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    METHOD FOR DERACEMIZATION OF ENANTIOMER MIXTURES
    9.
    发明申请
    METHOD FOR DERACEMIZATION OF ENANTIOMER MIXTURES 审中-公开
    促进剂混合物的制备方法

    公开(公告)号：US20110070630A1

    公开(公告)日：2011-03-24

    申请号：US12866612

    申请日：2009-03-26

    申请人： Christian Gruber ,  Wolfgang Kroutil ,  Constance Voss ,  Jan Pfeffer ,  Uwe Dingerdissen

    发明人： Christian Gruber ,  Wolfgang Kroutil ,  Constance Voss ,  Jan Pfeffer ,  Uwe Dingerdissen

    IPC分类号： C12P41/00

    CPC分类号： C12P41/002 ,  C12N9/0006 ,  C12P7/02

    摘要： The invention relates to a process for enzymatic deracemization of enantiomer mixtures of secondary alcohols by a combination of oxidation and reduction reactions by means of stereoselective alcohol dehydrogenases and the cofactors thereof, wherein one enantiomer of an optically active secondary alcohol is in a formal sense selectively oxidized to the corresponding ketone, which is subsequently reduced selectively to the optical antipode, while the reduced form of the cofactor is provided for the reduction reaction by means of an additional enzyme, characterized in that two alcohol dehydrogenases with opposite stereoselectivity and different cofactor selectivity and the two corresponding, different cofactors are used for the oxidation and reduction reactions, and the oxidized and reduced cofactors are interconverted in a parallel enzymatic reaction with the additional enzyme, the direction of the deracemization toward one of the two enantiomers being controllable by the selection of the two alcohol dehydrogenases or using the selectivity difference of the additional enzyme for the two cofactors.

    摘要翻译： 本发明涉及通过立体选择性醇脱氢酶及其辅因子通过氧化和还原反应的组合将仲醇的对映异构体混合物酶促脱水化的方法，其中光学活性仲醇的一种对映异构体具有形式上的选择性氧化 相应的酮，其随后被选择性地还原成光学对映体，而还原形式的辅因子被提供用于通过另外的酶的还原反应，其特征在于具有相反立体选择性和不同辅因子选择性的两种醇脱氢酶和 两个相应的不同的辅因子被用于氧化和还原反应，并且氧化的和还原的辅因子与另外的酶在平行的酶反应中相互转化，通过选择th可以控制两个对映异构体之一的旋转方向 使用两种醇脱氢酶或使用另外的酶对两种辅因子的选择性差异。

    PROCESS FOR THE OXIDATIVE CLEAVAGE OF VINYLAROMATICS USING PEROXIDASES OR LACCASES
    10.
    发明申请
    PROCESS FOR THE OXIDATIVE CLEAVAGE OF VINYLAROMATICS USING PEROXIDASES OR LACCASES 审中-公开
    使用过氧化物或薄荷脂的乙烯基氧化物的氧化过程

    公开(公告)号：US20100184174A1

    公开(公告)日：2010-07-22

    申请号：US12668640

    申请日：2008-07-09

    申请人： Wolfgang Kroutil ,  Miguel Lara

    发明人： Wolfgang Kroutil ,  Miguel Lara

    IPC分类号： C12P7/24 ,  C12P7/26

    CPC分类号： C12P7/24

    摘要： The invention relates to a method for the oxidative cleavage of vinyl aromatics of the formula (1) characterized in that (a) compound(s) of the formula (1) is/are oxidized to aldehydes and ketones of the formulas (2) and (3), respectively, in the presence of molecular oxygen using at least one enzyme selected from peroxidases and laccases as a catalyst, according to the following general reaction scheme: wherein n is an integer of 0 to 5; the R1 are selected from saturated or unsaturated hydrocarbon groups with 1 to 10 carbon atoms, wherein carbon atoms are optionally substituted by heteroatoms and are optionally further substituted, amino, C1-6 alkylamino and C1-6 dialkylamino groups, halogens, hydroxy and cyano, wherein two of the substituents R1 may be linked to form a ring; R2 and R3 are each independently hydrogen or one of the options for R1, wherein R2 and/or R3 may be linked with R1 to form a ring, in which case R2 and R3 may each represent a chemical bond.

    摘要翻译： 本发明涉及一种式（1）的乙烯基芳族化合物的氧化裂解方法，其特征在于（a）式（1）化合物被氧化成式（2）和（II）的醛和酮 （3），分别使用选自过氧化物酶和漆酶的至少一种酶作为催化剂，在分子氧存在下，根据以下一般反应方案：其中n为0至5的整数; R1选自具有1至10个碳原子的饱和或不饱和烃基，其中碳原子任选被杂原子取代，并且任选地被进一步取代，氨基，C 1-6烷基氨基和C 1-6二烷基氨基，卤素，羟基和氰基， 其中两个取代基R 1可以连接形成环; R 2和R 3各自独立地为氢或R 1的选择之一，其中R 2和/或R 3可以与R 1连接形成环，在这种情况下，R 2和R 3可各自表示化学键。