公开(公告)号：US5104407A

公开(公告)日：1992-04-14

申请号：US587486

申请日：1990-09-20

申请人： Hung L. Lam ,  Than Nguyen ,  Alain Carpentier

发明人： Hung L. Lam ,  Than Nguyen ,  Alain Carpentier

IPC分类号： A61F2/00 ,  A61F2/24

CPC分类号： A61F2/2448 ,  A61F2250/0018

摘要： An annuloplasty ring prosthesis which is formed from a selectively flexible body element having at least one defined length about its circumference which is substantially rigid. The remainder of the body element gradually increases in flexibility. The body element is a substantially annular shaped body element which is designed to be sutured to the annulus of a heart valve. The body element is formed from a non-corrosive, anti-magnetic material, and is wrapped in a material through which sutures can be drawn to suture the prosthesis to the heart valve annulus.

摘要翻译： 瓣膜成形术假体由选择性柔性的身体元件形成，该身体元件具有围绕其圆周的至少一个限定长度，其基本上是刚性的。 身体元素的其余部分的灵活性逐渐增加。 身体元件是被设计成被缝合到心脏瓣膜的环的基本环形的身体元件。 身体元件由非腐蚀性的抗磁性材料形成，并且被包裹在材料中，通过该材料可以将缝线拉出以将假体缝合到心脏瓣膜环。

公开(公告)号：US4917698A

公开(公告)日：1990-04-17

申请号：US290001

申请日：1988-12-22

申请人： Alain Carpentier ,  Hung L. Lam ,  Than Nguyen

发明人： Alain Carpentier ,  Hung L. Lam ,  Than Nguyen

IPC分类号： A61F2/24

CPC分类号： A61F2/2448

摘要： A ring prosthesis which provides different flexibilities at various points about the circumference of an associated heart valve. Specifically, the annuloplasty ring prosthesis of the invention includes a segmented body formed by two or more segments. The individual segments form a body which is substantially circular and shaped proportional to fit about the annulus of the associated heart valve. The individual segments are held in position with respect to each by a flexible joint. This flexible joint is formed by covering the segments with a flexible material which fits snugly about the segments. The cover is tied off between the adjacent segments to further restrain movement of the segments with respect to each other.

公开(公告)号：US06231602B1

公开(公告)日：2001-05-15

申请号：US09293215

申请日：1999-04-16

申请人： Alain Carpentier ,  Hung Ly Lam ,  Than Nguyen

发明人： Alain Carpentier ,  Hung Ly Lam ,  Than Nguyen

IPC分类号： A61F224

CPC分类号： A61F2/2445

摘要： An infra-annular annuloplasty prosthesis is disclosed including a flexibly semi-rigid frame, a portion of which is shaped to conform to the scalloped configuration of the normal circumference of an arterial heart valve annulus. Axially projecting legs spaced circumferentially to correspond to the location of tissue adjacent to the valve commissures are provided for support and anchoring of the annulus-conforming portion to the dense fibrous tissues adjacent each commissure. The prosthesis includes a one-or two-part frame having scalloped upper and lower edges defining peaks and valleys. The upper edge is shaped to follow the contour of the tissue underneath the valve leaflets, and thus supports the leaflets and aortic wall from below. The lower edge is similarly scallop-shaped, but with less pronounced peaks and valleys than the upper edge, and is thus shaped to conform to the aortic annulus shape and provide support directly thereto.

摘要翻译： 公开了一种环形瓣膜成形术假体，其包括柔性半刚性框架，其一部分成形为符合动脉心脏瓣膜环的正常圆周的扇形构型。 提供沿圆周方向间隔开的轴向突出的腿部，以对应于邻近瓣膜连合处的组织的位置，用于支撑并将环形部分锚固到邻近每个连合处的致密纤维组织。 假体包括具有扇形上下边缘的一个或两个部分的框架，其限定了峰和谷。 上边缘成形为跟随瓣叶下面的组织轮廓，从而从下方支撑传单和主动脉壁。 下边缘类似于扇形，但是具有比上边缘更不明显的峰和谷，并且因此被成形为符合主瓣环形状并直接向其提供支撑。

公开(公告)号：US06217610B1

公开(公告)日：2001-04-17

申请号：US09124657

申请日：1998-07-29

申请人： Alexandre Carpentier ,  Alain Carpentier ,  Hung Lam ,  Than Nguyen ,  Van Le Huynh ,  Crystal Cunanan

发明人： Alexandre Carpentier ,  Alain Carpentier ,  Hung Lam ,  Than Nguyen ,  Van Le Huynh ,  Crystal Cunanan

IPC分类号： A61F224

CPC分类号： A61F2/2448 ,  A61F2250/0004 ,  A61F2250/0082

摘要： An expandable annuloplasty ring which may either expand spontaneously, in situ, as the patient grows or be expanded by surgical intervention by balloon dilatation. The distensible annuloplasty ring of the invention may be usable in pediatric patients whose growth, subsequent to surgical implantation of the ring, will necessitate subsequent enlargement of the ring to accommodate growth of the annulus. The ring may include relatively expandable segments to enable the enlargement thereof. The ring segments may include engaging teeth which cooperate with notches or slots formed in the tubes to provide some resistance to ring distention, while preventing collapse of the ring in the opposite direction. The teeth may be of different sizes or shapes to regulate the amount of force needed to expand the ring at different stages of the patient's growth. Alternatively, the adjustable ring includes a solid core of non-elastic material which plastically retains its shape upon natural expansion of the annulus, or after surgical expansion. In one embodiment, segments are coupled together with a discontinuity around the ring periphery. Pivot regions are provided between adjacent segments that, along with the discontinuity, enable the ring to expand upon annulus growth. The discontinuity may be positioned along the anterior side of the ring or around the posterior side. A further version makes use of telescoped segments with no discontinuity. The segments are coupled together with tubular sheaths, and expand without decoupling. A fabric covering may be omitted.

摘要翻译： 可膨胀的瓣环成形术环，当患者通过球囊扩张的外科手术生长或扩大时，可以自发扩张。 本发明的可扩张瓣环成形术环可用于儿科患者，其生长在环的手术植入之后将需要随后的扩大环以适应环的生长。 环可以包括相对可扩展的部分，以使其能够扩大。 环段可以包括与形成在管中的凹口或槽配合的接合齿，以提供一定阻力的环膨胀，同时防止环在相反方向上的塌陷。 牙齿可以具有不同的尺寸或形状以调节在患者生长的不同阶段扩张环所需的力的量。 或者，可调环包括非弹性材料的实心芯，其在环的自然膨胀时塑性地保持其形状，或者在手术扩张之后。 在一个实施例中，段围绕环外围以不连续的方式耦合在一起。 在相邻段之间提供枢轴区域，随着不连续性，环可以在环形增长时扩张。 不连续性可以沿着环的前侧或者在后侧周围定位。 另一个版本使用无间断的伸缩部分。 这些节段与管状护套耦合在一起，并且在没有解耦的情况下膨胀。 可以省略织物覆盖物。

公开(公告)号：US08034104B2

公开(公告)日：2011-10-11

申请号：US12889223

申请日：2010-09-23

申请人： Alain Carpentier ,  Hung L. Lam

发明人： Alain Carpentier ,  Hung L. Lam

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2/24 ,  A61F2/2403 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2230/0008 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0095

摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase. For example, the flow orifice may be elliptical. A relatively wide sewing ring has a contoured inflow end and is attached to the base structure in such a way that the valve can be implanted in an intra-atrial position and the taller commissures do not extend too far into the left ventricle, therefore avoiding injury to the ventricle.

摘要翻译： 解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。 心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。 另外两个较小的小叶围绕阀的后部延伸。 为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。 较大的传单可以比其他两个传单更厚和/或更强。 基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。 例如，流动孔口可以是椭圆形的。 相对宽的缝合环具有轮廓流入端，并且以这样的方式附接到基部结构，使得瓣膜可以植入心房内的位置，并且更高的连合部不会延伸到太远的左心室，因此避免受伤 到脑室

公开(公告)号：US08728264B2

公开(公告)日：2014-05-20

申请号：US12599501

申请日：2008-04-28

申请人： Antoine Capel ,  Alain Carpentier ,  Marion Melot

发明人： Antoine Capel ,  Alain Carpentier ,  Marion Melot

IPC分类号： B29C51/10 ,  B29C51/12

CPC分类号： A61F2/2415 ,  A61L27/34 ,  A61L31/10 ,  Y10T428/3154 ,  C08L27/18

摘要： Disclosed is a method for producing a hemocompatible article. A non-thermally stabilized polytetrafluoroethylene membrane comprised of non-oriented fibers is heated to a temperature of around 400° C. and above the gel point of the polytetrafluoroethylene, while the membrane is being applied against a forming mold. The membrane is applied against the forming mold by generating a pressure differential between opposing faces of the membrane to form a conformed membrane. The conformed membrane is then cooled, thereby producing the hemocompatible article.

摘要翻译： 公开了一种生产血液兼容制品的方法。 将包含非取向纤维的非热稳定化聚四氟乙烯膜加热至约400℃和高于聚四氟乙烯凝胶点的温度，同时将膜施加到成形模上。 通过在膜的相对面之间产生压差来形成膜，从而将膜施加到成形模上。 然后将合适的膜冷却，从而产生血液兼容制品。

公开(公告)号：US20120089226A1

公开(公告)日：2012-04-12

申请号：US12812588

申请日：2009-01-07

申请人： Marc Grimme ,  Jean-Elie Gourgues ,  Alain Carpentier ,  Claude Wartelle

发明人： Marc Grimme ,  Jean-Elie Gourgues ,  Alain Carpentier ,  Claude Wartelle

IPC分类号： A61M1/10

CPC分类号： A61M1/106 ,  A61M1/1005 ,  A61M1/1037 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122

摘要： Implantable one-piece heart prosthesis. According to the invention, the prosthesis comprises a main hydraulic actuator (13t) arranged between the artificial ventricles (2 and 8) and designed to actuate, with desired flow rates, one (8) of said artificial ventricles, and also an auxiliary hydraulic actuator (7t) designed to correct the diastolic and systolic flow rates of the other (2) of said ventricles.

摘要翻译： 可植入的单件心脏假体。 根据本发明，假体包括设置在人造心室（2和8）之间的主液压致动器（13t），其被设计成以期望的流速驱动一个（8）所述人造心室，以及辅助液压致动器 （7t）设计用于校正其他（2）所述心室的舒张和收缩流量。

公开(公告)号：US20090192607A1

公开(公告)日：2009-07-30

申请号：US12304443

申请日：2007-06-11

申请人： Marc Grimme ,  Maurice Koechler ,  Jean-Marc Parquet ,  Alain Carpentier

发明人： Marc Grimme ,  Maurice Koechler ,  Jean-Marc Parquet ,  Alain Carpentier

IPC分类号： A61M1/10

CPC分类号： A61M1/106 ,  A61M1/1037 ,  A61M1/12 ,  A61M1/122

摘要： One-piece heart prosthesis implantable in an anatomical position. According to the invention, the artificial left and right ventricles (2,8) have general directions (14, 15) arranged in an asymmetrical V shape, such that said ventricles approach each other as they move away from the means (6, 12) of connection to the natural left and right auricles, and the individual hydraulic actuators (7, 13), associated respectively with said artificial left and light ventricles (2, 8), are arranged near each other, in proximity to said artificial left ventricle (2).

摘要翻译： 一体式心脏假体可植入解剖位置。 根据本发明，人造左心室和右心室具有布置成不对称V形的一般方向（14,15），使得所述心室在离开装置（6,12）时相互接近， 与所述天然左右耳廓的连接以及与所述人造左心室和所述轻心室（2,8）分别相关联的各个液压致动器（7,13）彼此靠近所述人造左心室 2）。

公开(公告)号：US20090157176A1

公开(公告)日：2009-06-18

申请号：US12028714

申请日：2008-02-08

申请人： Alain Carpentier ,  David Adams

发明人： Alain Carpentier ,  David Adams

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2445 ,  A61F2230/0034 ,  A61F2230/0065 ,  A61F2250/0018 ,  A61F2250/0037 ,  Y10T29/49

摘要： A set of annuloplasty rings progressively sized to take into account more of the common pathologies. The proportional shapes of each ring as the orifice size changes vary. For instance, the larger rings have larger minor axis dimensions relative to their major axis dimensions.

摘要翻译： 一组瓣环成形术环的尺寸逐渐增大，以考虑更多的常见病理。 每个环的比例形状随孔径尺寸的变化而变化。 例如，较大的环相对于其长轴尺寸具有较大的短轴尺寸。

公开(公告)号：US20070255423A1

公开(公告)日：2007-11-01

申请号：US11744614

申请日：2007-05-04

申请人： Alain Carpentier ,  Sophie Carpentier ,  Crystal Cunanan ,  Lillian Quintero ,  Michael Helmus ,  Christine Loshbaugh ,  H. Chris Sarner

发明人： Alain Carpentier ,  Sophie Carpentier ,  Crystal Cunanan ,  Lillian Quintero ,  Michael Helmus ,  Christine Loshbaugh ,  H. Chris Sarner

IPC分类号： A61F2/02

CPC分类号： A61L27/3691 ,  A61L2/0088 ,  A61L27/3604 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3687 ,  A61L33/12 ,  A61L2400/02 ,  A61L2430/40 ,  Y10S623/901 ,  Y10S623/915 ,  Y10S623/917 ,  Y10S623/92

摘要： A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.

摘要翻译： 一种用于固定生物组织的方法，以及通过这种方法制备的生物假体装置。 该方法通常包括以下步骤：A）固定组织，B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织，C）制备或形成生物假体（例如，形成 组织并附着任何非生物成分）和D）使生物假体进行终末灭菌。