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1.发明授权Focal position determining method, focal position determining apparatus, feeble light detecting apparatus and feeble light detecting method 有权焦点位置确定方法，焦点位置确定装置，微弱光检测装置和微弱光检测方法公开(公告)号：US08174686B2
公开(公告)日：2012-05-08
申请号：US12058150
申请日：2008-03-28
申请人： Akihiro Namba , Hirobumi Suzuki , Hiroshi Ishiwata
发明人： Akihiro Namba , Hirobumi Suzuki , Hiroshi Ishiwata
CPC分类号： G01N21/6458 , G02B21/244 , G02B21/245
摘要： A focal position determining method determines a focal position of an objective lens focused on an observed target region in a specimen. The focal position determining method includes measuring any one of the focal position of the objective lens at a near point and the focal position of the objective lens at a far point or both so as to determine the focal position of the objective lens focused on the observed target region based on the measured focal position.
摘要翻译： 焦点位置确定方法确定聚焦在样本中的观察目标区域上的物镜的焦点位置。 焦点位置确定方法包括测量物体在近点处的焦点位置和物镜在远点处的焦点位置中的任何一个或两者，以便确定聚焦在观察到的物体上的物镜的焦点位置 基于测量的焦点位置的目标区域。
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2.发明授权公开(公告)号：US08179597B2
公开(公告)日：2012-05-15
申请号：US12325852
申请日：2008-12-01
申请人： Akihiro Namba , Hirobumi Suzuki
发明人： Akihiro Namba , Hirobumi Suzuki
IPC分类号： G02B21/00
CPC分类号： G01N21/6458 , G02B21/0088 , G02B21/06 , G02B21/34 , G02B21/361 , G02B21/367
摘要： In a biological specimen imaging method, a biological specimen which is stored in a storing section of a substrate having plural storing sections and emitting a feeble light is imaged through an objective lens. The biological specimen imaging method includes moving any one of the substrate and the objective lens or both until the desired storing section falls within the field of view of the objective lens, measuring any one of a focal position at a near point and the focal position at a far point of the objective lens or both, determining the focal position of the objective lens focused on an observed target region in the biological specimen stored in the desired storing section based on the measured focal position, and adjusting the focal position of the objective lens to the determined focal position so as to image the biological specimen through the objective lens.
摘要翻译： 在生物样本成像方法中，通过物镜对存储在具有多个存储部分并且发出微弱光的基板的存储部分中的生物样本进行成像。 生物样本成像方法包括移动基板和物镜中的任何一个或两者，直到期望的存储部分落在物镜的视野内，测量近点处的焦点位置和焦点位置处的焦点位置 物镜的远点或两者，基于测量的焦点位置确定聚焦在存储在所需存储部分中的生物样本中的观察目标区域上的物镜的焦点位置，并且调整物镜的焦点位置 到确定的焦点位置，以便通过物镜对生物样本进行成像。
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公开(公告)号：US20100227316A1
公开(公告)日：2010-09-09
申请号：US12159198
申请日：2006-12-26
申请人： Hirobumi Suzuki , Yoko Ohashi , Chiaki Sato , Morinao Fukuoka , Akihiro Namba
发明人： Hirobumi Suzuki , Yoko Ohashi , Chiaki Sato , Morinao Fukuoka , Akihiro Namba
CPC分类号： G01N21/6458 , G02B21/0088
摘要： There is provided a novel luminescence measuring apparatus that enables measuring a luminescence amount or a luminescence intensity from plural living biological samples, such as tissues, cells, and biological individuals, into which a gene expressing a luminescent protein has been introduced, individually for the respective biological samples. The inventive luminescence measuring apparatus comprises an image acquisition portion that acquires a luminescence image of biological samples; a measurement region determination portion that determines at least one measurement region in the luminescence image; and a luminescence measurement portion that measures the luminescence amount or luminescence intensity in the determined measurement region; thereby measuring the luminescence amount or luminescence intensity individually by the biological sample(s) included in the measurement region. Irrespective of an efficiency of transfer of a luminescent protein gene into a cell, etc., it becomes possible to execute a luminescence measurement successfully while observing only biological samples having a gene expression.
摘要翻译： 提供了一种新颖的发光测量装置，其能够分别测量来自已经引入了表达发光蛋白质的基因的多个生物体生物样品（例如组织，细胞和生物个体）的发光量或发光强度 生物样品。 本发明的发光测量装置包括获取生物样品的发光图像的图像获取部分; 确定所述发光图像中的至少一个测量区域的测量区域确定部分; 以及测量所测定的测定区域的发光量或发光强度的发光测定部， 从而通过测量区域中包含的生物样品分别测量发光量或发光强度。 无论将发光蛋白质基因转移到细胞等中的效率如何，可以在仅观察具有基因表达的生物样品的同时成功地进行发光测定。
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4.发明授权公开(公告)号：US08465709B2
公开(公告)日：2013-06-18
申请号：US12851096
申请日：2010-08-05
申请人： Mitsuo Harada , Akihiro Namba , Morinao Fukuoka
发明人： Mitsuo Harada , Akihiro Namba , Morinao Fukuoka
IPC分类号： B01L3/00
CPC分类号： G02B21/33 , Y10T29/49826 , Y10T436/25
摘要： There is provided a retention mechanism for an immersion medium, for use in a device which observes/measures a sample by use of an immersion objective lens, includes a member which retains the immersion medium near a tip portion of the objective lens, wherein the member is configured to include at least first and second materials.
摘要翻译： 提供了一种用于浸没介质的保持机构，用于通过使用浸入式物镜观察/测量样品的装置，包括将浸没介质保持在物镜的末端部分附近的构件，其中构件 被配置为至少包括第一和第二材料。
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公开(公告)号：US20060109546A1
公开(公告)日：2006-05-25
申请号：US11290225
申请日：2005-11-30
申请人： Akihiro Namba , Ryuji Sawada
发明人： Akihiro Namba , Ryuji Sawada
IPC分类号： G02B21/06
CPC分类号： G01N21/76 , G01N21/6458 , G02B21/0076
摘要： A measuring apparatus includes a confocal optical microscopy, an excitation light source unit that emits excitation light for generating fluorescence from a fluorescent material, and a light-receiving unit. The confocal optical microscope includes an excitation light input port for taking in excitation light from the excitation light source unit, and an output port for outputting fluorescence generated by the excitation light. The light-receiving unit includes an input portion for taking in signal light containing fluorescence from the confocal optical microscope. An input portion of the light-receiving unit is optically connected to the output port of the confocal optical microscope through an optical fiber.
摘要翻译： 测量装置包括共焦光学显微镜，发射用于从荧光材料产生荧光的激发光的激发光源单元和光接收单元。 共焦光学显微镜包括用于从激发光源单元获取激发光的激发光输入端口和用于输出由激发光产生的荧光的输出端口。 光接收单元包括用于从共聚焦光学显微镜摄取含有荧光的信号光的输入部。 光接收单元的输入部分通过光纤与共焦光学显微镜的输出端口光学连接。
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公开(公告)号：US08797522B2
公开(公告)日：2014-08-05
申请号：US13701399
申请日：2011-07-01
申请人： Akihiro Namba , Fujio Onishi , Yasushi Terui
发明人： Akihiro Namba , Fujio Onishi , Yasushi Terui
摘要： To enable measurement over a wide dynamic range from weak light quantity to strong light quantity in a light quantity detection device for detecting the light quantity, a detection signal from a photon counting light detector is A/D converted. When the A/D converted detection signal has a preset threshold value or more, the detection signal is transmitted as it is to a number-of-photons calculation circuit in a subsequent stage, and when the detection signal has the threshold value or less, threshold value processing for transmitting a preset reference value to the subsequent stage is performed. In the number-of-photons calculation circuit, the number of photons or the light quantity incident on the photon counting light detector is acquired from the dimension of an acquired detection signal waveform until the light quantity measurement ends.
摘要翻译： 为了在用于检测光量的光量检测装置中的弱光量到强光量的宽动态范围内进行测量，来自光子计数光检测器的检测信号被A / D转换。 当A / D转换的检测信号具有预设的阈值或更大时，检测信号被原样发送到下一级中的光子数计算电路，并且当检测信号具有阈值或更小时， 执行用于将预设参考值发送到后级的阈值处理。 在光子数计算电路中，从所获取的检测信号波形的尺寸获取入射到光子计数光检测器上的光子数或光量直到光量测量结束。
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公开(公告)号：US20130114073A1
公开(公告)日：2013-05-09
申请号：US13701399
申请日：2011-07-01
申请人： Akihiro Namba , Fujio Onishi , Yasushi Terui
发明人： Akihiro Namba , Fujio Onishi , Yasushi Terui
IPC分类号： G01J1/44
摘要： To enable measurement over a wide dynamic range from weak light quantity to strong light quantity in a light quantity detection device for detecting the light quantity, a detection signal from a photon counting light detector is A/D converted. When the A/D converted detection signal has a preset threshold value or more, the detection signal is transmitted as it is to a number-of-photons calculation circuit in a subsequent stage, and when the detection signal has the threshold value or less, threshold value processing for transmitting a preset reference value to the subsequent stage is performed. In the number-of-photons calculation circuit, the number of photons or the light quantity incident on the photon counting light detector is acquired from the dimension of an acquired detection signal waveform until the light quantity measurement ends.
摘要翻译： 为了在用于检测光量的光量检测装置中的弱光量到强光量的宽动态范围内进行测量，来自光子计数光检测器的检测信号被A / D转换。 当A / D转换的检测信号具有预设的阈值或更大时，检测信号被原样发送到下一级中的光子数计算电路，并且当检测信号具有阈值或更小时， 执行用于将预设参考值发送到后级的阈值处理。 在光子数计算电路中，从所获取的检测信号波形的尺寸获取入射到光子计数光检测器上的光子数或光量直到光量测量结束。
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公开(公告)号：US20100321060A1
公开(公告)日：2010-12-23
申请号：US12816684
申请日：2010-06-16
申请人： Yoji Nishio , Yutaka Uematsu , Hideki Oosaka , Akihiro Namba , Satoshi Nakamura
发明人： Yoji Nishio , Yutaka Uematsu , Hideki Oosaka , Akihiro Namba , Satoshi Nakamura
IPC分类号： H03K19/003
CPC分类号： H03K19/003
摘要： In a signal transmission system, performing signal transmission via signal interconnections 4-1 to 4-3 between a memory 1 and a memory controller 2 mounted on a printed circuit board 3, noise or jitter may tend to be increased in the memory 1 and in the memory controller 2 at a specified data rate due to interconnection length resonance. Registers 6-1 and 6-2 are provided to hold information on the data rate. These registers 6-1 and 6-2 are provided in the signal transmission system along with a control system that modifies the relationship between clock frequency and interconnection length. The data rate or the propagation delay time is controlled to allow for avoiding the resonance.
摘要翻译： 在信号传输系统中，通过安装在印刷电路板3上的存储器1和存储器控制器2之间的信号互连4-1至4-3执行信号传输，在存储器1中可能倾向于增加噪声或抖动 存储器控制器2由于互连长度共振而以指定的数据速率。 提供寄存器6-1和6-2以保存关于数据速率的信息。 这些寄存器6-1和6-2与调制时钟频率和互连长度之间的关系的控制系统一起提供在信号传输系统中。 控制数据速率或传播延迟时间以避免共振。
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公开(公告)号：US07716811B2
公开(公告)日：2010-05-18
申请号：US11588866
申请日：2006-10-27
申请人： Takateru Seki , Akihiro Namba , Hideo Yamakura , Takahiro Noji
发明人： Takateru Seki , Akihiro Namba , Hideo Yamakura , Takahiro Noji
CPC分类号： G11B5/3166 , G11B5/102 , G11B5/3169 , G11B5/3173 , Y10T29/49032 , Y10T29/49037 , Y10T29/49041 , Y10T29/49046 , Y10T29/49048 , Y10T29/49052 , Y10T29/49798
摘要： Head elements are formed on a wafer to suppress deterioration in pinning strength of a pinned layer, which is caused by ESD generated during air bearing surface polishing of a thin film magnetic head. The wafer is cut into rovers in each of which are connected head elements. Rover air bearing surfaces are polished until an MR elements attain a predetermined height. A final polishing step finishes air bearing surfaces by applying an electroconductive polishing liquid to achieve a predetermined shape and surface roughness with high accuracy. A pinning defect occurrence rate is reduced by suppressing deterioration in pinning strength of a pinned layer of a read element. To achieve this, a specific resistance of the electroconductive polishing liquid is controlled to 5 GΩ·cm or less. A shallow rail and a deep rail are formed on the air bearing surfaces, and the rover is cut into thin film magnetic heads.
摘要翻译： 头元件形成在晶片上以抑制由薄膜磁头的空气轴承表面抛光期间产生的ESD引起的被钉扎层的钉扎强度的劣化。 将晶片切割成每个都连接的头元件的流动站。 流动车空气轴承表面被抛光直到MR元件达到预定高度。 最终的抛光步骤通过施加导电研磨液来完成空气轴承表面，以高精度实现预定的形状和表面粗糙度。 通过抑制读取元件的被钉扎层的钉扎强度的劣化来降低钉扎缺陷发生率。 为了达到这个目的，将导电研磨液的电阻值控制在5G＆OHgr·cm以下。 在空气轴承表面上形成浅轨和深轨，并将流动车切成薄膜磁头。
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公开(公告)号：US07294996B2
公开(公告)日：2007-11-13
申请号：US11511295
申请日：2006-08-29
申请人： Akihiro Namba
发明人： Akihiro Namba
CPC分类号： G01R31/022
摘要： The characteristic evaluating system of the present invention includes: a cable-driving transmitter transmitting a signal to one end of a cable to be measured; a load connected to the other end of the cable; a probe detecting a common mode current of the cable; a receiver receiving a signal detected by the probe; and a controller controlling the cable-driving transmitter, the load, and the receiver. The cable-driving transmitter is constructed such that a plural transmission condition is selectable when transmitting the signal. The load is constructed such that plural termination conditions corresponding to the signals transmitted to the cable is selectable. The characteristic of the cable is measured by scanning relative positions of the probe and the cable in a longitudinal direction of the cable.
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