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公开(公告)号：US08586020B2
公开(公告)日：2013-11-19
申请号：US13173783
申请日：2011-06-30
申请人： Soo-Chang Song , Thrimoorthy Potta , Mi-Ran Park
发明人： Soo-Chang Song , Thrimoorthy Potta , Mi-Ran Park
CPC分类号： A61L27/18 , A61L27/52 , A61L27/54 , A61L2300/80 , C08G79/02 , C08G79/025 , C08J3/075 , C08J2385/02 , C08L85/02
摘要： Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.
摘要翻译： 提供了用于生物材料的化学交联的聚（有机膦腈），与共价键合的生理活性物质的化学交联的聚（有机膦腈），其生物材料的用途及其制备方法的用途。 化学交联可以通过UV照射和/或交联剂，/或添加剂和/或酶进行，和/或至少一种聚合物的混合。
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公开(公告)号：US20170115275A1
公开(公告)日：2017-04-27
申请号：US15332928
申请日：2016-10-24
CPC分类号： C12N5/0693 , C08J3/075 , C08J2371/02 , C12N5/0068 , C12N2503/02 , C12N2533/30 , C12N2537/10 , G01N33/5011
摘要： Methods to form a novel aminoglycoside based hydrogel for high-throughput generation of 3D dormant, relapsed and micrometastatic tumor microenvironments are disclosed. In addition, methods of screening agents against tumor cells grown in the 3D environments disclosed herein that include, for example, screening of lead drugs and therapies for an effect on dormant, relapsed and/or micrometastatic tumor cells.
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公开(公告)号：US20200165572A1
公开(公告)日：2020-05-28
申请号：US16708027
申请日：2019-12-09
摘要： Methods to form a novel aminoglycoside based hydrogel for high-throughput generation of 3D dormant, relapsed and micrometastatic tumor microenvironments are disclosed. In addition, methods of screening agents against tumor cells grown in the 3D environments disclosed herein that include, for example, screening of lead drugs and therapies for an effect on dormant, relapsed and/or micrometastatic tumor cells.
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4.发明申请PHOSPHAZENE HYDROGELS WITH CHEMICAL CORSS-LINK, PREPARATION METHOD THEREOF AND USE THEREOF 有权具有化学连接性的PHOSPHAZENE HYDROGELS，其制备方法及其用途公开(公告)号：US20100297155A1
公开(公告)日：2010-11-25
申请号：US12452322
申请日：2008-05-23
申请人： Soo-Chang Song , Thrimoorthy Potta , Sun-Mi Lee
发明人： Soo-Chang Song , Thrimoorthy Potta , Sun-Mi Lee
IPC分类号： A61K39/00 , A61K35/00 , A61K35/12 , A61K35/14 , A61K47/30 , C08G79/02 , A61P35/00 , A61K35/44 , A61K35/34 , A61K35/30 , A61K35/32 , A61P37/04
CPC分类号： C08G79/025 , A61K9/06 , A61K47/34 , C08G65/33306 , C08G2650/50 , C08J3/075 , C08J3/246 , C08J3/28 , C08J2385/02 , C08L85/02 , C08L2203/02
摘要： A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, a method of preparing the same, and a hydrogel forming a chemical cross-linking by radiating ultraviolet and/or mixing with a cross-linking agent and/or an enzyme; where the hydrigel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration, are provided.
摘要翻译： 具有通过辐射紫外线（UV）和/或与交联剂和/或酶混合形成的化学交联的磷腈基聚合物水凝胶，其制备方法和形成化学交联的水凝胶通过 辐射紫外线和/或与交联剂和/或酶的混合; 其中水凝胶显示出溶胶 - 凝胶行为并且通过含有能够以一定浓度交联的磷腈基聚合物而具有优异的固化性。
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公开(公告)号：US09801954B2
公开(公告)日：2017-10-31
申请号：US15034425
申请日：2014-11-05
申请人： Kaushal Rege , Bhavani Miryala , Thrimoorthy Potta
发明人： Kaushal Rege , Bhavani Miryala , Thrimoorthy Potta
CPC分类号： A61K48/0041 , A61K47/543 , A61K47/59 , A61K47/61 , C12N15/87
摘要： A method to form a lipid-containing aminoglycoside-based polymer, where the method includes reacting an aminoglycoside with a diepoxide to form an aminoglycoside-based polymeric material, and then reacting the aminoglycoside-based polymeric material with an acyl chloride to form the lipid-containing aminoglycoside-based polymer.
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6.发明授权Phosphazene hydrogels with chemical corss-link, preparation method thereof and use thereof 有权具有化学结构的磷腈水凝胶，其制备方法和用途公开(公告)号：US08313771B2
公开(公告)日：2012-11-20
申请号：US12452322
申请日：2008-05-23
申请人： Soo-Chang Song , Thrimoorthy Potta , Sun-Mi Lee
发明人： Soo-Chang Song , Thrimoorthy Potta , Sun-Mi Lee
CPC分类号： C08G79/025 , A61K9/06 , A61K47/34 , C08G65/33306 , C08G2650/50 , C08J3/075 , C08J3/246 , C08J3/28 , C08J2385/02 , C08L85/02 , C08L2203/02
摘要： A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, and a method of preparing the same are provided. The hydrogel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration.
摘要翻译： 提供了具有通过辐射紫外线（UV）和/或与交联剂和/或酶混合形成的化学交联的磷腈基聚合物水凝胶及其制备方法。 水凝胶显示出溶胶 - 凝胶行为，并且通过含有能够以一定浓度进行交联的磷腈基聚合物而具有优异的固体性。
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公开(公告)号：US20240099971A1
公开(公告)日：2024-03-28
申请号：US18534301
申请日：2023-12-08
CPC分类号： A61K9/107 , A61K9/4808 , A61K9/4825 , A61K31/05 , A61K47/10 , A61K47/14 , A61K47/22
摘要： The present invention is directed to a self-emulsifying cannabidiol composition containing one or more surfactants. The present invention is further directed to a method of treating a disease comprising administering a composition of the present invention to a subject in need thereof. The present invention is further directed to a method of treating withdrawal symptoms.
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8.发明申请Lipid Substitution on Aminoglycoside Based Polymers: Plasmid Delivery, Anticancer Drug Delivery and Transgene Expression 有权基于氨基糖苷的聚合物的脂质取代：质粒递送，抗癌药物递送和转基因表达公开(公告)号：US20160279264A1
公开(公告)日：2016-09-29
申请号：US15034425
申请日：2014-11-05
申请人： Kaushal REGE , Bhavani MIRYALA , Thrimoorthy POTTA
发明人： Kaushal REGE , Bhavani MIRYALA , Thrimoorthy POTTA
CPC分类号： A61K48/0041 , A61K47/543 , A61K47/59 , A61K47/61 , C12N15/87
摘要： A method to form a lipid-containing aminoglycoside-based polymer, where the method includes reacting an aminoglycoside with a diepoxide to form an aminoglycoside-based polymeric material, and then reacting the aminoglycoside-based polymeric material with an acyl chloride to form the lipid-containing aminoglycoside-based polymer.
摘要翻译： 一种形成含脂质的氨基糖苷类聚合物的方法，其中所述方法包括使氨基糖苷与二环氧化物反应形成氨基糖苷类聚合物，然后使氨基糖苷类聚合物与酰氯反应形成脂质 - 含有氨基糖苷类聚合物。
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公开(公告)号：US20130004455A1
公开(公告)日：2013-01-03
申请号：US13173783
申请日：2011-06-30
申请人： Soo-Chang SONG , Thrimoorthy Potta , Mi-Ran Park
发明人： Soo-Chang SONG , Thrimoorthy Potta , Mi-Ran Park
CPC分类号： A61L27/18 , A61L27/52 , A61L27/54 , A61L2300/80 , C08G79/02 , C08G79/025 , C08J3/075 , C08J2385/02 , C08L85/02
摘要： Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.
摘要翻译： 提供了用于生物材料的化学交联的聚（有机膦腈），与共价键合的生理活性物质的化学交联的聚（有机膦腈），其生物材料的用途及其制备方法的用途。 化学交联可以通过UV照射和/或交联剂，/或添加剂和/或酶进行，和/或至少一种聚合物的混合。
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