made of cast iron through the above-described connection plate, and the upper end edge of the above-described cover is joined to the upper part of the above-described weight part made of the slab material. Since the base made of cast iron is attached to the vehicle frame, it is possible to form the attaching part to the vehicle frame at a low cost, simply, and with high precession.

    摘要翻译： 为了提供能够高精度地形成车架的安装部的配重，能够提高该车架的安装精度，并且还能够降低制造成本。 配重包括由铸铁制成的基座，该基座具有安装部，由此将配重安装在车架上; 以及由具有由坯料制成的块体的板坯材料制成的重量部件; 其特征在于，由所述板坯材料构成的所述重量部分安装在上述由铸铁制成的基座上。 由板坯材料制成的上述重量部分的外表面涂覆有盖。 另外，连接板安装在上述由铸铁制成的基座上，上述盖的下端缘通过上述连接板与铸铁底座接合，上端 上述盖的边缘连接到由板坯材料制成的上述重量部分的上部。 由于将铸铁制成的基座安装在车架上，所以能够以低成本，简单且高进动地将安装部件形成在车架上。

    Fungal inhibiting composition comprising Bacillus subtilis FERM BP-3418
    7.
    发明授权
    Fungal inhibiting composition comprising Bacillus subtilis FERM BP-3418 失效
    包含枯草芽孢杆菌FERM BP-3418的真菌抑制组合物

    公开(公告)号：US5667779A

    公开(公告)日：1997-09-16

    申请号：US660235

    申请日：1996-06-07

    申请人： Kazuhiro Kubo

    发明人： Kazuhiro Kubo

    IPC分类号： A01N63/00 ,  A23K1/00 ,  A23K1/18 ,  C12N1/20

    CPC分类号： C12R1/10 ,  A01N63/00 ,  A23K10/18 ,  A23K50/30 ,  C12R1/125 ,  Y10S426/807 ,  Y10S435/822 ,  Y10S435/839

    摘要： A bacterium belonging to Bacillus subtilis and having aflatoxin decomposing ability, as well as a fungal growth inhibitor, fermentation promoter and livestock fattening agent, all containing the bacterium as an active or effective ingredient. The Bacillus subtilis is strain FERM BP-3418. Also disclosed are methods for inhibiting or controlling a pathogenic fungus on a plant or animal.

    摘要翻译： 属于枯草芽孢杆菌的具有黄曲霉毒素分解能力的细菌，以及真菌生长抑制剂，发酵促进剂和家畜育肥剂，均含有细菌作为活性成分或有效成分。 枯草芽孢杆菌是菌株FERM BP-3418。 还公开了用于抑制或控制植物或动物上的病原真菌的方法。

    Hypotensive piperidine derivatives
    9.
    发明授权
    Hypotensive piperidine derivatives 失效
    低血压哌啶衍生物

    公开(公告)号：US4446141A

    公开(公告)日：1984-05-01

    申请号：US191339

    申请日：1980-02-02

    申请人： Nobuhiro Nakamizo ,  Hiroyuki Obase ,  Kazuhiro Kubo ,  Yutaka Kasuya

    发明人： Nobuhiro Nakamizo ,  Hiroyuki Obase ,  Kazuhiro Kubo ,  Yutaka Kasuya

    IPC分类号： A61K31/41 ,  A61P9/12 ,  C07D401/04 ,  C07D405/14 ,  A61K31/445

    CPC分类号： C07D401/04 ,  C07D405/14

    摘要： The present invention relates to a novel compound represented by the general formula: ##STR1## wherein Ar represents a naphthyl, phenyl or substituted phenyl group, Q represents ##STR2## wherein R.sub.1 represents a hydrogen atom, or an alkyl, alkanoyl or alkoxycarbonyl group, R represents a hydrogen atom or an alkyl group, and Z represents a substituted benzimidazolinyl group; the broken line in piperidine ring means that 3,4-positions in the piperidine ring are saturated or form a double bond. Said compound and the pharmaceutically acceptable acid addition salts thereof have a hypotensive action and therefore are useful as medicine.

    摘要翻译： PCT No.PCT / JP79 / 00141 Sec。 371日期1980年2月2日 102（e）日期1980年1月31日PCT申请日1979年6月1日PCT公布。 出版物WO80 / 1980年1月10日。本发明涉及以下通式表示的新化合物：其中Ar表示萘基，苯基或取代苯基，Q表示其中R1表示氢原子，或 烷基，烷酰基或烷氧基羰基，R表示氢原子或烷基，Z表示取代的苯并咪唑啉基; 哌啶环中的虚线表示哌啶环中的3,4-位饱和或形成双键。 所述化合物及其药学上可接受的酸加成盐具有降血压作用，因此可用作药物。

    Hypotensive piperidine derivatives
    10.
    发明授权
    Hypotensive piperidine derivatives 失效
    低血压哌啶衍生物

    公开(公告)号：US4410528A

    公开(公告)日：1983-10-18

    申请号：US264810

    申请日：1981-05-18

    申请人： Masayuki Teranishi ,  Hiroyuki Obase ,  Nobuhiro Nakamizo ,  Kazuhiro Kubo ,  Yutaka Kasuya

    发明人： Masayuki Teranishi ,  Hiroyuki Obase ,  Nobuhiro Nakamizo ,  Kazuhiro Kubo ,  Yutaka Kasuya

    IPC分类号： C07D211/58 ,  A61K31/505 ,  C07D401/04

    CPC分类号： C07D211/58

    摘要： A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R.sub.1 is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); (A).sub.m and R.sub.2 are usually used substituents; and Y is a monovalent group or a divalent group and is one of the following three groups: ##STR2## wherein when p is 0, B is --N.dbd.N--, ##STR3## and when p is 1, B is ##STR4## wherein (R.sub.3).sub.n is a usually used substituent, has hypotensive activity.

    摘要翻译： 由下式表示的新的哌啶衍生物：其中X是氧，硫，羰基，羟基亚甲基或亚甲基; R1是具有或不具有低级烷基取代基的具有1-4个碳原子的直链亚烷基; （A）m和R 2通常是取代基; （1）其中当p为0时，B为-N = N-，，当p为1时，B为 （3）其中（R3）n是通常使用的取代基，具有降血压作用。