公开(公告)号：US06709491B2

公开(公告)日：2004-03-23

申请号：US10227297

申请日：2002-08-26

申请人： Hiroyoshi Kawakami ,  Shoji Nagaoka ,  Yoshiaki Suzuki ,  Masaya Iwaki

发明人： Hiroyoshi Kawakami ,  Shoji Nagaoka ,  Yoshiaki Suzuki ,  Masaya Iwaki

IPC分类号： B01D7164

CPC分类号： B01D67/009 ,  B01D53/228 ,  B01D67/0009 ,  B01D67/0032 ,  B01D67/0072 ,  B01D71/64 ,  B01D2323/12 ,  B01D2325/022 ,  Y02C20/20 ,  Y10S55/05

摘要： The object of the present invention is to provide a novel gas separation membrane having a high gas permeability and a high gas selectivity, and a method of producing the same. The present invention provides a gas separation membrane comprising a polymeric material soluble in an organic solvent, wherein at least a part of the surface is modified by ion bombardment.

摘要翻译： 本发明的目的在于提供一种气体透过性高，气体选择性高的新型气体分离膜及其制造方法。 本发明提供了一种气体分离膜，其包含可溶于有机溶剂的聚合材料，其中表面的至少一部分被离子轰击改性。

公开(公告)号：US5079093A

公开(公告)日：1992-01-07

申请号：US465237

申请日：1990-06-04

申请人： Ryojiro Akashi ,  Shoji Nagaoka

发明人： Ryojiro Akashi ,  Shoji Nagaoka

IPC分类号： A61L27/34 ,  A61L29/08 ,  A61L31/10

CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  Y10T428/31504 ,  Y10T428/31576 ,  Y10T428/31699 ,  Y10T428/31797 ,  Y10T428/31928

摘要： The present invention provides a medical material having an easily-slippery property and durability which the conventional technologies have never provided by fixing a hydrophilic polymer on the surface of a base material through strong covalent bondings and a method for preparation thereof.

公开(公告)号：US5043278A

公开(公告)日：1991-08-27

申请号：US549251

申请日：1990-07-06

申请人： Shoji Nagaoka ,  Hajimu Kurumatani ,  Yuichi Mori

发明人： Shoji Nagaoka ,  Hajimu Kurumatani ,  Yuichi Mori

IPC分类号： A61L33/00 ,  B01J20/32 ,  C07K17/06 ,  C12N11/06 ,  C12N11/08 ,  G01N33/543 ,  G01N33/545

CPC分类号： A61L33/0029 ,  B01J20/262 ,  B01J20/264 ,  B01J20/265 ,  B01J20/28004 ,  B01J20/28023 ,  B01J20/289 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3272 ,  B01J20/3276 ,  C12N11/08 ,  G01N33/54353 ,  G01N33/545 ,  B01J2220/54 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/816

摘要： Fixation of a physiologically active substance on a carrier through an alkylene oxide chain allows the physioactive function of the substance to be retained to a high degree. The fixed physiologically-active substances are useful for separation and purification of materials. The carrier is preferably a thin fiber of 1.0 denier or less, and may be formed from a polymer. The alkylene oxide chain has an amino or epoxy group at one end which bonds to the carrier and a functional group at the other end which bonds to a physiologically-active substance.The carrier is preferably a thin fiber of 1.0 denier or less, and may be formed from a polymer. The alkylene oxide chain has an amino or epoxy group at one end which bonds to the carrier and a functional group at the other end which bonds to a physiologically-active substance.

公开(公告)号：US4936674A

公开(公告)日：1990-06-26

申请号：US334575

申请日：1989-04-07

申请人： Yasuo Ikeda ,  Kiyotaka Sakai ,  Ichiro Itagaki ,  Masato Mikami ,  Shoji Nagaoka

发明人： Yasuo Ikeda ,  Kiyotaka Sakai ,  Ichiro Itagaki ,  Masato Mikami ,  Shoji Nagaoka

IPC分类号： G01N11/14 ,  G01N15/00 ,  G01N15/02 ,  G01N33/48 ,  G01N33/50

CPC分类号： G01N33/48 ,  G01N15/0205 ,  G01N33/5091 ,  G01N11/14 ,  G01N2015/0084

摘要： An apparatus for determining the functioning properties of cells which includes a sample containing chamber, a rotor disposed in the chamber and having a conical surface which faces the inner bottom surface of the chamber at an angle of not greater than 2.degree., a ray transmission path from which a ray is projected into a sample of a cell suspension between the rotor and the inner bottom surface, and a transmitted ray detection path from which transmittance from the sample is detected. The optical path length in the sample is not smaller than 1 cm. An adequate shear stress is applied to the sample by adjusting the gap between the rotor and the inner bottom surface and rotating the rotor. A fine response by the cells caused by the applied shear stress, particularly the aggregation of platelets in a platelet suspension, can be accurately and quantitatively determined with a high sensitivity.

公开(公告)号：US20050008687A1

公开(公告)日：2005-01-13

申请号：US10788263

申请日：2004-03-01

申请人： Makoto Yuasa ,  Noriyoshi Matsukura ,  Aritomo Yamaguchi ,  Hiroyoshi Kawakami ,  Shoji Nagaoka ,  Masahiko Abe ,  Hitoshi Takebayashi ,  Aiko Horiuchi ,  Akihiko Ogata ,  Takeshi Sakaya

发明人： Makoto Yuasa ,  Noriyoshi Matsukura ,  Aritomo Yamaguchi ,  Hiroyoshi Kawakami ,  Shoji Nagaoka ,  Masahiko Abe ,  Hitoshi Takebayashi ,  Aiko Horiuchi ,  Akihiko Ogata ,  Takeshi Sakaya

IPC分类号： A61K9/127 ,  A61K31/409 ,  A61K31/4439 ,  A61K31/555

CPC分类号： A61K31/409 ,  A61K9/127 ,  A61K31/4439 ,  A61K31/555

摘要： An metalloporphyrin-complex-embedded liposome, comprising a cationic metalloporphyrin complex and a lipid having liposome forming ability is disclosed. As metalloporphyrin-complex-embedded liposomes according to the present invention act on superoxide anion radicals (O2−), and can surely lower their concentration, they can exhibit superb effects for the treatment of cancers and have excellent characteristics as antioxidants.

摘要翻译： 公开了包含阳离子金属卟啉络合物和具有脂质体形成能力的脂质的金属卟啉 - 复合物嵌入的脂质体。 由于根据本发明的金属卟啉 - 复合物嵌入的脂质体作用于超氧化物阴离子自由基（O 2 - ），并且可以确定地降低它们的浓度，它们对于治疗癌症表现出极好的效果，并且具有作为抗氧化剂的优异特征。

公开(公告)号：US4424311A

公开(公告)日：1984-01-03

申请号：US393655

申请日：1982-06-30

申请人： Shoji Nagaoka ,  Hidefumi Takiuchi ,  Yuichi Mori ,  Tetsuya Kikuchi

发明人： Shoji Nagaoka ,  Hidefumi Takiuchi ,  Yuichi Mori ,  Tetsuya Kikuchi

IPC分类号： C08F259/00 ,  A61L29/04 ,  A61L33/06 ,  B01D71/28 ,  B01D71/40 ,  B01D71/78 ,  B01D71/80 ,  C08F259/02 ,  C08F259/04 ,  C08F290/00 ,  C08F291/00 ,  C08F299/00 ,  C08L51/00

CPC分类号： C08L51/003 ,  A61L29/041 ,  A61L33/064 ,  B01D71/28 ,  B01D71/40 ,  B01D71/78 ,  B01D71/80 ,  C08F259/02 ,  C08F259/04

摘要： Provided is an antithrombogenic biomedical material comprising a copolymer of (A) not less than 5% by weight of one or more polymerizable monomers having a polyethylene oxide unit with a degree of polymerization not less than 5 and a polymerizable carbon-carbon double bond and (B) not more than 95% by weight of one or more monomers copolymerizable with said monomer (A).

摘要翻译： 本发明提供一种抗血栓性生物医学材料，其包含（A）不少于5重量％的一种或多种聚合单元，其聚合度为聚合度不小于5的可聚合单体和可聚合碳 - 碳双键的共聚物，和 B）不超过95重量％的可与所述单体（A）共聚的一种或多种单体。