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    Process for preparing optically active carboxylic acids and antipode esters thereof
    2.
    发明授权
    Process for preparing optically active carboxylic acids and antipode esters thereof 失效
    光学活性羧酸及其对映体酯的制备方法

    公开(公告)号：US4629701A

    公开(公告)日：1986-12-16

    申请号：US627093

    申请日：1984-07-02

    申请人： Akihiro Sakimae ,  Yuri Kagawa ,  Ryozo Numazawa ,  Hisao Onishi

    发明人： Akihiro Sakimae ,  Yuri Kagawa ,  Ryozo Numazawa ,  Hisao Onishi

    IPC分类号： C12P11/00 ,  C12P41/00

    CPC分类号： C12P41/00 ,  C12P11/00

    摘要： Organic carboxylic acid ester represented by the formula (II): ##STR1## wherein R.sub.1 is an alkyl, an aralkyl or an aryl group; R.sub.2 is an alkyl group; R.sub.3 is an alkyl group; n is 1 or 2, are synthesized in racemic form, and then the acid ester (II) is treated with a source containing enzyme capable of rearranging with or without asymmetrically hydrolyzing ester bond until either a d-form or 1-form optically active carboxylic acid ester represented by the formula (II) with or without the antipode acid thereof is produced.

    摘要翻译： 由式（II）表示的有机羧酸酯：其中R 1是烷基，芳烷基或芳基; R2是烷基; R3是烷基; n为1或2，以外消旋形式合成，然后用含有酶的酶处理酸酯（II），其能够或不具有不对称水解的酯键重排，直到d型或1-型光学活性羧基 制备了具有或不具有对映体酸的由式（II）表示的酸酯。

    Method of producing hyaluronic acid
    3.
    发明授权
    Method of producing hyaluronic acid 失效
    生产透明质酸的方法

    公开(公告)号：US4885244A

    公开(公告)日：1989-12-05

    申请号：US104219

    申请日：1987-10-05

    申请人： Takao Miyamori ,  Ryozo Numazawa ,  Akihiro Sakimae ,  Hisao Onishi

    发明人： Takao Miyamori ,  Ryozo Numazawa ,  Akihiro Sakimae ,  Hisao Onishi

    IPC分类号： C12P19/04 ,  C08B37/08 ,  C12N1/20 ,  C12P19/26 ,  C12R1/46

    CPC分类号： C08B37/0072 ,  C12P19/26 ,  Y10T436/188

    摘要： High molecular weight hyaluronic acid can be efficiently produced by incorporating one or more compounds having at least one aromatic ring to which one or more hydroxyl groups are attached into a medium for producing hyaluronic acid by a bacterium capable of producing hyaluronic acid. By using this method, a sufficient amount of hyaluronic acid can be easily obtained without decomposing the high molecular structure of hyaluronic acid so that the process for isolating and purifying hyaluronic acid from the medium can be simplified.

    摘要翻译： 高分子量透明质酸可以通过将一种或多种具有至少一个芳环的化合物（其中一个或多个羟基被连接到用于产生透明质酸的细菌的培养基中）而被能够产生透明质酸的细菌产生。 通过使用该方法，可以容易地获得足够量的透明质酸，而不会分解透明质酸的高分子结构，从而可以简化从培养基中分离和纯化透明质酸的方法。

    Process for the preparation of l-proline derivatives
    6.
    发明授权
    Process for the preparation of l-proline derivatives 失效
    制备脯氨酸衍生物的方法

    公开(公告)号：US5473081A

    公开(公告)日：1995-12-05

    申请号：US181168

    申请日：1994-01-13

    申请人： Yoshimasa Kobayashi ,  Kaori Tosa ,  Akihiro Sakimae ,  Ryozo Numazawa

    发明人： Yoshimasa Kobayashi ,  Kaori Tosa ,  Akihiro Sakimae ,  Ryozo Numazawa

    IPC分类号： C07D207/16 ,  C07D207/12

    CPC分类号： C07D207/16

    摘要： An L-proline derivative represented by: ##STR1## wherein R.sub.2 represents a lower alkyl group is prepared by reacting L-proline with a D-.alpha.-alkyl-.beta.-acylthiopropionic acid halide, ##STR2## wherein R.sub.1 represents an acyl group, X represents a halogen atom and R.sub.2 has the same meaning as defined above. The halide is added to an aqueous medium containing L-proline and a condensation agent for deacidification. The halide and L-proline are reacted while the reaction temperature and pH are maintained at 12.degree. C. or lower and within a range of 10.5-11.5, whereby a compound represented by: ##STR3## wherein R.sub.1 and R.sub.2 have the same meanings as defined above is obtained. The resulting compound is then subjected to deacylation under strong alkaline conditions without being isolated from the reaction mixture, thereby yielding the target L-proline derivative.

    摘要翻译： 由下式表示的L-脯氨酸衍生物：其中R2表示低级烷基，其通过L-脯氨酸与D-α-烷基-β-酰基硫代丙酰卤反应来制备，其中R1表示酰基，X 表示卤素原子，R2表示与上述相同的含义。 将卤化物加入到含有L-脯氨酸和用于脱酸的缩合剂的水性介质中。 使卤化物和L-脯氨酸反应，同时将反应温度和pH保持在12℃或更低并且在10.5-11.5的范围内，由此得到由下式表示的化合物：其中R1和R2具有相同的含义 获得上述定义。 然后将所得化合物在强碱性条件下进行脱酰基，而不从反应混合物中分离，从而得到目标L-脯氨酸衍生物。