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公开(公告)号：US08715647B2
公开(公告)日：2014-05-06
申请号：US11198426
申请日：2005-08-05
Applicant: Michael R. Bedford , Andrew J. Morgan , Timothy Fowler , Kathleen A. Clarkson , Michael Ward , Katherine D. Collier , Edmund A. Larenas
Inventor： Michael R. Bedford , Andrew J. Morgan , Timothy Fowler , Kathleen A. Clarkson , Michael Ward , Katherine D. Collier , Edmund A. Larenas
CPC classification number: C12Y302/01004 , A23K20/189 , A23K50/75 , C12N9/2437 , C12Y302/01091
Abstract: The use is provided composition as a feed additive which comprises one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the composition, of a cellobiohydrolase. The endoglycanases may be one or more of EGI, EGII, EGIII and any functionally active derivative of any thereof. Such endoglucanases may be obtained from a genetically modified strain of the fungus Trichoderma. Also provided is an enzyme-based feed additive which comprises EGI and/or EGII which lack the cellulose binding domain, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase. A further enzyme-based feed additive is provided which comprises a cereal-based carrier, one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase.
Abstract translation: 提供的组合物作为饲料添加剂，其包含一种或多种内切葡聚糖酶，并且基于组合物中纤维素酶蛋白质的含量为0-20重量％的纤维二糖水解酶。 所述凝集素可以是EGI，EGII，EGIII及其任何的任何功能活性衍生物中的一种或多种。 这样的内切葡聚糖酶可以从真菌木霉的遗传修饰菌株获得。 还提供了一种基于酶的饲料添加剂，其包含缺乏纤维素结合结构域的EGI和/或EGII，并且基于添加剂中纤维素酶蛋白质的含量为0-20重量％的纤维二糖水解酶。 提供了另外一种基于酶的饲料添加剂，其包含基于谷物的载体，一种或多种内切葡聚糖酶，和基于添加剂中的纤维素酶蛋白质含量为0-20重量％的纤维二糖水解酶。
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公开(公告)号：US5360901A
公开(公告)日：1994-11-01
申请号：US845989
申请日：1992-03-04
Applicant: Randy M. Berka , Timothy Fowler , Michael W. Rey
Inventor： Randy M. Berka , Timothy Fowler , Michael W. Rey
CPC classification number: C12N9/0065 , C12N15/80
Abstract: The invention discloses the application of genetic engineering techniques to create novel strains of A. niger which produce high levels of catalase (catR gene product, catalase-R) while generating minimal sodium gluconate waste material.
Abstract translation: 本发明公开了基因工程技术的应用，以产生高水平的过氧化氢酶（catR基因产物，过氧化氢酶-R）同时产生最小葡萄糖酸钠废料的新型黑曲霉菌株。
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公开(公告)号：US5360732A
公开(公告)日：1994-11-01
申请号：US846181
申请日：1992-03-04
Applicant: Randy M. Berka , Timothy Fowler , Michael W. Rey
Inventor： Randy M. Berka , Timothy Fowler , Michael W. Rey
CPC classification number: C12N9/0065 , C12N15/80
Abstract: The invention discloses the application of genetic engineering techniques to create novel strains of A. niger which produce high levels of catalase (catR gene product, catalase-R) while generating minimal sodium gluconate waste material.
Abstract translation: 本发明公开了基因工程技术的应用，以产生高水平的过氧化氢酶（catR基因产物，过氧化氢酶-R）同时产生最小葡萄糖酸钠废料的新型黑曲霉菌株。
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4.发明授权Method of detecting DNA encoding a .beta.-glucosidase from a filamentous fungus 失效从丝状真菌中检测编码β-葡糖苷酶的DNA的方法
公开(公告)号：US6103464A
公开(公告)日：2000-08-15
申请号：US463461
申请日：1995-06-05
Applicant: Timothy Fowler , Christopher C. Barnett , Sharon Shoemaker
Inventor： Timothy Fowler , Christopher C. Barnett , Sharon Shoemaker
IPC: A23L27/24 , C12G1/00 , C12G1/02 , C12H1/15 , C12N9/26 , C12N9/42 , C12P19/00 , C12Q1/68 , C07H21/04
CPC classification number: C12N9/2445 , A23L27/25 , C12G1/00 , C12G1/02 , C12N9/2408 , C12P19/00 , C12Q1/6895 , C12R1/885 , C12Y302/01021
Abstract: A process for expressing extracellular .beta.-glucosidase in a filamentous fungus by expressing a fungal DNA sequence encoding enhanced, deleted or altered .beta.-glucosidase in a recombinant host microorganism is disclosed. Recombinant fungal cellulase compositions containing enhanced, deleted or altered expression of .beta.-glucosidase is also disclosed.
Abstract translation: 公开了通过在重组宿主微生物中表达编码增强的，缺失的或改变的β-葡糖苷酶的真菌DNA序列来在丝状真菌中表达胞外β-葡糖苷酶的方法。 还公开了含有增强，缺失或改变的β-葡糖苷酶表达的重组真菌纤维素酶组合物。
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公开(公告)号：US20060193897A1
公开(公告)日：2006-08-31
申请号：US11198426
申请日：2005-08-05
Applicant: Michael Bedford , Andrew Morgan , Timothy Fowler , Kathleen Clarkson , Michael Ward , Katherine Collier , Edmund Larenas
Inventor： Michael Bedford , Andrew Morgan , Timothy Fowler , Kathleen Clarkson , Michael Ward , Katherine Collier , Edmund Larenas
CPC classification number: C12Y302/01004 , A23K20/189 , A23K50/75 , C12N9/2437 , C12Y302/01091
Abstract: The use is provided of a composition as a feed additive which comprises one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the composition, of a cellobiohydrolase. The endoglycanases may be one or more of EGI, EGII, EGIII and any functionally active derivative of any thereof. Such endoglucanases may be obtained from a genetically modified strain of the fungus Trichoderma. Also provided is an enzyme-based feed additive which comprises EGI and/or EGII which lack the cellulose binding domain, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase. A further enzyme-based feed additive is provided which comprises a cereal-based carrier, one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase.
Abstract translation: 提供的组合物作为饲料添加剂，其包含一种或多种内切葡聚糖酶，并且基于组合物中纤维素酶蛋白质的含量为0-20重量％的纤维二糖水解酶。 所述凝集素可以是EGI，EGII，EGIII及其任何的任何功能活性衍生物中的一种或多种。 这样的内切葡聚糖酶可以从真菌木霉的遗传修饰菌株获得。 还提供了一种基于酶的饲料添加剂，其包含缺乏纤维素结合结构域的EGI和/或EGII，并且基于添加剂中纤维素酶蛋白质的含量为0-20重量％的纤维二糖水解酶。 提供了另外一种基于酶的饲料添加剂，其包含基于谷物的载体，一种或多种内切葡聚糖酶，和基于添加剂中的纤维素酶蛋白质含量为0-20重量％的纤维二糖水解酶。
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Patent Agency Ranking
公开(公告)号：US06916646B1
公开(公告)日：2005-07-12
申请号：US08876132
申请日：1997-06-23
Applicant: Timothy Fowler , Stuart C. Causey
Inventor： Timothy Fowler , Stuart C. Causey
Abstract: Methods are provided for preparing improved fermentation strains of the family Enterobacteriaceae which comprise the steps of eliminating the cryptic plasmid from the progenitor strain thereby creating the improved strain. Methods for reducing the mobilization properties of resident plasmids in an Enterobacteriaceae strain containing a cryptic plasmid are also provided. The present invention provides the nucleic acid sequence of pS, a cryptic plasmid found in Pantoea which can be used to identify the cryptic plasmid in strains of Enterobacteriaceae.
Abstract translation: 提供了用于制备肠杆菌科的改良发酵菌株的方法，其包括从祖细胞菌株中消除神经质粒的步骤，从而产生改良的菌株。 还提供了用于降低含有隐性质粒的肠杆菌科菌株中驻留质粒的动员特性的方法。 本发明提供了在Pantoea中发现的可用于鉴定肠杆菌科菌株中的隐性质粒的隐神质的pS的核酸序列。
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公开(公告)号：US06620605B2
公开(公告)日：2003-09-16
申请号：US09916494
申请日：2001-07-27
Applicant: Timothy Fowler , Kathleen A. Clarkson , Michael Ward , Katherine D. Collier , Edmund Larenas
Inventor： Timothy Fowler , Kathleen A. Clarkson , Michael Ward , Katherine D. Collier , Edmund Larenas
IPC: C12N942
CPC classification number: D06P5/158 , A23K20/189 , C11D3/38645 , C12N9/2437 , C12N15/80 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , D06M16/003 , D06P5/02 , D06P5/137 , Y10T442/20
Abstract: Improved methods of treating cellulose containing fabrics with cellulase comprising contacting the cellulose fabrics with truncated cellulase enzyme. Treatment of cellulose containing fabrics with cellulase core domains of the invention are disclosed as offering specific advantages of reduced redeposition of dye and increased abrasion.
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8.发明授权公开(公告)号：US06582750B2
公开(公告)日：2003-06-24
申请号：US10261997
申请日：2002-09-30
Applicant: Timothy Fowler , Colin Mitchinson
Inventor： Timothy Fowler , Colin Mitchinson
IPC: A23K100
CPC classification number: C12N9/2437 , C12Y302/01004
Abstract: The present invention relates to variant EGIII cellulases that have improved stability and/or performance. The variant cellulases have replacements at sensitive residues to improve stability and/or performance.
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9.发明授权EGIII-like enzymes, DNA encoding such enzymes and methods for producing such enzymes 有权EGIII样酶，编码这些酶的DNA和用于制备这些酶的方法公开(公告)号：US07977051B2
公开(公告)日：2011-07-12
申请号：US11348013
申请日：2006-02-06
Applicant: Benjamin S. Bower , Timothy Fowler , Jay Ian Phillips
Inventor： Benjamin S. Bower , Timothy Fowler , Jay Ian Phillips
CPC classification number: C12N9/2437 , C12Y302/01004
Abstract: The present invention is directed to cellulase compositions which share unique highly conserved regions with a known useful cellulase. More specifically, the present invention relates to a series of newly discovered enzymes from fungi and bacteria which are related by virtue of having at least one of five important conserved amino acid sequences which are also present in EGIII.
Abstract translation: 本发明涉及用已知的有用的纤维素酶共享独特的高度保守区域的纤维素酶组合物。 更具体地，本发明涉及一系列新发现的真菌和细菌的酶，这些酶由于具有也存在于EGIII中的五个重要的保守氨基酸序列中的至少一个而相关。
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公开(公告)号：US20070105203A1
公开(公告)日：2007-05-10
申请号：US11652353
申请日：2007-01-11
Applicant: Timothy Fowler , Stuart Causey
Inventor： Timothy Fowler , Stuart Causey
Abstract: Methods are provided for preparing improved fermentation strains of the family Enterobacteriaceae which comprise the steps of eliminating the cryptic plasmid from the progenitor strain thereby creating the improved strain. Methods for reducing the mobilization properties of resident plasmids in an Enterobacteriaceae strain containing a cryptic plasmid are also provided. The present invention provides the nucleic acid sequence of pS, a cryptic plasmid found in Pantoea which can be used to identify the cryptic plasmid in strains of Enterobacteriaceae.
Abstract translation: 提供了用于制备肠杆菌科的改良发酵菌株的方法，其包括从祖细胞菌株中消除神经质粒的步骤，从而产生改良的菌株。 还提供了用于降低含有隐性质粒的肠杆菌科菌株中驻留质粒的动员特性的方法。 本发明提供了在Pantoea中发现的可用于鉴定肠杆菌科菌株中的隐性质粒的隐神质的pS的核酸序列。
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