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26 条记录 (耗时 0.024 秒)

    Aminoalkyl and acylaminoalkyl ethers, process for their preparation, and their use as bradykinin receptor antagonists
    2.
    发明授权
    Aminoalkyl and acylaminoalkyl ethers, process for their preparation, and their use as bradykinin receptor antagonists 失效
    氨基烷基和酰氨基烷基醚，其制备方法及其作为缓激肽受体拮抗剂的用途

    公开(公告)号：US6140341A

    公开(公告)日：2000-10-31

    申请号：US820321

    申请日：1997-03-12

    申请人： Holger Heitsch ,  Adalbert Wagner ,  Klaus Wirth ,  Bernward Scholkens ,  Gerhard Nolken

    发明人： Holger Heitsch ,  Adalbert Wagner ,  Klaus Wirth ,  Bernward Scholkens ,  Gerhard Nolken

    IPC分类号： C07D215/48 ,  A61K31/47 ,  A61P43/00 ,  C07D215/26 ,  C07D215/00 ,  C07D215/02

    CPC分类号： C07D215/26

    摘要： Aminoalkyl and acylaminoalkyl ethers which are distinguished by high affinity for the bradykinin B.sub.2 receptor and improved solubility in water are described. These aminoalkyl and acylaminoalkyl ethers can be represented by the formula (I) ##STR1## in which R.sup.1,R.sup.2,R.sup.3 are alkyl, aryl, alkylaryl, halogen, hydrogen, cycloalkyl, CHO, CO--O-alkyl, COOH; R.sup.4, R.sup.5 are hydrogen, halogen, alkoxy, nitro, cyano, S-alkyl; n is a number from 1 to 8; R.sup.6 is hydrogen, alkyl, alkylalkenyl, alkylaryl; R.sup.7 is hydrogen and a substituted or unsubstituted acyl radical. A process for preparing the compounds of the formula (I) is likewise described.

    摘要翻译： 描述了通过对缓激肽B2受体的高亲和力和改善的在水中的溶解度的区别的氨基烷基和酰基氨基烷基醚。 这些氨基烷基和酰基氨基烷基醚可以由其中R 1，R 2，R 3是烷基，芳基，烷基芳基，卤素，氢，环烷基，CHO，CO-O-烷基，COOH的式（I） R4，R5是氢，卤素，烷氧基，硝基，氰基，S-烷基; n是从1到8的数字; R6是氢，烷基，烷基烯基，烷基芳基; R7是氢和取代或未取代的酰基。 同样描述了制备式（I）化合物的方法。

    Support structure having alternative states of high strength or low thermal conductivity, and connecting strut
    9.
    发明授权
    Support structure having alternative states of high strength or low thermal conductivity, and connecting strut 失效
    支撑结构具有高强度或低热导率的替代状态，以及连接支柱

    公开(公告)号：US06439516B1

    公开(公告)日：2002-08-27

    申请号：US09898673

    申请日：2001-07-03

    申请人： Martin Roth ,  Franz Sperber ,  Adalbert Wagner

    发明人： Martin Roth ,  Franz Sperber ,  Adalbert Wagner

    IPC分类号： A47G2302

    CPC分类号： B64G1/641 ,  B64G1/645 ,  F17C13/088 ,  Y10S248/901

    摘要： A support structure includes at least one shaped component which is produced from a shape memory alloy and which, in a first operating state of the support structure, results in an increase in the strength of the support structure and, in a second operating state, results in a reduction in the thermal conductivity of the support structure. The first strut structure is surrounded by a second strut structure, which has a higher mechanical strength in comparison with the first strut structure, and the first strut structure is connected securely, at least at one of its ends, to the second strut structure. In addition, the first strut structure is connected to a holding device, and the second strut structure is releasably connected to the holding device by the at least one shaped component.

    摘要翻译： 支撑结构包括由形状记忆合金制成的至少一个成形部件，并且在支撑结构的第一操作状态下导致支撑结构的强度增加，并且在第二操作状态下，结果 在支撑结构的热导率的降低。 第一支柱结构被第二支柱结构包围，第二支柱结构与第一支柱结构相比具有较高的机械强度，并且第一支柱结构至少在其一端处可靠地连接到第二支柱结构。 此外，第一支柱结构连接到保持装置，并且第二支柱结构通过至少一个成形部件可释放地连接到保持装置。

    Fluoroalkyl- and fluoroalkoxy-substituted heterocyclic bradykinin antagonists, process for their preparation, and their use
    10.
    发明授权
    Fluoroalkyl- and fluoroalkoxy-substituted heterocyclic bradykinin antagonists, process for their preparation, and their use 失效
    氟烷基和氟烷氧基取代的杂环缓激肽拮抗剂，其制备方法及其应用

    公开(公告)号：US5859025A

    公开(公告)日：1999-01-12

    申请号：US819351

    申请日：1997-03-18

    申请人： Adalbert Wagner ,  Holger Heitsch ,  Gerhard Nolken ,  Klaus Wirth ,  Bernward Scholkens

    发明人： Adalbert Wagner ,  Holger Heitsch ,  Gerhard Nolken ,  Klaus Wirth ,  Bernward Scholkens

    IPC分类号： C07D237/28 ,  A61K31/345 ,  A61K31/47 ,  A61K31/495 ,  A61K31/53 ,  A61P43/00 ,  C07D215/04 ,  C07D215/26 ,  C07D239/72 ,  C07D239/74 ,  C07D241/36 ,  C07D241/44 ,  C07D253/04 ,  C07D253/065 ,  C07D257/10 ,  C07D215/14 ,  C07D215/20 ,  C07D215/38

    CPC分类号： C07D215/26

    摘要： Fluoroalkyl- and fluoroalkoxy-substituted heterocyclic bradykinin antagonists, process or their preparation, and their useHeterocyclic fluoroalkyl derivatives and fluoroalkoxy derivatives of the formula (I) having bradykinin-antagonistic action ##STR1## in which X.sub.1 -X.sub.3 are N or CR.sup.5, R.sup.1 and R.sup.2 are H or halogen, R.sup.3 and R.sup.4 are H, halogen, alkyl or alkenyl, R.sup.5 is H, halogen, (substituted) alkyl, O--R.sup.6, S--R.sup.6, NHR.sup.6, (substituted) aryl, (substituted)aryl-alkyl, --C(O)--OR.sup.6 or --C(O)--H, R.sup.6 and R.sup.8 H, alkyl, alkenyl or aryl-alkyl, R.sup.7 is (substituted) alkyl or (substituted) alkoxy, B is an aminocarboxylic acid, D is alkenediyl, alkanediyl or --(CH.sub.2).sub.n --Y.sub.p --(CH.sub.2).sub.m --, E is oxygen or sulfur, Y is oxygen, sulfur or NR.sup.8, n and m are a number 0-3, o is a number 1-3 and p is 0 or 1, and their physiologically tolerable salts and a process for their preparation are described.

    摘要翻译： 氟烷基和氟烷氧基取代的杂环缓激肽拮抗剂，方法或其制备及其用途具有缓激肽拮抗作用的式（I）的杂环氟烷基衍生物和氟代烷氧基衍生物，其中X1-X3为N或CR5 R 1和R 2为H或卤素，R 3和R 4为H，卤素，烷基或烯基，R 5为H，卤素，（取代的）烷基，O-R 6，S-R 6，NHR 6，（取代的） 芳基 - 烷基，-C（O）-OR 6或-C（O）-H，R 6和R 8 H，烷基，烯基或芳基 - 烷基，R 7是（取代的）烷基或（取代的）烷氧基，B是氨基羧酸 ，D为亚烯基，烷二基或 - （CH2）n-Yp-（CH2）m-，E为氧或硫，Y为氧，硫或NR8，n和m为0-3，o为1 -3和p为0或1，并且描述了它们的生理上可耐受的盐及其制备方法。