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    Sigma-2 receptor agonists and their use in the treatment of HIV infection
    1.
    发明申请
    Sigma-2 receptor agonists and their use in the treatment of HIV infection 审中-公开
    Sigma-2受体激动剂及其在治疗HIV感染中的应用

    公开(公告)号：US20060004036A1

    公开(公告)日：2006-01-05

    申请号：US11181797

    申请日：2005-07-15

    申请人： Wayne Bowen ,  Keith Crawford ,  James Hildreth

    发明人： Wayne Bowen ,  Keith Crawford ,  James Hildreth

    IPC分类号： A61K31/485

    CPC分类号： A61K31/485 ,  A61K31/00 ,  A61K31/435 ,  A61K31/44

    摘要： The present invention relates to sigma-2 receptor agonists and their use in the treatment of immunodeficiency virus infections, especially human immunodeficiency virus (HIV) infections. The invention particularly relates to sigma-2 agonists, especially CB-184 and its analogues, that decrease cellular production of sphingomyelin when provided to recipient cells, and inhibit HIV replication.

    摘要翻译： 本发明涉及σ-2受体激动剂及其在治疗免疫缺陷病毒感染，特别是人类免疫缺陷病毒（HIV）感染）中的用途。 本发明特别涉及当提供给受体细胞时减少鞘磷脂的细胞产生并抑制HIV复制的σ-2激动剂，特别是CB-184及其类似物。

    Process for production of ethylbenzene from dilute ethylene streams
    3.
    发明申请
    Process for production of ethylbenzene from dilute ethylene streams 有权
    从稀乙烯流中生产乙苯的方法

    公开(公告)号：US20070255080A1

    公开(公告)日：2007-11-01

    申请号：US11825422

    申请日：2007-07-06

    申请人： James Hildreth ,  Kerman Dukandar ,  Ronald Venner

    发明人： James Hildreth ,  Kerman Dukandar ,  Ronald Venner

    IPC分类号： C07C2/54

    CPC分类号： C07C15/073 ,  C07C2/64 ,  C10G2400/30

    摘要： An improvement in a process for the production of ethylbenzene from a dilute ethylene stream wherein an ethylene-containing stream derived from a cracking process is directed to an ethylene fractionator for separation of ethylene and ethane. The improvement includes providing the dilute ethylene stream by liquefying and separating out a portion of the ethylene-containing stream prior to directing the remainder of the ethylene-containing stream to the ethylene fractionator and/or by drawing off a side stream from the ethylene fractionator; and, directing the dilute ethylene stream as a feed to an alkylator for alkylation with benzene to produce ethylbenzene.

    摘要翻译： 从稀乙烯流中生产乙苯的方法的改进，其中将衍生自裂化过程的含乙烯的料流引导至用于分离乙烯和乙烷的乙烯分馏器。 该改进包括在将含乙烯流的剩余部分引导到乙烯分馏器之前和/或通过从乙烯分馏器中抽出侧流来液化和分出一部分含乙烯料流来提供稀乙烯料流; 并且将稀乙烯流作为进料引导到烷基化器以用苯烷基化以产生乙苯。

    Compositions and methods for preventing infection
    4.
    发明申请
    Compositions and methods for preventing infection 审中-公开
    防止感染的组合物和方法

    公开(公告)号：US20070173481A1

    公开(公告)日：2007-07-26

    申请号：US11637960

    申请日：2006-12-11

    申请人： George Scheele ,  James Hildreth

    发明人： George Scheele ,  James Hildreth

    IPC分类号： A61K31/724 ,  A01N1/02

    CPC分类号： A61K31/715 ,  Y10S514/841 ,  Y10S514/931 ,  Y10S514/934

    摘要： This invention relates to cholesterol-sequestering agents and methods of using cholesterol-sequestering agents to prevent infection. The compositions of the invention can be used to reduce or prevent maternal to fetal transmission of a microorganism and/or to reduce or eliminate a microorganism present in a blood sample or a blood product.

    摘要翻译： 本发明涉及胆固醇螯合剂和使用胆固醇螯合剂来预防感染的方法。 本发明的组合物可用于减少或预防母体胎儿传播微生物和/或减少或消除存在于血液样品或血液制品中的微生物。

    Beta-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases
    5.
    发明申请
    Beta-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases 失效
    β-环糊精组合物，用于预防性传播疾病的传播

    公开(公告)号：US20070088000A1

    公开(公告)日：2007-04-19

    申请号：US11605037

    申请日：2006-11-27

    申请人： James Hildreth

    发明人： James Hildreth

    IPC分类号： A61K31/724

    CPC分类号： A61K45/06 ,  A61K9/0034 ,  A61K31/724 ,  Y10S514/841 ,  Y10S514/931 ,  Y10S514/934 ,  A61K2300/00

    摘要： Methods of reducing the risk of transmission of a sexually transmitted pathogen by contacting the pathogen or cells susceptible to infection by the pathogen with a β-cyclodextrin are provided. Methods for reducing the risk of transmission of a sexually transmitted pathogen to or from a subject by contacting the pathogen or cells susceptible to the pathogen in the subject with a pharmaceutical composition containing a β-cyclodextrin also are provided. Accordingly, pharmaceutical compositions, which include 1) a β-cyclodextrin, which is in an amount that blocks passage of the pathogen through lipid rafts in the membrane of a cell susceptible to the pathogen, and 2) a contraceptive, an agent for treating a sexually transmitted disease, a lubricant, or a combination thereof, are provided, as are composition formulated from a solid substrate that contains an amount of β-cyclodextrin useful for reducing the risk of transmission of a sexually transmitted pathogen.

    摘要翻译： 提供了通过使病原体或易受病原体感染的细胞与β-环糊精接触来降低性传播病原体传播风险的方法。 还提供了通过使受试者中易感染病原体的病原体与含有β-环糊精的药物组合物接触来降低向受试者传播性传播病原体的风险的方法。 因此，药物组合物包括1）β-环糊精，其量阻止病原体通过脂质筏在对病原体敏感的细胞膜中，以及2）避孕药，用于治疗 提供性传播疾病，润滑剂或其组合，以及由固体底物配制的组合物，其含有一定量的β-环糊精，其可用于降低性传播病原体的传播风险。

    Beta-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases
    6.
    发明申请
    Beta-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases 有权
    β-环糊精组合物，用于预防性传播疾病的传播

    公开(公告)号：US20050215522A1

    公开(公告)日：2005-09-29

    申请号：US11025661

    申请日：2004-12-28

    申请人： James Hildreth

    发明人： James Hildreth

    IPC分类号： A61K9/00 ,  A61K31/724 ,  A61K45/06

    CPC分类号： A61K45/06 ,  A61K9/0034 ,  A61K31/724 ,  Y10S514/841 ,  Y10S514/931 ,  Y10S514/934 ,  A61K2300/00

    摘要： Methods of reducing the risk of transmission of a sexually transmitted pathogen by contacting the pathogen or cells susceptible to infection by the pathogen with a β-cyclodextrin are provided. Methods for reducing the risk of transmission of a sexually transmitted pathogen to or from a subject by contacting the pathogen or cells susceptible to the pathogen in the subject with a pharmaceutical composition containing a β-cyclodextrin also are provided. Accordingly, pharmaceutical compositions, which include 1) a β-cyclodextrin, which is in an amount that blocks passage of the pathogen through lipid rafts in the membrane of a cell susceptible to the pathogen, and 2) a contraceptive, an agent for treating a sexually transmitted disease, a lubricant, or a combination thereof, are provided, as are composition formulated from a solid substrate that contains an amount of β-cyclodextrin useful for reducing the risk of transmission of a sexually transmitted pathogen.

    摘要翻译： 提供了通过使病原体或易受病原体感染的细胞与β-环糊精接触来降低性传播病原体传播风险的方法。 还提供了通过使受试者中易感染病原体的病原体与含有β-环糊精的药物组合物接触来降低向受试者传播性传播病原体的风险的方法。 因此，药物组合物包括1）β-环糊精，其量阻止病原体通过脂质筏在对病原体敏感的细胞膜中，以及2）避孕药，用于治疗 提供性传播疾病，润滑剂或其组合，以及由固体底物配制的组合物，其含有一定量的β-环糊精，其可用于降低性传播病原体的传播风险。

    Process for production of ethylbenzene from dilute ethylene streams
    8.
    发明申请
    Process for production of ethylbenzene from dilute ethylene streams 有权
    从稀乙烯流中生产乙苯的方法

    公开(公告)号：US20050054888A1

    公开(公告)日：2005-03-10

    申请号：US10660065

    申请日：2003-09-08

    申请人： James Hildreth ,  Kerman Dukandar ,  Ronald Venner

    发明人： James Hildreth ,  Kerman Dukandar ,  Ronald Venner

    IPC分类号： C07C2/64 ,  C07C15/073 ,  C10G57/00 ,  C07C4/00

    CPC分类号： C07C15/073 ,  C07C2/64 ,  C10G2400/30

    摘要： An improvement in a process for the production of ethylbenzene from a dilute ethylene stream wherein an ethylene-containing stream derived from a cracking process is directed to an ethylene fractionator for separation of ethylene and ethane. The improvement includes providing the dilute ethylene stream by liquefying and separating out a portion of the ethylene-containing stream prior to directing the remainder of the ethylene-containing stream to the ethylene fractionator and/or by drawing off a side stream from the ethylene fractionator; and, directing the dilute ethylene stream as a feed to an alkylator for alkylation with benzene to produce ethylbenzene.

    摘要翻译： 从稀乙烯流中生产乙苯的方法的改进，其中将衍生自裂化过程的含乙烯的料流引导至用于分离乙烯和乙烷的乙烯分馏器。 该改进包括在将含乙烯流的剩余部分引导到乙烯分馏器之前和/或通过从乙烯分馏器中抽出侧流来液化和分出一部分含乙烯料流来提供稀乙烯料流; 并且将稀乙烯流作为进料引导到烷基化器以用苯烷基化以产生乙苯。