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    Vibrotactile stimulation device
    1.
    发明授权
    Vibrotactile stimulation device 有权

    公开(公告)号：US11160724B2

    公开(公告)日：2021-11-02

    申请号：US15529190

    申请日：2015-11-24

    申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE RENNES I

    发明人： Alfredo Hernandez

    IPC分类号： A61H23/02 ,  A61B5/00

    摘要： A vibrotactile stimulation device intended to be applied against a body environment (MC) to be stimulated and having a vibrating effector suitable for applying, to the environment, pulses of mechanical vibrational energy, and a controller controlling the effector according to stimulation rules. The device further includes vibration detector suitable for being exposed to the body environment in order to receive a part of the vibrational energy transmitted to the environment during the application of the pulses of vibrational energy, and determine a transmission characteristic of the vibrational energy between the effector and the environment to be stimulated, the vibration detector being linked to the controller. An application to improving the efficacy of body stimulation in combating sleep apnea is also disclosed.

    Methods for Predicting and Preventing Metastasis in Triple Negative Breast Cancers
    5.
    发明申请
    Methods for Predicting and Preventing Metastasis in Triple Negative Breast Cancers 审中-公开
    预防和预防三重阴性乳腺癌转移的方法

    公开(公告)号：US20150377888A1

    公开(公告)日：2015-12-31

    申请号：US14764326

    申请日：2014-01-31

    申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE DE RENNES I ,  ECOLES DES HAUTES ETUDES EN SANTE PUBLIQUE (EHESP) ,  CENTRE EUGENE MARQUIS ,  CHU DE RENNES ,  UNIVERSITE DES ANTILLES ET DE LA GUYANE

    发明人： Patrick Legembre ,  Marine Malleter ,  Sébastien Tauzin ,  Florence Godey ,  Jean Leveque

    IPC分类号： G01N33/574 ,  C07K16/24

    CPC分类号： G01N33/57415 ,  C07K16/241 ,  C07K2317/40 ,  C07K2319/30 ,  G01N2333/70575 ,  G01N2800/54

    摘要： In particular the present invention relates to a method for predicting the risk of relapse and distant metastasis in a patient suffering from a triple negative breast cancer comprising the step of i) determining the level of soluble CD95L in a blood sample obtained from the patient ii) comparing the level determined at step i) with a predetermined reference value and iii) concluding that the patient will exhibit an increased risk of relapse and distant metastasis when the level determined at step i) is higher than the predetermined reference value or concluding that the patient will exhibit a decreased risk of relapse and distant metastasis when the level determined at step i) is lower than the predetermined reference value. The present invention also relates to a method of preventing metastases in a subject suffering from triple negative breast cancer comprising the steps consisting of i) predicting the risk of relapse and distant metastasis by the method according to the invention and ii) administering the subject with a therapeutically effective amount of a CD95 antagonist when it is concluded at step i) that the subject will exhibit an increased risk of relapse and distant metastasis.

    摘要翻译： 特别地，本发明涉及用于预测患有三阴性乳腺癌的患者的复发和远处转移的风险的方法，包括以下步骤：i）确定从患者获得的血液样品中的可溶性CD95L水平ii） 将步骤i）中确定的水平与预定的参考值进行比较，以及iii）当步骤i）确定的水平高于预定的参考值时，推断出患者将呈现复发和远处转移的风险增加，或者得出结论：患者 当步骤i）确定的水平低于预定的参考值时，将呈现复发和远处转移的风险降低。 本发明还涉及一种预防患有三阴性乳腺癌的受试者转移的方法，其包括以下步骤：i）通过本发明的方法预测复发和远处转移的风险，以及ii） 治疗有效量的CD95拮抗剂，当在步骤i）得出结论时，受试者将表现出增加的复发和远处转移的风险。

    RAPID CHARACTERIZATION OF THE SOLUBILITY OF AMPHIPHILES
    10.
    发明申请
    RAPID CHARACTERIZATION OF THE SOLUBILITY OF AMPHIPHILES 审中-公开
    快速表征AMPHIPHILES的溶解性

    公开(公告)号：US20150355065A1

    公开(公告)日：2015-12-10

    申请号：US14764719

    申请日：2014-01-30

    申请人： THE TRUSTEES OF PRINCETON UNIVERSITY ,  CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE RENNES I ,  THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

    发明人： MATTHIEU ROCHE ,  HOWARD A. STONE ,  ISABELLE CANTAT ,  ARNAUD SAINT-JALMES ,  IAN GRIFFITHS ,  SEBASTIEN LE ROUX ,  ZHEN ZHEN LI

    IPC分类号： G01N13/02

    CPC分类号： G01N13/02 ,  G01N33/491 ,  G01N2013/0275 ,  G01N2013/0283 ,  G01N2015/0003

    摘要： Disclosed is a process and device allowing for fast measurements of the physicochemical properties of amphiphiles (lipids, surfactants, soaps, . . . ). A Marangoni flow is created and characterized using amphiphiles to be characterized. The observed flow is characterized, and using the disclosed process, one can deduce from this measurement many important physicochemical parameters of the amphiphiles such as their critical micellar concentration. Compared to existing techniques, the disclosed process offers the advantage that it requires a single experiment to deduce the parameters, when other techniques (pendant drop method, conductometry, etc . . . ) require the measurement of a quantity (interfacial tension, conductometry) against a systematically varied parameter (amphiphile concentration, . . . ). The disclosed process and devices are ideal to characterize and/or screen rapidly amphiphiles molecules based on their interaction with a solvent.

    摘要翻译： 公开了允许快速测量两亲物（脂质，表面活性剂，肥皂等）的物理化学性质的方法和装置。 使用要表征的两亲物来创建和表征马兰戈尼流。 观察到的流动被表征，并且使用所公开的方法，可以从该测量推断出许多重要的物理化学参数，例如它们的临界胶束浓度。 与现有技术相比，所公开的方法提供的优点在于，当其它技术（悬滴法，电导测量等）需要测量量（界面张力，电导率））时，需要单个实验来推导参数 系统变化的参数（两亲物浓度，...）。 基于它们与溶剂的相互作用，所公开的方法和装置是理想的表征和/或筛选快速两亲分子。