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公开(公告)号：US09505849B2
公开(公告)日：2016-11-29
申请号：US14774293
申请日：2014-03-17
发明人： Peter Kufer , Tobias Raum , Markus Muenz , Jochen Pendzialek , Walter Fiers , Xavier Saelens , Kenny Roose
CPC分类号： C07K16/468 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K16/1018 , C07K16/2809 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention relates to an antibody construct comprising a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e) and a second domain specific for CD3. Moreover, the invention provides a nucleic acid molecule encoding the antibody construct, a vector comprising said nucleic acid molecule and a host cell transformed or transfected with said nucleic acid molecule or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a pharmaceutical composition comprising said antibody construct, a medical use/method of treatment relating to said antibody construct, and a kit comprising said antibody construct.
摘要翻译： 本发明涉及包含对流感病毒包膜蛋白M2（M2e）细胞外部分特异的第一人结合结构域和CD3特异性第二结构域的抗体构建体。 此外，本发明提供编码抗体构建体的核酸分子，包含所述核酸分子的载体和用所述核酸分子或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，包含所述抗体构建体的药物组合物，与所述抗体构建体有关的医疗用途/治疗方法，以及包含所述抗体构建体的试剂盒。
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公开(公告)号：US20160039948A1
公开(公告)日：2016-02-11
申请号：US14774293
申请日：2014-03-17
发明人： Peter Kufer , Tobias Raum , Markus Muenz , Jochen Pendzialek , Walter Fiers , Xavier Saelens , Kenny Roose
CPC分类号： C07K16/468 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K16/1018 , C07K16/2809 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention relates to an antibody construct comprising a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e) and a second domain specific for CD3. Moreover, the invention provides a nucleic acid molecule encoding the antibody construct, a vector comprising said nucleic acid molecule and a host cell transformed or transfected with said nucleic acid molecule or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a pharmaceutical composition comprising said antibody construct, a medical use/method of treatment relating to said antibody construct, and a kit comprising said antibody construct.
摘要翻译： 本发明涉及包含对流感病毒包膜蛋白M2（M2e）细胞外部分特异的第一人结合结构域和CD3特异性第二结构域的抗体构建体。 此外，本发明提供编码抗体构建体的核酸分子，包含所述核酸分子的载体和用所述核酸分子或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，包含所述抗体构建体的药物组合物，与所述抗体构建体有关的医疗用途/治疗方法，以及包含所述抗体构建体的试剂盒。
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公开(公告)号：US20210046176A1
公开(公告)日：2021-02-18
申请号：US17041792
申请日：2019-03-27
申请人： SANOFI PASTEUR INC. , VIB VZW , UNIVERSITEIT GENT
发明人： Tod Strugnell , Eliud Oloo , Raymond Oomen , Thorsten Vogel , Xavier Saelens , Emma Job
IPC分类号： A61K39/145 , G16B30/10 , G16B15/20 , C12N9/24 , C12N7/00
摘要： The present disclosure relates to a cluster-based consensus approach for generating recombinant neuraminidase (NA) polypeptides. The disclosure further relates to influenza vaccine compositions comprising the recombinant NA polypeptides.
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公开(公告)号：US11248039B2
公开(公告)日：2022-02-15
申请号：US16566542
申请日：2019-09-10
申请人： VIB VZW , UNIVERSITEIT GENT , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , TRUSTEES OF DARTMOUTH COLLEGE
发明人： Xavier Saelens , Bert Schepens , Iebe Rossey , Barney Graham , Jason McLellan , Morgan Gilman
摘要： The present invention relates to immunoglobulin single variable domains (ISVDs) that are directed against respiratory syncytial virus (RSV). More specifically, it relates to ISVDs that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these ISVDs for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these ISVDs.
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公开(公告)号：US20210106673A1
公开(公告)日：2021-04-15
申请号：US17078704
申请日：2020-10-23
申请人： VIB VZW , Universiteit Gent
发明人： Xavier Saelens , Bert Schepens , Walter Fiers
IPC分类号： A61K39/155 , A61K39/12 , C12N7/02 , A61K39/385 , C07K16/10 , C07K7/06 , C07K14/005 , C07K14/78 , C12N7/00
摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.
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公开(公告)号：US20160376347A1
公开(公告)日：2016-12-29
申请号：US14651043
申请日：2013-12-11
IPC分类号： C07K16/10
CPC分类号： C07K16/1018 , A61K39/145 , A61K2039/505 , C07K2317/13 , C07K2317/35 , C07K2317/569 , C07K2317/626 , C07K2317/76
摘要： The present invention relates to an antibody that confers protection against influenza virus infection. More specifically, it relates to an anti-neuraminidase antibody, protecting against highly pathogenic H5N1 influenza strains. The invention relates further to the use of the antibody for prophylactic and/or therapeutic treatment of influenzavirusinfections, and to a pharmaceutical composition comprising the antibody.
摘要翻译： 本发明涉及赋予防止流感病毒感染的抗体。 更具体地说，本发明涉及一种抗神经氨酸酶抗体，可以防止高致病性H5N1流感病毒株。 本发明进一步涉及抗体用于预防和/或治疗流感病毒感染的用途，以及包含该抗体的药物组合物。
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公开(公告)号：US10023629B2
公开(公告)日：2018-07-17
申请号：US14651043
申请日：2013-12-11
IPC分类号： A61K39/145 , C07K16/10 , A61K39/00
摘要： The present invention relates to an antibody that confers protection against influenza virus infection. More specifically, it relates to an anti-neuraminidase antibody, protecting against highly pathogenic H5N1 influenza strains. The invention relates further to the use of the antibody for prophylactic and/or therapeutic treatment of influenza virus infections, and to a pharmaceutical composition comprising the antibody.
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公开(公告)号：US20190083605A1
公开(公告)日：2019-03-21
申请号：US16144007
申请日：2018-09-27
申请人： VIB VZW , Universiteit Gent
发明人： Xavier Saelens , Bert Schepens , Walter Fiers
IPC分类号： A61K39/155 , C12N7/00 , C07K16/10 , A61K39/385 , C07K14/78 , C07K14/005 , C07K7/06 , A61K39/12 , C12N7/02 , A61K39/00
摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.
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公开(公告)号：US10117926B2
公开(公告)日：2018-11-06
申请号：US15197001
申请日：2016-06-29
申请人： VIB VZW , Universiteit Gent
发明人： Xavier Saelens , Bert Schepens , Walter Fiers
IPC分类号： A61K39/155 , A61K39/12 , C07K16/10 , C12N7/02 , C07K7/06 , C07K14/005 , C07K14/78 , A61K39/385 , C12N7/00 , A61K39/00
摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.
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公开(公告)号：US20160346379A1
公开(公告)日：2016-12-01
申请号：US15197001
申请日：2016-06-29
申请人： VIB VZW , Universiteit Gent
发明人： Xavier Saelens , Bert Schepens , Walter Fiers
IPC分类号： A61K39/155 , C07K16/10 , A61K39/385 , C12N7/00
CPC分类号： A61K39/155 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6075 , A61K2039/6081 , A61K2039/645 , C07K7/06 , C07K14/005 , C07K14/78 , C07K16/1027 , C07K2317/10 , C07K2317/76 , C12N7/00 , C12N7/02 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571
摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.
摘要翻译： 描述了一种针对呼吸道合胞病毒（RSV）的疫苗。 更具体地，描述了包含RSV编码的小疏水（SH）蛋白的胞外域的重组亚单位疫苗。 SH的胞外域被称为SHe。 胞外结构域通常以低聚物或五聚体形式存在。 还描述了针对胞外结构域或针对胞外结构域特异性的抗体，以及它们用于保护受试者免受RSV感染和/或用于治疗受感染受试者的用途。
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