Physiologically active substances
    6.
    发明授权
    Physiologically active substances 失效
    生理活性物质

    公开(公告)号:US06645996B1

    公开(公告)日:2003-11-11

    申请号:US09700680

    申请日:2000-11-17

    IPC分类号: A61K3135

    CPC分类号: C07D493/10 C12P17/162

    摘要: The present invention provides a novel bioactive substance having an antiangiogenic effect. The chemical compound represented by the formula (1) (wherein, R1 represents hydrogen atom, aldehyde group or a lower acyl group, R2 and R3 are the same as or different from each other and represent hydrogen atom or a lower alkoxy group or are combined to represent oxygen atom, R4 represents a lower alkyl group and R5 represents hydrogen atom or a lower alkyl group, provided that compounds in which R1 is aldehyde group, R2 and R3are different from each other and are hydrogen atom or methoxy group, R4 is ethyl group and R5 is hydrogen atom are excluded), a salt thereof or a hydrate thereof was isolated from the culture broth of genus Streptomyces and the structure thereof was analyzed.

    摘要翻译: 本发明提供了具有抗血管生成作用的新型生物活性物质。式(1)表示的化合物(其中,R 1表示氢原子,醛基或低级酰基,R 2和R 3 >彼此相同或不同,表示氢原子或低级烷氧基,或者组合表示氧原子,R 4表示低级烷基,R 5表示氢原子或低级烷基, 条件是其中R 1为醛基,R 2和R 3的化合物彼此不同,为氢原子或甲氧基,R 4为乙基,R 5为氢原子 被除去),其盐或其水合物从链霉菌属的培养肉汤中分离,并分析其结构。

    Front structure of vehicle
    10.
    发明授权
    Front structure of vehicle 有权
    车辆前部结构

    公开(公告)号:US08567854B2

    公开(公告)日:2013-10-29

    申请号:US13212853

    申请日:2011-08-18

    IPC分类号: B62D25/08

    摘要: An impact absorption member is provided behind a bumper face, a lower stiffener is provided below this member and projects forward to sweep a leg portion of an object hitting against a front potion of a vehicle, and headlamp units are provided at both side portions of the bumper face. A lamp housing of the headlamp unit is supported at a vehicle-body member located in back of the lamp housing, a load absorption portion provided on the inside of and rearward from an edge of the bumper face to absorb an impact load is provided integrally at the lamp housing, and a load transmission portion to transmit the impact load inputted to the bumper face to the load absorption portion is provided at the bumper face.

    摘要翻译: 冲击吸收部件设置在保险杠面的后方,下部加强件设置在该部件的下方,向前方突出,以抵挡撞击车辆的前部的物体的腿部,并且在两侧部分设置头灯单元 保险杠脸。 头灯单元的灯壳被支撑在位于灯壳后部的车体部件上,一体设置在保险杠面的内侧并设置在吸收冲击负荷的内侧的负载吸收部, 所述灯壳体和负载传递部分,其将输入到所述保险杠面的冲击载荷传递到所述负载吸收部分,设置在所述保险杠面上。