公开(公告)号：US20230212268A1

公开(公告)日：2023-07-06

申请号：US17436782

申请日：2020-03-04

Applicant: Ravi DURVASULA ,  Steven BRADFUTE ,  Adinarayana KUNAMNENI ,  UNM RAINFOREST INNOVATIONS

Inventor： Ravi Durvasula ,  Steven Bradfute ,  Adinarayana Kunamneni

IPC: C07K16/10 ,  G01N33/569 ,  A61P31/14

CPC classification number: C07K16/1018 ,  G01N33/56983 ,  A61P31/14 ,  C07K2317/565 ,  C07K2317/92

Abstract: An antibody that binds to a filovirus glycoprotein generally includes include a complementarity determining region (CDR) of any one of SEQ ID NO:27-36 or a combination of such CDRs. The antibody may be used in to detect filovirus in a biological sample obtained from a subject. The antibody also may be formulated into a pharmaceutical composition for administering to a subject having, or at risk of having, a filovirus infection.

公开(公告)号：US09572820B2

公开(公告)日：2017-02-21

申请号：US14116581

申请日：2012-05-10

Applicant: Vojo Deretic ,  Eliseo Castillo ,  Steven Bradfute ,  Larry A. Sklar

Inventor： Vojo Deretic ,  Eliseo Castillo ,  Steven Bradfute ,  Larry A. Sklar

IPC: A61K31/519 ,  A61K31/12 ,  A61K31/65 ,  C07K16/18 ,  G01N33/68 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/473 ,  A61K31/517 ,  A61K31/522 ,  A61K31/54 ,  A61K31/546 ,  A61K31/5685 ,  A61K31/585 ,  G01N33/569

CPC classification number: A61K31/436 ,  A61K31/12 ,  A61K31/136 ,  A61K31/4184 ,  A61K31/4365 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/473 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/54 ,  A61K31/546 ,  A61K31/5685 ,  A61K31/585 ,  A61K31/65 ,  C07K16/18 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2333/9015

Abstract: The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.

Abstract translation: 本发明提供了治疗自噬介导的疾病和病症以及相关药物组合物，诊断，筛选技术和试剂盒的方法。 在一个实施方案中，本发明提供了一种通过评估LC3水平来确定受试者是否患有或有发展风险和自噬介导的疾病状态和/或状况的方法。

公开(公告)号：US12265081B2

公开(公告)日：2025-04-01

申请号：US17436782

申请日：2020-03-04

Applicant: UNM RAINFOREST INNOVATIONS ,  Ravi Durvasula ,  Steven Bradfute ,  Adinarayana Kunamneni

Inventor： Ravi Durvasula ,  Steven Bradfute ,  Adinarayana Kunamneni

IPC: G01N33/569 ,  A61P31/14 ,  C07K16/10

Abstract: An antibody that binds to a filovirus glycoprotein generally includes include a complementarity determining region (CDR) of any one of SEQ ID NO:27-36 or a combination of such CDRs. The antibody may be used in to detect filovirus in a biological sample obtained from a subject. The antibody also may be formulated into a pharmaceutical composition for administering to a subject having, or at risk of having, a filovirus infection.

公开(公告)号：US20130323243A1

公开(公告)日：2013-12-05

申请号：US13882041

申请日：2011-10-28

Applicant: Gerardo Kaplan ,  Krishnamurthy Konduru ,  Jerome Jacques ,  Sina Bavari ,  Steven Bradfute

Inventor： Gerardo Kaplan ,  Krishnamurthy Konduru ,  Jerome Jacques ,  Sina Bavari ,  Steven Bradfute

IPC: A61K39/12

CPC classification number: G01N33/6854 ,  A61K39/12 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/6056 ,  C07K14/005 ,  C07K2319/30 ,  C07K2319/43 ,  C12N2760/14122 ,  C12N2760/14134 ,  G01N33/56983 ,  G01N2333/08 ,  G01N2469/20 ,  G01N2800/26

Abstract: This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.

公开(公告)号：US09347951B2

公开(公告)日：2016-05-24

申请号：US13882041

申请日：2011-10-28

Applicant: Gerardo Kaplan ,  Krishnamurthy Konduru ,  Jerome Jacques ,  Sina Bavari ,  Steven Bradfute

Inventor： Gerardo Kaplan ,  Krishnamurthy Konduru ,  Jerome Jacques ,  Sina Bavari ,  Steven Bradfute

IPC: G01N33/68 ,  A61K39/12 ,  G01N33/569 ,  C07K14/005 ,  A61K39/00

CPC classification number: G01N33/6854 ,  A61K39/12 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/6056 ,  C07K14/005 ,  C07K2319/30 ,  C07K2319/43 ,  C12N2760/14122 ,  C12N2760/14134 ,  G01N33/56983 ,  G01N2333/08 ,  G01N2469/20 ,  G01N2800/26

Abstract: This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.

Abstract translation: 本发明提供包含病毒糖蛋白片段和免疫球蛋白多肽片段的融合蛋白。 融合蛋白可用于免疫原性组合物中，以防止人类和非人类动物中的诸如埃博拉病毒之类的病毒如伊洛韦病毒感染。 融合蛋白也可用于诊断测定法以检测病毒感染。

公开(公告)号：US20140135296A1

公开(公告)日：2014-05-15

申请号：US14116581

申请日：2012-05-10

Applicant: Vojo Deretic ,  Eliseo Castillo ,  Steven Bradfute ,  Larry A. Sklar

Inventor： Vojo Deretic ,  Eliseo Castillo ,  Steven Bradfute ,  Larry A. Sklar

IPC: A61K31/65 ,  A61K31/4535 ,  A61K31/4365 ,  A61K31/472 ,  A61K31/5685 ,  G01N33/569 ,  A61K31/517 ,  A61K31/546 ,  A61K31/436 ,  A61K31/522 ,  A61K31/54 ,  A61K31/585 ,  A61K31/473 ,  A61K31/519

CPC classification number: A61K31/436 ,  A61K31/12 ,  A61K31/136 ,  A61K31/4184 ,  A61K31/4365 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/473 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/54 ,  A61K31/546 ,  A61K31/5685 ,  A61K31/585 ,  A61K31/65 ,  C07K16/18 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2333/9015

Abstract: The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.

Abstract translation: 本发明提供了治疗自噬介导的疾病和病症以及相关药物组合物，诊断，筛选技术和试剂盒的方法。 在一个实施方案中，本发明提供了一种通过评估LC3水平来确定受试者是否患有或有发展风险和自噬介导的疾病状态和/或状况的方法。