公开(公告)号：US20120040906A1

公开(公告)日：2012-02-16

申请号：US13202482

申请日：2010-02-26

Applicant: Afshin Samali ,  Sanjeev Gupta

Inventor： Afshin Samali ,  Sanjeev Gupta

IPC: A61K38/02 ,  C40B30/04 ,  A61K31/7105 ,  G06F19/18 ,  C12Q1/68 ,  G01N33/68 ,  A61P9/00 ,  A61P9/04 ,  C07H21/02 ,  C07K14/47

CPC classification number: C12Q1/6883 ,  C12N15/111 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2330/10 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  G16B15/00 ,  G16B20/00 ,  G16B30/00

Abstract: MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte apoptosis, it is envisaged that protein targets involved in same can be identified through specifically selected microRNAs. The microRNAs targeted are miR-351, miR-322, miR-125, miR-424 and miR-7a. Furthermore, the potential application of these identified proteins in the treatment of cardiovascular disease, in particular congestive heart failure, is disclosed.

Abstract translation: 已经显示MicroRNA严格参与控制细胞存活和细胞死亡决定。 通过鉴定涉及内质网应激诱导的心肌细胞凋亡的微小RNA，设想通过特异选择的微小RNA可以鉴定参与其中的蛋白质靶标。 靶向的miRNA是miR-351，miR-322，miR-125，miR-424和miR-7a。 此外，公开了这些鉴定的蛋白质在治疗心血管疾病，特别是充血性心力衰竭中的潜在应用。

公开(公告)号：US20130280269A1

公开(公告)日：2013-10-24

申请号：US13702649

申请日：2011-06-08

Applicant: Afshin Samali ,  Sanjeev Gupta ,  Aysawaria Deepti

Inventor： Afshin Samali ,  Sanjeev Gupta ,  Aysawaria Deepti

IPC: C12N9/12

CPC classification number: C12N9/12 ,  C07K14/47 ,  C12N5/0018 ,  C12N2501/07 ,  C12N2510/02

Abstract: The present invention relates to methods that manipulate the level of interaction between the proteins Hsp70 and IRE1α. In particular, the invention relates to methods of manipulating this interaction in order to increase protein yield, and to methods of manipulating this interaction in order to treat diseases associated with abnormal apoptotic activity, including cancer and autoimmune diseases.

Abstract translation: 本发明涉及操纵蛋白质Hsp70和IRE1α之间的相互作用水平的方法。 特别地，本发明涉及操纵该相互作用以增加蛋白质产量的方法，以及操纵该相互作用的方法以便治疗与异常凋亡活性相关的疾病，包括癌症和自身免疫性疾病。

公开(公告)号：US20230197699A1

公开(公告)日：2023-06-22

申请号：US17553995

申请日：2021-12-17

Applicant: Ronald L. Spreitzer ,  Ankur Agrawal ,  Guiyun Bai ,  Eleanor Patricia Paras Rabadam ,  Sanjeev Gupta

Inventor： Ronald L. Spreitzer ,  Ankur Agrawal ,  Guiyun Bai ,  Eleanor Patricia Paras Rabadam ,  Sanjeev Gupta

IPC: H01L25/16 ,  G01S7/481 ,  H01L23/00 ,  H01L25/075

CPC classification number: H01L25/167 ,  G01S7/481 ,  H01L24/17 ,  H01L25/0756 ,  H01L2924/12042

Abstract: Various embodiments disclosed relate to semiconductor packaging for photonic modules in LiDAR systems. The present disclosure includes semiconductor assemblies using an organic substrate interposer surface mounted to the printed circuit board, with an electronic integrated circuit die attached to the organic substrate and a photonic integrated circuit die attached to the organic substrate, wherein the electronic integrated circuit die, and the photonic integrated circuit die are electrically coupled to each other through the organic substrate interposer.

公开(公告)号：US20220390562A1

公开(公告)日：2022-12-08

申请号：US17557290

申请日：2021-12-21

Applicant: Guiyun Bai ,  Sushrutha Gujjula ,  Ronald L. Spreitzer ,  Naresh Satyan ,  David Mathine ,  Sam Khalili ,  Sanjeev Gupta ,  Eleanor Patricia Paras Rabadam ,  Ankur Agrawal ,  Kenneth Brown ,  Jonathan Doylend ,  Daniel Grodensky ,  Israel Petronius

Inventor： Guiyun Bai ,  Sushrutha Gujjula ,  Ronald L. Spreitzer ,  Naresh Satyan ,  David Mathine ,  Sam Khalili ,  Sanjeev Gupta ,  Eleanor Patricia Paras Rabadam ,  Ankur Agrawal ,  Kenneth Brown ,  Jonathan Doylend ,  Daniel Grodensky ,  Israel Petronius

IPC: G01S7/481 ,  B81B7/02 ,  G01S17/931

Abstract: Disclosed herein are microelectronics packages and methods for manufacturing the same. The microelectronics packages may include a photonic integrated circuit (PIC), an electrical integrated circuit (EIC), and an interconnect. The interconnect may connect the EIC to the PIC. The interconnect may include a plurality of paths between the EIC and the PIC and the individual paths of the plurality of paths are less than 100 micrometers long.

公开(公告)号：US20070014847A1

公开(公告)日：2007-01-18

申请号：US11480574

申请日：2006-07-05

Applicant: Salah Ahmed ,  Sivakumar Vaithiyalingam ,  Sanjeev Gupta

Inventor： Salah Ahmed ,  Sivakumar Vaithiyalingam ,  Sanjeev Gupta

IPC: A61K9/28 ,  A61K9/48 ,  A61K9/64

CPC classification number: A61K9/4816 ,  A61K9/4891

Abstract: The present invention relates to coated capsules with increased capsule shell pliability and resilience and methods of making the coated capsules. The present invention relates to methods of making coated capsules, the methods comprising applying a coating solution comprising sodium carboxymethylcellulose or sodium alginate to the exterior of a capsule to form a coating and drying the coating to produce a coated capsule.

Abstract translation: 本发明涉及具有增加的胶囊壳柔韧性和弹性的涂覆胶囊以及制备涂覆胶囊的方法。 本发明涉及制备涂覆胶囊的方法，所述方法包括将包含羧甲基纤维素钠或藻酸钠的包衣溶液施用于胶囊的外部以形成包衣并干燥该包衣以产生涂覆的胶囊。

公开(公告)号：US20060010418A1

公开(公告)日：2006-01-12

申请号：US11221447

申请日：2005-09-07

Applicant: Sanjeev Gupta ,  Ajai Kapoor ,  Ravi Shankar ,  Corvin Bazgan ,  Anthony Hoang

Inventor： Sanjeev Gupta ,  Ajai Kapoor ,  Ravi Shankar ,  Corvin Bazgan ,  Anthony Hoang

IPC: G06F9/44

CPC classification number: G06Q10/06 ,  G06Q10/0631

Abstract: A method on a computer for providing critical chain-based project management is disclosed. The method includes generating a list of sequential time periods for a project comprising a plurality of tasks and calculating a number of tasks for each time period. The method further includes generating a graphic that visually indicates the number of tasks for each time period and a priority of each task and providing the graphic to a user.

Abstract translation: 公开了一种计算机上提供关键链式项目管理的方法。 该方法包括生成包括多个任务并且计算每个时间段的任务数量的项目的连续时间段的列表。 该方法还包括生成图形，其可视地指示每个时间段的任务数量以及每个任务的优先级并将图形提供给用户。

公开(公告)号：US20110016121A1

公开(公告)日：2011-01-20

申请号：US12504527

申请日：2009-07-16

Applicant: Hemanth Sambrani ,  Rohan Monga ,  Sudharsan Vasudevan ,  Sanjeev Gupta

Inventor： Hemanth Sambrani ,  Rohan Monga ,  Sudharsan Vasudevan ,  Sanjeev Gupta

IPC: G06F17/30

CPC classification number: G06F17/30702 ,  G06F17/30867 ,  G06Q30/02

Abstract: A method and apparatus for activity-based users' interests modeling for determining relevance of the content distributed to the users is provided. Modeling of the user's interests starts by collecting information about the actions that the user performed and about the contents that were associated with the actions. That information may be used to determine how much interest the user has had in the individual subjects up to date, and to determine which subjects became more or less important to the user over time. Further processing of the information about the interests of each of the individual users in a group of users may produce characteristics indicating the interests of the group as a whole. Additional processing may generate the information reflecting relative importance of the interests of an individual user in the group to the interests of other users in the same group.

Abstract translation: 提供了一种用于基于活动的用户兴趣建模的方法和装置，用于确定分发给用户的内容的相关性。 对用户兴趣的建模首先是收集有关用户执行的操作的信息以及与操作相关联的内容。 该信息可以用于确定用户在最新的个体主题中具有多少兴趣，并且确定哪些对象随着时间对用户变得越来越重要。 关于用户组中每个用户的兴趣的信息的进一步处理可以产生表示整个组的兴趣的特征。 附加处理可以产生反映组中个别用户的兴趣的相对重要性的信息，以使同一组中的其他用户的兴趣。

公开(公告)号：US20060294108A1

公开(公告)日：2006-12-28

申请号：US11403792

申请日：2006-04-13

Applicant: Alex Adelson ,  Steven Verhoest ,  Sanjeev Gupta ,  John Heffer

Inventor： Alex Adelson ,  Steven Verhoest ,  Sanjeev Gupta ,  John Heffer

IPC: G06F17/30

CPC classification number: G06Q10/06 ,  A61B5/4833 ,  G06F19/3456

Abstract: A compliance/adherence management and automated data collection system uses a plurality of communications modalities implemented over wireless or wired communications systems for redundantly and persistently transmitting messages to and/or receiving messages from an end user for managing compliance/adherence of the end user concerning schedules and medication and treatment protocols. The system also uses wireless or wired communications modalities for automating real time collection of information from the end user concerning, for example, compliance with the schedule and/or protocol. The collected data can be remotely accessed, in real time, to monitor compliance/adherence and an end user's experiences resulting from compliance/adherence. Further, the management messages are so designed as to be highly personalized in order to achieve a more favorable response from the end user.

Abstract translation: 合规/遵守管理和自动数据收集系统使用通过无线或有线通信系统实现的多个通信模式，用于从最终用户冗余地且持续地向终端用户发送消息和/或从终端用户接收消息，以管理最终用户关于时间表的遵从/遵守 以及药物治疗方案。 该系统还使用无线或有线通信模式来自动地从最终用户实时收集关于例如遵守时间表和/或协议的信息。 收集的数据可以实时远程访问，以监控合规性/遵守情况以及由遵守/遵守导致的最终用户体验。 此外，管理消息被设计为高度个性化以便从最终用户获得更有利的响应。

公开(公告)号：US20060167177A1

公开(公告)日：2006-07-27

申请号：US10813972

申请日：2004-03-31

Applicant: Saimani Sundar ,  Vijayalakshmi Narasimhan ,  Sanjeev Gupta ,  Rajaraman Ranganathan ,  Ganga Radhakrishnan

Inventor： Saimani Sundar ,  Vijayalakshmi Narasimhan ,  Sanjeev Gupta ,  Rajaraman Ranganathan ,  Ganga Radhakrishnan

IPC: C08G18/08 ,  C08F283/04

CPC classification number: C14C11/006 ,  C08F283/006 ,  C08F283/04 ,  C08F290/06 ,  C08F290/067 ,  C08G18/10 ,  C08G18/12 ,  C08G18/4238 ,  C08G18/4277 ,  C08G18/4825 ,  C08G18/4854 ,  C08L51/08 ,  C08L53/00 ,  C09D151/08 ,  C09D153/00 ,  C09D175/04 ,  C08G18/3215 ,  C08L2666/02

Abstract: This invention describes a process to synthesize water based coating composition having polyurethane and vinyl polymers in the same backbone, which can be used as topcoat in leather. Polyurethane having iniferter groups are synthesized which is then used to incorporate vinyl monomers. The ionic groups are incorporated into PU by selecting vinyl monomers having carboxyl group. The controlled addition of the vinyl monomers is successfully achieved. Finally, it is dispersed in water to obtain the PU dispersion. The suitability of the product for coating application is evaluated on leather. The coating meets desirable protective and aesthetic demands.

Abstract translation: 本发明描述了一种在同一主干中合成具有聚氨酯和乙烯基聚合物的水性涂料组合物的方法，其可以用作皮革的面漆。 合成具有引发剂基团的聚氨酯，然后将其用于引入乙烯基单体。 通过选择具有羧基的乙烯基单体将离子基团并入PU中。 成功地实现了乙烯基单体的可控添加。 最后，将其分散在水中以获得PU分散体。 在皮革上评估了产品在涂料应用中的适用性。 涂层符合理想的保护和美观要求。

公开(公告)号：US20050229151A1

公开(公告)日：2005-10-13

申请号：US11147479

申请日：2005-06-08

Applicant: Sanjeev Gupta ,  Ajai Kapoor ,  Ravi Shankar ,  Prakash Pati ,  Subramanian Muthu ,  Anthony Hoang ,  Sridharan Chandrasekaran

Inventor： Sanjeev Gupta ,  Ajai Kapoor ,  Ravi Shankar ,  Prakash Pati ,  Subramanian Muthu ,  Anthony Hoang ,  Sridharan Chandrasekaran

IPC: G06F9/44 ,  G06Q10/00

CPC classification number: G06Q10/06 ,  G06F8/10 ,  G06F8/20 ,  G06F8/71

Abstract: A method on a computer for providing critical chain-based project management is disclosed. The method includes receiving at least one project plan for a project comprising a plurality of tasks and calculating a task priority for each of the plurality of tasks based on the at least one project plan. The method further includes receiving at least one sub-task for a first task of the plurality of tasks and assigning the at least one sub-task a task priority identical to the task priority of the first task. In one alternative, the method further includes receiving a new task priority for the first task, assigning the new task priority to the first task and assigning the new task priority to the at least one sub-task of the first task. The method may also include an interface to allow starting of sub-tasks only when the parent task is started.

Abstract translation: 公开了一种计算机上提供关键链式项目管理的方法。 所述方法包括：接收至少一个项目计划，用于包括多个任务的项目，并且基于所述至少一个项目计划来计算所述多个任务中的每一个的任务优先级。 所述方法还包括：为所述多个任务的第一任务接收至少一个子任务，并且将所述至少一个子任务分配给与所述第一任务的任务优先级相同的任务优先级。 在一个替代方案中，该方法还包括接收第一任务的新任务优先级，将新任务优先级分配给第一任​​务，并将新任务优先级分配给第一任​​务的至少一个子任务。 该方法还可以包括仅在父任务开始时允许启动子任务的接口。