利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

34 条记录 (耗时 0.023 秒)

    METHOD FOR EFFECTIVE SEARCH FOR TARGET MOLECULE
    4.
    发明申请
    METHOD FOR EFFECTIVE SEARCH FOR TARGET MOLECULE 审中-公开
    有效搜索目标分子的方法

    公开(公告)号：US20090042318A1

    公开(公告)日：2009-02-12

    申请号：US11814986

    申请日：2006-01-26

    申请人： Akito Tanaka ,  Akira Yamazaki ,  Masayuki Haramura

    发明人： Akito Tanaka ,  Akira Yamazaki ,  Masayuki Haramura

    IPC分类号： G01N33/545

    CPC分类号： G01N33/54393 ,  B01J20/3227 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3285 ,  G01N33/54306

    摘要： The present invention provides a solid phase carrier capable of adsorbing a highly hydrophobic target molecule, for example, a membrane associated protein, and a solid phase carrier optimized not only for a highly hydrophobic target molecule, but also for an optionally chosen target molecule. More specifically, the present invention provides a solid phase carrier having a ligand and a capping agent immobilized thereon, with the hydrophobic property of the surface thereof adjusted to enable the binding of the target molecule to the ligand, or to increase the amount of target molecule bound to the ligand; various methods using the solid phase carrier (for example, method of concentrating, isolating, or purifying a target molecule, a method of selectively adsorbing a particular target molecule to the solid phase carrier, or a method of analyzing the interaction between ligand and target molecule therefor); a production method for the solid phase carrier; and an improvement method for a solid phase carrier having a ligand and a capping agent immobilized thereon and the like.

    摘要翻译： 本发明提供了能够吸附高度疏水的靶分子例如膜相关蛋白的固相载体，以及不仅对于高度疏水的靶分子而且优选任选地选择的靶分子优化的固相载体。 更具体地说，本发明提供一种具有固定在其上的配体和封端剂的固相载体，其表面的疏水性被调节以使靶分子与配体结合，或增加靶分子的量 与配体结合; 使用固相载体的各种方法（例如，浓缩，分离或纯化靶分子的方法，将特定靶分子选择性吸附到固相载体上的方法或分析配体与靶分子之间的相互作用的方法 为此） 一种固相载体的制备方法; 以及其上固定有配体和封端剂等的固相载体的改进方法。

    Novel target protein of anticancer agent and novel anticancer agent (spnal) corresponding thereto
    5.
    发明申请
    Novel target protein of anticancer agent and novel anticancer agent (spnal) corresponding thereto 失效
    抗癌剂的新型靶蛋白和与其对应的新型抗癌剂（spnal）

    公开(公告)号：US20070082955A1

    公开(公告)日：2007-04-12

    申请号：US10573166

    申请日：2004-11-30

    申请人： Akito Tanaka ,  Akira Yamazaki ,  Takeshi Tsutsumi ,  Tomohiro Terada ,  Masayuki Haramura

    发明人： Akito Tanaka ,  Akira Yamazaki ,  Takeshi Tsutsumi ,  Tomohiro Terada ,  Masayuki Haramura

    IPC分类号： A61K31/192 ,  C07C321/24 ,  G01N33/53

    CPC分类号： C07D231/12 ,  A61K45/06 ,  C07C317/44 ,  C07C323/62

    摘要： The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound that specifically binds to KSRP or a functional fragment thereof, and a screening method for the compound. KSRP is a novel target protein for anticancer agents; a compound capable of regulating the expression and activity of such a protein and a pharmaceutical composition containing it are highly useful for proliferative diseases, particularly as anticancer agents. By providing the novel target protein, the mechanism behind the anticancer effect that has conventionally been unexplainable can be elucidated.

    摘要翻译： 本发明提供含有与KSRP或其功能片段特异性结合的化合物作为活性成分的药物组合物和该化合物的筛选方法。 KSRP是抗癌剂的新型靶蛋白; 能够调节这种蛋白质的表达和活性的化合物和含有该蛋白质的药物组合物对于增殖性疾病，特别是作为抗癌剂是非常有用的。 通过提供新的靶蛋白，可以阐明通常不可解释的抗癌作用背后的机制。

    NOVEL TARGET PROTEIN OF ANTICANCER AGENT AND NOVEL ANTICANCER AGENT (SPNAL) CORRESPONDING THERETO
    6.
    发明申请
    NOVEL TARGET PROTEIN OF ANTICANCER AGENT AND NOVEL ANTICANCER AGENT (SPNAL) CORRESPONDING THERETO 审中-公开
    新药抗体药剂和新型抗感染药物（SPNAL）相关药物的新目标蛋白

    公开(公告)号：US20110189789A1

    公开(公告)日：2011-08-04

    申请号：US12632905

    申请日：2009-12-08

    申请人： Akito Tanaka ,  Akira Yamazaki ,  Takeshi Tsutsumi ,  Tomohiro Terada ,  Masayuki Haramura

    发明人： Akito Tanaka ,  Akira Yamazaki ,  Takeshi Tsutsumi ,  Tomohiro Terada ,  Masayuki Haramura

    IPC分类号： G01N33/53

    CPC分类号： C07D231/12 ,  A61K45/06 ,  C07C317/44 ,  C07C323/62

    摘要： The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound that specifically binds to KSRP or a functional fragment thereof, and a screening method for the compound. KSRP is a novel target protein for anticancer agents; a compound capable of regulating the expression and activity of such a protein and a pharmaceutical composition containing it are highly useful for proliferative diseases, particularly as anticancer agents. By providing the novel target protein, the mechanism behind the anticancer effect that has conventionally been unexplainable can be elucidated.

    摘要翻译： 本发明提供含有与KSRP或其功能片段特异性结合的化合物作为活性成分的药物组合物和该化合物的筛选方法。 KSRP是抗癌剂的新型靶蛋白; 能够调节这种蛋白质的表达和活性的化合物和含有该蛋白质的药物组合物对于增殖性疾病，特别是作为抗癌剂是非常有用的。 通过提供新的靶蛋白，可以阐明通常不可解释的抗癌作用背后的机制。

    Target protein of anticancer agent and novel anticancer agent (spnal) corresponding thereto
    8.
    发明授权
    Target protein of anticancer agent and novel anticancer agent (spnal) corresponding thereto 失效
    抗癌剂的靶蛋白和与其对应的新型抗癌剂（spnal）

    公开(公告)号：US07659426B2

    公开(公告)日：2010-02-09

    申请号：US10573166

    申请日：2004-11-30

    申请人： Akito Tanaka ,  Akira Yamazaki ,  Takeshi Tsutsumi ,  Tomohiro Terada ,  Masayuki Haramura

    发明人： Akito Tanaka ,  Akira Yamazaki ,  Takeshi Tsutsumi ,  Tomohiro Terada ,  Masayuki Haramura

    IPC分类号： A01N41/10

    CPC分类号： C07D231/12 ,  A61K45/06 ,  C07C317/44 ,  C07C323/62

    摘要： The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound that specifically binds to KSRP or a functional fragment thereof, and a screening method for the compound. KSRP is a novel target protein for anticancer agents; a compound capable of regulating the expression and activity of such a protein and a pharmaceutical composition containing it are highly useful for proliferative diseases, particularly as anticancer agents. By providing the novel target protein, the mechanism behind the anticancer effect that has conventionally been unexplainable can be elucidated.

    摘要翻译： 本发明提供含有与KSRP或其功能片段特异性结合的化合物作为活性成分的药物组合物和该化合物的筛选方法。 KSRP是抗癌剂的新型靶蛋白; 能够调节这种蛋白质的表达和活性的化合物和含有该蛋白质的药物组合物对于增殖性疾病，特别是作为抗癌剂是非常有用的。 通过提供新的靶蛋白，可以阐明通常不可解释的抗癌作用背后的机制。

    Method of inhibiting nonspecific interaction between molecules on solid phase support
    9.
    发明申请
    Method of inhibiting nonspecific interaction between molecules on solid phase support 有权
    抑制固相载体上分子之间非特异性相互作用的方法

    公开(公告)号：US20060177943A1

    公开(公告)日：2006-08-10

    申请号：US10522716

    申请日：2003-07-30

    申请人： Akito Tanaka ,  Tomohiro Terada ,  Tsuruki Tamura ,  Takaaki Shiyama ,  Akira Yamazaki ,  Minoru Furuya ,  Masayuki Haramura

    发明人： Akito Tanaka ,  Tomohiro Terada ,  Tsuruki Tamura ,  Takaaki Shiyama ,  Akira Yamazaki ,  Minoru Furuya ,  Masayuki Haramura

    IPC分类号： G01N33/543 ,  C07C229/64

    CPC分类号： C08G65/33396 ,  G01N33/54393

    摘要： The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.

    摘要翻译： 本发明提供了抑制分子之间非特异性相互作用的方法，其特征在于在将分子固定在固相载体上并分析分子与与固相分子特异性相互作用的分子之间的特异性相互作用的方法 调节固相载体中固相表面的疏水性，特别是在将分子固定在固相载体上时，亲水间隔物被嵌入，该方法可以抑制分子之间的非特异性相互作用 ，并减少对固相的非特异性吸附。

    Solid support having ligand immobilized thereon by using photocleavable linker
    10.
    发明授权
    Solid support having ligand immobilized thereon by using photocleavable linker 有权
    通过使用可光致发光的接头，其上固定有配体的固体支持物

    公开(公告)号：US07456022B2

    公开(公告)日：2008-11-25

    申请号：US11572972

    申请日：2005-07-28

    申请人： Masayuki Haramura ,  Akito Tanaka

    发明人： Masayuki Haramura ,  Akito Tanaka

    IPC分类号： B01J20/26 ,  G01N33/547

    CPC分类号： B01J20/289 ,  B01J20/261 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/54 ,  G01N33/54353 ,  Y10T436/207497

    摘要： The present invention provides a method of analyzing the interaction between a ligand and a target molecule, which uses a solid support wherein the ligand is immobilized via a linker cleavable by photoirradiation, particularly a method of searching and purifying a target molecule. By intervening a linker specifically cleavable by photoirradiation between the ligand molecule and the solid support, release and elution of the target molecule from the solid support without using a ligand or salt at a high concentration can be enabled, and suppression of release and elution of a nonspecific protein can be enabled.

    摘要翻译： 本发明提供了一种分析配体和靶分子之间的相互作用的方法，其使用固体支持物，其中通过光照射可切割的接头固定配体，特别是搜索和纯化靶分子的方法。 通过插入通过配体分子和固体支持体之间的光照射可以特异性地切割的接头，可以使得目标分子从固体支持物中释放和洗脱而不使用高浓度的配体或盐，并且抑制释放和洗脱 可以启用非特异性蛋白质。