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1.发明授权公开(公告)号：US11931739B2
公开(公告)日：2024-03-19
申请号：US16639471
申请日：2018-08-16
IPC分类号： B01L3/00 , G01N1/40 , G01N33/537
CPC分类号： B01L3/502753 , G01N1/4077 , G01N33/537 , B01L2300/0681 , G01N2001/4088
摘要： Provided are methods, devices, and kits for the isolation and detection of one or more analytes of interest from a biological sample using microslit filter membranes. In various examples, the methods use capture particles and binding agents for specific recognition of one or more analytes of interest.
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公开(公告)号：US20200330931A1
公开(公告)日：2020-10-22
申请号：US16959872
申请日：2019-01-07
申请人： SiMPore Inc.
发明人： Jared A. CARTER , James A. ROUSSIE
IPC分类号： B01D67/00 , B01L3/00 , C01B33/02 , C07F7/18 , B01D71/02 , B01D71/46 , B01D71/60 , B01D69/02 , B01D61/02 , B01D61/24
摘要： Provided are methods using and making functionalized silicon membranes, such as, for example, functionalized silicon nanomembranes. The methods may combine one or more (e.g., two) surface modification processes (e.g., using a combination of aldehydes and silanes). Also described are fluidic devices containing functionalized membranes of the present disclosure and uses thereof. The fluidic devices of the present disclosure include one or more functionalized silicon membrane.
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公开(公告)号：US09789239B2
公开(公告)日：2017-10-17
申请号：US14911879
申请日：2014-08-15
申请人： SiMPore, Inc.
CPC分类号： A61M1/1631 , B01D61/243 , B01D63/088 , B01D67/0037 , B01D67/0062 , B01D69/06 , B01D71/02 , B82Y40/00
摘要： Provided are nanoporous silicon nitride membranes and methods of making such membranes. The membranes can be part of a monolithic structure or free-standing. The membranes can be made by transfer of the nanoporous structure of a nanoporous silicon or silicon oxide film by, for example, reactive ion etching. The membranes can be used in, for example, filtration applications, hemodialysis applications, hemodialysis devices, laboratory separation devices, multi-well cell culture devices, electronic biosensors, optical biosensors, active pre-concentration filters for microfluidic devices.
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4.发明申请公开(公告)号：US20160340778A1
公开(公告)日：2016-11-24
申请号：US15037542
申请日：2014-11-19
申请人： SiMPore INC.
CPC分类号： C23C16/402 , C23C16/01 , C23C16/401 , C23C16/505 , C23C16/56 , G01N21/03 , G02B21/34 , H01J37/20
摘要： Provided is a free-standing silicon oxide film that is under tensile stress. Also, provided are methods of making a free-standing silicon oxide film that is under tensile stress. The methods use low-power PECVD deposition of silicon oxide. Methods of imaging one or more objects (e.g., cells) using a free-standing silicon oxide film that is under tensile stress is also provided.
摘要翻译： 提供了在拉伸应力下的独立的氧化硅膜。 此外，提供了制造在拉伸应力下的独立氧化硅膜的方法。 该方法使用低功率PECVD沉积氧化硅。 还提供了使用处于拉伸应力下的独立氧化硅膜对一个或多个物体（例如，电池）进行成像的方法。
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5.发明申请公开(公告)号：US20200333311A1
公开(公告)日：2020-10-22
申请号：US16959869
申请日：2019-01-07
摘要： Provided are methods of preparing, detecting, and/or assaying an analyte of interest from a sample. The methods utilize functionalized silicon membranes, such as, for example, functionalized silicon nanomembranes. Samples that can be used in the methods may be biological samples, food samples, environmental samples, industrial samples, or a combination thereof. Also provided are kits to perform methods of the present disclosure.
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公开(公告)号：US10668436B2
公开(公告)日：2020-06-02
申请号：US15772488
申请日：2016-10-31
申请人： SiMPore Inc.
IPC分类号： B01D67/00 , B01D69/02 , B01D61/24 , B01D69/12 , B01D71/02 , B81C1/00 , C12M1/12 , C12M1/26 , G01N1/34 , G03F7/00 , B01D61/18 , C23F1/04
摘要： Provided are monolithic structures comprising one or more suspended, nanoporous membranes that are in contact with one or more fluidic cavities, methods of making same, and exemplary uses of same. The monolithic structures can be formed using a transmembrane etch. The monolithic structures can be used, as examples, as filters and filtration modules in microfluidic devices, dialysis devices, and concentration devices in laboratory, industrial, and medical processes.
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公开(公告)号：US10391219B2
公开(公告)日：2019-08-27
申请号：US15783757
申请日：2017-10-13
申请人： SiMPore, Inc.
摘要： Provided are nanoporous silicon nitride membranes and methods of making such membranes. The membranes can be part of a monolithic structure or free-standing. The membranes can be made by transfer of the nanoporous structure of a nanoporous silicon or silicon oxide film by, for example, reactive ion etching. The membranes can be used in, for example, filtration applications, hemodialysis applications, hemodialysis devices, laboratory separation devices, multi-well cell culture devices, electronic biosensors, optical biosensors, active pre-concentration filters for microfluidic devices.
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8.发明公开公开(公告)号：US20240342717A1
公开(公告)日：2024-10-17
申请号：US18607405
申请日：2024-03-15
IPC分类号： B01L3/00 , G01N1/40 , G01N33/537
CPC分类号： B01L3/502753 , G01N1/4077 , G01N33/537 , B01L2300/0681 , G01N2001/4088
摘要： Provided are methods, devices, and kits for the isolation and detection of one or more analytes of interest from a biological sample using microslit filter membranes. In various examples, the methods use capture particles and binding agents for specific recognition of one or more analytes of interest.
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公开(公告)号：US11635357B2
公开(公告)日：2023-04-25
申请号：US17382505
申请日：2021-07-22
申请人： SiMPore Inc.
摘要： Provided are methods, devices, and kits for the isolation of extracellular vesicles using silicon nanomembranes. A method for EV isolation includes the steps of collecting a biofluid sample, contacting the biofluid sample with a pre-filtration membrane, thereby forming a first filtrate and a first retentate, optionally, washing the first retentate of the pre-filtration membrane, contacting the first filtrate from the pre-filtration membrane with a capture membrane, thereby forming a second filtrate and a second retentate, optionally, washing the second retentate, and eluting the second retentate from the capture membrane or lysing the second retentate to recover the contents.
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公开(公告)号：US20210215584A1
公开(公告)日：2021-07-15
申请号：US17268330
申请日：2019-08-16
申请人： SIMPORE INC.
发明人： Jared A. Carter , James A. Roussie
摘要： Provided are methods, devices, and kits for the isolation and enumeration of one or more components of interest within a liquid sample using microslit filter membranes. This disclosure relates to the enumeration of components within a sample of interest, and more particularly, the capture of such components by efficient isolation using microslit filters with high permeation capacity and precision molecular cut-off characteristics.
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