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    ANTIBODY CONSTRUCTS FOR INFLUENZA M2 AND CD3
    2.
    发明申请
    ANTIBODY CONSTRUCTS FOR INFLUENZA M2 AND CD3 有权
    用于流感M2和CD3的抗体构建体

    公开(公告)号：US20160039948A1

    公开(公告)日：2016-02-11

    申请号：US14774293

    申请日：2014-03-17

    申请人： AMGEN RESEARCH (MUNICH) GMBH ,  VIB VZW ,  UNIVERSITEIT GENT

    发明人： Peter Kufer ,  Tobias Raum ,  Markus Muenz ,  Jochen Pendzialek ,  Walter Fiers ,  Xavier Saelens ,  Kenny Roose

    IPC分类号： C07K16/46 ,  A61K39/42 ,  A61K45/06

    CPC分类号： C07K16/468 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/1018 ,  C07K16/2809 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

    摘要： The present invention relates to an antibody construct comprising a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e) and a second domain specific for CD3. Moreover, the invention provides a nucleic acid molecule encoding the antibody construct, a vector comprising said nucleic acid molecule and a host cell transformed or transfected with said nucleic acid molecule or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a pharmaceutical composition comprising said antibody construct, a medical use/method of treatment relating to said antibody construct, and a kit comprising said antibody construct.

    摘要翻译： 本发明涉及包含对流感病毒包膜蛋白M2（M2e）细胞外部分特异的第一人结合结构域和CD3特异性第二结构域的抗体构建体。 此外，本发明提供编码抗体构建体的核酸分子，包含所述核酸分子的载体和用所述核酸分子或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，包含所述抗体构建体的药物组合物，与所述抗体构建体有关的医疗用途/治疗方法，以及包含所述抗体构建体的试剂盒。

    Cross-species-specific single domain bispecific single chain antibody
    5.
    发明授权
    Cross-species-specific single domain bispecific single chain antibody 有权

    公开(公告)号：US11987633B2

    公开(公告)日：2024-05-21

    申请号：US17204166

    申请日：2021-03-17

    申请人： AMGEN RESEARCH (MUNICH) GMBH

    发明人： Peter Kufer ,  Tobias Raum ,  Roman Kischel ,  Ralf Lutterbüse ,  Patrick Hoffmann ,  Matthias Klinger ,  Doris Rau ,  Susanne Mangold

    IPC分类号： C07K16/18 ,  C07K16/28

    CPC分类号： C07K16/2863 ,  C07K16/2803 ,  C07K16/2878 ,  C07K16/2884 ,  C07K2317/31 ,  C07K2317/34

    摘要： The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain consisting of one antibody variable domain capable of binding to an epitope of the human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to an epitope of a human and a non-chimpanzee primate tumor target antigen. The invention further relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3ε (epsilon) chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain consisting of one antibody variable domain capable of binding to an epitope of a human and a non-chimpanzee primate tumor target antigen. The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.