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1.发明授权Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors 失效取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-腈和取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-甲酰胺作为微管蛋白聚合抑制剂公开(公告)号：US08410163B2
公开(公告)日：2013-04-02
申请号：US13263489
申请日：2010-02-09
申请人： Paul P. Beroza , Komath V. Damodaran , Stella Lui , Wenli Ma , Zhuo Wang , Hua Xu
发明人： Paul P. Beroza , Komath V. Damodaran , Stella Lui , Wenli Ma , Zhuo Wang , Hua Xu
IPC分类号： A61K31/381 , C07D409/10 , C07D333/38
CPC分类号： A61K31/381 , C07D333/38 , C07D409/12
摘要： Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.
摘要翻译： 取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-腈和取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-甲酰胺及其盐是微管蛋白聚合抑制剂，可用于 治疗癌症。
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2.发明申请SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBONITRILES AND SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBOXAMIDES AS TUBULIN POLYMERIZATION INHIBITORS 失效取代的4-氨基-5-苯甲酰基-2-（苯甲酰基）硫代-3-碳
青霉素和取代的4-氨基-5-苯甲酰基-2-（苯甲酰基）噻吩-3-羰基氧化物作为管蛋白聚合抑制剂公开(公告)号：US20120101286A1
公开(公告)日：2012-04-26
申请号：US13263489
申请日：2010-02-09
申请人： Paul P. Beroza , Komath V. Damodaran , Stella Lui , Wenli Ma , Zhuo Wang , Hua Xu
发明人： Paul P. Beroza , Komath V. Damodaran , Stella Lui , Wenli Ma , Zhuo Wang , Hua Xu
IPC分类号： C07D409/10 , C07D333/38
CPC分类号： A61K31/381 , C07D333/38 , C07D409/12
摘要： Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.
摘要翻译： 取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-腈和取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-甲酰胺及其盐是微管蛋白聚合抑制剂，可用于 治疗癌症。
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公开(公告)号：US08093231B2
公开(公告)日：2012-01-10
申请号：US11779234
申请日：2007-07-17
申请人： David R. Allen , Wenli Ma , Brian T. Peterson , Louise Robinson , Steven R. Schow , Songyuan Shi , Reyna J. Simon , Kevin T. Weber , Michael M. Wick
发明人： David R. Allen , Wenli Ma , Brian T. Peterson , Louise Robinson , Steven R. Schow , Songyuan Shi , Reyna J. Simon , Kevin T. Weber , Michael M. Wick
CPC分类号： C07F9/2458 , C07F9/2408 , C07F9/572 , C07F9/58 , C07F9/59 , C07F9/650952 , C07F9/6533 , C07F9/65515 , C07F9/655345 , C07F9/65616
摘要： Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
摘要翻译： 磺基乙基和硫代乙基磷酰二胺，它们的制备和中间体在制备中，含有它们的制剂及其药物用途。 该化合物可用于单独治疗和与其它抗癌疗法组合治疗癌症。
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公开(公告)号：US20080125398A1
公开(公告)日：2008-05-29
申请号：US11564744
申请日：2006-11-29
申请人： Wenli Ma , Kevin T. Weber , Robert M. Yee
发明人： Wenli Ma , Kevin T. Weber , Robert M. Yee
CPC分类号： C07F9/2408 , C07F9/572 , C07F9/59
摘要： 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N,N′,N′-tetrakis(2-chloroethyl)-phosphorodiamidates, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
摘要翻译： 2 - {[2-（取代氨基）乙基]磺酰基}乙基N，N，N'，N'-四（2-氯乙基） - 磷酰二胺，其制备方法及其制备中间体，含有它们的药物组合物， 治疗使用它们。 该化合物可用于单独治疗和与其它抗癌疗法组合治疗癌症。
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![2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates](/abs-image/US/2010/02/02/US07655799B2/abs.jpg.150x150.jpg)
5.发明授权2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates 失效2 {[2-（取代氨基）乙基]磺酰基}乙基N，N，N'，N'-四（2-氯乙基）磷酰胺公开(公告)号：US07655799B2
公开(公告)日：2010-02-02
申请号：US11564744
申请日：2006-11-29
申请人： Wenli Ma , Kevin T. Weber , Robert M. Yee
发明人： Wenli Ma , Kevin T. Weber , Robert M. Yee
IPC分类号： A61K31/435 , C07F9/572 , C07F9/576
CPC分类号： C07F9/2408 , C07F9/572 , C07F9/59
摘要： 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N,N′,N′-tetrakis(2-chloroethyl)-phosphorodiamidates, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
摘要翻译： 2 - {[2-（取代氨基）乙基]磺酰基}乙基N，N，N'，N'-四（2-氯乙基） - 磷酰二胺，其制备方法及其制备中间体，含有它们的药物组合物， 治疗使用它们。 该化合物可用于单独治疗和与其它抗癌疗法组合治疗癌症。
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![2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates](/abs-image/US/2011/01/18/US07872134B2/abs.jpg.150x150.jpg)
6.发明授权2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates 失效2 - {[2-（取代氨基）乙基]磺酰基}乙基N，N-双（2-氯乙基）磷酰胺公开(公告)号：US07872134B2
公开(公告)日：2011-01-18
申请号：US11955177
申请日：2007-12-12
申请人： Edgardo Laborde , Andrew B. Kelson , Wenli Ma , Kevin T. Weber
发明人： Edgardo Laborde , Andrew B. Kelson , Wenli Ma , Kevin T. Weber
IPC分类号： C07F9/572 , C07F9/576 , C07F9/24 , A61K31/664 , A61K31/675
CPC分类号： C07F9/2458 , C07F9/2408
摘要： 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer and autoimmune diseases, alone and in combination with other therapies.
摘要翻译： 2 - {[2-（取代氨基）乙基]磺酰基}乙基N，N-双（2-氯乙基）磷酰胺及其盐，其制备方法和中间体，含有它们的药物组合物，以及使用它们的处理方法。 该化合物可用于单独治疗癌症和自身免疫性疾病，并与其他疗法结合使用。
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公开(公告)号：US20090156559A1
公开(公告)日：2009-06-18
申请号：US11955177
申请日：2007-12-12
申请人： Edgardo Laborde , Andrew B. Kelson , Wenli Ma , Kevin T. Weber
发明人： Edgardo Laborde , Andrew B. Kelson , Wenli Ma , Kevin T. Weber
IPC分类号： A61K31/675 , C07F9/24 , A61K31/664 , A61P37/02 , A61P35/00
CPC分类号： C07F9/2458 , C07F9/2408
摘要： 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer and autoimmune diseases, alone and in combination with other therapies.
摘要翻译： 2 - {[2-（取代氨基）乙基]磺酰基}乙基N，N-双（2-氯乙基）磷酰胺及其盐，其制备方法和中间体，含有它们的药物组合物，以及使用它们的处理方法。 该化合物可用于单独治疗癌症和自身免疫性疾病，并与其他疗法结合使用。
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公开(公告)号：US20080039429A1
公开(公告)日：2008-02-14
申请号：US11779234
申请日：2007-07-17
申请人： David Allen , Wenli Ma , Brian Peterson , Louise Robinson , Steven Schow , Songyuan Shi , Reyna Simon , Kevin Weber , Michael Wick
发明人： David Allen , Wenli Ma , Brian Peterson , Louise Robinson , Steven Schow , Songyuan Shi , Reyna Simon , Kevin Weber , Michael Wick
CPC分类号： C07F9/2458 , C07F9/2408 , C07F9/572 , C07F9/58 , C07F9/59 , C07F9/650952 , C07F9/6533 , C07F9/65515 , C07F9/655345 , C07F9/65616
摘要： Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
摘要翻译： 磺基乙基和硫代乙基磷酰二胺，它们的制备和中间体在制备中，含有它们的制剂及其药物用途。 该化合物可用于单独治疗和与其它抗癌疗法组合治疗癌症。
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公开(公告)号：US20050267075A1
公开(公告)日：2005-12-01
申请号：US11134218
申请日：2005-05-20
申请人： David Allen , Wenli Ma , Brian Peterson , Louise Robinson , Steven Schow , Songyuan Shi , Reyna Simon , Kevin Weber , Michael Wick
发明人： David Allen , Wenli Ma , Brian Peterson , Louise Robinson , Steven Schow , Songyuan Shi , Reyna Simon , Kevin Weber , Michael Wick
IPC分类号： A61K31/66 , C07F9/00 , C07F9/02 , C07F9/24 , C07F9/572 , C07F9/58 , C07F9/59 , C07F9/6509 , C07F9/6533 , C07F9/655 , C07F9/6553 , C07F9/6561
CPC分类号： C07F9/2458 , C07F9/2408 , C07F9/572 , C07F9/58 , C07F9/59 , C07F9/650952 , C07F9/6533 , C07F9/65515 , C07F9/655345 , C07F9/65616
摘要： Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
摘要翻译： 磺基乙基和硫代乙基磷酰二胺，它们的制备和中间体在制备中，含有它们的制剂及其药物用途。 该化合物可用于单独治疗和与其它抗癌疗法组合治疗癌症。
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10.发明授权公开(公告)号：US06962926B2
公开(公告)日：2005-11-08
申请号：US10637746
申请日：2003-08-08
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Wenli Ma , Yukiharu Matsumoto , Kunihisa Baba , Hideaki Inagaki , Katsumasa Tanaka , Yoshiro Ishiwata , Shoji Yokochi , Masayuki Okamoto , Takashi Nakamura , Atsushi Miyachi , Mitsuaki Takeuchi , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Wenli Ma , Yukiharu Matsumoto , Kunihisa Baba , Hideaki Inagaki , Katsumasa Tanaka , Yoshiro Ishiwata , Shoji Yokochi , Masayuki Okamoto , Takashi Nakamura , Atsushi Miyachi , Mitsuaki Takeuchi , Kouji Matsushima
IPC分类号： A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , A61P29/00 , C07D471/04 , C07D498/04 , C07D519/00 , C61K31/5377
CPC分类号： A61K31/437 , A61K9/0019 , A61K9/2054 , A61K9/4866 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D231/56 , C07D471/04 , A61K2300/00
摘要： Compounds of formula A and formula B: and their pharmaceutically acceptable salts, compositions comprising them, methods for their use, and their use in the preparation of medicaments. The compounds are antagonists of MCP-1 function, and are useful in the prevention and treatment of chronic or acute inflammatory or autoimmune diseases, such as multiple sclerosis, and in the prevention and treatment of allergic hypersensitivity disorders.
摘要翻译： 式A和式B化合物及其药学上可接受的盐，包含它们的组合物，其使用方法及其在制备药物中的用途。 该化合物是MCP-1功能的拮抗剂，可用于预防和治疗慢性或急性炎性或自身免疫性疾病如多发性硬化，以及预防和治疗过敏性超敏反应性疾病。
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