摘要:
Improved duplicate and near-duplicate detection techniques may assign a number of fingerprints to a given document by (i) extracting parts from the document, (ii) assigning the extracted parts to one or more of a predetermined number of lists, and (iii) generating a fingerprint from each of the populated lists. Two documents may be considered to be near-duplicates if any one of their fingerprints match.
摘要:
Power utilized in a local power network may be managed. The local power network may include a power management system. The power management system may communicate with one or more of a circuit controller, a switch controller, and/or an outlet controller in order to manage power utilization.
摘要:
A magnetic filter device and method for using same, for removing ferromagnetic particles from a liquid, which device comprises a vessel having an inlet for liquid to flow into the vessel and an outlet for the liquid to flow out of the vessel, and the vessel having one or more magnets suspended therein for removing ferromagnetic particles from liquid flowing between the inlet and outlet, characterised in that: the vessel is a horizontal pipe with the inlet at one end and the outlet at the other end, the magnets are suspended transverse to the longitudinal axis of the pipe in one or more sets, and the vessel has one or more helical flow generators which in use, generate helical flow of the liquid as it flows between the inlet and outlet, and/or one or more turbulent flow generators which in use, generate turbulent flow of the liquid as it flows between the inlet and outlet. The helical and/or turbulent flow of the liquid may mitigate the potential problems of liquid and/or particles by-passing the magnet or magnets, for example arising from laminar flow of the liquid and/or uneven distribution of particles in the liquid.
摘要:
A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
摘要翻译:描述了一类新型的羟化酶,其具有SEQ ID NO:2,4,6和8的氨基酸序列,其变体和片段具有HIF羟基化活性。 本发明的多肽特别是脯氨酰羟化酶活性。 测定方法监测HIF羟化酶与底物的相互作用。 提供HIF羟化酶的调节剂用于治疗与增加或降低的HIF水平或活性有关的病症,或用于治疗期望调节HIF水平或活性的病症。
摘要:
A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. Preferably the substrate is a HIF polypeptide comprising HIF-1α, a fragment thereof comprising Asn 803 of HIF-1α or a peptide analogue of HIF-1α or fragment thereof comprising an asparagine equivalent to Asn 803 of HIF-1α and wherein hydroxylation of Asn 803 or of a said equivalent asparagine is determined.
摘要:
Improved duplicate and near-duplicate detection techniques may assign a number of fingerprints to a given document by (i) extracting parts from the document, (ii) assigning the extracted parts to one or more of a predetermined number of lists, and (iii) generating a fingerprint from each of the populated lists. Two documents may be considered to be near-duplicates if any one of their fingerprints match.
摘要:
Improved methods of software diagnostics are provided. Searches of data sources are conducted using search terms from internal computer information to obtain searched data. The searched data is processed by extracting technical features. The technical features are indexed to create indexes that can be searched via machine state. Filtering is conducted over the gathered data to create feeds that are available to customers.
摘要:
The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor &agr; subunits, by targeting HIF &agr; for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF &agr; subunit sequence which may modulate this interaction.
摘要:
A liquid crystal display structure includes a liquid crystal display cell having a front surface and a back surface. One or more intrinsic polarizers lacking protective coatings thereon, such as K-type polarizers and thin KE polarizer sheets, are disposed adjacent to the front and back surfaces of the liquid crystal display cell. Alternatively, thinly cladded or encased iodine polarizers are disposed adjacent to the front and back surfaces of the liquid crystal display cell. The liquid crystal display structure may be used in conjunction with other optical display elements to enhance the brightness and contrast of the liquid crystal display.
摘要:
A grinding rod chemistry enhances wearability and durability of a steel rod and comprises levels of carbon to achieve a surface hardness in excess of 55 Rockwell C and levels of chromium which achieve significant depth in the formed outer martensite shell. The grinding rod has a core greater than 99% pearlite with a hardness less than 45 Rockwell C and the end portions of the rod are soft and have a hardness less than 35 Rockwell C. The steel bar of the selected chemistry is treated by reheating to above its austenitising temperature, transferring with minimal cooling to an open tubular quench vessel while securing the bar in the vessel to minimize bar warping, introducing quench water into the inlet end of the vessel and passing the liquid through the vessel to ensure uniform heat removal. The outer martensite shell is tempered by allowing the bar to soak back after quenching. The bar end portions are reheated in a furnace to elevate the end portions above the austenitising temperature and air cooling each end portion to provide the engineered end portion hardness of less than 35 Rockwell C.