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57 条记录 (耗时 0.034 秒)

    Agent for Treatment of Eye Diseases
    1.
    发明申请
    Agent for Treatment of Eye Diseases 有权
    眼部疾病治疗药物

    公开(公告)号：US20140148416A1

    公开(公告)日：2014-05-29

    申请号：US13876596

    申请日：2011-09-30

    申请人： Akira Kakizuka ,  Seiji Hori ,  Hanako Ikeda ,  Nagahisa Yoshimura ,  Noriko Nakano ,  Toshiyuki Shudo ,  Tomohiro Fuchigami

    发明人： Akira Kakizuka ,  Seiji Hori ,  Hanako Ikeda ,  Nagahisa Yoshimura ,  Noriko Nakano ,  Toshiyuki Shudo ,  Tomohiro Fuchigami

    IPC分类号： C07D213/76

    CPC分类号： C07D213/76 ,  A61K31/4418 ,  C07D213/77

    摘要： The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) wherein R is as defined in the description.

    摘要翻译： 本发明提供了有效治疗眼睛疾病的药剂，包含它们的药物组合物，用于治疗眼部疾病的药物的制备方法，包括使用该药剂，制备用于治疗眼部疾病的药物的用途以及治疗眼部疾病的方法的用途，所述方法包括 给药或药物组合物。 通过本发明治疗的眼部疾病特别包括青光眼，特别是正常的紧张性青光眼或色素性视网膜炎。 本发明提供其中R如说明书中所定义的式（I）化合物。

    Agent for treatment of eye diseases
    2.
    发明授权
    Agent for treatment of eye diseases 有权
    眼病治疗药

    公开(公告)号：US09206129B2

    公开(公告)日：2015-12-08

    申请号：US13876596

    申请日：2011-09-30

    申请人： Akira Kakizuka ,  Seiji Hori ,  Hanako Ikeda ,  Nagahisa Yoshimura ,  Noriko Nakano ,  Toshiyuki Shudo ,  Tomohiro Fuchigami

    发明人： Akira Kakizuka ,  Seiji Hori ,  Hanako Ikeda ,  Nagahisa Yoshimura ,  Noriko Nakano ,  Toshiyuki Shudo ,  Tomohiro Fuchigami

    IPC分类号： C07D213/76 ,  A61K31/4418 ,  C07D213/77

    CPC分类号： C07D213/76 ,  A61K31/4418 ,  C07D213/77

    摘要： The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) wherein R is as defined in the description.

    摘要翻译： 本发明提供了有效治疗眼睛疾病的药剂，包含它们的药物组合物，用于治疗眼部疾病的药物的制备方法，包括使用该药剂，制备用于治疗眼部疾病的药物的用途以及治疗眼部疾病的方法的用途，所述方法包括 给药或药物组合物。 通过本发明治疗的眼部疾病特别包括青光眼，特别是正常的紧张性青光眼或色素性视网膜炎。 本发明提供其中R如说明书中所定义的式（I）化合物。

    Webbing take-up device
    5.
    发明授权
    Webbing take-up device 有权
    织带收卷装置

    公开(公告)号：US08662435B2

    公开(公告)日：2014-03-04

    申请号：US12849551

    申请日：2010-08-03

    申请人： Yoshiaki Maekubo ,  Seiji Hori

    发明人： Yoshiaki Maekubo ,  Seiji Hori

    IPC分类号： B60R22/28 ,  B60R22/34

    CPC分类号： B60R22/3413 ,  B60R2022/287

    摘要： Assembling performance of a torsion bar to a spool is improved. When a webbing take-up device is assembled, the torsion bar is inserted into the spool while catch projections of a serration pillar of the torsion bar are corresponded to insertion grooves of an insertion hole of the spool. Subsequently, in a state where the serration pillar of the torsion bar arrives at an catch hole of the spool, the torsion bar is rotated in a winding direction with respect to the spool, so that the catch projections are caught by catch surfaces of catch grooves of the catch hole, whereby the torsion bar is made non-removable from the spool. Therefore, a direction in which the torsion bar is assembled to the spool is made to be only an axial direction of the spool, and assembling performance of the torsion bar to the spool can be improved.

    摘要翻译： 扭杆对卷轴的组装性能得到改善。 当组装卷带装置时，扭杆被插入卷轴中，而扭杆的锯齿柱的卡止突起与卷轴的插入孔的插入槽对应。 随后，在扭杆的锯齿柱到达卷轴的卡止孔的状态下，扭杆相对于卷轴沿卷绕方向旋转，使得卡合突起被捕获槽的卡止表面卡住 从而使扭杆从阀芯不可移除。 因此，将扭杆组装到卷轴上的方向仅被制成为卷轴的轴向方向，并且可以提高扭杆对卷轴的组装性能。

    CYCLIC AMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE
    6.
    发明申请
    CYCLIC AMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE 审中-公开
    周期性化合物及其在治疗疾病中的应用

    公开(公告)号：US20130267532A1

    公开(公告)日：2013-10-10

    申请号：US13885727

    申请日：2011-11-18

    申请人： Shinya Tosaki ,  Seiji Hori

    发明人： Shinya Tosaki ,  Seiji Hori

    IPC分类号： C07D403/10

    CPC分类号： C07D403/10

    摘要： The invention concerns compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein n, R1 and R2 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, novel intermediates useful in the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of disease, for example cancer.

    摘要翻译： 本发明涉及式（I）的化合物：（I）及其药学上可接受的盐，其中n，R 1和R 2如说明书中所定义。 本发明还涉及制备这些化合物的方法，可用于制备这些化合物的新型中间体，含有它们的药物组合物及其在治疗疾病例如癌症中的用途。

    SILICONE-TYPE PRESSURE-SENSITIVE ADHESIVE COMPOSITION, PRESSURE-SENSITIVE ADHESIVE SHEET, AND SILICONE RUBBER LAMINATE
    7.
    发明申请
    SILICONE-TYPE PRESSURE-SENSITIVE ADHESIVE COMPOSITION, PRESSURE-SENSITIVE ADHESIVE SHEET, AND SILICONE RUBBER LAMINATE 失效
    硅胶压敏粘合剂组合物，压敏粘合片和硅橡胶层压板

    公开(公告)号：US20100285312A1

    公开(公告)日：2010-11-11

    申请号：US12810584

    申请日：2008-12-25

    申请人： Haruna Mizuno ,  Seiji Hori ,  Takateru Yamada

    发明人： Haruna Mizuno ,  Seiji Hori ,  Takateru Yamada

    IPC分类号： B32B27/04 ,  C08K5/04 ,  C08K5/56

    CPC分类号： C08L83/04 ,  C08G77/12 ,  C08G77/16 ,  C08G77/18 ,  C08G77/20 ,  C08G2170/40 ,  C08L83/00 ,  C09J183/04 ,  Y10T428/2852 ,  Y10T428/31663

    摘要： A silicone-type pressure-sensitive adhesive composition comprising (A) 100 weight parts of organopolysiloxane condensation reaction product that has at least two alkenyl groups and that is yielded by a condensation reaction between (a) hydroxyl-functional diorganopolysiloxane and (b) organopolysiloxane resin, (B) organohydrogenpolysiloxane having at least two silicon-bonded hydrogen atoms in the molecule, in an amount sufficient to provide from 1 to 200 silicon-bonded hydrogen atoms with reference to all the alkenyl groups in the composition, (C) an organotitanium compound, at from 0.1 to 20 weight parts, and (D) a platinum catalyst in a catalytic quantity.

    摘要翻译： 一种硅氧烷型压敏粘合剂组合物，其包含（A）100重量份的具有至少两个烯基的有机聚硅氧烷缩合反应产物，并且通过（a）羟基官能的二有机聚硅氧烷和（b）有机聚硅氧烷树脂之间的缩合反应 ，（B）分子中具有至少两个与硅键合的氢原子的有机氢聚硅氧烷，其量足以提供与组合物中所有烯基相关的1〜200个与硅键合的氢原子，（C）有机钛化合物 ，0.1〜20重量份，（D）催化剂量的铂催化剂。

    Pretensioner
    8.
    发明授权
    Pretensioner 有权
    预紧器

    公开(公告)号：US06454199B1

    公开(公告)日：2002-09-24

    申请号：US09531007

    申请日：2000-03-20

    申请人： Seiji Hori ,  Tomonori Nagata

    发明人： Seiji Hori ,  Tomonori Nagata

    IPC分类号： B65H7548

    CPC分类号： B60R22/4633 ,  B60R2022/468

    摘要： There is provided a pretensioner which can as a whole be made smaller. A rack and pinion type pretensioner is disposed outside a second leg plate of a webbing take-up device. A driving mechanism of the pretensioner includes, as principal components, a piston formed as a rack bar, and a pinion. The pinion includes a toothed portion and a clutch portion, and is directly connected to a winding shaft. Accordingly, as compared with a conventional system in which intermediate gears are disposed between the pinion and the rack bar, the pretensioner can as a whole be made smaller both in radial and axial directions thereof.

    摘要翻译： 提供了一个可以整体缩小的预张紧器。 齿条和小齿轮型预张紧器布置在织带卷绕装置的第二腿板的外侧。 预紧器的驱动机构包括形成为齿杆的活塞和小齿轮作为主要部件。 小齿轮包括齿形部分和离合器部分，并且直接连接到卷绕轴。 因此，与将中间齿轮配置在小齿轮和齿条之间的常规系统相比，预紧器整体上可以在其径向和轴向上都变小。

    Gear mechanism and webbing retractor
    9.
    发明授权
    Gear mechanism and webbing retractor 失效
    齿轮机构和织带牵引器

    公开(公告)号：US5816523A

    公开(公告)日：1998-10-06

    申请号：US598843

    申请日：1996-02-09

    申请人： Seiji Hori

    发明人： Seiji Hori

    IPC分类号： B60R22/44 ,  B60R22/34 ,  B60R22/38 ,  B60R22/48 ,  F16H27/08

    CPC分类号： F16H27/08 ,  B60R22/34 ,  B60R22/48 ,  B60R2022/4825

    摘要： A gear mechanism for reducing a rotational speed of a driving gear and transferring the reduced rotational speed to a gear to be driven comprises an arbitrary number of gear teeth attached to the driving gear and smaller than the number of teeth determined by a module and a stopper having a stopper surface which is attached to the driving gear so as to be displaced relative to said gear teeth along the axial direction of the driving gear and which draws a circle identical in size to a circle drawn by a locus of rotation of an addendum of each gear tooth upon rotation of the driving gear and meshes with gear teeth of the driven gear upon disengagement of the gear teeth from the teeth of the driven gear so that the rotation of the driven gear is controlled by the stopper. Thus, when the gear teeth are in disengagement with the teeth of the driven gear, the stopper is maintained in meshing engagement with the gear teeth of the driven gear so as to prevent the driven gear from rotating.

    摘要翻译： 用于减小驱动齿轮的旋转速度并将降低的转速传递到待驱动齿轮的齿轮机构包括附接到驱动齿轮的任意数量的齿轮，并且小于由模块和止动件确定的齿数 具有止动器表面，该止动表面附接到驱动齿轮，以便沿着驱动齿轮的轴向方向相对于所述齿轮齿移动，并且将尺寸相等的圆圈与由附录 当齿轮齿与从动齿轮的齿分离时，驱动齿轮旋转时的每个齿轮齿与从动齿轮的齿轮啮合，使得从动齿轮的转动由止动器控制。 因此，当齿轮齿与从动齿轮的齿脱离时，止动件保持与从动齿轮的齿轮啮合，从而防止从动齿轮旋转。

    Room-temperature-curable silicone elastomer composition
    10.
    发明授权
    Room-temperature-curable silicone elastomer composition 失效
    室温固化硅橡胶组合物

    公开(公告)号：US5705587A

    公开(公告)日：1998-01-06

    申请号：US791306

    申请日：1997-01-30

    申请人： Hidekatsu Hatanaka ,  Seiji Hori

    发明人： Hidekatsu Hatanaka ,  Seiji Hori

    IPC分类号： C08L83/06 ,  C08K5/5415 ,  C08L83/04 ,  C09K3/10 ,  C08G77/18

    CPC分类号： C08L83/04 ,  C08G77/14 ,  C08G77/16 ,  Y10S528/901

    摘要： A room-temperature-curable silicone elastomer composition obtained from diorganopolysiloxane that is endblocked by silanol at both molecular chain terminals and diorganopolysiloxane that is endblocked at one molecular chain terminal by silanol and at the other terminal by trialkylsiloxy; an alkoxy functional silane; an organopolysiloxane resin; a curing catalyst; and a diorganopolysiloxane that contains at least 2 carboxyl groups. The room-temperature-curable silicone elastomer composition has an excellent pre-cure workability and cures into a low-modulus, high-elongation silicone elastomer.

    摘要翻译： 由分子链末端的硅烷醇封端的二有机聚硅氧烷获得的室温可固化的硅氧烷弹性体组合物和在一个分子链末端被硅烷醇封端，另一个末端被三烷基甲硅烷氧基封端的二有机聚硅氧烷; 烷氧基官能的硅烷; 有机聚硅氧烷树脂; 固化催化剂; 和含有至少2个羧基的二有机聚硅氧烷。 室温可固化的硅氧烷弹性体组合物具有优异的预固化可加工性并固化成低模量，高伸长率的硅氧烷弹性体。