公开(公告)号：US20160108244A1

公开(公告)日：2016-04-21

申请号：US14891278

申请日：2014-05-16

申请人： Thomas E. Kane

发明人： Thomas E. Kane ,  Brian A. Jones

IPC分类号： C09B67/08 ,  B05D1/18 ,  B05D7/00 ,  C09D7/12

CPC分类号： C09B67/0007 ,  A61K8/0241 ,  A61K8/25 ,  A61K2800/412 ,  A61K2800/61 ,  A61K2800/651 ,  A61Q1/02 ,  B05D1/18 ,  B05D7/57 ,  B05D7/58 ,  C09B65/00 ,  C09B67/0013 ,  C09B67/0097 ,  C09D7/62

摘要： A pigment particle for use in artist color media comprises a silica containing core particle having pore channels formed therein, at least one colorant present in the pore channels in at least part of the silica particle, and a nonporous silica layer coated over the pore channels. A method of manufacturing colored particles for use in artist color media comprises providing a core silica particle having pore channels formed therein, loading at least one colorant into the pore channels of the particle, and depositing a silica layer over the pore channels using fluorosilicic acid. Another method of manufacturing colored particles for use in artist color media comprises providing a porous silica particle having pore channels formed therein, and depositing a silica layer over the pore channels using a fluorosilicic acid where a colorant is present in the fluorosilicic acid.

摘要翻译： 用于艺术家彩色介质的颜料颗粒包括其中形成有孔通道的二氧化硅核心颗粒，存在于至少部分二氧化硅颗粒中的孔通道中的至少一种着色剂和涂覆在孔道上的无孔二氧化硅层。 制造用于艺术家彩色介质的有色颗粒的制造方法包括提供其中形成有孔隙的核心二氧化硅颗粒，将至少一种着色剂加载到颗粒的孔通道中，以及使用氟硅酸在孔道上沉积二氧化硅层。 制造用于艺术家彩色培养基的彩色颗粒的另一种方法包括提供一种其中形成有孔隙通道的多孔二氧化硅颗粒，并使用氟硅酸在氟硅酸中沉积二氧化硅层，其中着色剂存在于氟硅酸中。

公开(公告)号：US08656753B1

公开(公告)日：2014-02-25

申请号：US12157202

申请日：2008-06-06

申请人： Paul H. Silvis ,  Thomas E. Kane

发明人： Paul H. Silvis ,  Thomas E. Kane

IPC分类号： G01N30/60

CPC分类号： G01N30/12

摘要： A sleeve unit for preparing a sample for gas chromatographic analysis comprises an inlet liner having a bore therein, an inlet to the bore, and an outlet from the bore, and an inlet liner insert located with the bore. The inlet liner insert extends across the bore to cause a sample being prepared for gas chromatographic analysis to flow through the inlet liner insert. The inlet liner insert comprises an arrangement of wire, the arrangement creating a restricted pathway for the sample as the sample flows through the bore of the inlet liner to the outlet of the bore, and the wire having a surface having a high thermal conductivity and being substantially chemically inert to the sample.

摘要翻译： 用于制备用于气相色谱分析的样品的套筒单元包括其中具有孔的入口衬套，所述孔的入口和来自所述孔的出口以及位于所述孔的入口衬垫插入件。 入口衬套插入件延伸穿过孔，以使准备用于气相色谱分析的样品流过入口衬垫插入件。 入口衬套插入件包括线的布置，该布置在样品流过入口衬套的孔到孔的出口时产生用于样品的限制路径，并且线具有具有高热导率的表面，并且是 对样品基本上是化学惰性的。

公开(公告)号：US20130081484A1

公开(公告)日：2013-04-04

申请号：US13516359

申请日：2010-12-15

申请人： Brian A. Jones ,  Scott L. Grossman ,  Valerie S. Strohm ,  Thomas E. Kane

发明人： Brian A. Jones ,  Scott L. Grossman ,  Valerie S. Strohm ,  Thomas E. Kane

IPC分类号： G01N33/00 ,  B05D1/18 ,  G01K13/00

CPC分类号： G01N33/00 ,  B01L3/50 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/0832 ,  B05D1/18 ,  G01K13/00 ,  G01N30/04 ,  G01N2030/126 ,  G01N2030/167

摘要： A container used for chromatographic sample analysis has (a) at least one silica uppermost layer, which is deposited onto the container using a liquid phase deposition process, and, optionally, (b) at least one indicator present in at least part of the at least one silica uppermost layer for visually distinguishing the container from other containers, and/or determining the “use status” of the container, and/or identifying the proper orientation of the container when it is to be put in use, and/or providing a means of decoration, identification, or counterfeit detection. In one preferred embodiment, the indicator is thermochromic. In another preferred embodiment, the indicator is photochromic.

摘要翻译： 用于色谱样品分析的容器具有（a）至少一个二氧化硅最上层，其使用液相沉积工艺沉积到容器上，并且任选地（b）至少一个指示剂存在于至少一部分 至少一个二氧化硅最上层，用于将容器与其他容器视觉上区分开，和/或确定容器的使用状态，和/或在容器被使用时识别容器的正确取向，和/或提供一种装置 的装饰，鉴定或假冒检测。 在一个优选实施方案中，指示剂是热变色的。 在另一个优选实施方案中，指示剂是光致变色的。

公开(公告)号：US08366814B2

公开(公告)日：2013-02-05

申请号：US12660241

申请日：2010-02-23

申请人： Brian A. Jones ,  Thomas E. Kane

发明人： Brian A. Jones ,  Thomas E. Kane

IPC分类号： B01D53/02

CPC分类号： G01N30/12

摘要： A gas chromatography inlet liner comprises a glass tube formed by a glass wall, the glass wall having pore channels formed therein, and an indicator present in the pore channels in at least part of the inlet liner. The indicator may be any element, compound, dopant, or mixture additive that modifies color or transparency of the inlet liner.

摘要翻译： 气相色谱入口衬套包括由玻璃壁形成的玻璃管，其中形成有孔隙通道的玻璃壁和存在于入口衬里的至少一部分中的孔通道中的指示器。 指示剂可以是改变入口衬里的颜色或透明度的任何元素，化合物，掺杂剂或混合物添加剂。

公开(公告)号：US20110011185A1

公开(公告)日：2011-01-20

申请号：US12460246

申请日：2009-07-15

申请人： William D. Grove ,  Brandon A. Tarr ,  Gerald W. Johnston ,  Thomas E. Kane

发明人： William D. Grove ,  Brandon A. Tarr ,  Gerald W. Johnston ,  Thomas E. Kane

IPC分类号： G01F1/20

CPC分类号： G01F1/36 ,  G01F1/363

摘要： An acoustic displacement flowmeter for determining flow rate of a fluid has a fluid flow line defining a flow path for the fluid. The fluid flow line has an inlet and an outlet. A controllable valve is positioned along the fluid flow line for opening and closing the flow path as desired, and an acoustic displacement transducer having a fluid port is coupled to the fluid flow line upstream from the controllable valve. The outlet of the fluid flow line extends through a wall isolating fluid exhausted from the outlet of the fluid flow line from electrical and/or mechanical components residing inside the flowmeter, thereby preventing the exhausted fluid, if explosive, from contacting such electrical and/or mechanical components which may act as potential ignition sources. Preferably, a manifold having a rigid body is provided in which the fluid flow line is formed. An acoustic displacement transducer (ADT) chamber wall is formed on the manifold body, and has an ADT chamber inlet port formed therein, and the fluid flow line has a branched portion connecting the fluid flow line to the ADT chamber inlet port. The outlet of the fluid flow line extends through a wall formed in the manifold body to isolate fluid exhausted from the outlet of the fluid flow line from electrical and/or mechanical components residing inside the flowmeter.

摘要翻译： 用于确定流体流速的声位移流量计具有限定流体流动路径的流体流动线。 流体流动管线具有入口和出口。 沿着流体流动管线定位可控阀，以根据需要打开和关闭流路，并且具有流体端口的声位移传感器联接到可控阀上游的流体流动管线。 流体流动管线的出口延伸通过流体流动管线出口从位于流量计内部的电气和/或机械部件排出的壁的隔离壁延伸，从而防止排出的流体（如果有爆炸性物质）接触这种电气和/或 可能作为潜在点火源的机械部件。 优选地，提供具有刚性体的歧管，其中形成流体流动线。 声学位移传感器（ADT）室壁形成在歧管主体上，并具有形成在其中的ADT室入口，流体流动线具有将流体流动线连接到ADT室入口的分支部分。 流体流动管线的出口延伸穿过形成在歧管体中的壁，以将从流体流动管线的出口排出的流体与驻留在流量计内部的电气和/或机械部件分离。

公开(公告)号：US07459070B2

公开(公告)日：2008-12-02

申请号：US11204773

申请日：2005-08-15

申请人： Changsheng Liu ,  Thomas E. Kane ,  Qingbo Li

发明人： Changsheng Liu ,  Thomas E. Kane ,  Qingbo Li

IPC分类号： G01N27/447 ,  G01N27/453

CPC分类号： C07K1/26 ,  G01N27/44704 ,  G01N27/44743 ,  G01N27/44782 ,  Y10T436/2575

摘要： An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.

摘要翻译： 公开了一种自动化毛细管区域电泳系统。 该系统采用具有多个毛细管的毛细管盒。 盒具有从板的一侧突出的第一阵列的毛细管端。 毛细管端部的第一阵列以与标准尺寸的微量托盘的孔基本相同的方式间隔开。 这允许人们同时对存在于托盘的每个孔中的样品进行毛细管电泳。 该系统包括堆叠的双转盘装置，以消除由连续的电泳执行中重复使用相同的缓冲盘引起的交叉污染。 该系统还具有连接到毛细管的检测端的容器。 该容器设置有阀，其有助于清洁毛细管，将缓冲液加载到毛细管中，将待电泳的样品引入毛细管中，并在这样引入的样品上进行毛细管区带电泳。

公开(公告)号：US06365024B1

公开(公告)日：2002-04-02

申请号：US09372151

申请日：1999-08-11

申请人： Qingbo Li ,  Thomas E. Kane ,  Changsheng Liu ,  Bernard Sonnenschein ,  Michael V. Sharer ,  John R. Kernan

发明人： Qingbo Li ,  Thomas E. Kane ,  Changsheng Liu ,  Bernard Sonnenschein ,  Michael V. Sharer ,  John R. Kernan

IPC分类号： G01N2726

CPC分类号： G01N27/44721 ,  G01N27/44782

摘要： An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a gel delivery module containing a gel syringe/a stepper motor or a high pressure chamber with a pump to quickly and uniformly deliver gel through the capillary tubes. The system further includes a multi-wavelength beam generator to generate a laser beam which produces a beam with a wide range of wavelengths. An off-line capillary reconditioner thoroughly cleans a capillary cartridge to enable simultaneous execution of electrophoresis with another capillary cartridge. The streamlined nature of the off-line capillary reconditioner offers the advantage of increased system throughput with a minimal increase in system cost.

摘要翻译： 公开了一种自动电泳系统。 该系统采用具有多个毛细管的毛细管盒。 盒具有从板的一侧突出的第一阵列的毛细管端。 毛细管端部的第一阵列以与标准尺寸的微量托盘的孔基本相同的方式间隔开。 这允许人们同时对存在于托盘的每个孔中的样品进行毛细管电泳。 该系统包括堆叠的双转盘装置，以消除由连续的电泳执行中重复使用相同的缓冲盘引起的交叉污染。 该系统还具有含有凝胶注射器/步进电机或具有泵的高压室的凝胶递送模块，以通过毛细管快速均匀地输送凝胶。 该系统还包括多波长光束发生器，以产生产生具有宽波长范围的光束的激光束。 离线毛细管修复器彻底清洁毛细管柱，以便同时执行另一个毛细管柱的电泳。 离线毛细管再生器的流线型性质提供了增加系统吞吐量的优点，同时最小化了系统成本。

公开(公告)号：US06352633B1

公开(公告)日：2002-03-05

申请号：US09388125

申请日：1999-08-31

申请人： Changsheng Liu ,  Thomas E Kane ,  Qingbo Li

发明人： Changsheng Liu ,  Thomas E Kane ,  Qingbo Li

IPC分类号： G01N2726

CPC分类号： C07K1/26 ,  G01N27/44704 ,  G01N27/44743 ,  G01N27/44782 ,  Y10T436/2575

摘要： An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.

摘要翻译： 公开了一种自动化毛细管区域电泳系统。 该系统采用具有多个毛细管的毛细管盒。 盒具有从板的一侧突出的第一阵列的毛细管端。 毛细管端部的第一阵列以与标准尺寸的微量托盘的孔基本相同的方式间隔开。 这允许人们同时对存在于托盘的每个孔中的样品进行毛细管电泳。 该系统包括堆叠的双转盘装置，以消除由连续的电泳执行中重复使用相同的缓冲盘引起的交叉污染。 该系统还具有连接到毛细管的检测端的容器。 该容器设置有阀，其有助于清洁毛细管，将缓冲液加载到毛细管中，将待电泳的样品引入毛细管中，并在这样引入的样品上进行毛细管区带电泳。

公开(公告)号：US06241949B1

公开(公告)日：2001-06-05

申请号：US09376076

申请日：1999-08-17

申请人： Thomas E. Kane

发明人： Thomas E. Kane

IPC分类号： B01L300

CPC分类号： B01L3/5085

摘要： Microtitre trays and their spill-resistant open lids prevent cross contamination of samples and also accommodate fragile and flexible probes of automated biological sample analysis systems. The open-lids can be in the form of sleeves located on the top sides of each well of microtitre trays. In one version, one microtitre tray with its bottom sections severed is stacked on top of another microtitre tray to provide the open-lids. A cutting tool is also provided to sever the bottom sections of each well from microtitre trays. The cutting tool includes a lever, a blade and a clamping device.

摘要翻译： 微量滴定塔及其防溢油开盖防止样品交叉污染，并且还适应自动化生物样品分析系统的脆弱灵活的探针。 开盖可以是位于微量托盘每个孔的顶侧上的袖子的形式。 在一个版本中，将一个其底部切断的微量托盘堆叠在另一个微量托盘的顶部以提供开放盖。 还提供了一种切割工具来切割每个孔的底部部分与微量托盘。 切割工具包括杆，刀片和夹紧装置。

公开(公告)号：US08438933B2

公开(公告)日：2013-05-14

申请号：US12460246

申请日：2009-07-15

申请人： William D. Grove ,  Brandon A. Tarr ,  Gerald W. Johnston ,  Thomas E. Kane

发明人： William D. Grove ,  Brandon A. Tarr ,  Gerald W. Johnston ,  Thomas E. Kane

IPC分类号： G01F1/00

CPC分类号： G01F1/36 ,  G01F1/363

摘要： An acoustic displacement flowmeter for determining flow rate of a fluid has a fluid flow line defining a flow path for the fluid. The fluid flow line has an inlet and an outlet. A controllable valve is positioned along the fluid flow line for opening and closing the flow path as desired, and an acoustic displacement transducer having a fluid port is coupled to the fluid flow line upstream from the controllable valve. The outlet of the fluid flow line extends through a wall isolating fluid exhausted from the outlet of the fluid flow line from electrical and/or mechanical components residing inside the flowmeter, thereby preventing the exhausted fluid, if explosive, from contacting such electrical and/or mechanical components which may act as potential ignition sources. Preferably, a manifold having a rigid body is provided in which the fluid flow line is formed. An acoustic displacement transducer (ADT) chamber wall is formed on the manifold body, and has an ADT chamber inlet port formed therein, and the fluid flow line has a branched portion connecting the fluid flow line to the ADT chamber inlet port. The outlet of the fluid flow line extends through a wall formed in the manifold body to isolate fluid exhausted from the outlet of the fluid flow line from electrical and/or mechanical components residing inside the flowmeter.

摘要翻译： 用于确定流体流速的声位移流量计具有限定流体流动路径的流体流动线。 流体流动管线具有入口和出口。 沿着流体流动管线定位可控阀，以根据需要打开和关闭流路，并且具有流体端口的声位移传感器联接到可控阀上游的流体流动管线。 流体流动管线的出口延伸通过流体流动管线出口从位于流量计内部的电气和/或机械部件排出的壁的隔离壁延伸，从而防止排出的流体（如果有爆炸性物质）接触这种电气和/或 可能作为潜在点火源的机械部件。 优选地，提供具有刚性体的歧管，其中形成流体流动线。 声学位移传感器（ADT）室壁形成在歧管主体上，并具有形成在其中的ADT室入口，流体流动线具有将流体流动线连接到ADT室入口的分支部分。 流体流动管线的出口延伸穿过形成在歧管体中的壁，以将从流体流动管线的出口排出的流体与驻留在流量计内部的电气和/或机械部件分离。