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    Nanofilter devices using elastomeric micro to nanochannel interfaces and methods based thereon
    1.
    发明授权
    Nanofilter devices using elastomeric micro to nanochannel interfaces and methods based thereon 有权
    使用弹性体微纳通道界面的纳滤器装置和基于此的方法

    公开(公告)号：US08691588B2

    公开(公告)日：2014-04-08

    申请号：US13391508

    申请日：2010-08-20

    申请人： Seung-min Park ,  Yun Suk Huh ,  David Erickson ,  Harold G. Craighead

    发明人： Seung-min Park ,  Yun Suk Huh ,  David Erickson ,  Harold G. Craighead

    IPC分类号： B29C43/44 ,  B29C43/00 ,  B29C59/02

    CPC分类号： G01N21/658 ,  B01D67/0088 ,  B01D71/70 ,  B01D2323/283 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0816 ,  B01L2300/0896 ,  B01L2300/123 ,  B01L2400/0421 ,  B81B2201/058 ,  B81C1/00071 ,  B82Y30/00 ,  G01N33/48721

    摘要： A method is provided for fabricating a nanochannel. The method comprises providing a microchannel and controlling collapse of the microchannel so that it collapses to form a nanochannel of desired dimensions. The method employs a collapsible, flexible material such as the elastomer polydimethylsiloxane (PDMS) to form the nanochannel. A master is provided that is configured to have geometric conditions that promote a desired frequency of microchannel collapse. A collapsible material having a stiffness that also promotes a desired frequency of microchannel collapse is molded on the master. The molded collapsible material is removed from the master and bonded to a base, thereby forming the microchannel, which then collapses (or is collapsed) to form the nanochannel of desired dimensions. Nanofluidic and microfluidic devices comprising complex nanochannel structures and micro to nanochannel transitions are also provided.

    摘要翻译： 提供了制造纳米通道的方法。 该方法包括提供微通道并控制微通道的塌陷，使得其塌缩以形成具有期望尺寸的纳米通道。 该方法采用可折叠的柔性材料，例如弹性体聚二甲基硅氧烷（PDMS）以形成纳米通道。 提供了一个主设备，其配置为具有促进微通道倒塌的期望频率的几何条件。 在主体上模制具有也促进所需频率的微通道塌陷的刚度的可折叠材料。 模制的可折叠材料从主体中取出并结合到基底上，从而形成微通道，然后将其收缩（或折叠）以形成所需尺寸的纳米通道。 还提供了包括复杂纳米通道结构和微到纳通道转换的纳流体和微流体装置。

    Surface enhanced raman scattering (SERS) apparatus, methods and applications
    3.
    发明授权
    Surface enhanced raman scattering (SERS) apparatus, methods and applications 有权
    表面增强拉曼散射（SERS）装置，方法和应用

    公开(公告)号：US09001322B2

    公开(公告)日：2015-04-07

    申请号：US13597688

    申请日：2012-08-29

    申请人： David Erickson ,  Aram J. Chung ,  Yun Suk Huh

    发明人： David Erickson ,  Aram J. Chung ,  Yun Suk Huh

    IPC分类号： G01J3/44 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/65

    CPC分类号： B82Y30/00 ,  B82Y40/00 ,  G01N21/658

    摘要： Surface enhanced Raman scattering (SERS) substrates may be fabricated using a shadow mask assisted evaporation (SMAE) method to provide for enhanced detection sensitivity with respect to target molecules that are located upon, and sensitized by, the SERS enhanced substrates. Such SERS substrates provide a two dimensional array of repeating nanostructures that may include, but are not limited to nano-pillar, nano-nib, nano-elliptical cylinder and nano-triangular tip nanostructures, any of which may be augmented with gold nanospheres. The particular SERS enhanced substrates in accordance with the embodiments, in particular when augmented with gold nanospheres, provide desirably enhanced sensitivity.

    摘要翻译： 可以使用荫罩辅助蒸发（SMAE）方法制造表面增强拉曼散射（SERS）衬底，以提供相对于位于SERS增强衬底上并由其敏化的靶分子的增强的检测灵敏度。 这样的SERS衬底提供重复纳米结构的二维阵列，其可以包括但不限于纳米柱，纳米笔尖，纳米椭圆形圆柱体和纳米三角形尖端纳米结构，其中任何一种可以用金纳米球增强。 特别是根据实施例的特殊的SERS增强基板，特别是当用金纳米球增强时，提供期望的增强的灵敏度。

    SURFACE ENHANCED RAMAN SCATTERING (SERS) APPARATUS, METHODS AND APPLICATIONS
    4.
    发明申请
    SURFACE ENHANCED RAMAN SCATTERING (SERS) APPARATUS, METHODS AND APPLICATIONS 有权
    表面增强拉曼散射（SERS）装置，方法和应用

    公开(公告)号：US20130050695A1

    公开(公告)日：2013-02-28

    申请号：US13597688

    申请日：2012-08-29

    申请人： David Erickson ,  Aram J. Chung ,  Yun Suk Huh

    发明人： David Erickson ,  Aram J. Chung ,  Yun Suk Huh

    IPC分类号： G01J3/44 ,  B32B37/24

    CPC分类号： B82Y30/00 ,  B82Y40/00 ,  G01N21/658

    摘要： Surface enhanced Raman scattering (SERS) substrates may be fabricated using a shadow mask assisted evaporation (SMAE) method to provide for enhanced detection sensitivity with respect to target molecules that are located upon, and sensitized by, the SERS enhanced substrates. Such SERS substrates provide a two dimensional array of repeating nanostructures that may include, but are not limited to nano-pillar, nano-nib, nano-elliptical cylinder and nano-triangular tip nanostructures, any of which may be augmented with gold nanospheres. The particular SERS enhanced substrates in accordance with the embodiments, in particular when augmented with gold nanospheres, provide desirably enhanced sensitivity.

    摘要翻译： 可以使用荫罩辅助蒸发（SMAE）方法制造表面增强拉曼散射（SERS）衬底，以提供相对于位于SERS增强衬底上并由其敏化的靶分子的增强的检测灵敏度。 这样的SERS衬底提供重复纳米结构的二维阵列，其可以包括但不限于纳米柱，纳米笔尖，纳米椭圆形圆柱体和纳米三角形尖端纳米结构，其中任何一种可以用金纳米球增强。 特别是根据实施例的特殊的SERS增强基板，特别是当用金纳米球增强时，提供期望的增强的灵敏度。