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公开(公告)号：US20100136693A1
公开(公告)日：2010-06-03
申请号：US12463239
申请日：2009-05-08
CPC分类号： C12N15/102 , C12N9/1205 , C12N15/01 , C12N15/1058
摘要： The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y, X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging to related classes. The mutants D133E and R104Q of desoxycytidine kinase (DCK) were obtained; both of said mutations result in acquisition of thymidine kinase activity by DCK.
摘要翻译： 本发明涉及蛋白质人体体内进化的方法，所述方法使得可以通过相互作用的相关蛋白Y，X和Y的互补来实现蛋白X的进化，这两者属于同一类酶委员会（EC ）命名或属于相关类。 获得脱氧胞苷激酶（DCK）的突变体D133E和R104Q; 所述两个突变导致通过DCK获得胸苷激酶活性。
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公开(公告)号：US07229797B1
公开(公告)日：2007-06-12
申请号：US10049750
申请日：2000-08-18
申请人： Wilhelm Tischer , Hans-Georg Ihlenfeldt , Octavian Barzu , Hiroshi Sakamoto , Elisabeth Pistotnik , Philippe Marlière , Sylvie Pochet
发明人： Wilhelm Tischer , Hans-Georg Ihlenfeldt , Octavian Barzu , Hiroshi Sakamoto , Elisabeth Pistotnik , Philippe Marlière , Sylvie Pochet
CPC分类号： C12N9/0006 , C12N9/1051 , C12N9/1077 , C12N9/1205 , C12N9/88 , C12N9/90 , C12P9/00 , C12P19/02 , C12P19/24 , C12P19/38
摘要： The present invention relates to a method for the in vitro enzymatic synthesis of deoxyribonucleosides and enzymes suitable for this method.
摘要翻译： 本发明涉及一种适用于该方法的体外酶合成脱氧核糖核苷和酶的方法。
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公开(公告)号：US20130331351A1
公开(公告)日：2013-12-12
申请号：US13976826
申请日：2011-12-22
申请人： Sylvie Pochet , Gilles Labesse , Muriel Gelin , Liliane Assairi , Olivier Dussurget , Guillaume Poncet-Montange
发明人： Sylvie Pochet , Gilles Labesse , Muriel Gelin , Liliane Assairi , Olivier Dussurget , Guillaume Poncet-Montange
CPC分类号： C07H19/16 , C07H19/167 , C12Q1/485
摘要： The present invention relates to compounds of formula (I): wherein Rj, R2, R3, R4, Xi, X2, X3 and Z are as defined in claim 1. The compounds are useful in the prevention and/or treatment of bacterial infections.
摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，R 4，X 1，X 2，X 3和Z如权利要求1中所定义。该化合物可用于预防和/或治疗细菌感染。
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4.发明申请Aryl, Pyrimidyl Compounds, Pharmaceutical Compositions Comprising them, Their Use as Antimicrobial Agents 审中-公开芳基，嘧啶基化合物，包含它们的药物组合物，它们用作抗微生物剂公开(公告)号：US20080096907A1
公开(公告)日：2008-04-24
申请号：US11718764
申请日：2005-11-04
IPC分类号： A61K31/513 , A61P31/06 , C07D239/545 , C07D239/553
CPC分类号： C07D239/54 , C07D239/553 , C07D239/557
摘要： Substituted aryl pyrimidyl compounds responding to formula (I) and their use for the preparation of a medicament for the prevention and/or treatment of a pathology caused by a mycobacteria.
摘要翻译： 响应式（I）的取代的芳基嘧啶基化合物及其在制备用于预防和/或治疗由分枝杆菌引起的病理学的药物中的用途。
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公开(公告)号：US08927520B2
公开(公告)日：2015-01-06
申请号：US13976826
申请日：2011-12-22
申请人： Sylvie Pochet , Gilles Labesse , Muriel Gelin , Liliane Assairi , Olivier Dussurget , Guillaume Poncet-Montange
发明人： Sylvie Pochet , Gilles Labesse , Muriel Gelin , Liliane Assairi , Olivier Dussurget , Guillaume Poncet-Montange
IPC分类号： A01N43/04 , A61K31/70 , C07H19/16 , C07H19/167 , C12Q1/48
CPC分类号： C07H19/16 , C07H19/167 , C12Q1/485
摘要： The present invention relates to compounds of formula (I): wherein Rj, R2, R3, R4, Xi, X2, X3 and Z are as defined in claim 1. The compounds are useful in the prevention and/or treatment of bacterial infections.
摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，R 4，X 1，X 2，X 3和Z如权利要求1中所定义。该化合物可用于预防和/或治疗细菌感染。
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公开(公告)号：US07547513B2
公开(公告)日：2009-06-16
申请号：US11132445
申请日：2005-05-19
CPC分类号： C12N15/102 , C12N9/1205 , C12N15/01 , C12N15/1058
摘要： The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y, X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging to related classes. The mutants D133E and R104Q of desoxycytidine kinase (DCK) were obtained; both of said mutations result in acquisition of thymidine kinase activity by DCK.
摘要翻译： 本发明涉及蛋白质人体体内进化的方法，所述方法使得可以通过相互作用的相关蛋白Y，X和Y的互补来实现蛋白X的进化，这两者属于同一类酶委员会（EC ）命名或属于相关类。 获得脱氧胞苷激酶（DCK）的突变体D133E和R104Q; 所述两个突变导致通过DCK获得胸苷激酶活性。
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公开(公告)号：US20060270005A1
公开(公告)日：2006-11-30
申请号：US10510953
申请日：2003-04-28
申请人： Philippe Marliere , Pierre-Alexandre Kaminski , Frederique Galisson , Madaleine Bouzon , Sylvie Pochet , Jean Weissenbach , William Saurin , Catherine Robert , Virginie VIco
发明人： Philippe Marliere , Pierre-Alexandre Kaminski , Frederique Galisson , Madaleine Bouzon , Sylvie Pochet , Jean Weissenbach , William Saurin , Catherine Robert , Virginie VIco
CPC分类号： C07K14/005 , C07D473/16 , C12N7/00 , C12N2795/10022
摘要： The invention relates to the genome sequence and the nucleotide sequences coding for polypeptides of cyanophage S-2L. According to the invention, the polypeptides include, but are not limited to, polypeptides involved in the synthesis, transcription and replication of purine bases. In particular, determining the genome of cyanophage S-2L is useful for supplying genes which, expressed in recombinant bacteria, enable the synthesis of DNA monomers incorporating base D (2,6 diaminopurine instead of base A (adenine), thereby producing chemically-remodelled nucleic acids in the bacteria.
摘要翻译： 本发明涉及编码嗜蓝藻S-2L多肽的基因组序列和核苷酸序列。 根据本发明，多肽包括但不限于涉及嘌呤碱基的合成，转录和复制的多肽。 特别地，确定蓝藻S-2L的基因组可用于提供在重组细菌中表达的能够合成掺入碱基D（2,6-二氨基嘌呤代替碱基A（腺嘌呤））的DNA单体的基因，从而产生化学改性的 细菌中的核酸。
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8.发明申请公开(公告)号：US20100286386A1
公开(公告)日：2010-11-11
申请号：US11984225
申请日：2007-11-14
申请人： Philippe Marliere , Sylvie Pochet
发明人： Philippe Marliere , Sylvie Pochet
IPC分类号： C07H21/04 , C12Q1/68 , C12P19/28 , C12P19/30 , C40B30/04 , C40B40/06 , C07H21/02 , C07H19/052
CPC分类号： C07H19/06 , A61K31/7052 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/16 , C07H21/00 , C12N15/102 , C40B40/00 , Y02P20/55
摘要： Nucleotide analogues comprising a reactive hydrazide function (formula II) used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of inhibiting a DNA polymerase or a kinase provided. Nucleic acids comprising the nucleotide and nucleoside analogues are also provided. Methods of using the compounds are also provided.
摘要翻译： 用作初始合成子的反应酰肼功能（式II）的核苷酸类似物用于制备能够诱导突变或能够抑制提供的DNA聚合酶或激酶的化合物（式I）。 还提供了包含核苷酸和核苷类似物的核酸。 还提供了使用该化合物的方法。
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9.发明授权公开(公告)号：US07319148B2
公开(公告)日：2008-01-15
申请号：US10297999
申请日：2001-06-13
申请人： Philippe Marliere , Sylvie Pochet
发明人： Philippe Marliere , Sylvie Pochet
IPC分类号： C07D215/38 , C07D405/04
CPC分类号： C07H19/06 , A61K31/7052 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/16 , C07H21/00 , C12N15/102 , C40B40/00 , Y02P20/55
摘要： The invention concerns novel nucleotide analogues comprising a reactive hydrazide function used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of inhibiting a DNA polymerase or a kinase. The invention also concerns nucleic acids comprising said nucleotide and nucleoside analogues. Among such compounds, can be cited in particular the compound of formula (I)
摘要翻译： 本发明涉及新的核苷酸类似物，其包含用作制备能够诱导突变或能够抑制DNA聚合酶或激酶的化合物（式I）的初始合成子的反应性酰肼功能。 本发明还涉及包含所述核苷酸和核苷类似物的核酸。 在这些化合物中，特别可以列举式（I）的化合物，
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公开(公告)号：US20070037269A1
公开(公告)日：2007-02-15
申请号：US11132445
申请日：2005-05-19
IPC分类号： C12N9/00
CPC分类号： C12N15/102 , C12N9/1205 , C12N15/01 , C12N15/1058
摘要： The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y,X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging to related classes. The mutants D133E and R104Q of desoxycytidine kinase (DCK) were obtained; both of said mutations result in acquisition of thymidine kinase activity by DCK.
摘要翻译： 本发明涉及蛋白质人体体内进化的方法，所述方法使得可以通过相互作用的相关蛋白Y，X和Y的互补来实现蛋白X的进化，这两者属于同一类酶委员会（EC ）命名或属于相关类。 获得脱氧胞苷激酶（DCK）的突变体D133E和R104Q; 所述两个突变导致通过DCK获得胸苷激酶活性。
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