公开(公告)号：US4917698A

公开(公告)日：1990-04-17

申请号：US290001

申请日：1988-12-22

申请人： Alain Carpentier ,  Hung L. Lam ,  Than Nguyen

发明人： Alain Carpentier ,  Hung L. Lam ,  Than Nguyen

IPC分类号： A61F2/24

CPC分类号： A61F2/2448

摘要： A ring prosthesis which provides different flexibilities at various points about the circumference of an associated heart valve. Specifically, the annuloplasty ring prosthesis of the invention includes a segmented body formed by two or more segments. The individual segments form a body which is substantially circular and shaped proportional to fit about the annulus of the associated heart valve. The individual segments are held in position with respect to each by a flexible joint. This flexible joint is formed by covering the segments with a flexible material which fits snugly about the segments. The cover is tied off between the adjacent segments to further restrain movement of the segments with respect to each other.

公开(公告)号：US08034104B2

公开(公告)日：2011-10-11

申请号：US12889223

申请日：2010-09-23

申请人： Alain Carpentier ,  Hung L. Lam

发明人： Alain Carpentier ,  Hung L. Lam

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2/24 ,  A61F2/2403 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2230/0008 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0095

摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase. For example, the flow orifice may be elliptical. A relatively wide sewing ring has a contoured inflow end and is attached to the base structure in such a way that the valve can be implanted in an intra-atrial position and the taller commissures do not extend too far into the left ventricle, therefore avoiding injury to the ventricle.

摘要翻译： 解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。 心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。 另外两个较小的小叶围绕阀的后部延伸。 为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。 较大的传单可以比其他两个传单更厚和/或更强。 基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。 例如，流动孔口可以是椭圆形的。 相对宽的缝合环具有轮廓流入端，并且以这样的方式附接到基部结构，使得瓣膜可以植入心房内的位置，并且更高的连合部不会延伸到太远的左心室，因此避免受伤 到脑室

公开(公告)号：US5104407A

公开(公告)日：1992-04-14

申请号：US587486

申请日：1990-09-20

申请人： Hung L. Lam ,  Than Nguyen ,  Alain Carpentier

发明人： Hung L. Lam ,  Than Nguyen ,  Alain Carpentier

IPC分类号： A61F2/00 ,  A61F2/24

CPC分类号： A61F2/2448 ,  A61F2250/0018

摘要： An annuloplasty ring prosthesis which is formed from a selectively flexible body element having at least one defined length about its circumference which is substantially rigid. The remainder of the body element gradually increases in flexibility. The body element is a substantially annular shaped body element which is designed to be sutured to the annulus of a heart valve. The body element is formed from a non-corrosive, anti-magnetic material, and is wrapped in a material through which sutures can be drawn to suture the prosthesis to the heart valve annulus.

摘要翻译： 瓣膜成形术假体由选择性柔性的身体元件形成，该身体元件具有围绕其圆周的至少一个限定长度，其基本上是刚性的。 身体元素的其余部分的灵活性逐渐增加。 身体元件是被设计成被缝合到心脏瓣膜的环的基本环形的身体元件。 身体元件由非腐蚀性的抗磁性材料形成，并且被包裹在材料中，通过该材料可以将缝线拉出以将假体缝合到心脏瓣膜环。

公开(公告)号：US08728264B2

公开(公告)日：2014-05-20

申请号：US12599501

申请日：2008-04-28

申请人： Antoine Capel ,  Alain Carpentier ,  Marion Melot

发明人： Antoine Capel ,  Alain Carpentier ,  Marion Melot

IPC分类号： B29C51/10 ,  B29C51/12

CPC分类号： A61F2/2415 ,  A61L27/34 ,  A61L31/10 ,  Y10T428/3154 ,  C08L27/18

摘要： Disclosed is a method for producing a hemocompatible article. A non-thermally stabilized polytetrafluoroethylene membrane comprised of non-oriented fibers is heated to a temperature of around 400° C. and above the gel point of the polytetrafluoroethylene, while the membrane is being applied against a forming mold. The membrane is applied against the forming mold by generating a pressure differential between opposing faces of the membrane to form a conformed membrane. The conformed membrane is then cooled, thereby producing the hemocompatible article.

摘要翻译： 公开了一种生产血液兼容制品的方法。 将包含非取向纤维的非热稳定化聚四氟乙烯膜加热至约400℃和高于聚四氟乙烯凝胶点的温度，同时将膜施加到成形模上。 通过在膜的相对面之间产生压差来形成膜，从而将膜施加到成形模上。 然后将合适的膜冷却，从而产生血液兼容制品。

公开(公告)号：US20120089226A1

公开(公告)日：2012-04-12

申请号：US12812588

申请日：2009-01-07

申请人： Marc Grimme ,  Jean-Elie Gourgues ,  Alain Carpentier ,  Claude Wartelle

发明人： Marc Grimme ,  Jean-Elie Gourgues ,  Alain Carpentier ,  Claude Wartelle

IPC分类号： A61M1/10

CPC分类号： A61M1/106 ,  A61M1/1005 ,  A61M1/1037 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122

摘要： Implantable one-piece heart prosthesis. According to the invention, the prosthesis comprises a main hydraulic actuator (13t) arranged between the artificial ventricles (2 and 8) and designed to actuate, with desired flow rates, one (8) of said artificial ventricles, and also an auxiliary hydraulic actuator (7t) designed to correct the diastolic and systolic flow rates of the other (2) of said ventricles.

摘要翻译： 可植入的单件心脏假体。 根据本发明，假体包括设置在人造心室（2和8）之间的主液压致动器（13t），其被设计成以期望的流速驱动一个（8）所述人造心室，以及辅助液压致动器 （7t）设计用于校正其他（2）所述心室的舒张和收缩流量。

公开(公告)号：US20090192607A1

公开(公告)日：2009-07-30

申请号：US12304443

申请日：2007-06-11

申请人： Marc Grimme ,  Maurice Koechler ,  Jean-Marc Parquet ,  Alain Carpentier

发明人： Marc Grimme ,  Maurice Koechler ,  Jean-Marc Parquet ,  Alain Carpentier

IPC分类号： A61M1/10

CPC分类号： A61M1/106 ,  A61M1/1037 ,  A61M1/12 ,  A61M1/122

摘要： One-piece heart prosthesis implantable in an anatomical position. According to the invention, the artificial left and right ventricles (2,8) have general directions (14, 15) arranged in an asymmetrical V shape, such that said ventricles approach each other as they move away from the means (6, 12) of connection to the natural left and right auricles, and the individual hydraulic actuators (7, 13), associated respectively with said artificial left and light ventricles (2, 8), are arranged near each other, in proximity to said artificial left ventricle (2).

摘要翻译： 一体式心脏假体可植入解剖位置。 根据本发明，人造左心室和右心室具有布置成不对称V形的一般方向（14,15），使得所述心室在离开装置（6,12）时相互接近， 与所述天然左右耳廓的连接以及与所述人造左心室和所述轻心室（2,8）分别相关联的各个液压致动器（7,13）彼此靠近所述人造左心室 2）。

公开(公告)号：US20090157176A1

公开(公告)日：2009-06-18

申请号：US12028714

申请日：2008-02-08

申请人： Alain Carpentier ,  David Adams

发明人： Alain Carpentier ,  David Adams

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2445 ,  A61F2230/0034 ,  A61F2230/0065 ,  A61F2250/0018 ,  A61F2250/0037 ,  Y10T29/49

摘要： A set of annuloplasty rings progressively sized to take into account more of the common pathologies. The proportional shapes of each ring as the orifice size changes vary. For instance, the larger rings have larger minor axis dimensions relative to their major axis dimensions.

摘要翻译： 一组瓣环成形术环的尺寸逐渐增大，以考虑更多的常见病理。 每个环的比例形状随孔径尺寸的变化而变化。 例如，较大的环相对于其长轴尺寸具有较大的短轴尺寸。

公开(公告)号：US20070255423A1

公开(公告)日：2007-11-01

申请号：US11744614

申请日：2007-05-04

申请人： Alain Carpentier ,  Sophie Carpentier ,  Crystal Cunanan ,  Lillian Quintero ,  Michael Helmus ,  Christine Loshbaugh ,  H. Chris Sarner

发明人： Alain Carpentier ,  Sophie Carpentier ,  Crystal Cunanan ,  Lillian Quintero ,  Michael Helmus ,  Christine Loshbaugh ,  H. Chris Sarner

IPC分类号： A61F2/02

CPC分类号： A61L27/3691 ,  A61L2/0088 ,  A61L27/3604 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3687 ,  A61L33/12 ,  A61L2400/02 ,  A61L2430/40 ,  Y10S623/901 ,  Y10S623/915 ,  Y10S623/917 ,  Y10S623/92

摘要： A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.

摘要翻译： 一种用于固定生物组织的方法，以及通过这种方法制备的生物假体装置。 该方法通常包括以下步骤：A）固定组织，B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织，C）制备或形成生物假体（例如，形成 组织并附着任何非生物成分）和D）使生物假体进行终末灭菌。

公开(公告)号：US5972020A

公开(公告)日：1999-10-26

申请号：US801129

申请日：1997-02-14

申请人： Alain Carpentier ,  Charles S. Taylor

发明人： Alain Carpentier ,  Charles S. Taylor

IPC分类号： A61B17/00 ,  A61B17/02 ,  A61B17/34 ,  A61F2/24 ,  A61B17/28

CPC分类号： A61B17/3421 ,  A61B2017/00243 ,  A61B2017/0243 ,  A61B2017/3445 ,  A61B2017/3449 ,  A61B2017/3488 ,  A61F2/2427

摘要： The invention is an apparatus and method to perform a surgical procedure within the beating heart. The instrument provides a seal to surround cardiac tissue, thereby defining a segregated surgical field within the body of the instrument. A suction device is preferred to remove blood and fluids from the surgical field so that a surgical procedure can be performed while the heart continues to beat. The instrument is particularly suitable for a procedure to repair defective or diseased cardiac valves, such as the mitral valve; a procedure which previously required that the heart be stopped so that the corrective surgical procedure could be performed.

摘要翻译： 本发明是一种在搏动心脏内执行外科手术的装置和方法。 仪器提供围绕心脏组织的密封，从而在仪器体内限定分离的外科视野。 抽吸装置优选从外科手术区域移除血液和流体，使得可以在心脏继续击打时进行外科手术。 该仪器特别适用于修复有缺陷或患病的心脏瓣膜如二尖瓣的手术; 以前需要停止心脏以便可以执行矫正外科手术的程序。

公开(公告)号：US5961550A

公开(公告)日：1999-10-05

申请号：US894513

申请日：1997-08-21

申请人： Alain Carpentier ,  Vincent Garitey ,  Michel Hassler

发明人： Alain Carpentier ,  Vincent Garitey ,  Michel Hassler

IPC分类号： A61F2/24

CPC分类号： A61F2/2403

摘要： An activating system is provided for a heart valve having a seat (1) and at least one pivoting flap (2a, 2b) mounted on the seat (1). The activating system includes at least one mobile magnetic element (4) connected with said flap (2a, 2b) and at least one fixed magnetic element (3) on the seat (1), with the magnetic elements (3, 4) producing interacting fields that create a force which is exerted on said flap (2a, 2b) during its opening and/or closing movements.

摘要翻译： PCT No.PCT / FR97 / 00312 Sec。 371日期1997年8月21日 102（e）日期1997年8月21日PCT 1997年2月20日PCT PCT。 公开号WO97 / 30658 日本1997年8月28日提供了一种用于具有座椅（1）和安装在座椅（1）上的至少一个枢转翼片（2a，2b）的心脏瓣膜的活动系统。 所述激活系统包括与所述翼片（2a，2b）连接的至少一个移动磁性元件（4）和所述座椅（1）上的至少一个固定磁性元件（3），所述磁性元件（3,4）产生相互作用 在其打开和/或关闭运动期间产生施加在所述翼片（2a，2b）上的力的场。