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    ELECTRODE FOR ACTIVE OXYGEN SPECIES AND SENSOR USING THE ELECTRODE
    4.
    发明申请
    ELECTRODE FOR ACTIVE OXYGEN SPECIES AND SENSOR USING THE ELECTRODE 审中-公开
    用于活性氧物质的电极和使用电极的传感器

    公开(公告)号：US20140061063A1

    公开(公告)日：2014-03-06

    申请号：US14071265

    申请日：2013-11-04

    申请人： Makoto Yuasa ,  Hitoshi Takebayashi ,  Masahiko Abe

    发明人： Makoto Yuasa ,  Masahiko Abe ,  Aritomo Yamaguchi ,  Asako Shiozawa ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Shigeru Kido

    IPC分类号： G01N27/333 ,  G01N27/327

    CPC分类号： G01N27/3335 ,  A61B5/1473 ,  C11D3/0015 ,  C11D3/2093 ,  C11D3/50 ,  G01N27/3271 ,  G01N33/4925

    摘要： An electrode for active oxygen species comprising a conductive component with a polymer membrane of a metal porphyrin complex formed on the surface is disclosed. The electrode for active oxygen species can detect active oxygen species such as superoxide anion radicals, hydrogen peroxide, and .OH and other active radical species (NO, ONOO—, etc.) in any environment including in vivo environment as well as in vitro environment. The electrode thus can be used for specifying various diseases and examining active oxygen species in food or in water such as tap water and sewage water.

    摘要翻译： 公开了一种用于活性氧物质的电极，其包含在表面上形成的具有金属卟啉络合物的聚合物膜的导电组分。 用于活性氧的电极可以在包括体内环境以及体外环境的任何环境中检测活性氧，如超氧阴离子自由基，过氧化氢和.OH等活性自由基（NO，ONOO-等） 。 因此，电极可以用于指定各种疾病并检查食物或水中的活性氧，例如自来水和污水。

    Niosome Having Metal Porphyrin Complex Embedded Therein, Process For Producing The Same And Drug With The Use Thereof
    6.
    发明申请
    Niosome Having Metal Porphyrin Complex Embedded Therein, Process For Producing The Same And Drug With The Use Thereof 审中-公开
    具有金属卟啉复合物的Niosome，其制造方法与其使用相同和药物

    公开(公告)号：US20080269184A1

    公开(公告)日：2008-10-30

    申请号：US10591658

    申请日：2004-03-04

    申请人： Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Yukihiro Hanyuu ,  Kazunori Kasahara ,  Masayasu Komuro

    发明人： Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Yukihiro Hanyuu ,  Kazunori Kasahara ,  Masayasu Komuro

    IPC分类号： A61K31/555 ,  C07D487/22 ,  A61P35/04 ,  A61P3/00 ,  A61P29/00 ,  A61P25/00

    CPC分类号： A61K9/1272 ,  A61K9/0019 ,  A61K31/409 ,  A61K31/555 ,  A61K45/06

    摘要： A niosome having a metalloporphyrin complex embedded therein comprising a cationized metalloporphyrin complex and a niosome-forming substance. The niosome having a metalloporphyrin complex embedded therein has an SOD activity, can interact with superoxide anionic radicals (O2−.) as a target, and can reduce these radicals without fail. The niosome having a metalloporphyrin complex embedded therein can reach cells in living bodies such as cancer cells due to properties of a niosome. Therefore, the niosome having a metalloporphyrin complex embedded therein can exhibit an excellent effect of treating cancer by reducing O2-. in cancer cells. In addition, since the effect is selective, the niosome can be used as a novel anticancer agent without side effects. Moreover, the niosome having a metalloporphyrin complex embedded therein can be retained in the blood while exhibiting a superior antioxidation effect. The niosome can thus protect living bodies from hindrance brought about by active oxygen species.

    摘要翻译： 具有嵌入其中的金属卟啉络合物的组合物包含阳离子化金属卟啉络合物和形成niosome的物质。 嵌入其中的金属卟啉络合物的组合物具有SOD活性，可与超氧化物阴离子自由基（O 2 O 2）作为靶，并且可以不失败地减少这些基团 。 具有嵌入其中的金属卟啉复合物的组合物可以由于niosome的性质而到达活体内的细胞，例如癌细胞。 因此，嵌入其中的金属卟啉复合物的组合物可以通过减少O2-表现出优异的治疗癌症的效果。 在癌细胞中。 此外，由于效果是选择性的，所以可以用作新型抗癌剂而没有副作用。 此外，具有嵌入其中的金属卟啉复合物的组合物可以保留在血液中，同时具有优异的抗氧化作用。 因此，保护​​活体可以保护活体免受活性氧引起的阻碍。

    Porphyrin-based electrode catalyst
    7.
    发明申请
    Porphyrin-based electrode catalyst 审中-公开
    卟啉类电极催化剂

    公开(公告)号：US20090048096A1

    公开(公告)日：2009-02-19

    申请号：US11920152

    申请日：2006-05-10

    申请人： Naoko Iwata ,  Tetsuo Nagami ,  Hidetaka Nishikoori ,  Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Mizuki Kitao ,  Takuya Imai ,  Shigeru Kido

    发明人： Naoko Iwata ,  Tetsuo Nagami ,  Hidetaka Nishikoori ,  Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Mizuki Kitao ,  Takuya Imai ,  Shigeru Kido

    IPC分类号： B01J31/18

    CPC分类号： H01M4/9008 ,  B01J31/1815 ,  B01J37/086 ,  B01J2531/845 ,  C07D487/22 ,  H01M4/9083

    摘要： This invention provides a macrocyclic-organic-compound-based catalyst for reducing oxygen having high oxygen-reducing activity. This oxygen-reducing catalyst comprises a conductive support and, supported thereon, a porphyrin complex represented by formula (I): wherein Rs each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a halogen atom, an amino group, a hydroxyl group, a nitro group, a phenyl group, or a cyano group or adjacent Rs together form a methylene chain having 2 to 6 carbon atoms or aromatic ring; R's each independently represent a thienyl group; and M represents a metal atom selected from the group consisting of Cu, Zn, Fe, Co, Ni, Ru, Pb, Rh, Pd, Pt, Mn, Sn, Au, Mg, Cd, Al, In, Ge, Cr, and Ti, provided that M may bind to a halogen atom, an oxygen atom, —OH, a nitrogen atom, NO, or ═CO.

    摘要翻译： 本发明提供了一种用于还原具有高氧还原活性的氧的大环 - 有机 - 化合物基催化剂。 该氧还原催化剂包括导电载体，并在其上负载由式（I）表示的卟啉络合物：其中R 5各自独立地表示氢原子，具有1至6个碳原子的烷基，卤素原子，氨基 ，羟基，硝基，苯基或氰基或相邻的Rs一起形成具有2至6个碳原子的亚甲基或芳香环; R各自独立地表示噻吩基; 并且M表示选自Cu，Zn，Fe，Co，Ni，Ru，Pb，Rh，Pd，Pt，Mn，Sn，Au，Mg，Cd，Al，In，Ge，Cr， 和Ti，条件是M可以与卤素原子，氧原子，-OH，氮原子，NO或-CO结合。

    ELECTRODE FOR SUPEROXIDE ANION AND SENSOR INCLUDING THE SAME
    8.
    发明申请
    ELECTRODE FOR SUPEROXIDE ANION AND SENSOR INCLUDING THE SAME 审中-公开
    用于超氧化物阴离子和包括其的传感器的电极

    公开(公告)号：US20150160152A1

    公开(公告)日：2015-06-11

    申请号：US14531666

    申请日：2014-11-03

    申请人： Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Tomohiro Kobayashi ,  Satoshi Tsutsui ,  Yuujirou Toyoda

    发明人： Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Tomohiro Kobayashi ,  Satoshi Tsutsui ,  Yuujirou Toyoda

    IPC分类号： G01N27/333 ,  C25D5/00

    CPC分类号： G01N27/3335 ,  C25D5/00

    摘要： An electrode for superoxide anions characterized by comprising a conductive component and, superimposed on a surface thereof, a film resulting from electrolytic polymerization of a metal thiofurylporphyrin/axial ligand complex; and a sensor for measuring a superoxide anion concentration including the same. The electrode for superoxide anions, by virtue of not only the excellent performance of electrode provided with the metal porphyrin complex polymer film, but also the presence of the axial ligand, can prevent poisoning by a catalyst poison such as hydrogen peroxide. Accordingly, in any of in vitro or in vivo environments, this electrode for superoxide anions enables detection of superoxide anion radicals without suffering any influence from a catalyst poison such as hydrogen peroxide. Moreover, quantitative assay of superoxide anions can be performed by the use of this electrode for superoxide anion in combination with a counter electrode or a reference electrode. Thus, this electrode for superoxide anions can find wide applicability in various fields.

    摘要翻译： 一种超氧化物阴离子的电极，其特征在于包括导电成分，并且在其表面上叠加由金属硫代卟啉/轴配体络合物的电解聚合得到的膜; 以及用于测量包含该超氧化物阴离子浓度的超氧化物阴离子浓度的传感器。 超氧化物阴离子电极不仅具有金属卟啉复合聚合物膜的电极的优异性能，而且还具有轴配体的存在，可以防止催化剂毒物如过氧化氢的中毒。 因此，在任何体外或体内环境中，这种超氧化物阴离子电极能够检测超氧阴离子自由基，而不会受到诸如过氧化氢等催化剂毒物的任何影响。 此外，超氧阴离子的定量测定可以通过将该电极与对电极或参比电极结合使用来实现超氧阴离子。 因此，这种超氧阴离子电极可以在各个领域得到广泛的应用。

    ELECTRODE FOR SUPEROXIDE ANION AND SENSOR INCLUDING THE SAME
    9.
    发明申请
    ELECTRODE FOR SUPEROXIDE ANION AND SENSOR INCLUDING THE SAME 审中-公开
    用于超氧化物阴离子和包括其的传感器的电极

    公开(公告)号：US20120145562A1

    公开(公告)日：2012-06-14

    申请号：US13270608

    申请日：2011-10-11

    申请人： Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Tomohiro Kobayashi ,  Satoshi Tsutsui ,  Yuujirou Toyoda

    发明人： Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Tomohiro Kobayashi ,  Satoshi Tsutsui ,  Yuujirou Toyoda

    IPC分类号： G01N27/333 ,  G01N27/26

    CPC分类号： G01N27/3335 ,  C25D5/00

    摘要： An electrode for superoxide anions which contains a conductive component and, superimposed on a surface thereof, a film resulting from electrolytic polymerization of a metal thiofurylporphyrin/axial ligand complex; and a sensor for measuring a superoxide anion concentration including the same. The electrode for superoxide anions can prevent poisoning by a catalyst poison such as hydrogen peroxide. Accordingly, in any of in vitro or in vivo environments, this electrode for superoxide anions enables detection of superoxide anion radicals without suffering any influence from a catalyst poison such as hydrogen peroxide. Moreover, quantitative assay of superoxide anions can be performed with this electrode for superoxide anion in combination with a counter electrode or a reference electrode. Thus, this electrode for superoxide anions can find wide applicability in various fields.

    摘要翻译： 一种超氧阴离子的电极，其包含导电成分，并且在其表面上叠加由金属硫卟啉/轴配位体络合物的电解聚合得到的膜; 以及用于测量包含该超氧阴离子浓度的超氧化物阴离子浓度的传感 超氧化物阴离子电极可以防止催化剂毒物如过氧化氢中毒。 因此，在任何体外或体内环境中，这种超氧化物阴离子电极能够检测超氧阴离子自由基，而不会受到诸如过氧化氢等催化剂毒物的任何影响。 此外，超氧化物阴离子的定量测定可以用该电极进行，其中超氧阴离子与对电极或参比电极组合。 因此，这种超氧阴离子电极可以在各个领域得到广泛的应用。

    Electrode for Superoxide Anion and Sensor Including the Same
    10.
    发明申请
    Electrode for Superoxide Anion and Sensor Including the Same 审中-公开
    超氧阴离子电极及其传感器

    公开(公告)号：US20080289960A1

    公开(公告)日：2008-11-27

    申请号：US10592469

    申请日：2004-03-12

    申请人： Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Tomohiro Kobayashi ,  Satoshi Tsutsui ,  Yuujirou Toyoda

    发明人： Makoto Yuasa ,  Kenichi Oyaizu ,  Aritomo Yamaguchi ,  Masuhide Ishikawa ,  Katsuya Eguchi ,  Tomohiro Kobayashi ,  Satoshi Tsutsui ,  Yuujirou Toyoda

    IPC分类号： G01N27/26

    CPC分类号： G01N27/3335 ,  C25D5/00

    摘要： An electrode for superoxide anions characterized by comprising a conductive component and, superimposed on a surface thereof, a film resulting from electrolytic polymerization of a metal thiofurylporphyrin/axial ligand complex; and a sensor for measuring a superoxide anion concentration including the same. The electrode for superoxide anions, by virtue of not only the excellent performance of electrode provided with the metal porphyrin complex polymer film, but also the presence of the axial ligand, can prevent poisoning by a catalyst poison such as hydrogen peroxide. Accordingly, in any of in vitro or in vivo environments, this electrode for superoxide anions enables detection of superoxide anion radicals without suffering any influence from a catalyst poison such as hydrogen peroxide. Moreover, quantitative assay of superoxide anions can be performed by the use of this electrode for superoxide anion in combination with a counter electrode or a reference electrode. Thus, this electrode for superoxide anions can find wide applicability in various fields.

    摘要翻译： 一种超氧化物阴离子的电极，其特征在于包括导电成分，并且在其表面上叠加由金属硫代卟啉/轴配体络合物的电解聚合得到的膜; 以及用于测量包含该超氧化物阴离子浓度的超氧化物阴离子浓度的传感器。 超氧化物阴离子电极不仅具有金属卟啉复合聚合物膜的电极的优异性能，而且还具有轴配体的存在，可以防止催化剂毒物如过氧化氢的中毒。 因此，在任何体外或体内环境中，这种超氧化物阴离子电极能够检测超氧阴离子自由基，而不会受到诸如过氧化氢等催化剂毒物的任何影响。 此外，超氧阴离子的定量测定可以通过将该电极与对电极或参比电极结合使用来实现超氧阴离子。 因此，这种超氧阴离子电极可以在各个领域得到广泛的应用。