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公开(公告)号：US20120114754A1
公开(公告)日：2012-05-10
申请号：US13291873
申请日：2011-11-08
申请人： Rajeev A. Jain , Stephen B. RUDDY , Kenneth Iain CUMMING , Maurice Joseph Anthony CLANCY , Janet Elizabeth CODD
发明人： Rajeev A. Jain , Stephen B. RUDDY , Kenneth Iain CUMMING , Maurice Joseph Anthony CLANCY , Janet Elizabeth CODD
IPC分类号： A61K9/14 , A61K31/4422 , A61P29/00 , A61K31/192 , A61K31/4965 , B82Y40/00 , B82Y5/00
CPC分类号： A61K9/5161 , A61K9/0056 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/5192
摘要： Disclosed is a rapidly disintegrating solid oral dosage form of a poorly soluble active ingredient and at least one pharmaceutically acceptable water-soluble or water-dispersible excipient, wherein the poorly soluble active ingredient particles have an average diameter, prior to inclusion in the dosage form, of less than about 2000 nm. The dosage form of the invention has the advantage of combining rapid presentation and rapid dissolution of the active ingredient in the oral cavity.
摘要翻译： 公开了一种快速崩解的难溶性活性成分和至少一种药学上可接受的水溶性或水分散性赋形剂的固体口服剂型，其中所述难溶性活性成分颗粒在包含在剂型之前具有平均直径， 小于约2000nm。 本发明的剂型具有将活性成分快速呈现和快速溶解在口腔中的优点。
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公开(公告)号：US07276249B2
公开(公告)日：2007-10-02
申请号：US10444066
申请日：2003-05-23
申请人： Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
发明人： Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
CPC分类号： A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要： The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
摘要翻译： 本发明涉及具有改善的药代动力学特征和降低的进食/禁食变异性的贝特类组合物。 组合物的贝特类颗粒具有小于约2000nm的有效平均粒度。
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公开(公告)号：US5503723A
公开(公告)日：1996-04-02
申请号：US385531
申请日：1995-02-08
申请人： Stephen B. Ruddy , W. Mark Eickhoff
发明人： Stephen B. Ruddy , W. Mark Eickhoff
CPC分类号： A61K9/146 , B03C3/00 , G01N15/0266 , Y10S977/773 , Y10S977/901
摘要： The present invention is a method and apparatus for further reducing the size of nanoparticles. Nanoparticles are defined as having an effective average particle size of less than about 400 nm. The present invention separates the nanoparticles further using electric fields.
摘要翻译： 本发明是进一步减小纳米颗粒尺寸的方法和装置。 纳米颗粒被定义为具有小于约400nm的有效平均粒度。 本发明使用电场进一步分离纳米颗粒。
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4.发明授权Compositions of iodophenoxy alkylene ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract 失效碘苯氧基亚烷基醚的组合物和用于胃肠道可视化的药学上可接受的粘土
公开(公告)号：US5492687A
公开(公告)日：1996-02-20
申请号：US237502
申请日：1994-05-03
IPC分类号： A61K49/04 , C07C43/225
CPC分类号： A61K49/0404 , A61K49/04 , A61K49/0409 , A61K49/0461 , C07C43/225
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkylene ethers and pharmaceutically acceptable clays in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
摘要翻译： 公开了用于口服或逆行检查胃肠道的x射线造影剂组合物，其包含药学上可接受的载体中的碘苯氧基亚烷基醚和药学上可接受的粘土; 以及它们用于胃肠道诊断放射学的方法。
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公开(公告)号：US07927627B2
公开(公告)日：2011-04-19
申请号：US11802542
申请日：2007-05-23
申请人： Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
发明人： Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
IPC分类号： A61K9/14 , A61K31/235 , A61K9/50 , A61P3/04 , A61P43/00 , A61P9/00 , C07C69/767 , C13K13/00
CPC分类号： A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要： The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
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6.发明授权公开(公告)号：US07695739B2
公开(公告)日：2010-04-13
申请号：US11650412
申请日：2007-01-08
申请人： Eugene R. Cooper , John A. Bullock , John R. Chippari , John L. Schaefer , Rakesh A. Patel , Rajeev Jain , Joost Strasters , Niels P. Ryde , Stephen B. Ruddy
发明人： Eugene R. Cooper , John A. Bullock , John R. Chippari , John L. Schaefer , Rakesh A. Patel , Rajeev Jain , Joost Strasters , Niels P. Ryde , Stephen B. Ruddy
CPC分类号： A61K9/1635 , A61K9/0095 , A61K9/145 , A61K9/146 , A61K9/1623
摘要： Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions.
摘要翻译： 公开了用于评价水溶性差的活性剂的剂型的体内再分散性的体外方法。 该方法利用代表体内人体生理条件的介质。
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7.发明授权公开(公告)号：US06908626B2
公开(公告)日：2005-06-21
申请号：US10268928
申请日：2002-10-11
申请人： Eugene R. Cooper , Stephen B. Ruddy
发明人： Eugene R. Cooper , Stephen B. Ruddy
IPC分类号： A61K9/16 , A61K9/12 , A61K9/14 , A61K9/20 , A61K9/48 , A61K9/50 , A61K9/51 , A61K9/64 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/32 , A61K47/36 , A61K47/38 , A61K9/24 , A61K9/46
CPC分类号： A61K9/5084 , A61K9/146
摘要： Disclosed are compositions exhibiting a combination of immediate release and controlled release characteristics. The compositions comprise at least one poorly soluble active ingredient having a nanoparticulate particle size, at least one surface stabilizer adsorbed onto the surface of the nanoparticulate active agent particles, and at least one active ingredient having a microparticulate particle size.
摘要翻译： 公开了显示即时释放和控释特征组合的组合物。 所述组合物包含至少一种具有纳米颗粒粒度的难溶性活性成分，至少一种吸附在纳米颗粒活性剂颗粒表面上的表面稳定剂和至少一种具有微粒尺寸的活性成分。
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公开(公告)号：US5718919A
公开(公告)日：1998-02-17
申请号：US393648
申请日：1995-02-24
申请人： Stephen B. Ruddy , Mary E. Roberts
发明人： Stephen B. Ruddy , Mary E. Roberts
IPC分类号： A61K9/14 , A61K31/192 , A61K9/16
CPC分类号： A61K9/146 , A61K31/192 , Y10S977/775 , Y10S977/915
摘要： There is described a composition comprised of nanoparticles of a therapeutic agent having a surface modifier adsorbed on the surface thereof. The present composition is characterized in that the therapeutic agent is ibuprofen or fenoprofen which is substantially enriched in the R(-) enantiomer.
摘要翻译： 描述了由表面改性剂吸收在其表面上的具有治疗剂的纳米颗粒组成的组合物。 本发明的组合物的特征在于治疗剂是基本上富含R（ - ）对映异构体的布洛芬或非诺洛芬。
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9.发明授权
公开(公告)号：US5593657A
公开(公告)日：1997-01-14
申请号：US386027
申请日：1995-02-09
IPC分类号： A61K49/04
CPC分类号： A61K49/0404 , Y10S514/941 , Y10S977/773 , Y10S977/927 , Y10S977/928
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising nanoparticles of a barium salt having associated with its surface non-ionic and anionic stabilizers; and methods for their use in diagnostic radiology of the gastrointestinal tract.
摘要翻译： 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含与其表面非离子和阴离子稳定剂相关联的钡盐纳米颗粒; 以及它们用于胃肠道诊断放射学的方法。
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10.发明授权
公开(公告)号：US5466440A
公开(公告)日：1995-11-14
申请号：US367407
申请日：1994-12-30
IPC分类号： A61K49/04
CPC分类号： B82Y5/00 , A61K49/0423 , A61K49/0433 , Y10S514/941 , Y10S514/942
摘要： Nanoparticulate crystalline substances formulated with stabilizers and pharmaceutically acceptable clays to enhance contact between the crystalline substances and the gastrointestinal tract. These formulations have improved safety profiles, a low potential for absorption, are not viscous and are not contraindicated for GI perforations or intestinal obstructions. The properties of the surfactant stabilizers are independent of the crystalline drug used and largely determine the extent to which the formulation coats the GI tract.
摘要翻译： 用稳定剂和药学上可接受的粘土配制的纳米微晶状物质，以增强结晶物质与胃肠道之间的接触。 这些制剂具有改善的安全性，吸收的低潜力不粘稠，并且不禁忌GI穿孔或肠梗阻。 表面活性剂稳定剂的性质与使用的结晶药物无关，并且在很大程度上决定了制剂涂敷胃肠道的程度。
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