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8 条记录 (耗时 0.032 秒)

    Method of immobilizing compound on solid phase support
    1.
    发明申请
    Method of immobilizing compound on solid phase support 失效
    将化合物固定在固相载体上的方法

    公开(公告)号：US20060024845A1

    公开(公告)日：2006-02-02

    申请号：US10533237

    申请日：2003-10-31

    申请人： Akito Tanaka ,  Tomohiro Terada ,  Akira Yamazaki ,  Tsuruki Tamura ,  Hidenori Nakajima

    发明人： Akito Tanaka ,  Tomohiro Terada ,  Akira Yamazaki ,  Tsuruki Tamura ,  Hidenori Nakajima

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54353 ,  B01D15/3804 ,  B01J20/286 ,  B01J20/289 ,  G01N2500/00 ,  Y10S436/823 ,  Y10S436/824

    摘要： The present invention provides a method of analyzing the specific interaction between a molecule to be analyzed and a molecule that specifically interacts with the former molecule on a solid phase using a molecule-immobilized solid phase support mixture prepared by binding the subject molecule to the solid phase support without specifying the binding position on the molecule side, particularly a method wherein the immobilization is conducted via a spacer introduced to the molecule without specifying the binding position on the molecule side, which method makes it possible to identify and select only a molecule that exhibits a specific interaction with a molecule to be analyzed, without an investigation of structure-activity correlation, which has conventionally been essential, and hence enables an analysis of the interaction between these molecules.

    摘要翻译： 本发明提供了一种分析待分析分子与在固相上与前一分子特异性相互作用的分子之间的特异性相互作用的方法，其中所述分子固定的固相支持混合物是通过将受试分子与固相结合而制备的 特别是一种方法，其中通过分子引入的间隔物进行固定，而不指定分子侧的结合位置，该方法使得可以仅鉴定和选择表现出分子侧的结合位置的分子， 与待分析的分子的特异性相互作用，而不具有传统上必需的结构 - 活性相关性的研究，因此能够分析这些分子之间的相互作用。

    Method of immobilizing compound on solid phase support
    2.
    发明授权
    Method of immobilizing compound on solid phase support 失效
    将化合物固定在固相载体上的方法

    公开(公告)号：US07645614B2

    公开(公告)日：2010-01-12

    申请号：US10533237

    申请日：2003-10-31

    申请人： Akito Tanaka ,  Tomohiro Terada ,  Akira Yamazaki ,  Tsuruki Tamura ,  Hidenori Nakajima

    发明人： Akito Tanaka ,  Tomohiro Terada ,  Akira Yamazaki ,  Tsuruki Tamura ,  Hidenori Nakajima

    IPC分类号： G01N33/53

    CPC分类号： G01N33/54353 ,  B01D15/3804 ,  B01J20/286 ,  B01J20/289 ,  G01N2500/00 ,  Y10S436/823 ,  Y10S436/824

    摘要： The present invention provides a method of analyzing the specific interaction between a molecule to be analyzed and a molecule that specifically interacts with the former molecule on a solid phase using a molecule-immobilized solid phase support mixture prepared by binding the subject molecule to the solid phase support without specifying the binding position on the molecule side, particularly a method wherein the immobilization is conducted via a spacer introduced to the molecule without specifying the binding position on the molecule side, which method makes it possible to identify and select only a molecule that exhibits a specific interaction with a molecule to be analyzed, without an investigation of structure-activity correlation, which has conventionally been essential, and hence enables an analysis of the interaction between these molecules.

    摘要翻译： 本发明提供了一种分析待分析分子与在固相上与前一分子特异性相互作用的分子之间的特异性相互作用的方法，其中所述分子固定的固相支持混合物是通过将受试分子与固相结合而制备的 特别是一种方法，其中通过分子引入的间隔物进行固定，而不指定分子侧的结合位置，该方法使得可以仅鉴定和选择表现出分子侧的结合位置的分子， 与待分析的分子的特异性相互作用，而不具有传统上必需的结构 - 活性相关性的研究，因此能够分析这些分子之间的相互作用。

    Method of inhibiting nonspecific interaction between molecules on solid phase support
    5.
    发明申请
    Method of inhibiting nonspecific interaction between molecules on solid phase support 有权
    抑制固相载体上分子之间非特异性相互作用的方法

    公开(公告)号：US20060177943A1

    公开(公告)日：2006-08-10

    申请号：US10522716

    申请日：2003-07-30

    申请人： Akito Tanaka ,  Tomohiro Terada ,  Tsuruki Tamura ,  Takaaki Shiyama ,  Akira Yamazaki ,  Minoru Furuya ,  Masayuki Haramura

    发明人： Akito Tanaka ,  Tomohiro Terada ,  Tsuruki Tamura ,  Takaaki Shiyama ,  Akira Yamazaki ,  Minoru Furuya ,  Masayuki Haramura

    IPC分类号： G01N33/543 ,  C07C229/64

    CPC分类号： C08G65/33396 ,  G01N33/54393

    摘要： The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.

    摘要翻译： 本发明提供了抑制分子之间非特异性相互作用的方法，其特征在于在将分子固定在固相载体上并分析分子与与固相分子特异性相互作用的分子之间的特异性相互作用的方法 调节固相载体中固相表面的疏水性，特别是在将分子固定在固相载体上时，亲水间隔物被嵌入，该方法可以抑制分子之间的非特异性相互作用 ，并减少对固相的非特异性吸附。

    Molecule detecting method, molecule counting method, molecule localization detecting method, and molecule detecting device used for them
    6.
    发明申请
    Molecule detecting method, molecule counting method, molecule localization detecting method, and molecule detecting device used for them 审中-公开
    分子检测方法，分子计数法，分子定位检测法，分子检测装置等

    公开(公告)号：US20060216814A1

    公开(公告)日：2006-09-28

    申请号：US10553747

    申请日：2004-04-16

    申请人： Teruyuki Kobayashi ,  Noriyuki Nakayama ,  Tsuruki Tamura ,  Munsok Kim

    发明人： Teruyuki Kobayashi ,  Noriyuki Nakayama ,  Tsuruki Tamura ,  Munsok Kim

    IPC分类号： C12M1/34 ,  B05D3/02

    CPC分类号： G01Q30/04 ,  G01N33/543

    摘要： The present invention relates to a molecular detection method in which a chain molecule immobilized on a substrate is visualized and identified by probing with a scanning probe microscope in solution. Furthermore, the present invention relates to a system for detecting a chain molecule immobilized on a substrate, the system being equipped with a jig for holing the substrate, a container housing the substrate and a solution, a probe, a probe detector, a drive mechanism for scanning the substrate or the probe in three dimensions, and a drive control circuit for controlling the drive mechanism. In accordance with the present invention, a chain molecule immobilized on a substrate can be detected clearly, which has been difficult conventionally.

    摘要翻译： 本发明涉及一种分子检测方法，其中固定在基质上的链分子通过用扫描探针显微镜在溶液中探测而显现和鉴定。 此外，本发明涉及一种用于检测固定在基板上的链分子的系统，该系统配备有用于使基板进行孔的夹具，容纳基底的容器和溶液，探针，探针检测器，驱动机构 用于三维扫描基板或探针，以及用于控制驱动机构的驱动控制电路。 根据本发明，可以清楚地检测固定在基板上的链分子，这在传统上是困难的。

    DRUG TARGET PROTEIN AND TARGET GENE, AND SCREENING METHOD
    8.
    发明申请
    DRUG TARGET PROTEIN AND TARGET GENE, AND SCREENING METHOD 审中-公开
    药物靶标蛋白和目标基因，筛选方法

    公开(公告)号：US20090136482A1

    公开(公告)日：2009-05-28

    申请号：US12065303

    申请日：2006-09-01

    申请人： Yorimasa Suwa ,  Tadakazu Yamauchi ,  Morikazu Kito ,  Yuko Isono ,  Tsuruki Tamura ,  Motoi Tobita

    发明人： Yorimasa Suwa ,  Tadakazu Yamauchi ,  Morikazu Kito ,  Yuko Isono ,  Tsuruki Tamura ,  Motoi Tobita

    IPC分类号： A61K39/395 ,  G01N33/00 ,  C12Q1/68 ,  G01N33/566 ,  A61K38/02 ,  A61K31/7088 ,  A61K31/7105

    CPC分类号： G01N33/68 ,  A61K45/06 ,  C07K14/47 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/6845 ,  G01N33/94 ,  G01N2500/00 ,  Y10T436/143333

    摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. More specifically, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.

    摘要翻译： 本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。 更具体地，本发明提供用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂 生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。