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    METHODS FOR PREPARATION OF AMMONIUM SALTS OF C4 DIACIDS BY FERMENTATION AND INTEGRATED METHODS FOR MAKING C4 DERIVATIVES THEREOF
    3.
    发明申请
    METHODS FOR PREPARATION OF AMMONIUM SALTS OF C4 DIACIDS BY FERMENTATION AND INTEGRATED METHODS FOR MAKING C4 DERIVATIVES THEREOF 审中-公开
    通过发酵和制备C4衍生物的一体化方法制备C4 DIACIDS的氨基磺酸盐的方法

    公开(公告)号：US20170029353A1

    公开(公告)日：2017-02-02

    申请号：US15278649

    申请日：2016-09-28

    Applicant: ARCHER DANIELS MIDLAND COMPANY

    Inventor： ChiCheng Ma ,  Todd Werpy

    IPC: C07C51/493 ,  C12P7/46

    CPC classification number: C07C51/493 ,  C07C29/149 ,  C07C51/412 ,  C07C51/42 ,  C07D207/267 ,  C07D307/33 ,  C12P7/46 ,  C07C55/02 ,  C07C57/15 ,  C07C59/245 ,  C07C55/10

    Abstract: Disclosed herein are methods for forming ammonium salts of C4 diacids in a fermentation process with simultaneous removal of divalent metal carbonate salts. The pH of fermentation broths obtained during the production of fumaric, maleic, malic, and/or succinic acid by a microorganism is controlled by using alkaline oxygen containing calcium or magnesium compounds in the hydroxide, oxide, carbonate or bicarbonate forms—forming divalent metal salts of the diacids that are partially or wholly insoluble in the broth. The calcium or magnesium salts of the diacids are substituted with ammonium by introduction of ammonium salts at elevated temperature and pressure dissolving precipitated divalent metal cation salts of the diacids and forming soluble ammonium salts thereof. Carbonate in the form of CO2 or bicarbonate is simultaneously added to the fermentation media at the elevated temperature and pressure. The temperature and pressure are then reduced forming insoluble divalent metal carbonate salts that are separated from the solubilized ammonium diacid salts. The recovered metal carbonate salts can be recycled as pH control materials in subsequent fermentation reactions. Also disclosed is use of the solubilized ammonium diacid salts directly as a reagent for hydrogenation to form the derivatives N-methyl-2-pyrrolidone (NMP) gamma-butyrolactone (GBL) and 1,4-butane-diol (BDO) in single pot reactions.

    Abstract translation: 本文公开了在发酵过程中形成C4二酸铵盐的方法，同时除去二价金属碳酸盐。 在微生物生产富马酸，马来酸，苹果酸和/或琥珀酸期间获得的发酵肉汤的pH值通过在氢氧化物，氧化物，碳酸盐或碳酸氢盐形式的二价金属盐中使用含有钙或镁的化合物来控制 的部分或完全不溶于肉汤的二酸。 二元酸的钙盐或镁盐通过在升高的温度下引入铵盐和溶解二酸的沉淀二价金属阳离子盐并形成其可溶性铵盐而被铵取代。 CO 2或碳酸氢盐形式的碳酸盐在升高的温度和压力下同时加入到发酵培养基中。 然后降低温度和压力，形成不溶性二价金属碳酸盐，其与可溶性二铵酸盐分离。 回收的金属碳酸盐可以在随后的发酵反应中作为pH控制材料再循环。 还公开了将溶解的二铵二酸盐直接用作氢化的试剂以在单锅中形成N-甲基-2-吡咯烷酮（NMP）γ-丁内酯（GBL）和1,4-丁二醇（BDO） 反应。

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