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公开(公告)号：US20160130618A1
公开(公告)日：2016-05-12
申请号：US14990047
申请日：2016-01-07
Applicant: AJINOMOTO CO., INC.
Inventor： Yoshihiko Hara , Keita Fukui , Akito Chinen , Suguru Yamakami
IPC: C12P13/14
CPC classification number: C12P13/14 , C12P7/00 , C12P13/001 , C12P13/04
Abstract: A method for producing an objective substance is provided. An objective substance is produced by culturing a microorganism which has been modified so that the activity of a dicarboxylic acid exporter protein is reduced in a medium, and collecting the objective substance from the medium.
Abstract translation: 提供了制造目标物质的方法。 通过培养已经被修饰以使得二羧酸出口蛋白的活性在培养基中降低并从培养基中收集目标物质的微生物产生目标物质。
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Patent Agency Ranking
公开(公告)号：US08753849B2
公开(公告)日：2014-06-17
申请号：US13774153
申请日：2013-02-22
Applicant: Ajinomoto Co., Inc.
Inventor： Yury Ivanovich Kozlov , Akito Chinen , Hiroshi Izui , Yoshihiko Hara , Hisashi Yasueda , Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Joanna Yosifovna Katashkina
IPC: C12P13/14
CPC classification number: C12P13/24 , C12N9/88 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12Y401/02009 , C12Y401/02022
Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
Abstract translation: 本发明提供一种具有生产乙酰辅酶A的有用代谢物的能力，例如L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-精氨酸，L-亮氨酸，L-半胱氨酸，琥珀酸酯 和聚羟基丁酸酯，其中所述细菌被修饰，使得D-木酮糖-5-磷酸磷酸酮糖苷酶和/或果糖-6-磷酸磷酸酮醇酶的活性增强。 本发明还提供了使用该细菌生产有用代谢物的方法。
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公开(公告)号：US20130157321A1
公开(公告)日：2013-06-20
申请号：US13774153
申请日：2013-02-22
Applicant: Ajinomoto Co., Inc.
Inventor： Yury Ivanovich Kozlov , Akito Chinen , Hiroshi Izui , Yoshihiko Hara , Hisashi Yasueda , Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Joanna Yosifovna Katashkina
CPC classification number: C12P13/24 , C12N9/88 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12Y401/02009 , C12Y401/02022
Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
Abstract translation: 本发明提供一种具有生产乙酰辅酶A的有用代谢物的能力，例如L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-精氨酸，L-亮氨酸，L-半胱氨酸，琥珀酸酯 和聚羟基丁酸酯，其中所述细菌被修饰，使得D-木酮糖-5-磷酸磷酸酮糖苷酶和/或果糖-6-磷酸磷酸酮醇酶的活性增强。 本发明还提供了使用该细菌生产有用代谢物的方法。
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公开(公告)号：US10047385B2
公开(公告)日：2018-08-14
申请号：US14990047
申请日：2016-01-07
Applicant: AJINOMOTO CO., INC.
Inventor： Yoshihiko Hara , Keita Fukui , Akito Chinen , Suguru Yamakami
CPC classification number: C12P13/14 , C12P7/00 , C12P13/001 , C12P13/04
Abstract: A method for producing an objective substance is provided. An objective substance is produced by culturing a microorganism which has been modified so that the activity of a dicarboxylic acid exporter protein is reduced in a medium, and collecting the objective substance from the medium.
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公开(公告)号：US08969048B2
公开(公告)日：2015-03-03
申请号：US14268110
申请日：2014-05-02
Applicant: Ajinomoto Co., Inc.
Inventor： Yury Ivanovich Kozlov , Akito Chinen , Hiroshi Izui , Yoshihiko Hara , Hisashi Yasueda , Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Joanna Yosifovna Katashkina
IPC: C12P13/24 , C12N9/88 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/14 , C12P7/44 , C12P13/12 , C12P13/20 , C12P7/42
CPC classification number: C12P13/24 , C12N9/88 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12Y401/02009 , C12Y401/02022
Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
Abstract translation: 本发明提供一种具有生产乙酰辅酶A的有用代谢物的能力，例如L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-精氨酸，L-亮氨酸，L-半胱氨酸，琥珀酸酯 和聚羟基丁酸酯，其中所述细菌被修饰，使得D-木酮糖-5-磷酸磷酸酮糖苷酶和/或果糖-6-磷酸磷酸酮醇酶的活性增强。 本发明还提供了使用该细菌生产有用代谢物的方法。
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公开(公告)号：US20140242643A1
公开(公告)日：2014-08-28
申请号：US14268110
申请日：2014-05-02
Applicant: AJINOMOTO CO., INC.
Inventor： Yury Ivanovich Kozlov , Akito Chinen , Hiroshi Izui , Yoshihiko Hara , Hisashi Yasueda , Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Joanna Yosifovna Katashkina
CPC classification number: C12P13/24 , C12N9/88 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12Y401/02009 , C12Y401/02022
Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
Abstract translation: 本发明提供一种具有生产乙酰辅酶A的有用代谢物的能力，例如L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-精氨酸，L-亮氨酸，L-半胱氨酸，琥珀酸酯 和聚羟基丁酸酯，其中所述细菌被修饰，使得D-木酮糖-5-磷酸磷酸酮糖苷酶和/或果糖-6-磷酸磷酸酮醇酶的活性增强。 本发明还提供了使用该细菌生产有用代谢物的方法。
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