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公开(公告)号：US09585777B2
公开(公告)日：2017-03-07
申请号：US14858355
申请日：2015-09-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti
CPC classification number: A61F2/90 , A61F2/89 , A61F2/915 , A61F2002/91566 , A61F2230/0069 , A61F2240/001 , A61F2250/0067 , A61F2250/0068 , A61F2250/0098 , A61K49/04 , A61L31/022 , A61L31/16 , A61L31/18
Abstract: An implantable prosthesis can comprise a strut having a lumen, radiopaque particles within the lumen, and a polymer binder. The polymer binder retains the radiopaque particles within the lumen. The strut may have side holes through which a therapeutic agent may pass and through which the radiopaque particles are incapable of passing. The polymer binder may be absent or optional. The radiopaque particles can have sizes that prevent them from escaping out of the lumen through the side holes. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure.
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公开(公告)号：US20160263293A1
公开(公告)日：2016-09-15
申请号：US15161084
申请日：2016-05-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Ni Ding , Stephen Pacetti , Marika Kamberi , Cameron Kerrigan
IPC: A61L31/16 , A61L31/10 , A61L31/14 , A61K31/436 , A61K47/48
CPC classification number: A61L31/16 , A61K31/436 , A61K47/593 , A61K47/6957 , A61L31/10 , A61L31/148 , A61L2300/416 , A61L2420/02 , C08L67/04
Abstract: Disclosed herein are drug delivery medical devices. A polymer coating for a medical device is provided which comprises a minimum amount of a drug bonded to the polymer in the coating.
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公开(公告)号：US20160175582A1
公开(公告)日：2016-06-23
申请号：US14574684
申请日：2014-12-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Benny Serna , Stephen Pacetti , John Stankus
CPC classification number: A61N1/0551 , A61B18/08 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/0212 , A61B2018/0262 , A61B2018/044 , A61B2018/1435 , A61M25/10184 , A61M25/1029 , A61N1/36117 , A61N7/00 , A61N2007/0021 , A61N2007/0026 , A61N2007/003
Abstract: An apparatus for vascular denervation, comprising a catheter configured for delivery into a vessel of a patient. A balloon is mounted on a distal tip of the catheter, the balloon being configured to be inflatable and further configured so that, upon inflation, the balloon adopts a shape that includes a first edge and a second edge that wind around each other in a double helix, the first edge and the second edge being separated from each other by a first crease and a second crease that also wind around each other in a double helix. A first electrode is attached to the balloon and is located to extend along the first edge.
Abstract translation: 一种用于血管去神经支配的装置，包括被配置为输送到患者血管中的导管。 气囊被安装在导管的远侧末端上，气囊构造成可充气并进一步构造，使得在充气时，气囊采用包括第一边缘和第二边缘的形状，该第一边缘和第二边缘以双重方式彼此缠绕 螺旋，第一边缘和第二边缘通过第一折痕和第二折痕彼此分开，第二折痕还以双螺旋缠绕在彼此。 第一电极附接到球囊并且被定位成沿着第一边缘延伸。
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4.发明授权Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating 有权药物输送支架或具有基于丙烯酰胺的涂层的支架，使得Novolimus具有最小量的与涂层的结合量公开(公告)号：US09364588B2
公开(公告)日：2016-06-14
申请号：US14298616
申请日：2014-06-06
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Ni Ding , Stephen Pacetti , Marika Kamberi , Cameron Kerrigan
CPC classification number: A61L31/16 , A61K31/436 , A61K47/593 , A61K47/6957 , A61L31/10 , A61L31/148 , A61L2300/416 , A61L2420/02 , C08L67/04
Abstract: Disclosed herein are drug delivery medical devices. A polymer coating for a medical device is provided which comprises a minimum amount of a drug bonded to the polymer in the coating.
Abstract translation: 本文公开了药物递送医疗装置。 提供了一种用于医疗装置的聚合物涂层，其包括与涂层中的聚合物结合的最少量的药物。
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公开(公告)号：US20150366682A1
公开(公告)日：2015-12-24
申请号：US14843462
申请日：2015-09-02
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti
CPC classification number: A61F2/86 , A61B90/39 , A61B2090/3966 , A61F2/90 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2250/0068 , A61F2250/0098 , B22F5/00 , B22F7/04
Abstract: An implantable prosthesis can comprise a strut having a lumen, and radiopaque particles within the lumen. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure. The radiopaque particles can be bonded to each other to prevent the radiopaque particles from escaping out of the strut.
Abstract translation: 可植入假体可以包括具有内腔的支柱和内腔内的不透射线的颗粒。 放置在内腔内的不透射线颗粒可以改善植入术期间假体的可视化。 不透射线的颗粒可以彼此结合，以防止不透射线的颗粒从支柱中逸出。
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Patent Agency Ranking
公开(公告)号：US20150290336A1
公开(公告)日：2015-10-15
申请号：US14750732
申请日：2015-06-25
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Syed Hossainy , Stephen Pacetti , Jessica DesNoyer
IPC: A61K47/48 , A61K47/34 , A61K31/727
CPC classification number: A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
Abstract translation: 本文描述了由特定类型的聚（酯酰胺）（PEA），治疗剂和水混溶性溶剂形成的治疗剂递送系统。 通过将由PEA聚合物，治疗剂和水混溶性溶剂形成的治疗剂递送系统递送到生理环境来递送治疗剂递送系统的方法，并分离治疗剂递送系统的相以形成膜 还描述了在生理环境中含有治疗剂的聚合物。 另外公开了一种试剂盒，其包括注射器内的注射器和治疗剂递送系统。
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公开(公告)号：US10039656B2
公开(公告)日：2018-08-07
申请号：US13910998
申请日：2013-06-05
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Erik David Eli , Syed Hossainy , Mikael Trollsas , Michael H. Ngo , Stephen Pacetti , Michael Green , John Papp
Abstract: A scaffold is formed by several segments joined or connected to each other by only at least one coupling. The coupling decouples the segments in the axial direction over a finite distance of axial displacement. The scaffold when implanted in a peripheral vessel reduces loading on rings of a segment due to the decoupling of the segments in the axial direction over the finite distance.
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公开(公告)号：US20160008151A1
公开(公告)日：2016-01-14
申请号：US14858336
申请日：2015-09-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti
CPC classification number: A61F2/90 , A61F2/89 , A61F2/915 , A61F2002/91566 , A61F2230/0069 , A61F2240/001 , A61F2250/0067 , A61F2250/0068 , A61F2250/0098 , A61K49/04 , A61L31/022 , A61L31/16 , A61L31/18
Abstract: An implantable prosthesis can comprise a strut having a lumen, radiopaque particles within the lumen, and a polymer binder. The polymer binder retains the radiopaque particles within the lumen. The strut may have side holes through which a therapeutic agent may pass and through which the radiopaque particles are incapable of passing. The polymer binder may be absent or optional. The radiopaque particles can have sizes that prevent them from escaping out of the lumen through the side holes. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure.
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9.发明申请公开(公告)号：US20150024039A1
公开(公告)日：2015-01-22
申请号：US14506038
申请日：2014-10-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Dariush Davalian , Stephen Pacetti , Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Kimchi Tran
IPC: A61K9/00
CPC classification number: A61K9/0019 , A61F2/95 , A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61M25/0084 , A61M25/104 , A61M2025/105
Abstract: This invention relates to methods of enhancing the permeability of blood vessels to therapeutic agents.
Abstract translation: 本发明涉及增强血管对治疗剂的渗透性的方法。
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公开(公告)号：US20140336747A1
公开(公告)日：2014-11-13
申请号：US14253760
申请日：2014-04-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Richard Rapoza , Nadine Ding , Yunbing Wang , Stephen Pacetti , Derek Mortisen
CPC classification number: A61F2/82 , A61L29/146 , A61L29/148 , A61L29/16 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/414 , A61L2300/42
Abstract: Implants for treating insufficient blood flow to a heart muscle with transmyocardial revascularization are disclosed. Methods of treating insufficient blood flow to a heart muscle with the implant are also disclosed. The implant can have a body with an inner lumen that supports a channel in the heart muscle to allow for increased blood flow through the lumen upon implantation. The implant can include active agents to prevent or inhibit thrombotic closure of the channel, to promote vascularization, or both.
Abstract translation: 公开了用于治疗心肌血运重建的心肌不足的植入物。 还公开了用植入物治疗心肌不足的方法。 植入物可以具有内部内腔的主体，其支撑心肌中的通道，以允许在植入时通过内腔增加血流量。 植入物可以包括活性剂以预防或抑制通道的血栓闭塞，促进血管形成，或两者。
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