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    Method of sterilization
    2.
    发明申请
    Method of sterilization 审中-公开
    灭菌方法

    公开(公告)号：US20050013729A1

    公开(公告)日：2005-01-20

    申请号：US10716778

    申请日：2003-11-19

    Applicant: Susan Brown-Skrobot ,  Stephen Beaton ,  Eric Bussey ,  James Ebel ,  Gregory Hill ,  James Peck ,  John Heaton ,  David Cristol ,  Timothy Newton ,  John Enns

    Inventor： Susan Brown-Skrobot ,  Stephen Beaton ,  Eric Bussey ,  James Ebel ,  Gregory Hill ,  James Peck ,  John Heaton ,  David Cristol ,  Timothy Newton ,  John Enns

    IPC: A61L2/08 ,  A61L2/10 ,  A61L12/06 ,  B65B25/00 ,  B65B55/08 ,  G02C13/00

    CPC classification number: A61L2/10 ,  A61L12/063 ,  B65B25/008

    Abstract: This invention provides a process of sterilizing a medical device, and preferably the contents of a sealed container which comprises said medical device, comprising the step of exposing said medical device to ultraviolet radiation whereby the Dvalue of Bacillus stearothermophilus (ATCC 7953) is at least 3.9 mJ/cm2 ultraviolet radiation in the range of 240-280 nm to the spore. Further, this invention provides a process of sterilizing a medical device comprising the step of subjecting said medical device to ultraviolet radiation wherein the minimum total energy density of said ultraviolet radiation in the range of 240-280 nm which reaches the microorganisms present on said medical device is at least 18 mJ/cm2. This invention further provides an apparatus for delivering UV radiation to a medical device for sterilization comprising a radiation source and a reflector for said radiation source wherein said reflector directs radiation from said radiation source such that at least 3 J/cm2 broad spectrum radiation of which at least 50 mJ/cm2 of said radiation is UV radiation in the range of 240-280 nm to a treatment area for said medical device, said treatment area is at the focal plane of said reflector. This invention provides a process and apparatus in which sterilization can be achieved in less than 20 seconds, preferably less than 15 seconds, more preferably in less than 5 seconds. The process and apparatus are efficient and continuous.

    Abstract translation: 本发明提供一种消毒医疗装置的方法，优选包括所述医疗装置的密封容器的内容物，其包括使所述医疗装置暴露于紫外线辐射的步骤，由此嗜热脂肪芽孢杆菌（ATCC 7953）的D值至少为3.9 mJ / cm 2紫外线辐射在240-280nm范围内。 此外，本发明提供一种消毒医疗装置的方法，包括对所述医疗装置进行紫外线照射的步骤，其中所述紫外线辐射的最小总能量密度在240-280nm的范围内，其达到存在于所述医疗装置上的微生物 至少18mJ / cm 2。 本发明进一步提供一种用于将UV辐射递送到用于灭菌的医疗装置的装置，包括用于所述辐射源的辐射源和反射器，其中所述反射器引导来自所述辐射源的辐射，使得至少3J / cm 2的广谱辐射 其中至少50mJ / cm 2的所述辐射是在240-280nm范围内的UV辐射与所述医疗装置的治疗区域之间，所述治疗区域在所述反射器的焦平面处。 本发明提供一种方法和装置，其中可以在少于20秒，优选小于15秒，更优选在少于5秒内实现灭菌。 该方法和设备是有效和连续的。

    Inhibition of expression of beta-lactamase using esters of fatty acid alcohols
    4.
    发明授权
    Inhibition of expression of beta-lactamase using esters of fatty acid alcohols 失效
    使用脂肪酸醇酯抑制β-内酰胺酶的表达

    公开(公告)号：US5466685A

    公开(公告)日：1995-11-14

    申请号：US61222

    申请日：1993-05-13

    Applicant: Susan Brown-Skrobot ,  Richard P. Novick ,  Steven J. Projan

    Inventor： Susan Brown-Skrobot ,  Richard P. Novick ,  Steven J. Projan

    IPC: A61K31/23 ,  A61K31/43 ,  A61K31/545 ,  A61K31/20 ,  A61K31/22 ,  A61K31/225

    CPC classification number: A61K31/43 ,  A61K31/23 ,  A61K31/545

    Abstract: A class of chemical compounds comprising fatty acid ester derivatives used to inhibit beta-lactamase production by infectious bacteria. These inhibitors have been found to retard the resistance of certain strains of bacteria to beta-lactam antibiotics, such as penicillin, by interfering with the transcription of the beta-lactamase gene and precluding expression of beta-lactamase. In accordance therewith, these inhibitors permit effective treatment of infections of otherwise resistive bacteria with antibiotics.

    Abstract translation: 一类含有用于抑制感染性细菌产生β-内酰胺酶的脂肪酸酯衍生物的化合物。 已经发现这些抑制剂通过干扰β-内酰胺酶基因的转录并阻止β-内酰胺酶的表达来延缓某些细菌菌株对β-内酰胺类抗生素如青霉素的抗性。 因此，这些抑制剂允许用抗生素有效地治疗其他抗性细菌的感染。

    Inhibition of expression of beta-lactamase using esters of fatty acid alcohols
    5.
    发明授权
    Inhibition of expression of beta-lactamase using esters of fatty acid alcohols 失效
    使用脂肪酸醇酯抑制β-内酰胺酶的表达

    公开(公告)号：US5633245A

    公开(公告)日：1997-05-27

    申请号：US470997

    申请日：1995-06-06

    Applicant: Susan Brown-Skrobot ,  Richard P. Novick ,  Steven J. Projan

    Inventor： Susan Brown-Skrobot ,  Richard P. Novick ,  Steven J. Projan

    IPC: A61K31/23 ,  A61K31/43 ,  A61K31/545 ,  A61K31/20 ,  A61K31/22 ,  A61K31/225

    CPC classification number: A61K31/43 ,  A61K31/23 ,  A61K31/545

    Abstract: A class of chemical compounds comprising fatty acid ester derivatives used to inhibit beta-lactamase production by infectious bacteria. These inhibitors have been found to retard the resistance of certain strains of bacteria to beta-lactam antibiotics, such as penicillin, by interfering with the transcription of the beta-lactamase gene and precluding expression of beta-lactamase. In accordance therewith, these inhibitors permit effective treatment of infections of otherwise resistive bacteria with antibiotics.

    Abstract translation: 一类含有用于抑制感染性细菌产生β-内酰胺酶的脂肪酸酯衍生物的化合物。 已经发现这些抑制剂通过干扰β-内酰胺酶基因的转录并阻止β-内酰胺酶的表达来延缓某些细菌菌株对β-内酰胺类抗生素如青霉素的抗性。 因此，这些抑制剂允许用抗生素有效地治疗其他抗性细菌的感染。

    Method and apparatus of sterilization using monochromatic UV radiation source
    8.
    发明申请
    Method and apparatus of sterilization using monochromatic UV radiation source 有权
    使用单色紫外线辐射源灭菌的方法和设备

    公开(公告)号：US20050079096A1

    公开(公告)日：2005-04-14

    申请号：US10939818

    申请日：2004-09-13

    Applicant: Susan Brown-Skrobot ,  James Ebel ,  John Enns ,  Gregory Hill ,  Allan Kimble

    Inventor： Susan Brown-Skrobot ,  James Ebel ,  John Enns ,  Gregory Hill ,  Allan Kimble

    IPC: A61L2/10 ,  A61L12/06 ,  B65B25/00

    CPC classification number: A61L12/063 ,  A61L2/10 ,  B65B25/008

    Abstract: This invention provides a process of sterilizing a medical device, and preferably the contents of a sealed container which comprises said medical device, comprising the step of exposing said medical device to monochromatic ultraviolet radiation whereby the Dvalue of Bacillus stearothermophilus (ATCC 7953) is at least 23.7 mJ/cm2 monochromatic ultraviolet radiation at 257 nm to the spore. Further, this invention provides a process of sterilizing a medical device comprising the step of subjecting said medical device to monochromatic ultraviolet radiation wherein the minimum total energy density of said monochromatic ultraviolet radiation at 257 nm which reaches the microorganisms present on said medical device is at least 284 mJ/cm2. This invention further provides an apparatus for delivering UV radiation to a medical device for sterilization comprising a laser and a scanner for the laser such that at least 284 mJ/cm2 at 257 nm is applied to a treatment area for said medical device. This invention provides a process and apparatus in which sterilization can be achieved in less than 20 seconds, preferably less than 15 seconds, more preferably in less than 5 seconds. The process and apparatus are efficient and continuous.

    Abstract translation: 本发明提供了一种对医疗装置进行灭菌的方法，优选包括所述医疗装置的密封容器的内容物，其包括将所述医疗装置暴露于单色紫外线辐射的步骤，由此使嗜热脂肪芽孢杆菌（ATCC 7953）的D值至少为 对于孢子，在257nm处具有23.7mJ / cm 2的单色紫外线辐射。 此外，本发明提供一种消毒医疗装置的方法，包括以下步骤：对所述医疗装置进行单色紫外线辐射，其中到达所述医疗装置上存在的微生物的257nm处的所述单色紫外线辐射的最小总能量密度至少为 284mJ / cm 2。 本发明还提供了一种用于将UV辐射递送到用于灭菌的医疗装置的装置，包括用于激光的激光器和扫描器，使得在257nm处的至少284mJ / cm 2被施加到所述医疗装置的治疗区域。 本发明提供一种方法和装置，其中可以在少于20秒，优选小于15秒，更优选在少于5秒内实现灭菌。 该方法和设备是有效和连续的。

    Controlling plant fungi using streptomycetes grown on chitin
    9.
    发明授权
    Controlling plant fungi using streptomycetes grown on chitin 失效
    使用在几丁质上生长的链霉菌控制植物真菌

    公开(公告)号：US4534965A

    公开(公告)日：1985-08-13

    申请号：US536025

    申请日：1983-09-26

    Applicant: Lewis R. Brown ,  Susan Brown-Skrobot

    Inventor： Lewis R. Brown ,  Susan Brown-Skrobot

    IPC: A01N63/00 ,  A01N63/02 ,  C12P1/06 ,  C12P1/00 ,  C12N15/00 ,  C12N1/20 ,  C12R1/465 ,  A01C1/06 ,  A01B79/00

    CPC classification number: A01N63/02 ,  A01N63/00 ,  C12P1/06 ,  Y10S435/886

    Abstract: A method and composition is provided to control fungal infection of seeds and seedlings. Certain species of Streptomyces are grown on dried ground shrimp waste preferably suspended in a mineral salts medium. The supernate derived from the culture provides fungal infection control when used as a seed-coating or seed-soaking material. The residue, consisting of unused shrimp waste and a Streptomyces species, also provides protection against fungal infection of plants such as cotton seedlings. The residue is employed as a amendment to the soil in the immediate area of the newly planted seed.

    Abstract translation: 提供了一种方法和组合物来控制种子和幼苗的真菌感染。 将某些种类的链霉菌生长在优选悬浮于无机盐培养基中的干燥的对虾废料上。 当用作种子包衣或种子浸泡材料时，来自培养物的上清液提供真菌感染控制。 由未使用的虾废料和链霉菌属物种组成的残留物也提供防止植物如棉花幼苗真菌感染的保护。 残留物被用作新种植种子附近土壤的修正物。

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