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公开(公告)号:US08992998B2
公开(公告)日:2015-03-31
申请号:US13820209
申请日:2011-09-02
申请人: Toshihisa Kawai , Mikihito Kajiya , Kimihiro Sato
发明人: Toshihisa Kawai , Mikihito Kajiya , Kimihiro Sato
CPC分类号: A61K33/00 , A23L2/52 , C25B1/04 , Y02E60/366
摘要: A method of treating inflammation in a subject by administering a composition including hydrogen, releasing hydrogen in the subject, suppressing mitogen-activated protein kinase (MAPK) phosphorylation and upregulating expression of MKP-1, and down-regulating inflammatory responses of monocyte lineage cells.
摘要翻译: 通过施用包含氢的组合物,释放受试者中的氢,抑制丝裂原活化蛋白激酶(MAPK)磷酸化和上调MKP-1的表达以及下调单核细胞谱系细胞的炎症反应来治疗受试者的炎症的方法。
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公开(公告)号:US20130266540A1
公开(公告)日:2013-10-10
申请号:US13820209
申请日:2011-09-02
申请人: Toshihisa Kawai , Mikihito Kajiya , Kimihiro Sato
发明人: Toshihisa Kawai , Mikihito Kajiya , Kimihiro Sato
CPC分类号: A61K33/00 , A23L2/52 , C25B1/04 , Y02E60/366
摘要: A method of treating and protecting a subject from endotoxin shock by administering a composition including hydrogen, releasing hydrogen in the subject, and down-regulating production of TNF-α and IL-6. A method of treating inflammation in a subject. A method of suppressing hydroxyl radical in a subject. A method of treating inflammation in a subject. A method of reducing the basal level of phosphorylation of MAPKs in non-stimulated monocyte lineage cells in a subject. Methods of performing drug screen tests for compounds that can treat the above conditions. A diagnostic method for diagnosing patients with diseases caused by the MAPK pathway.
摘要翻译: 通过施用包含氢的组合物,释放受试者中的氢和下调TNF-α和IL-6的产生来治疗和保护受试者免受内毒素休克的方法。 治疗受试者的炎症的方法。 抑制受试者中羟基自由基的方法。 治疗受试者的炎症的方法。 降低受试者非刺激单核细胞谱系细胞中MAPK磷酸化基础水平的方法。 对可以治疗上述病症的化合物进行药物筛选试验的方法。 一种用于诊断由MAPK通路引起的疾病患者的诊断方法。
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公开(公告)号:US20070261950A1
公开(公告)日:2007-11-15
申请号:US11678129
申请日:2007-02-23
申请人: Kimihiro Sato , Toshihisa Kawai
发明人: Kimihiro Sato , Toshihisa Kawai
IPC分类号: C01B3/00
CPC分类号: C02F1/4618 , C02F2303/04 , Y02E60/324
摘要: A drink for promoting health benefits to the user, the drink including hypochlorite free ionized water. Hypochlorite free ionized water and a method of forming hypochlorite free water by dissolving a non-hypochlorite generating salt in water and electrolyzing the water containing the dissolved salt.
摘要翻译: 用于促进使用者健康的饮料,饮料中含有次氯酸盐的电离水。 不含次氯酸盐的离子水和通过将非次氯酸盐生成的盐溶解在水中并电解含有溶解盐的水来形成不含次氯酸盐的水的方法。
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4.
公开(公告)号:US09925204B2
公开(公告)日:2018-03-27
申请号:US15187339
申请日:2016-06-20
申请人: Toshihisa Kawai , Kenneth I. Kohn
发明人: Toshihisa Kawai , Kenneth I. Kohn
IPC分类号: A61K9/48 , A61K31/7016 , A61K45/06 , A61K31/192 , A61K31/197 , A61K31/365 , A61K31/40 , A61K31/635 , A61K31/7004 , A61K31/733 , A61K33/00 , A61K9/16 , A61K31/415 , A61K9/08 , A61K31/715
CPC分类号: A61K31/7016 , A61K9/08 , A61K9/167 , A61K9/48 , A61K31/192 , A61K31/197 , A61K31/365 , A61K31/40 , A61K31/415 , A61K31/635 , A61K31/7004 , A61K31/715 , A61K31/733 , A61K33/00 , A61K45/06 , A61K2300/00
摘要: A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.
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公开(公告)号:US08399220B2
公开(公告)日:2013-03-19
申请号:US12762234
申请日:2010-04-16
IPC分类号: C12P21/04
CPC分类号: A61K31/192 , A61K39/0005 , C07K14/47 , C07K16/18
摘要: The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.
摘要翻译: 本发明涉及包含三羟基苯甲酸酯衍生物的口服抗菌组合物,例如可用于治疗牙龈疾病(例如牙龈炎或牙周炎)和使用这些组合物的方法。
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6.
公开(公告)号:US20160317575A1
公开(公告)日:2016-11-03
申请号:US15187339
申请日:2016-06-20
申请人: Toshihisa Kawai , Kenneth I. Kohn
发明人: Toshihisa Kawai , Kenneth I. Kohn
IPC分类号: A61K33/00 , A61K31/192 , A61K31/635 , A61K31/715 , A61K9/08 , A61K45/06 , A61K31/197 , A61K31/7016 , A61K31/365
CPC分类号: A61K31/7016 , A61K9/08 , A61K9/167 , A61K9/48 , A61K31/192 , A61K31/197 , A61K31/365 , A61K31/40 , A61K31/415 , A61K31/635 , A61K31/7004 , A61K31/715 , A61K31/733 , A61K33/00 , A61K45/06 , A61K2300/00
摘要: A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.
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公开(公告)号:US20100330070A1
公开(公告)日:2010-12-30
申请号:US12762212
申请日:2010-04-16
IPC分类号: A61K39/395 , C07K14/00 , A61K39/00 , C12P21/04 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , A61K38/16 , C12Q1/68 , G01N33/53 , A61P37/00
CPC分类号: A61K31/192 , A61K39/0005 , C07K14/47 , C07K16/18
摘要: The present invention relates to new methods for making antibodies that involves chemically modifying the antigen with methylglyoxal. The present invention further relates to antibodies made in this manner, and include antibodies specific to LL-37. The present invention pertains to assays that utilize anti-LL-37 antibodies and assess compounds that stimulate LL-37 production. Such compounds are useful in antimicrobial compositions.
摘要翻译: 本发明涉及用于制备涉及用甲基乙二醛化学修饰抗原的抗体的新方法。 本发明还涉及以这种方式制备的抗体,并且包括对LL-37特异的抗体。 本发明涉及利用抗LL-37抗体并评估刺激LL-37生产的化合物的测定法。 这些化合物可用于抗微生物组合物。
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公开(公告)号:US20100330001A1
公开(公告)日:2010-12-30
申请号:US12762234
申请日:2010-04-16
IPC分类号: A61K9/68 , C12N5/00 , A61P31/04 , A61P1/02 , A61P31/10 , A61P1/04 , A61K38/43 , A61K31/192 , A61K31/235 , A61K31/353 , G01N33/50 , G01N33/53 , C07C65/05 , G01N33/543 , C12Q1/68 , C07C69/88 , C07D311/62
CPC分类号: A61K31/192 , A61K39/0005 , C07K14/47 , C07K16/18
摘要: The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.
摘要翻译: 本发明涉及包含三羟基苯甲酸酯衍生物的口服抗菌组合物,例如可用于治疗牙龈疾病(例如牙龈炎或牙周炎)和使用这些组合物的方法。
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公开(公告)号:US20170056504A1
公开(公告)日:2017-03-02
申请号:US15254316
申请日:2016-09-01
申请人: Kenneth I. Kohn , Toshihisa Kawai
发明人: Kenneth I. Kohn , Toshihisa Kawai
CPC分类号: A61K47/26 , A61K47/44 , A61K2039/505 , C07K16/32 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: A composition for extending the half-life of a crystalline antibody, including synergistically effective amounts of a half-life-extending compound and a crystalline antibody. A composition for extending the half-life of a crystalline antibody including synergistically effective amounts of lactulose and a crystalline anti-PCSK9 antibody. A method of extending the half-life of a crystalline antibody, by administering a synergistically effective amount of a half-life-extending compound and a crystalline antibody to an individual, and extending the half-life of the crystalline antibody. A method of promoting antibody recycling by affecting a receptor for an antibody to recycle the antibody.
摘要翻译: 一种用于延长结晶抗体半衰期的组合物,包括协同有效量的半衰期延长化合物和结晶抗体。 一种用于延长结晶抗体的半衰期的组合物,包括协同有效量的乳果糖和结晶抗PCSK9抗体。 通过对个体施用协同有效量的半衰期延长的化合物和结晶抗体并延长结晶抗体的半衰期,延长结晶抗体的半衰期的方法。 通过影响抗体的受体以再循环抗体来促进抗体再循环的方法。
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公开(公告)号:US08728456B2
公开(公告)日:2014-05-20
申请号:US13386950
申请日:2010-08-02
IPC分类号: A61K39/35 , A61K39/00 , A61K38/20 , A61K38/19 , A61P37/04 , A61P37/06 , A61P3/10 , A61P29/00 , A61P37/08
CPC分类号: A61K39/0008 , A61K39/0011 , A61K39/102 , A61K39/35 , A61K39/39 , A61K2039/5158 , A61K2039/55522 , A61K2039/55561 , A61K2039/577 , A61K2039/70
摘要: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
摘要翻译: 生物材料系统,例如凝胶支架,用于体内募集免疫细胞并促进其向非炎症表型的活化,从而导致炎症的抑制。 组合物和方法可用于降低自身免疫,慢性炎症,过敏和牙周病的严重性。
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