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公开(公告)号：US11097021B2
公开(公告)日：2021-08-24
申请号：US16280171
申请日：2019-02-20
发明人： Bruce Nathaniel Gray
摘要： The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix stably incorporated radionuclide, processes for its production and method of radiation therapy utilising the particulate material.
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公开(公告)号：US10232063B2
公开(公告)日：2019-03-19
申请号：US14793603
申请日：2015-07-07
发明人： Jens Ricke , Holger Amthauer , Oliver Grober
摘要： Accordingly, the present invention provides a method of treating lung neoplasia in a subject in need of treatment, by subjecting the patient to SIRT.
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公开(公告)号：US20140099255A1
公开(公告)日：2014-04-10
申请号：US13968921
申请日：2013-08-16
发明人： Bruce Nathaniel Gray
IPC分类号： A61K51/12
CPC分类号： A61K51/1251 , A61K51/06 , A61K51/1255
摘要： The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix and stably incorporated radionuclide, processes for its production and a method of radiation therapy utilising the particulate material.
摘要翻译： 本发明涉及直径在5至200微米范围内的颗粒材料，其包含聚合物基质并稳定地并入放射性核素，其生产方法和使用该颗粒材料的放射治疗方法。
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公开(公告)号：US10849900B2
公开(公告)日：2020-12-01
申请号：US15114058
申请日：2015-01-23
发明人： David Cade , Michael Tapner
IPC分类号： A61K31/519 , A61K31/513 , A61K45/06 , C07K16/22 , A61K31/555 , A61K31/282 , A61K51/12 , A61K41/00 , A61K39/395 , A61N5/10 , C07K16/30 , A61K39/00
摘要： A method of treating cancer in a patient comprising administering to the patient an a systemic chemotherapeutic drug regime in combination with radioactively doped particle, characterised in that the two therapies when introduced into the patient have an improved anticancer effect.
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公开(公告)号：US20170000795A1
公开(公告)日：2017-01-05
申请号：US15114058
申请日：2015-01-23
发明人： David Cade , Michael Tapner
IPC分类号： A61K31/519 , A61K31/513 , A61N5/10 , A61K39/395 , A61K45/06 , C07K16/30 , A61K31/282 , C07K16/22
CPC分类号： A61K31/519 , A61K31/282 , A61K31/513 , A61K31/555 , A61K39/3955 , A61K41/0038 , A61K45/06 , A61K51/1244 , A61K2039/505 , A61K2039/545 , A61N5/1001 , C07K16/22 , C07K16/30 , C07K2317/24 , A61K2300/00
摘要： A method of treating cancer in a patient comprising administering to the patient an a systemic chemotherapeutic drug regime in combination with radioactively doped particle, characterised in that the two therapies when introduced into the patient have an improved anticancer effect.
摘要翻译： 一种治疗患者的癌症的方法，包括与放射活性掺杂颗粒组合给予患者全身化学治疗药物方案，其特征在于当引入患者体内时，两种疗法具有改善的抗癌作用。
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公开(公告)号：US20160008497A1
公开(公告)日：2016-01-14
申请号：US14793603
申请日：2015-07-07
发明人： Jens Ricke , Holger Amthauer , Oliver Grober
CPC分类号： A61K51/1251 , A61K45/06 , A61N5/1001 , A61N2005/1021
摘要： Accordingly, the present invention provides a method of treating lung neoplasia in a subject in need of treatment, by subjecting the patient to SIRT.
摘要翻译： 因此，本发明提供了通过对患者进行SIRT治疗需要治疗的受试者的肺瘤形成的方法。
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公开(公告)号：US20170304151A1
公开(公告)日：2017-10-26
申请号：US15515754
申请日：2015-09-30
发明人： Brendon VAN DEN BERG , Gilman WONG
CPC分类号： A61J1/2013 , A61J1/1425 , A61J1/1481 , A61J1/2065 , A61J1/2089 , A61J1/2096 , A61M5/32 , G01F13/00 , G21F5/015 , G21F5/12 , G21F5/14
摘要： A device for transferring a toxic substance from a dispensing vessel to at least one receiving vessel comprising: (i) a receiving portion arranged to receive a dispensing vessel containing a toxic substance; and (ii) a transfer apparatus having a first infusion line adapted for fluid communication with the dispensing vessel to transfer a carrier fluid into said vessel and a second infusion line having one end adapted for fluid communication to withdraw and transfer the carrier fluid and the toxic substance from the dispensing vessel and the other end of the second infusion line arranged to connect with the at least one receiving vessel.
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公开(公告)号：US20040220135A1
公开(公告)日：2004-11-04
申请号：US10428448
申请日：2003-04-30
发明人： Bruce Nathaniel Gray
IPC分类号： A61K031/7072 , A61K051/00
CPC分类号： A61K31/7072 , A61K31/513 , A61K51/1244 , A61K2300/00
摘要： The present invention concerns an unexpected synergistic combination of known antineoplastic therapies, which provides unexpectedly greater efficacy than either therapy alone in the treatment of neoplasia. Accordingly, the present invention provides a method that has utility in the treatment of various forms of cancer and tumours, but particularly in the treatment of brain and colorectal liver metastases and more specifically in the treatment of primary and secondary cancer of the liver. It is to be understood that the selective internal radiation therapies described herein should not be limited to radioactive microparticles, but may be extended to any radioactive particles that are suitable for use in the treatment methods described herein.
摘要翻译： 本发明涉及已知的抗肿瘤疗法的意想不到的协同组合，其在治疗瘤形成中单独提供任何疗法提供意想不到的功效。 因此，本发明提供了一种可用于治疗各种形式的癌症和肿瘤的方法，特别是在治疗脑和结肠直肠肝转移中，更具体地，用于治疗肝癌的原发性和继发性癌症。 应当理解，本文所述的选择性内部放射疗法不应限于放射性微粒，而是可以延伸到适用于本文所述治疗方法的任何放射性粒子。
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公开(公告)号：US11241362B2
公开(公告)日：2022-02-08
申请号：US15515754
申请日：2015-09-30
发明人： Brendon Van Den Berg , Gilman Wong
摘要： A device for transferring a toxic substance from a dispensing vessel to at least one receiving vessel comprising: (i) a receiving portion arranged to receive a dispensing vessel containing a toxic substance; and (ii) a transfer apparatus having a first infusion line adapted for fluid communication with the dispensing vessel to transfer a carrier fluid into said vessel and a second infusion line having one end adapted for fluid communication to withdraw and transfer the carrier fluid and the toxic substance from the dispensing vessel and the other end of the second infusion line arranged to connect with the at least one receiving vessel.
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公开(公告)号：US20190175768A1
公开(公告)日：2019-06-13
申请号：US16280171
申请日：2019-02-20
发明人： Bruce Nathaniel Gray
摘要： The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix stably incorporated radionuclide, processes for its production and method of radiation therapy utilising the particulate material.
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