CRYSTALLINE FORM OF A PYRIDYL-PIPERAZINYL HEPATITIS C VIRUS INHIBITOR
    1.
    发明申请
    CRYSTALLINE FORM OF A PYRIDYL-PIPERAZINYL HEPATITIS C VIRUS INHIBITOR 有权
    吡啶并吡啶类抗生素C病毒抑制剂的结晶形式

    公开(公告)号:US20130295048A1

    公开(公告)日:2013-11-07

    申请号:US13870244

    申请日:2013-04-25

    摘要: The invention provides crystalline solid forms of (((S)-1-{(S)-2-[4-(4′-{[6-((2R,5S)-2,5-dimethyl-4-methylcarbamoyl-piperazin-1-yl)-pyridine-3-carbonyl]-amino}-2′-trifluoromethoxy-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester. The invention also provides pharmaceutical compositions comprising such crystalline solid forms, methods of using such crystalline solid forms to treat hepatitis C virus infection, and processes useful for preparing such crystalline solid forms.

    摘要翻译: 本发明提供((S)-1 - {(S)-2- [4-(4' - {[6 - ((2R,5S)-2,5-二甲基-4-甲基氨基甲酰基 - 哌嗪-1-基) - 吡啶-3-羰基] - 氨基} -2'-三氟甲氧基 - 联苯-4-基)-1H-咪唑-2-基] - 吡咯烷-1-羰基} -2-甲基 - 丙基 本发明还提供包含这种结晶固体形式的药物组合物,使用这种结晶固体形式治疗丙型肝炎病毒感染的方法,以及可用于制备这种结晶固体形式的方法。

    Determination of dipole shear anisotropy of earth formations
    3.
    发明授权
    Determination of dipole shear anisotropy of earth formations 有权
    测定地球地层的偶极剪切各向异性

    公开(公告)号:US06718266B1

    公开(公告)日:2004-04-06

    申请号:US10284612

    申请日:2002-10-31

    IPC分类号: G01V128

    CPC分类号: G01V1/48

    摘要: A method for determining formation shear slowness of formations surrounding an earth borehole that includes: transmitting sonic energy into the formations from a dipole source in the borehole; measuring signals from orthogonal wave components that have traveled through the formations at each of a plurality of receiver locations in the borehole, spaced at a respective plurality of distances from the transmitter location; transforming the signals to the frequency domain and separating dispersive and non-dispersive portions of the transformed signals; and determining fast and slow shear slowness of the formation from the low frequency asymptotes of the dispersive portions of the transformed signals. Related methods for determining shear directionality and the magnitude of anisotropy of anisotropic formations surrounding an earth borehole and associated apparatus are also described.

    摘要翻译: 确定地球钻孔周围地层形成剪切慢度的方法,其包括:将声能从井眼中的偶极源传播到地层中; 测量来自在穿过钻孔中的多个接收器位置中的每一个处的地层的正交波分量的信号,其间隔距离发射机位置相应的多个距离; 将信号变换到频域并分离变换信号的色散和非色散部分; 以及从变换信号的色散部分的低频渐近线确定地层的快速和慢剪切慢度。 还描述了用于确定剪切方向性和围绕地球钻孔及相关联装置的各向异性形状的各向异性的大小的相关方法。

    Crystalline form of a pyridyl-piperazinyl hepatitis C virus inhibitor
    4.
    发明授权
    Crystalline form of a pyridyl-piperazinyl hepatitis C virus inhibitor 有权
    吡啶基 - 哌嗪基丙型肝炎病毒抑制剂的结晶形式

    公开(公告)号:US08883135B2

    公开(公告)日:2014-11-11

    申请号:US13870244

    申请日:2013-04-25

    摘要: The invention provides crystalline solid forms of (((S)-1-{(S)-2-[4-(4′-{[6-((2R,5S)-2,5-dimethyl-4-methylcarbamoyl-piperazin-1-yl)-pyridine-3-carbonyl]-amino}-2′-trifluoromethoxy-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester. The invention also provides pharmaceutical compositions comprising such crystalline solid forms, methods of using such crystalline solid forms to treat hepatitis C virus infection, and processes useful for preparing such crystalline solid forms.

    摘要翻译: 本发明提供((S)-1 - {(S)-2- [4-(4' - {[6 - ((2R,5S)-2,5-二甲基-4-甲基氨基甲酰基 - 哌嗪-1-基) - 吡啶-3-羰基] - 氨基} -2'-三氟甲氧基 - 联苯-4-基)-1H-咪唑-2-基] - 吡咯烷-1-羰基} -2-甲基 - 丙基 本发明还提供包含这种结晶固体形式的药物组合物,使用这种结晶固体形式治疗丙型肝炎病毒感染的方法,以及可用于制备这种结晶固体形式的方法。

    Digital Content Counting System and Method
    6.
    发明申请
    Digital Content Counting System and Method 审中-公开
    数字内容计数系统及方法

    公开(公告)号:US20100218239A1

    公开(公告)日:2010-08-26

    申请号:US12681976

    申请日:2008-05-16

    CPC分类号: G06Q30/02 G06Q50/184

    摘要: A digital content counting system and a method thereof are provided for achieving the credible transaction counting mechanism established between the owner of copyrights and the seller, to make the owner of copyrights and the seller collectively confirm the transaction information of the digital contents. The system comprises a sale subsystem, an authorization service subsystem and a transaction clearing subsystem; the sale subsystem and the authorization service subsystem authenticate each other; the transaction clearing subsystem and the authorization service subsystem authenticate each other; the transaction clearing subsystem authenticates the sale subsystem; the sale subsystem generates transaction request information according to a purchase list, sends the transaction request information to the authenticated authorization service subsystem, and records transaction success information; after receiving and confirming the transaction request information, the authorization service subsystem sends transaction success information to a client device, the sale subsystem and authenticated transaction clearing subsystem, sends an approach for obtaining an authorization file to the client device, records the transaction request information, and issues the authorization file; the transaction clearing subsystem records the transaction success information.

    摘要翻译: 提供数字内容计数系统及其方法,用于实现在版权所有者和卖方之间建立的可信交易计数机制,使版权所有者和卖方共同确认数字内容的交易信息。 该系统包括销售子系统,授权服务子系统和交易清算子系统; 销售子系统和授权服务子系统进行认证; 交易清算子系统和授权服务子系统进行认证; 交易清算子系统认证销售子系统; 销售子系统根据购买清单生成交易请求信息,将交易请求信息发送给认证授权服务子系统,记录交易成功信息; 授权服务子系统收到并确认交易请求信息后,向客户端设备,销售子系统和认证交易清算子系统发送交易成功信息,向客户端发送获取授权文件的方法,记录交易请求信息, 并发出授权文件; 交易清算子系统记录交易成功信息。

    Method and Apparatus for Estimating Formation Slowness
    7.
    发明申请
    Method and Apparatus for Estimating Formation Slowness 有权
    估算地层缓慢的方法和装置

    公开(公告)号:US20080027650A1

    公开(公告)日:2008-01-31

    申请号:US11791810

    申请日:2005-12-22

    IPC分类号: G01V1/40 G01V3/38

    CPC分类号: G01V1/50 G01V1/48

    摘要: A method and apparatus for estimating the slowness of a geological formation using waveforms recorded by an acoustic borehole logging tool. Phase slowness coherence is extracted from the recorded waveforms after transformation to the frequency domain (804) at various frequencies (806), and this is converted into a formation slowness curve (808) which can be used as an objective function from which an anomaly, such as a local maximum or minimum (810), can be identified as representative of an estimate of the formation slowness.

    摘要翻译: 一种用声波测井仪记录的波形估算地质构造慢度的方法和装置。 在以各种频率(806)转换到频域(804)之后的记录波形中提取相位慢度相干性,并且将其转换为可用作目标函数的地层慢度曲线(808) 例如局部最大或最小(810)可以被识别为代表地层缓慢的估计。

    METHOD AND SYSTEM FOR DISPLAYING ACTIVITIES OF FRIENDS AND COMPUTER STORAGE MEDIUM THEREFOR
    9.
    发明申请
    METHOD AND SYSTEM FOR DISPLAYING ACTIVITIES OF FRIENDS AND COMPUTER STORAGE MEDIUM THEREFOR 审中-公开
    用于显示朋友活动的方法和系统及其计算机存储介质

    公开(公告)号:US20130132393A1

    公开(公告)日:2013-05-23

    申请号:US13744077

    申请日:2013-01-17

    IPC分类号: G06F17/30

    CPC分类号: G06F16/285 G06F16/9535

    摘要: Method and system for displaying activities of friends. The method includes, generating activity information from the activities of friends according to the friend relationship chain; classifying the activity information according to the preset classification rule to obtain the corresponding classification collection; acquiring the screening condition, extracting activity information that meets the screening condition from the classification collection, and displaying the activity information extracted. According to the method and system, through the classification and screening of activity information, the activities of friends which meet screening conditions entered by a user can be obtained and displayed. Using this method and the system, a large amount of information can be quickly screened and all the friends' effective activities can be provided to the user allowing user to achieve personalized browsing.

    摘要翻译: 展示朋友活动的方法和系统。 该方法包括根据朋友关系链从朋友的活动中产生活动信息; 根据预设分类规则对活动信息进行分类,得到相应的分类收集; 获取筛选条件,从分类收集中提取满足筛选条件的活动信息,并显示所提取的活动信息。 根据方法和系统,通过活动信息的分类和筛选,可以获得并显示满足用户输入的筛选条件的朋友的活动。 使用这种方法和系统,可以快速筛选大量信息,并且可以向用户提供所有朋友的有效活动,从而允许用户实现个性化浏览。

    Three dimensional high aspect ratio micromachining

    公开(公告)号:US20060157807A1

    公开(公告)日:2006-07-20

    申请号:US11375860

    申请日:2006-03-15

    IPC分类号: H01L29/84

    摘要: Multi-level structures are formed in a semiconductor substrate by first forming a pattern of lines or structures of different widths. Width information on the pattern is decoded by processing steps into level information to form a MEMS structure. The pattern is etched to form structures having a first floor. The structures are oxidized until structures of thinner width are substantially fully oxidized. A portion of the oxide is then etched to expose the first floor. The first floor is then etched to form a second floor. The oxide is then optionally removed, leaving a multi-level structure. In one embodiment, high aspect ratio comb actuators are formed using the multi-level structure process.