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1.发明授权公开(公告)号：US08938292B2
公开(公告)日：2015-01-20
申请号：US12263065
申请日：2008-10-31
CPC分类号： A61N1/36521 , A61B5/021 , A61B5/0215 , A61B5/02158 , A61B5/053 , A61B5/0535 , A61B5/0538 , A61B5/7239 , A61N1/36564
摘要： Techniques for estimating a cardiac chamber or vascular pressure based upon impedance are described. A device or system may measure an impedance between at least two electrodes implanted within or proximate to a cardiovascular system. The device or system may estimate a pressure of an element of the cardiovascular system based on a relationship between impedance and volume of the element, and based on a empirical relationship between the volume and the pressure. The device or system may also estimate the dimension of the element based on the impedance-volume relationship, or other characteristics based on the impedance. Because the impedance measurements may be obtained, in some examples, by using electrodes and leads implanted within the cardiovascular system and coupled to an implantable medical device, a practical estimation of a cardiovascular pressure can be obtained on a chronic basis without requiring the use other invasive sensors, such as micronanometer transducers.
摘要翻译： 描述了基于阻抗估计心室或血管压力的技术。 装置或系统可以测量植入在心血管系统内或其附近的至少两个电极之间的阻抗。 装置或系统可以基于元件的阻抗和体积之间的关系，并且基于体积和压力之间的经验关系来估计心血管系统的元件的压力。 装置或系统还可以基于阻抗 - 体积关系或基于阻抗的其它特性来估计元件的尺寸。 由于可以获得阻抗测量值，在一些示例中，通过使用植入心血管系统内并连接到可植入医疗装置的电极和引线，可以长期获得心血管压力的实际估计，而不需要使用其它侵入性 传感器，如微量计传感器。
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2.发明申请公开(公告)号：US20120029365A1
公开(公告)日：2012-02-02
申请号：US13093166
申请日：2011-04-25
CPC分类号： A61N1/36564 , A61B5/0031 , A61B5/0215 , A61B5/024 , A61B5/0422 , A61B5/6847 , A61B5/686 , A61B5/6869 , A61B5/6876 , A61B5/7239 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/125 , A61N1/37247 , A61N1/3962 , A61N1/3987
摘要： Various techniques for measuring cardiac cycle length and pressure metrics based on pulmonary artery pressures are described. One example method described includes identifying a point within a derivative signal of a cardiovascular pressure signal without reference to electrical activity of a heart, initiating a time window from the identified point in the derivative signal, identifying a point within the cardiovascular signal within the time window, and determining at least one of a systolic pressure or diastolic pressure based on the identified point.
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3.发明申请公开(公告)号：US20120029364A1
公开(公告)日：2012-02-02
申请号：US13093146
申请日：2011-04-25
CPC分类号： A61N1/36564 , A61B5/0031 , A61B5/0215 , A61B5/024 , A61B5/0422 , A61B5/6847 , A61B5/686 , A61B5/6869 , A61B5/6876 , A61B5/7239 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/125 , A61N1/37247 , A61N1/3962 , A61N1/3987
摘要： Various techniques for measuring cardiac cycle length and pressure metrics based on pulmonary artery pressures are described. One example method described includes identifying a point within a derivative signal of a cardiovascular pressure signal without reference to electrical activity of a heart, initiating a time window from the identified point in the derivative signal, identifying a point within the cardiovascular signal within the time window, and determining at least one of a systolic pressure or diastolic pressure based on the identified point.
摘要翻译： 描述了基于肺动脉压力测量心脏周期长度和压力指标的各种技术。 所描述的一个示例性方法包括识别心血管压力信号的导数信号内的点，而不参考心脏的电活动，从导数信号中的识别点开始时间窗口，识别时间窗内的心血管信号内的点 并且基于所识别的点来确定收缩压或舒张压中的至少一个。
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公开(公告)号：US08062227B2
公开(公告)日：2011-11-22
申请号：US12261389
申请日：2008-10-30
IPC分类号： A61B5/0215
CPC分类号： A61B5/0452 , A61B5/0215 , A61B5/053 , A61B5/0538 , A61N1/3627 , A61N1/36521 , A61N1/36564
摘要： Heart failure decompensation is detected by sensing at least one physiological signal. Values of at least two different heart failure variables are derived using one or more physiological signals and a threshold for the first heart failure variable is adjusted in response to the value of the second heart failure variable. The value of the first heart failure variable is compared to first threshold for detecting a heart failure condition.
摘要翻译： 通过感测至少一个生理信号来检测心力衰竭失代偿。 使用一个或多个生理信号导出至少两个不同的心力衰竭变量的值，并且响应于第二心力衰竭变量的值调整第一心力衰竭变量的阈值。 将第一心力衰竭变量的值与用于检测心力衰竭状况的第一阈值进行比较。
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公开(公告)号：US20110251496A1
公开(公告)日：2011-10-13
申请号：US13164145
申请日：2011-06-20
IPC分类号： A61B5/0205
CPC分类号： A61B5/0215 , A61M5/14276 , A61M2205/3523 , A61N1/36521 , A61N1/36564 , A61N1/37258
摘要： Detection of volume depletion, particularly after an incidence of volume overload is disclosed. Various methods, systems, and devices are disclosed that sense and analyze a physiological parameter related to a patient's fluid level in order to warn patients of potentially dangerous volume depletion conditions while minimizing false notifications.
摘要翻译： 体积消耗的检测，特别是容量过载发生之后。 公开了各种方法，系统和装置，其感测和分析与患者的液体水平相关的生理参数，以便在最小化假通知的同时警告患者潜在危险的体积消耗条件。
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公开(公告)号：US20110201952A1
公开(公告)日：2011-08-18
申请号：US13026913
申请日：2011-02-14
申请人： YONG K. CHO , TERESA A. WHITMAN , MARK L. BROWN , SCOTT W. DAVIE , KAREN J. KLECKNER , CHARLES R. GORDON
发明人： YONG K. CHO , TERESA A. WHITMAN , MARK L. BROWN , SCOTT W. DAVIE , KAREN J. KLECKNER , CHARLES R. GORDON
CPC分类号： A61B5/0402 , A61B5/6846 , A61B5/7203 , A61N1/36585 , A61N1/3962
摘要： A method and apparatus for sensing improvement using pressure data. The method and apparatus may be used in an implantable medical device to confirm that an EGM event signifies a true mechanical cardiac activity and not just electrical oversensing. The mechanical activity may be used to create a mechanical marker channel in the implantable medical device.
摘要翻译： 一种使用压力数据感测改进的方法和装置。 该方法和装置可以用于可植入医疗装置中，以确认EGM事件表示真正的机械心脏活动，而不仅仅是电过盈。 机械活动可用于在可植入医疗装置中产生机械标记通道。
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公开(公告)号：US20110077616A1
公开(公告)日：2011-03-31
申请号：US12571091
申请日：2009-09-30
申请人： Tommy D. Bennett , Yong K. Cho
发明人： Tommy D. Bennett , Yong K. Cho
CPC分类号： A61B5/0215 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/125 , A61N1/36521 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/37282
摘要： An implantable medical device system and associated method for use in guiding an acute decompensated heart failure therapy set an optimal fluid status measurement level. A physiological sensor signal sensed by an implantable medical device is used to compute the fluid status measurement. A target rate of change of the fluid status measurement is computed for guiding the therapy.
摘要翻译： 用于引导急性失代偿性心力衰竭治疗的可植入医疗装置系统和相关方法设定最佳流体状态测量水平。 由可植入医疗装置感测到的生理传感器信号用于计算流体状态测量。 计算流体状态测量的目标变化率用于指导治疗。
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8.发明申请公开(公告)号：US20100076324A1
公开(公告)日：2010-03-25
申请号：US12262307
申请日：2008-10-31
申请人： Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Maneesh Shrivastav , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling , Robert A. Corey
发明人： Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Maneesh Shrivastav , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling , Robert A. Corey
IPC分类号： A61B5/0205 , A61B5/08
CPC分类号： A61B5/6846 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0816 , A61B5/4818 , A61N1/36514 , A61N1/3702 , A61N1/37258
摘要： A medical device for determining a respiratory effort having a pressure sensor to sense pressure signals, a housing having system components positioned therein, and a microprocessor positioned within the housing, wherein the microprocessor detects an inspiration and an expiration in response to the pressure signals, detects a breath in response to the detected inspiration and the detected expiration, and determines the respiratory effort in response to the detected breath.
摘要翻译： 一种用于确定具有用于感测压力信号的压力传感器的呼吸力的医疗装置，具有定位在其中的系统部件的壳体和位于壳体内的微处理器，其中微处理器响应于压力信号检测吸气和呼气，检测 响应于检测到的吸气和检测到的呼气而呼吸，并且响应于检测到的呼吸来确定呼吸力。
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9.发明申请METHOD AND APPARATUS TO DETECT AND MONITOR THE FREQUENCY OF OBSTRUCTIVE SLEEP APNEA 有权检测和监测阻塞性睡眠呼吸暂停频率的方法和装置公开(公告)号：US20090209880A1
公开(公告)日：2009-08-20
申请号：US12369899
申请日：2009-02-12
CPC分类号： A61B5/0538 , A61B5/04 , A61B5/0809 , A61B5/1118 , A61B5/4818
摘要： The present invention provides a method and apparatus for detecting and monitoring obstructive sleep apnea. The apparatus includes an intracardiac impedance sensor to measure intracardiac impedance, a movement sensor to measure an amount of movement of a patient, and a controller operatively coupled to said intracardiac impedance sensor and said movement sensor, said controller adapted to receive at least one of an intracardiac impedance and the amount of movement of the patient and detect obstructive sleep apnea based upon said intracardiac impedance and said movement.
摘要翻译： 本发明提供一种用于检测和监测阻塞性睡眠呼吸暂停的方法和装置。 该装置包括用于测量心内阻抗的心内阻抗传感器，用于测量患者的移动量的运动传感器以及可操作地耦合到所述心内阻抗传感器和所述运动传感器的控制器，所述控制器适于接收至少一个 心内阻抗和患者的运动量，并且基于所述心内阻塞和所述移动来检测阻塞性睡眠呼吸暂停。
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10.发明授权Method and apparatus to detect and monitor the frequency of obstructive sleep apnea 有权检测和监测阻塞性睡眠呼吸暂停频率的方法和装置公开(公告)号：US07509164B2
公开(公告)日：2009-03-24
申请号：US11284283
申请日：2005-11-21
IPC分类号： A61B5/053
CPC分类号： A61B5/0538 , A61B5/04 , A61B5/0809 , A61B5/1118 , A61B5/4818
摘要： The present invention provides a method and apparatus for detecting and monitoring obstructive sleep apnea. The apparatus includes an intracardiac impedance sensor to measure intracardiac impedance, a movement sensor to measure an amount of movement of a patient, and a controller operatively coupled to said intracardiac impedance sensor and said movement sensor, said controller adapted to receive at least one of an intracardiac impedance and the amount of movement of the patient and detect obstructive sleep apnea based upon said intracardiac impedance and said movement.
摘要翻译： 本发明提供一种用于检测和监测阻塞性睡眠呼吸暂停的方法和装置。 该装置包括用于测量心内阻抗的心内阻抗传感器，用于测量患者的移动量的运动传感器以及可操作地耦合到所述心内阻抗传感器和所述运动传感器的控制器，所述控制器适于接收至少一个 心内阻抗和患者的运动量，并且基于所述心内阻塞和所述移动来检测阻塞性睡眠呼吸暂停。
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