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公开(公告)号:US07834039B2
公开(公告)日:2010-11-16
申请号:US12002196
申请日:2007-12-14
申请人: Adrian D. Hobson , Shannon R. Fix-Stenzel , Kevin P. Cusack , Eric C. Breinlinger , Graham K. Ansell , Robert H. Stoffel , Kevin R. Woller , Pintipa Grongsaard
发明人: Adrian D. Hobson , Shannon R. Fix-Stenzel , Kevin P. Cusack , Eric C. Breinlinger , Graham K. Ansell , Robert H. Stoffel , Kevin R. Woller , Pintipa Grongsaard
IPC分类号: A61K31/4245 , C07D271/06
CPC分类号: C07D271/07 , C07D271/06 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
摘要翻译: 新型恶二唑化合物,含有这些化合物的药物组合物以及这些化合物或组合物作为G蛋白偶联受体的S1P家族的激动剂或拮抗剂用于治疗与调节S1P家族受体活性有关的疾病的用途,特别是通过提供有益的免疫抑制 效果被公开。
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公开(公告)号:US20110207704A1
公开(公告)日:2011-08-25
申请号:US12861931
申请日:2010-08-24
申请人: Kevin P. Cusack , Eric C. Breinlinger , Shannon R. Fix-Stenzel , Robert H. Stoffel , Kevin R. Woller , Adrian D. Hobson , Pintipa Grongsaard
发明人: Kevin P. Cusack , Eric C. Breinlinger , Shannon R. Fix-Stenzel , Robert H. Stoffel , Kevin R. Woller , Adrian D. Hobson , Pintipa Grongsaard
IPC分类号: A61K31/675 , C07D271/06 , A61K31/4245 , C07D413/12 , C07D413/10 , C07D413/04 , A61K31/4439 , C07D401/14 , A61K31/439 , C07F9/40 , A61K31/4709 , A61K31/454 , A61K31/5377 , A61K31/397 , C07D487/04 , A61K31/4985 , A61P11/00 , A61P31/14 , A61P25/28 , A61P17/06 , A61P19/02 , A61P1/04
CPC分类号: C07D271/06 , C07D271/07 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
摘要翻译: 新型恶二唑化合物,含有这些化合物的药物组合物以及这些化合物或组合物作为G蛋白偶联受体的S1P家族的激动剂或拮抗剂用于治疗与调节S1P家族受体活性有关的疾病的用途,特别是通过提供有益的免疫抑制 效果被公开。
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公开(公告)号:US20080280876A1
公开(公告)日:2008-11-13
申请号:US12002196
申请日:2007-12-14
申请人: Adrian D. Hobson , Shannon R. Fix-Stenzel , Kevin P. Cusack , Eric C. Breinlinger , Graham K. Ansell , Robert H. Stoffel
发明人: Adrian D. Hobson , Shannon R. Fix-Stenzel , Kevin P. Cusack , Eric C. Breinlinger , Graham K. Ansell , Robert H. Stoffel
IPC分类号: A61K31/4245 , C07D271/06 , A61K31/4439 , A61K31/5377 , A61P37/00 , C07D413/14 , A61K31/4985 , C07D487/04 , A61K31/4725 , A61P25/00 , C07D491/052 , A61K31/454 , C07D413/02
CPC分类号: C07D271/07 , C07D271/06 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
摘要翻译: 新型恶二唑化合物,含有这些化合物的药物组合物以及这些化合物或组合物作为G蛋白偶联受体的S1P家族的激动剂或拮抗剂用于治疗与调节S1P家族受体活性有关的疾病的用途,特别是通过提供有益的免疫抑制 效果被公开。
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公开(公告)号:US20090069288A1
公开(公告)日:2009-03-12
申请号:US12218364
申请日:2008-07-15
申请人: Eric C. Breinlinger , Kevin P. Cusack , Adrian D. Hobson , Bin Li , Thomas D. Gordon , Robert H. Stoffel , Grier A. Wallace , Pintipa Grongsaard , Lu Wang , Lu Wang
发明人: Eric C. Breinlinger , Kevin P. Cusack , Adrian D. Hobson , Bin Li , Thomas D. Gordon , Robert H. Stoffel , Grier A. Wallace , Pintipa Grongsaard , Lu Wang , Lu Wang
IPC分类号: A61K31/4196 , C07D249/10 , C07D403/12 , C07D261/14 , A61K31/42 , A61K31/415 , C07D231/14 , A61P35/00
CPC分类号: C07D249/10 , C07D231/14 , C07D249/06 , C07D261/14 , C07D261/18 , C07D273/02 , C07D333/36 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要: Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.
摘要翻译: 本文公开了式(I)的新化合物,其中变量如本文所定义。 式(I)的化合物可用作激酶抑制剂,因此可用于治疗某些病症和疾病,特别是炎性疾病和疾病以及增殖性疾病如癌症。
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公开(公告)号:US6054590A
公开(公告)日:2000-04-25
申请号:US261670
申请日:1999-03-03
申请人: Graham S. Poindexter , Ildiko Antal , Leah M. Giupponi , Robert H. Stoffel , Kevin Gillman , Mendi Higgins
发明人: Graham S. Poindexter , Ildiko Antal , Leah M. Giupponi , Robert H. Stoffel , Kevin Gillman , Mendi Higgins
IPC分类号: A61K31/4164 , A61K31/4166 , A61K31/4178 , A61K31/4192 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P3/04 , A61P43/00 , C07D233/70 , C07D233/72 , C07D233/74 , C07D233/76 , C07D233/78 , C07D233/84 , C07D233/86 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/10 , C07D233/32 , C07D233/48
CPC分类号: A61K31/4174 , A61K31/4166 , A61K31/4178 , C07D233/70 , C07D233/74 , C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/06
摘要: A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of phenyl derivatives of imidazolone compounds of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
摘要翻译: 已经合成了一系列NPY的非肽能拮抗剂,并且由式I的咪唑啉酮化合物的苯基衍生物组成。作为NPY诱导的进食行为的拮抗剂,这些化合物和已知的类似物被期望作为促进重量的有效的厌氧剂 损失和治疗饮食失调。
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公开(公告)号:US06348472B1
公开(公告)日:2002-02-19
申请号:US09586146
申请日:2000-06-02
IPC分类号: C07D47110
CPC分类号: C07D471/10
摘要: A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of spiroisoquinolinone derivatives of Formula I. As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
摘要翻译: 已经合成了一系列NPY的非肽能拮抗剂,并且由式I的螺异喹啉酮衍生物组成。作为NPY诱导的进食行为的拮抗剂,这些化合物和已知的类似物被期望作为有效的厌氧剂来促进体重减轻和治疗 饮食失调。
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