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公开(公告)号：US07029897B2
公开(公告)日：2006-04-18
申请号：US10433794
申请日：2001-12-04
申请人： Henry Yue , Li Ding , Preeti G. Lal , Jennifer A. Griffin , Rajagopal Gururajan , Mariah R. Baughn , Craig H. Ison , Jayalaxmi Ramkumar , Catherine M. Tribouley , Anita Swarnakar , Neil Burford , Olga Bandman , Michael Thornton , Farrah A. Khan , Narinder K. Chawla , Danniel B. Nguyen , Vicki S. Elliott , Yuming Xu , Yan Lu , April J. A. Hafalia , Monique G. Yao , Ameena R. Gandhi , Chandra S. Arvizu , Ian J. Forsythe
发明人： Henry Yue , Li Ding , Preeti G. Lal , Jennifer A. Griffin , Rajagopal Gururajan , Mariah R. Baughn , Craig H. Ison , Jayalaxmi Ramkumar , Catherine M. Tribouley , Anita Swarnakar , Neil Burford , Olga Bandman , Michael Thornton , Farrah A. Khan , Narinder K. Chawla , Danniel B. Nguyen , Vicki S. Elliott , Yuming Xu , Yan Lu , April J. A. Hafalia , Monique G. Yao , Ameena R. Gandhi , Chandra S. Arvizu , Ian J. Forsythe
CPC分类号： C12N9/1205 , C07H21/04 , C12N9/16
摘要： The invention provides human kinases and phosphatases (KAP) and polnucleotides which identify and encode KAP. The invention also provides expresson vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KAP.
摘要翻译： 本发明提供鉴定和编码KAP的人激酶和磷酸酶（KAP）和核苷酸。 本发明还提供了表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与KAP的异常表达相关的疾病的方法。
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公开(公告)号：US20130058942A1
公开(公告)日：2013-03-07
申请号：US13562088
申请日：2012-07-30
申请人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J.A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
发明人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J.A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
CPC分类号： C12N9/16 , C12N9/12 , C12N9/1205 , G01N33/573 , G01N2800/70
摘要： Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.
摘要翻译： 本发明的各种实施方案提供鉴定和编码KPP的人激酶和磷酸酶（KPP）多肽和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与KPP异常表达相关的紊乱的方法。
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公开(公告)号：US07829682B1
公开(公告)日：2010-11-09
申请号：US10554917
申请日：2004-03-24
申请人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J. A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
发明人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J. A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
CPC分类号： C12N9/16 , C12N9/12 , C12N9/1205 , G01N33/573 , G01N2800/70
摘要： Various embodiments of the invention provide human kinases and phosphatases (KPP) and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.
摘要翻译： 本发明的各种实施方案提供鉴定和编码KPP的人类激酶和磷酸酶（KPP）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与KPP异常表达相关的紊乱的方法。
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公开(公告)号：US07608704B2
公开(公告)日：2009-10-27
申请号：US11378616
申请日：2006-03-20
申请人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan M. Sanjanwala , Michael Thorton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
发明人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan M. Sanjanwala , Michael Thorton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
CPC分类号： C12N15/1055 , A61K39/3955 , A61K47/64 , A61K47/643 , A61K2039/505 , C07K14/47 , C07K14/4711 , C07K14/4713 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/5023
摘要： The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
摘要翻译： 本发明提供鉴定和编码SECP的人分泌蛋白（SECP）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与SECP异常表达相关的疾病的方法。
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公开(公告)号：US20100099617A1
公开(公告)日：2010-04-22
申请号：US12585371
申请日：2009-09-14
申请人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder K. Chawla , Madhusudan M. Sanjanwala , Michael B. Thornton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
发明人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder K. Chawla , Madhusudan M. Sanjanwala , Michael B. Thornton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
IPC分类号： A61K38/16 , C07K14/00 , A61K38/22 , C07K14/575 , A61P35/00 , A61P29/00 , A61P37/00 , A61P25/00 , A61P9/00 , C12P21/02
CPC分类号： C12N15/1055 , A61K39/3955 , A61K47/64 , A61K47/643 , A61K2039/505 , C07K14/47 , C07K14/4711 , C07K14/4713 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/5023
摘要： The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
摘要翻译： 本发明提供鉴定和编码SECP的人分泌蛋白（SECP）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与SECP异常表达相关的疾病的方法。
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公开(公告)号：US08779106B2
公开(公告)日：2014-07-15
申请号：US13562088
申请日：2012-07-30
申请人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J. A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
发明人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J. A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
CPC分类号： C12N9/16 , C12N9/12 , C12N9/1205 , G01N33/573 , G01N2800/70
摘要： Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.
摘要翻译： 本发明的各种实施方案提供鉴定和编码KPP的人激酶和磷酸酶（KPP）多肽和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与KPP异常表达相关的紊乱的方法。
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公开(公告)号：US08569445B2
公开(公告)日：2013-10-29
申请号：US12585371
申请日：2009-09-14
申请人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan M. Sanjanwala , Michael Thorton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
发明人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder Chawla , Madhusudan M. Sanjanwala , Michael Thorton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
CPC分类号： C12N15/1055 , A61K39/3955 , A61K47/64 , A61K47/643 , A61K2039/505 , C07K14/47 , C07K14/4711 , C07K14/4713 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/5023
摘要： The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
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公开(公告)号：US20120014937A1
公开(公告)日：2012-01-19
申请号：US12923407
申请日：2010-09-20
申请人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J. A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
发明人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J. A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
IPC分类号： A61K38/45 , A61P37/00 , A61P25/00 , A61P35/00 , C12N5/10 , C12Q1/48 , G01N33/573 , C40B40/10 , C12N1/21 , C12N1/19 , A61P9/00 , C12N9/12
CPC分类号： C12N9/16 , C12N9/12 , C12N9/1205 , G01N33/573 , G01N2800/70
摘要： Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.
摘要翻译： 本发明的各种实施方案提供鉴定和编码KPP的人激酶和磷酸酶（KPP）多肽和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与KPP异常表达相关的紊乱的方法。
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公开(公告)号：US07112426B2
公开(公告)日：2006-09-26
申请号：US10288798
申请日：2002-11-01
申请人： Olga Bandman , Danniel B Nguyen , Narinder K Chawla , April J A Hafalia , Monique G Yao , Ameena R Gandhi , Rajagopal Gururajan , Li Ding , Chandra S Arvizu , Henry Yue , Mariah R Baughn , Catherine M Tribouley , Michael B Thornton , Vicki S Elliott , Yan Lu , Craig H Ison , Janice K Au-Young , Y Tom Tang , Yalda Azimzai , John D Burrill , Gregory A Marcus , Kurt A Zingler , Dyung Aina M Lu , Preeti G Lai , Jayalaxmi Ramkumar , Bridget A Warren , Liam Kearney , Jennifer L Policky , Kavitha Thangavelu , Neil Burford
发明人： Olga Bandman , Danniel B Nguyen , Narinder K Chawla , April J A Hafalia , Monique G Yao , Ameena R Gandhi , Rajagopal Gururajan , Li Ding , Chandra S Arvizu , Henry Yue , Mariah R Baughn , Catherine M Tribouley , Michael B Thornton , Vicki S Elliott , Yan Lu , Craig H Ison , Janice K Au-Young , Y Tom Tang , Yalda Azimzai , John D Burrill , Gregory A Marcus , Kurt A Zingler , Dyung Aina M Lu , Preeti G Lai , Jayalaxmi Ramkumar , Bridget A Warren , Liam Kearney , Jennifer L Policky , Kavitha Thangavelu , Neil Burford
CPC分类号： C07K14/4702 , A01K2217/05
摘要： The invention provides human human kinases (PKIN) and polynucleotides which identify and encode PKIN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PKIN.
摘要翻译： 本发明提供人类人类激酶（PKIN）和识别和编码PKIN的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与PKIN的异常表达相关的障碍的方法。
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公开(公告)号：US08263378B2
公开(公告)日：2012-09-11
申请号：US12923407
申请日：2010-09-20
申请人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J. A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
发明人： Vicki S. Elliott , Reena Khare , Thomas W. Richardson , Joseph P. Marquis , Anita Swarnakar , April J. A. Hafalia , Shanya D. Becha , Narinder K. Chawla-Walia , Mariah R. Baughn , Soo Yeun Lee , Uyen K. Tran , Henry Yue , Danniel B. Nguyen , Michael B. Thornton , Rajagopal Gururajan , Ameena R. Gandhi , Yan Lu , Monique G. Yao , Joana X. Li , Wen Luo , Ernestine A. Lee , Ian J. Forsythe , Craig H. Ison , Amy D. Wilson , Pei Jin
IPC分类号： C12N9/12
CPC分类号： C12N9/16 , C12N9/12 , C12N9/1205 , G01N33/573 , G01N2800/70
摘要： Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.
摘要翻译： 本发明的各种实施方案提供鉴定和编码KPP的人激酶和磷酸酶（KPP）多肽和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与KPP异常表达相关的紊乱的方法。
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