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1.发明申请POROUS GRAPHENE FILM REPRESENTING EXCELLENT ELECTRICAL PROPERTIES AND METHOD OF MANUFACTURING THE SAME 审中-公开多孔石墨膜表现出优异的电气特性及其制造方法公开(公告)号：US20130258552A1
公开(公告)日：2013-10-03
申请号：US13472168
申请日：2012-05-15
申请人： Bong-Gill Choi , Yun-Suk Huh
发明人： Bong-Gill Choi , Yun-Suk Huh
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/182 , H01G11/36 , Y02E60/13
摘要： Disclosed is a method of manufacturing a porous graphene film representing superior electrical properties. The method includes preparing a graphene/polymer composite dispersed solution by adding polymer particles to a first graphene dispersed solution obtained by dispersing graphene powders into a solvent, manufacturing a graphene/polymer composite film by using the graphene/polymer composite dispersed solution, and manufacturing the porous graphene film by removing the polymer particles from the graphene/polymer composite film.
摘要翻译： 公开了一种制造表现出优异电性能的多孔石墨烯膜的方法。 该方法包括通过向通过将石墨烯粉末分散在溶剂中而获得的第一石墨烯分散溶液中加入聚合物颗粒来制备石墨烯/聚合物复合分散溶液，通过使用石墨烯/聚合物复合分散溶液制造石墨烯/聚合物复合膜，并制造 通过从石墨烯/聚合物复合膜中除去聚合物颗粒而形成多孔石墨烯膜。
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2.发明申请SURFACE ENHANCED RAMAN SCATTERING (SERS) APPARATUS, METHODS AND APPLICATIONS 有权表面增强拉曼散射（SERS）装置，方法和应用公开(公告)号：US20130050695A1
公开(公告)日：2013-02-28
申请号：US13597688
申请日：2012-08-29
申请人： David Erickson , Aram J. Chung , Yun Suk Huh
发明人： David Erickson , Aram J. Chung , Yun Suk Huh
CPC分类号： B82Y30/00 , B82Y40/00 , G01N21/658
摘要： Surface enhanced Raman scattering (SERS) substrates may be fabricated using a shadow mask assisted evaporation (SMAE) method to provide for enhanced detection sensitivity with respect to target molecules that are located upon, and sensitized by, the SERS enhanced substrates. Such SERS substrates provide a two dimensional array of repeating nanostructures that may include, but are not limited to nano-pillar, nano-nib, nano-elliptical cylinder and nano-triangular tip nanostructures, any of which may be augmented with gold nanospheres. The particular SERS enhanced substrates in accordance with the embodiments, in particular when augmented with gold nanospheres, provide desirably enhanced sensitivity.
摘要翻译： 可以使用荫罩辅助蒸发（SMAE）方法制造表面增强拉曼散射（SERS）衬底，以提供相对于位于SERS增强衬底上并由其敏化的靶分子的增强的检测灵敏度。 这样的SERS衬底提供重复纳米结构的二维阵列，其可以包括但不限于纳米柱，纳米笔尖，纳米椭圆形圆柱体和纳米三角形尖端纳米结构，其中任何一种可以用金纳米球增强。 特别是根据实施例的特殊的SERS增强基板，特别是当用金纳米球增强时，提供期望的增强的灵敏度。
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3.发明申请ENHANCED ON-CHIP SERS BASED BIOMOLECULAR DETECTION USING ELECTROKINETICALLY ACTIVE MICROWELLS 有权使用电动活性微球增强基于片上SERS的生物分子检测公开(公告)号：US20110294691A1
公开(公告)日：2011-12-01
申请号：US13124296
申请日：2009-10-14
申请人： David Erickson , Yun Suk Huh , Carl A. Batt , Adam Joseph Lowe
发明人： David Erickson , Yun Suk Huh , Carl A. Batt , Adam Joseph Lowe
CPC分类号： C12Q1/6827 , B01F13/0076 , B01L3/50273 , B01L3/502761 , B01L2300/0636 , B01L2300/0654 , B01L2300/0809 , B01L2300/0829 , B01L2300/0887 , B01L2400/0415 , B01L2400/0424 , C12Q1/6862 , C12Q2565/632 , G01N21/658 , C12Q2563/137 , C12Q2531/137
摘要： A method for detecting target nucleic acids such as SNPs is provided. The method comprises performing a ligase detection reaction (LDR), performing surface enhanced Raman scattering (SERS) on the LDR, and analyzing the outcome of the LDR using analysis and/or quantification of the SERS by detecting an emitted Raman signature. The LDR-SERS method can be used for sensitive and specific detection of any nucleic acid sequence of interest. A microfluidic SERS detection device is also provided. The device comprises electrokinetically active microwells for mixing and concentrating analytes and in which analytes can be quantified. The device can be used for performing the LDR-SERS method in optofluidic chip format.
摘要翻译： 提供了检测目标核酸如SNP的方法。 该方法包括在LDR上进行连接酶检测反应（LDR），进行表面增强拉曼散射（SERS），并通过检测发射的拉曼特征来分析和/或定量SERS来分析LDR的结果。 LDR-SERS方法可用于感兴趣的任何核酸序列的敏感和特异性检测。 还提供了微流体SERS检测装置。 该装置包括用于混合和浓缩分析物的电动活性微孔，并且其中可分析物被量化。 该器件可用于以光流体芯片格式执行LDR-SERS方法。
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4.发明授权Nanofilter devices using elastomeric micro to nanochannel interfaces and methods based thereon 有权使用弹性体微纳通道界面的纳滤器装置和基于此的方法公开(公告)号：US08691588B2
公开(公告)日：2014-04-08
申请号：US13391508
申请日：2010-08-20
CPC分类号： G01N21/658 , B01D67/0088 , B01D71/70 , B01D2323/283 , B01L3/502707 , B01L3/502761 , B01L2200/0663 , B01L2300/0816 , B01L2300/0896 , B01L2300/123 , B01L2400/0421 , B81B2201/058 , B81C1/00071 , B82Y30/00 , G01N33/48721
摘要： A method is provided for fabricating a nanochannel. The method comprises providing a microchannel and controlling collapse of the microchannel so that it collapses to form a nanochannel of desired dimensions. The method employs a collapsible, flexible material such as the elastomer polydimethylsiloxane (PDMS) to form the nanochannel. A master is provided that is configured to have geometric conditions that promote a desired frequency of microchannel collapse. A collapsible material having a stiffness that also promotes a desired frequency of microchannel collapse is molded on the master. The molded collapsible material is removed from the master and bonded to a base, thereby forming the microchannel, which then collapses (or is collapsed) to form the nanochannel of desired dimensions. Nanofluidic and microfluidic devices comprising complex nanochannel structures and micro to nanochannel transitions are also provided.
摘要翻译： 提供了制造纳米通道的方法。 该方法包括提供微通道并控制微通道的塌陷，使得其塌缩以形成具有期望尺寸的纳米通道。 该方法采用可折叠的柔性材料，例如弹性体聚二甲基硅氧烷（PDMS）以形成纳米通道。 提供了一个主设备，其配置为具有促进微通道倒塌的期望频率的几何条件。 在主体上模制具有也促进所需频率的微通道塌陷的刚度的可折叠材料。 模制的可折叠材料从主体中取出并结合到基底上，从而形成微通道，然后将其收缩（或折叠）以形成所需尺寸的纳米通道。 还提供了包括复杂纳米通道结构和微到纳通道转换的纳流体和微流体装置。
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5.发明授权Enhanced on-chip SERS based biomolecular detection using electrokinetically active microwells 有权使用电动活性微孔增强基于片上SERS的生物分子检测公开(公告)号：US09057099B2
公开(公告)日：2015-06-16
申请号：US13124296
申请日：2009-10-14
申请人： David Erickson , Yun Suk Huh , Carl A. Batt , Adam Joseph Lowe
发明人： David Erickson , Yun Suk Huh , Carl A. Batt , Adam Joseph Lowe
CPC分类号： C12Q1/6827 , B01F13/0076 , B01L3/50273 , B01L3/502761 , B01L2300/0636 , B01L2300/0654 , B01L2300/0809 , B01L2300/0829 , B01L2300/0887 , B01L2400/0415 , B01L2400/0424 , C12Q1/6862 , C12Q2565/632 , G01N21/658 , C12Q2563/137 , C12Q2531/137
摘要： A method for detecting target nucleic acids such as SNPs is provided. The method comprises performing a ligase detection reaction (LDR), performing surface enhanced Raman scattering (SERS) on the LDR, and analyzing the outcome of the LDR using analysis and/or quantification of the SERS by detecting an emitted Raman signature. The LDR-SERS method can be used for sensitive and specific detection of any nucleic acid sequence of interest. A microfluidic SERS detection device is also provided. The device comprises electrokinetically active microwells for mixing and concentrating analytes and in which analytes can be quantified. The device can be used for performing the LDR-SERS method in optofluidic chip format.
摘要翻译： 提供了检测目标核酸如SNP的方法。 该方法包括在LDR上进行连接酶检测反应（LDR），进行表面增强拉曼散射（SERS），并通过检测发射的拉曼特征来分析和/或定量SERS来分析LDR的结果。 LDR-SERS方法可用于感兴趣的任何核酸序列的敏感和特异性检测。 还提供了微流体SERS检测装置。 该装置包括用于混合和浓缩分析物的电动活性微孔，并且其中可分析物被量化。 该器件可用于以光流体芯片格式执行LDR-SERS方法。
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6.发明申请NANOFILTER DEVICES USING ELASTOMERIC MICRO TO NANOCHANNEL INTERFACES AND METHODS BASED THEREON 有权使用弹性微型纳米通道接口的纳滤器器件及其方法公开(公告)号：US20120196376A1
公开(公告)日：2012-08-02
申请号：US13391508
申请日：2010-08-20
IPC分类号： G01N33/48 , G01N27/447 , B29C43/44 , H01L27/146 , G01J3/44 , B01L3/00 , B29C59/02 , B82Y5/00 , B82Y40/00
CPC分类号： G01N21/658 , B01D67/0088 , B01D71/70 , B01D2323/283 , B01L3/502707 , B01L3/502761 , B01L2200/0663 , B01L2300/0816 , B01L2300/0896 , B01L2300/123 , B01L2400/0421 , B81B2201/058 , B81C1/00071 , B82Y30/00 , G01N33/48721
摘要： A method is provided for fabricating a nanochannel. The method comprises providing a microchannel and controlling collapse of the microchannel so that it collapses to form a nanochannel of desired dimensions. The method employs a collapsible, flexible material such as the elastomer polydimethylsiloxane (PDMS) to form the nanochannel. A master is provided that is configured to have geometric conditions that promote a desired frequency of microchannel collapse. A collapsible material having a stiffness that also promotes a desired frequency of microchannel collapse is molded on the master. The molded collapsible material is removed from the master and bonded to a base, thereby forming the microchannel, which then collapses (or is collapsed) to form the nanochannel of desired dimensions. Nanofluidic and microfluidic devices comprising complex nanochannel structures and micro to nanochannel transitions are also provided.
摘要翻译： 提供了制造纳米通道的方法。 该方法包括提供微通道并控制微通道的塌陷，使得其塌缩以形成具有期望尺寸的纳米通道。 该方法采用可折叠的柔性材料，例如弹性体聚二甲基硅氧烷（PDMS）以形成纳米通道。 提供了一个主设备，其配置为具有促进微通道倒塌的期望频率的几何条件。 在主体上模制具有也促进所需频率的微通道塌陷的刚度的可折叠材料。 模制的可折叠材料从主体中取出并结合到基底上，从而形成微通道，然后将其收缩（或折叠）以形成所需尺寸的纳米通道。 还提供了包括复杂纳米通道结构和微到纳通道转换的纳流体和微流体装置。
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7.发明授权Surface enhanced raman scattering (SERS) apparatus, methods and applications 有权表面增强拉曼散射（SERS）装置，方法和应用公开(公告)号：US09001322B2
公开(公告)日：2015-04-07
申请号：US13597688
申请日：2012-08-29
申请人： David Erickson , Aram J. Chung , Yun Suk Huh
发明人： David Erickson , Aram J. Chung , Yun Suk Huh
CPC分类号： B82Y30/00 , B82Y40/00 , G01N21/658
摘要： Surface enhanced Raman scattering (SERS) substrates may be fabricated using a shadow mask assisted evaporation (SMAE) method to provide for enhanced detection sensitivity with respect to target molecules that are located upon, and sensitized by, the SERS enhanced substrates. Such SERS substrates provide a two dimensional array of repeating nanostructures that may include, but are not limited to nano-pillar, nano-nib, nano-elliptical cylinder and nano-triangular tip nanostructures, any of which may be augmented with gold nanospheres. The particular SERS enhanced substrates in accordance with the embodiments, in particular when augmented with gold nanospheres, provide desirably enhanced sensitivity.
摘要翻译： 可以使用荫罩辅助蒸发（SMAE）方法制造表面增强拉曼散射（SERS）衬底，以提供相对于位于SERS增强衬底上并由其敏化的靶分子的增强的检测灵敏度。 这样的SERS衬底提供重复纳米结构的二维阵列，其可以包括但不限于纳米柱，纳米笔尖，纳米椭圆形圆柱体和纳米三角形尖端纳米结构，其中任何一种可以用金纳米球增强。 特别是根据实施例的特殊的SERS增强基板，特别是当用金纳米球增强时，提供期望的增强的灵敏度。
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