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    Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
    2.
    发明申请
    Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease 失效

    公开(公告)号：US20030134776A1

    公开(公告)日：2003-07-17

    申请号：US10234652

    申请日：2002-09-03

    申请人： deCODE genetics ehf.

    发明人： Hakon Hakonarson

    IPC分类号： A61K031/00 ,  C12Q001/68

    CPC分类号： C12Q1/6809 ,  G01N33/5047 ,  G01N2800/52

    摘要： Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific cytokines and/or mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarities between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating the inflammatory disease in the patient.

    Method for desalting nucleic acids
    4.
    发明申请
    Method for desalting nucleic acids 失效
    脱盐核酸的方法

    公开(公告)号：US20030186247A1

    公开(公告)日：2003-10-02

    申请号：US10109587

    申请日：2002-03-27

    申请人： deCODE genetics ehf.

    发明人： Sigurdur V. Smarason ,  Albert V. Smith

    IPC分类号： C12Q001/68 ,  C07H021/04

    CPC分类号： C12Q1/6806 ,  C12Q2527/125

    摘要： The present invention relates to a method for desalting nucleic acid samples. The method involves contacting a liquid sample comprising a nucleic acid and an ionic salt with an ion exchanger comprising an insoluble phosphate salt, removing said liquid, and eluting said nucleic acid from the ion exchanger. The desalted nucleic acids provided by the methods of the invention are suitable for a wide variety of analytic and diagnostic applications, including high-throughput assays.

    摘要翻译： 本发明涉及一种脱盐核酸样品的方法。 该方法包括将包含核酸和离子盐的液体样品与包含不溶性磷酸盐的离子交换剂接触，除去所述液体，并从离子交换器中洗脱所述核酸。 通过本发明的方法提供的脱盐核酸适用于各种各样的分析和诊断应用，包括高通量测定。

    Human osteoporosis gene
    5.
    发明申请
    Human osteoporosis gene 审中-公开
    人类骨质疏松症基因

    公开(公告)号：US20030176344A1

    公开(公告)日：2003-09-18

    申请号：US10346723

    申请日：2003-01-16

    申请人： deCODE genetics ehf.

    发明人： Unnur Styrkarsdottir ,  Vala Drofn Johannsdottir

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  C07K014/475

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： A role of the human BMP2 nucleic acid in osteoporosis is disclosed. Methods for diagnosis, prediction of clinical course and treatment for osteoporosis or a susceptibility to osteoporosis using polymorphisms in the BMP2 nucleic acid, alone or in combination with other assays, are also disclosed.

    摘要翻译： 公开了人BMP2核酸在骨质疏松症中的作用。 还公开了诊断，临床病程预测和骨质疏松症治疗或使用BMP2核酸中多态性单独或与其他测定组合的骨质疏松易感性的方法。

    Nucleic acid isolation method and apparatus for performing same
    7.
    发明申请
    Nucleic acid isolation method and apparatus for performing same 审中-公开
    核酸分离方法及其执行装置

    公开(公告)号：US20030087293A1

    公开(公告)日：2003-05-08

    申请号：US10268598

    申请日：2002-10-10

    申请人： deCODE genetics ehf.

    发明人： Pall Gestsson

    IPC分类号： C12Q001/68 ,  C12M001/34

    CPC分类号： B01L3/5025 ,  B01L2400/049 ,  C12N15/1003 ,  G01N1/34

    摘要： Methods for purifying nucleic acids from biological fluids are disclosed as well as an apparatus for preforming the methods. The methods and apparatus circumvent traditional centrifugation steps using a plurality of vacuum steps to separate and isolate nucleic acids. The vacuum processing and apparatus allow the direct collection of bound nucleic acids from to collection vessels avoiding further manipulation.

    摘要翻译： 公开了从生物流体中纯化核酸的方法以及用于预处理方法的装置。 该方法和设备绕过传统的离心步骤，使用多个真空步骤来分离和分离核酸。 真空处理和装置允许从收集容器直接收集结合的核酸，避免进一步的操作。

    Drug advice expert
    8.
    发明申请
    Drug advice expert 审中-公开
    药物咨询专家

    公开(公告)号：US20020173993A1

    公开(公告)日：2002-11-21

    申请号：US10138097

    申请日：2002-05-02

    申请人： deCODE genetics ehf. corporation

    发明人： Halldor Skulason ,  Hjortur Sturluson ,  Ivar Sigurjon Helgason ,  Julius Helgi Schopka

    IPC分类号： G06F017/60

    CPC分类号： G06F19/326 ,  G06F19/3456 ,  G06Q30/02 ,  G06Q50/24

    摘要： A user-interactive computer program provides drug advice. Drugs are grouped according to their clinical and chemical characteristics in a supporting data base. For each drug, a drug database contains detailed information on pharmacokinetics, pharmaco-dynamics and drug-specific details. In response to user interaction with areas displayed on the screen, the computer program obtains pertinent drug interaction information from the database. With the obtained information, the computer program supports display of graphical screen views. Contents of the screen views include symbols for indicating respective drugs, geometrically distinguishing lines for indicating interaction between drugs, and text descriptions of drug information. Further included in the screen views are respective symbols for indicating drug warnings for pregnant or lactating women and sportspersons. Color coding may also be employed in the screen views to indicate degree of effect or warning.

    摘要翻译： 用户交互式计算机程序提供药物咨询。 药物根据其临床和化学特性在支持数据库中分组。 对于每种药物，药物数据库包含药代动力学，药物动力学和药物特异性细节的详细信息。 响应于与屏幕上显示的区域的用户交互，计算机程序从数据库获得相关药物交互信息。 通过获得的信息，计算机程序支持显示图形屏幕视图。 屏幕视图的内容包括用于指示各种药物的符号，用于指示药物之间的相互作用的几何区分线和药物信息的文本描述。 进一步包括在屏幕视图中的是用于表示怀孕或哺乳期妇女和运动员的药物警告的各自的符号。 也可以在屏幕视图中使用颜色编码来指示效果或警告的程度。

    Method and system for defining sets by querying relational data using a set definition language
    9.
    发明申请
    Method and system for defining sets by querying relational data using a set definition language 有权
    通过使用集合定义语言查询关系数据来定义集合的方法和系统

    公开(公告)号：US20040153435A1

    公开(公告)日：2004-08-05

    申请号：US10603112

    申请日：2003-06-24

    申请人： deCODE genetics ehf.

    发明人： Hakon Gudbjartsson ,  Thorvaldur S. Arnarson ,  Pavol Rovensky ,  Vilmundur Palmason

    IPC分类号： G06F017/30

    CPC分类号： G06F17/30595 ,  Y10S707/99943

    摘要： The present invention relates to the usage pattern, commonly found in many software applications, of defining sets of objects based on object attributes. A specifically designed set definition language for defining sets, called SDL, is described and a software system that implements this language efficiently on top of a standard relational database management system (RDBMS) is presented. The unique features of the SDL language are the implicit constraints that are enforced on the relational data that belong to the objects. Unique to the SDL system is also the logical metadata of dimensions that enables the SDL system to enforce these constraints across relations. The SDL system utilizes several optimization techniques to enable efficient implementation on top of RDBMS. It is also shown how the SDL language and the SQL language can be merged with bidirectional inlining using syntactic gates. Query composition tools are also described that facilitate the creation of SDL expressions.

    摘要翻译： 本发明涉及许多软件应用中通常发现的基于对象属性定义对象集合的使用模式。 描述了一种用于定义集合的专门设计的集合定义语言，称为SDL，并且提供了在标准关系数据库管理系统（RDBMS）之上有效实现该语言的软件系统。 SDL语言的独特功能是对属于对象的关系数据执行的隐式约束。 SDL系统特有的也是维度的逻辑元数据，使SDL系统能够跨越关系强制实施这些约束。 SDL系统利用多种优化技术，在RDBMS之上实现高效的实现。 还显示了如何使用语法门将SDL语言和SQL语言与双向内联合并。 还描述了查询组合工具，以便于创建SDL表达式。